当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.

Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.

Abstract：

:Neutrophil apoptosis is a constitutive process that can be enhanced or delayed by various stimuli. In this study, the effect of brefeldin A (BFA), which affects the biological process of secretion, on constitutive and delayed apoptosis of neutrophils was investigated. Neutrophil apoptosis was determined after culturing for 20 h in vitro by morphological changes, annexin V staining, and DNA electrophoresis. BFA dose-dependently increased the constitutive apoptotic rate of neutrophils. The delay of apoptosis induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) and lipopolysaccharide (LPS) was also blocked by BFA. However, this effect of BFA was less marked when neutrophils were treated with dexamethasone, interleukin-8 (IL-8), or dibutyryl cAMP (dbcAMP). Moreover, the delay of neutrophil apoptosis induced by rottlerin, a specific inhibitor of protein kinase C (PKC)-delta, was significantly abrogated by BFA. Although BFA-induced apoptosis was not blocked by the caspase-3 inhibitor, zDEVD-fmk, myeloid cell leukemia-1 (Mcl-1) expression levels were downregulated by BFA. These results suggest that derangement of vesicular protein transport may be involved in the apoptosis of neutrophils, and that the action of BFA on apoptosis is dependent on changes in the expression of Mcl-1.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Lee MJ,Park JY,Lee SY,Lee JS,Jung DK,Bae YS,Kwak JY

doi

10.1016/S1567-5769(03)00052-3

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

835-43

issue

6

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(03)00052-3

journal_volume

3

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Distinct immunosuppressive effect by Isodon serra extracts.

    abstract：:Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS). After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.06.016

    authors： Zhang Y,Liu J,Jia W,Zhao A,Li T

    更新日期：2005-12-01 00:00:00

  • Neutrophil extracellular traps promote corneal neovascularization-induced by alkali burn.

    abstract：OBJECTIVES:To investigate the effects of neutrophil extracellular traps (NETs) on angiogenesis in vitro and in vivo and the regulatory role of mammalian target of rapamycin (mTOR) activity in it. METHODS:The regulatory role of mTOR in NETs formation was explored. In vitro, human neutrophils were pretreated with rapamy...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106902

    authors： Yuan K,Zheng J,Huang X,Zhang Y,Han Y,Hu R,Jin X

    更新日期：2020-11-01 00:00:00

  • Differential roles of constitutively activated ERK1/2 and NF-kappa B in cytotoxicity and proliferation by human NK cell lines.

    abstract：:Compared with freshly isolated peripheral blood natural killer (NK) cells, the YT and NK-92 cell lines are characterized by elevated cytolytic activity. The molecular mechanisms underlying the rapid proliferation and enhanced lytic activity of NK cell lines are poorly understood. Investigation of these cell lines reve...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.12.016

    authors： Liang S,Zhang J,Wei H,Sun R,Tian Z

    更新日期：2005-05-01 00:00:00

  • Evaluation of Poly(I:C) and combination of CpG ODN plus Montanide ISA adjuvants to enhance the efficacy of outer membrane vesicles as an acellular vaccine against Brucella melitensis infection in mice.

    abstract：:Brucellosis is the most common zoonotic disease worldwide and still there is no vaccine for human use. The commercial animal vaccines also have major problems that limit their use. Therefore, there is a need for an effective Brucella vaccine which is multivalent and produces a good protective immunity with minimal dis...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106573

    authors： Golshani M,Amani M,Amirzadeh F,Nazeri E,Davar Siadat S,Nejati-Moheimani M,Arsang A,Bouzari S

    更新日期：2020-07-01 00:00:00

  • Correlation of Tc17 cells at early stages after allogeneic hematopoietic stem cell transplantation with acute graft-versus-host disease.

