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Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXRα.

Abstract：

:Here, we investigated the role of LXRα in capsaicin mediated anti-inflammatory effects. Results revealed that capsaicin inhibits LPS-induced IL-1β, IL-6 and TNF-α production in a time- and dose-dependent manner. Moreover, capsaicin increases LXRα expression through PPARγ pathway. Inhibition of LXRα activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1β, IL-6 and TNF-α production. Additionally, LXRα siRNA abrogated the inhibitory action of capsaicin on p65 NF-κB protein expression. Thus, we propose that the anti-inflammatory effects of capsaicin are LXRα dependent, and LXRα may potentially link the capsaicin mediated PPARγ activation and NF-κB inhibition in LPS-induced inflammatory response.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Tang J,Luo K,Li Y,Chen Q,Tang D,Wang D,Xiao J

doi

10.1016/j.intimp.2015.06.007

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

264-9

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(15)00298-2

journal_volume

28

pub_type

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