    abstract：:Acute graft-versus-host disease (aGVHD) is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, IL-17-producing T cells including Th17 and Tc17 cells have been implicated in immune-related diseases. However, their roles in aGVHD remain uncertain. In the study, we analyzed IL-17-producin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.11.003

    authors： Wang L,Zhao P,Song L,Yan F,Shi C,Li Y,Han M,Lan K

    更新日期：2016-12-01 00:00:00

  • Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice.

    abstract：:Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.06.005

    authors： Amirshahrokhi K

    更新日期：2013-10-01 00:00:00

  • Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects.

    abstract：:Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects. The objective of the study is to investigate the effects of melatonin in hepatic ischemia/reperfusion (I/R) induced lung injury and explore its underlying mechanisms. Hepatic I/R injury was induced via portal vein and h...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.10.012

    authors： Zhou L,Zhao D,An H,Zhang H,Jiang C,Yang B

    更新日期：2015-12-01 00:00:00

  • Analysis of immune subtypes based on immunogenomic profiling identifies prognostic signature for cutaneous melanoma.

    abstract：:Skin cutaneous melanoma (SKCM) is the most invasive form of skin cancer with poor prognosis. Growing evidence has demonstrated that tumor immune microenvironment plays a key contributing role in tumorigenesis and predicting clinical outcomes. The aim of this study was to recognize immune classification and a reliable ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107162

    authors： Hu B,Wei Q,Zhou C,Ju M,Wang L,Chen L,Li Z,Wei M,He M,Zhao L

    更新日期：2020-12-01 00:00:00

  • NFAT-1 hyper-activation by methionine enkephalin (MENK) significantly induces cell apoptosis of rats C6 glioma in vivo and in vitro.

    abstract：:The aim of the work was to investigate the effect and possible mechanism of MENK on the growth of rat C6 glioma in vivo or in vitro. Our findings showed that MENK could inhibit the growth of rat C6 glioma, prolong median survival times in tumor-bearing rats, and induce glioma cell apoptosis. Moreover, MENK could incre...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.01.005

    authors： Lu WC,Xie H,Tie XX,Wang R,Wu AH,Shan FP

    更新日期：2018-03-01 00:00:00

  • MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway.

    abstract：BACKGROUND:Accumulating evidence has revealed the roles of microRNAs (miRs) in sepsis, hence, the aim of the present study was to investigate whether miR-208a-5p affects sepsis whilst attempting to elucidate the mechanisms by which the suppressors of cytokine signaling 2 (SOCS2)-mediated nuclear factor-kappaB/hypoxia-i...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106204

    authors： Ouyang H,Tan Y,Li Q,Xia F,Xiao X,Zheng S,Lu J,Zhong J,Hu Y

    更新日期：2020-04-01 00:00:00

  • Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock.

    abstract：:Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.07.006

    authors： Cruz EA,Da-Silva SA,Muzitano MF,Silva PM,Costa SS,Rossi-Bergmann B

    更新日期：2008-12-10 00:00:00

  • Intramolecular signal transduction by the bradykinin B2 receptor.

    abstract：:To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00167-4

    authors： Mueller S,Liebmann C,Reissmann S

    更新日期：2002-12-01 00:00:00

  • Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 via Aryl hydrocarbon receptor.

    abstract：BACKGROUND:Ambient fine particulate matter (PM2.5) could induce lung injury. Aryl hydrocarbon receptor (AhR) is involved in the molecular mechanisms of prooxidative and pro-inflammatory effect of PM2.5. Molecular hydrogen has antioxidant properties. The protective effect and mechanism of hydrogen on PM2.5-induced lung ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105939

    authors： Feng S,Duan E,Shi X,Zhang H,Li H,Zhao Y,Chao L,Zhong X,Zhang W,Li R,Yan X

    更新日期：2019-12-01 00:00:00

  • Progesterone as an immunomodulatory molecule.

    abstract：:Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens gamma/delta TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator prot...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1567-5769(01)00035-2

    authors： Szekeres-Bartho J,Barakonyi A,Par G,Polgar B,Palkovics T,Szereday L

    更新日期：2001-06-01 00:00:00

  • Berberine alleviates endothelial glycocalyx degradation and promotes glycocalyx restoration in LPS-induced ARDS.

    abstract：:In the pathogenesis of acute respiratory distress syndrome (ARDS), an increase in vascular endothelial permeability may trigger pulmonary edema and ultimately lead to respiratory failure. Endothelial glycocalyx damage is an important factor that causes an increase in vascular endothelial permeability. Berberine (BBR) ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.10.001

    authors： Huang L,Zhang X,Ma X,Zhang D,Li D,Feng J,Pan X,Lü J,Wang X,Liu X

    更新日期：2018-12-01 00:00:00

  • Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXRα.

    abstract：:Here, we investigated the role of LXRα in capsaicin mediated anti-inflammatory effects. Results revealed that capsaicin inhibits LPS-induced IL-1β, IL-6 and TNF-α production in a time- and dose-dependent manner. Moreover, capsaicin increases LXRα expression through PPARγ pathway. Inhibition of LXRα activation by siRNA...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.06.007

    authors： Tang J,Luo K,Li Y,Chen Q,Tang D,Wang D,Xiao J

    更新日期：2015-09-01 00:00:00

  • Administration of SB239063, a potent p38 MAPK inhibitor, alleviates acute lung injury induced by intestinal ischemia reperfusion in rats associated with AQP4 downregulation.

    abstract：:Acute lung injury (ALI), induced by intestinal ischemia reperfusion (II/R) injury, is characterized by pulmonary edema and inflammation. Aquaporin 4 (AQP4), has been pointed out recently involving in edema development. Previous studies have shown that p38 mitogen activated protein kinase (MAPK) activation resulted in ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.03.036

    authors： Xiong LL,Tan Y,Ma HY,Dai P,Qin YX,Yang RA,Xu YY,Deng Z,Zhao W,Xia QJ,Wang TH,Zhang YH

    更新日期：2016-09-01 00:00:00

  • Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes.

    abstract：:Interleukin-10 is a potent suppressive factor that down-regulates cellular immune response via inhibition of the production of TH1 cytokines. Histamine shifts the TH1/TH2 balance from TH1 to TH2 cytokines making the effects of histamine on IL-10 secretion an important factor in this switch. This study was designed to ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0162-3109(00)00268-x

    authors： Osna N,Elliott K,Khan MM

    更新日期：2001-01-01 00:00:00

  • Chlorogenic acid ameliorated concanavalin A-induced hepatitis by suppression of Toll-like receptor 4 signaling in mice.

    abstract：:Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.01.017

    authors： Yuan Y,Gong X,Zhang L,Jiang R,Yang J,Wang B,Wan J

    更新日期：2017-03-01 00:00:00

  • Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.

    abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.05.012

    authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

    更新日期：2014-08-01 00:00:00

  • The therapeutic potential of microbial proteasome inhibitors.

    abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.11.013

    authors： Momose I,Kawada M

    更新日期：2016-08-01 00:00:00

  • Immunomodulatory activity of analog of muramyl dipeptide and their use as adjunct to chemotherapy of Leishmania donovani in hamster.

    abstract：:In search of a potent immunomodulator to be used as an immunoprophylactic agent and as adjunct to chemotherapy against Leishmania infection, two analogs of muramyl dipeptide, viz. N.Ac-norMur-MeVal-D-isoGln (86/448) and N.AcMur-Acc-D-isoGln (89/729) were evaluated for desired activity. Effect of these peptides on cell...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.12.015

    authors： Puri A,Sahai R,Haq W,Zaidi A,Guru PY,Tripathi LM,Srivastava VM

    更新日期：2005-06-01 00:00:00

  • Primary immunosuppression with tacrolimus after liver transplantation: 12-years follow-up.

    abstract：:The early safety and efficacy of tacrolimus after liver transplantation has been shown in two multicenter trials. Herein, we report our single-center long-term follow-up of a randomized controlled trial. As part of a European multicenter trial, 121 patients entered the study at our institution and were randomly assign...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.intimp.2004.09.014

    authors： Jonas S,Neuhaus R,Junge G,Klupp J,Theruvat T,Langrehr JM,Settmacher U,Neuhaus P

    更新日期：2005-01-01 00:00:00

  • A novel chrysin thiazole derivative polarizes macrophages to an M1 phenotype via targeting TLR4.

    abstract：:Tumor-associated macrophages (TAMs) are an important cause of tumorigenesis and tumor development. M2 macrophages can promote tumor growth while M1 macrophages kill tumor cells, therefore, polarizing macrophages to achieve a functional M1 phenotype could effectively play its anti-tumor role. In the current study, we s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106986

    authors： Feng X,Yu W,Cao L,Meng F,Cong M

    更新日期：2020-11-01 00:00:00

  • Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis.

    abstract：:Paraquat is one of the most extensively used herbicides and has high toxicity for humans and animals. However, there is no effective treatment for paraquat poisoning. The aim of the present study was to evaluate the effects of chloroquine on paraquat-induced lung injury in mice. Mice received a single intraperitoneal ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.02.020

    authors： Shen H,Wu N,Wang Y,Zhao H,Zhang L,Li T,Zhao M

    更新日期：2017-05-01 00:00:00

  • ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx.

    abstract：:Monocytes recruited and adhering to the inflamed arteries are crucial for atherosclerosis development. Here, we report the role of zinc (Zn2+) homeostasis in monocyte adhesion and recruitment. By comparing the expression levels of Zn2+ transporters between non-adhering and adhering monocytes, we found that the Zn2+ im...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.06.018

    authors： Cheng G,Chang FJ,You PH,Lin J,Huang XY,Wu HY,Yan L,Deng JZ,You HJ,Sun CF

    更新日期：2018-09-01 00:00:00

  • Angiotensin II contributes to intratumoral immunosuppressionvia induction of PD-L1 expression in non-small cell lung carcinoma.

    abstract：:The formation of an immunosuppressive microenvironment and up-regulation of PD-L1 protein are the main causes of tumor immune escape. Previous reports suggest that Angiotensin II (Ang II) can modulate the immune status of tumor microenvironment in non-small cell lung cancer (NSCLC), but the underlying mechanism remain...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106507

    authors： Yang K,Zhou J,Chen Y,Chen Y,Chen L,Zhang P,Ma L,Jiang Z,Bian J,Yin W

    更新日期：2020-07-01 00:00:00

  • Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.

    abstract：:The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. In...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105842

    authors： Luo X,Lin B,Gao Y,Lei X,Wang X,Li Y,Li T

    更新日期：2019-11-01 00:00:00

  • Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4+ CD25+ FoxP3+ T reg cells in vivo.

    abstract：BACKGROUND:Development of agents that specifically kill cancer cells and simultaneously elicit antitumor immune response is a step forward in cancer therapy. In the present study, we investigated whether the administration of artemether contributes to the augmentation of antitumor immunity and the regression of tumor t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.07.008

    authors： Farsam V,Hassan ZM,Zavaran-Hosseini A,Noori S,Mahdavi M,Ranjbar M

    更新日期：2011-11-01 00:00:00

  • Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling.

    abstract：:Andrographolide (AG), an ingredient extracted from traditional Chinese herbal medicine Andrographis paniculata, has been demonstrated to have potent anti-inflammatory and anti-oxidative stress properties. The purpose of this study was to investigate whether and how AG attenuated CSE-induced mitochondrial dysfunction, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106230

    authors： Zhang XF,Ding MJ,Cheng C,Zhang Y,Xiang SY,Lu J,Liu ZB

    更新日期：2020-04-01 00:00:00