当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes.

Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes.

Abstract：

OBJECTIVE:To evaluate the anti-inflammatory potential of ICT in LPS stimulated human innate immune cells. BACKGROUND:3, 5, 7-Trihydroxy-4'-methoxy-8-(3-hydroxy-3- methylbutyl)-flavone (ICT) is a novel derivative of icariin, the major active ingredient of Herba Epimedii, an herb used in traditional Chinese medicine. We previously demonstrated its anti-inflammatory potential in a murine macrophage cell line as well as in mouse models. METHODS:We measured TNF-α production by ELISA, TLR4/CD14 expression by flow cytometry, and NF-κB and MAPK activation by western blot all in LPS-stimulated PBMC, human monocytes, or THP-1 cells after treatment with ICT. RESULTS:ICT inhibited LPS-induced TNF-α production in THP-1 cells, PBMCs and human monocytes in a dose-dependent manner. ICT treatment resulted in down-regulation of the expression of CD14/TLR4 and attenuated NF-κB and MAPK activation induced by LPS. CONCLUSION:We illustrate the anti-inflammatory property of ICT in human immune cells, especially in monocytes. These effects were mediated, at least partially, via inhibition of the CD14/TLR4 signaling pathway.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Wu J,Zhou J,Chen X,Fortenbery N,Eksioglu EA,Wei S,Dong J

doi

10.1016/j.intimp.2011.10.015

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

74-9

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(11)00413-9

journal_volume

12

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Anandamide prior to sensitization increases cell-mediated immunity in mice.

    abstract：:The endocannabinoid system has become a topic of great interest in pharmacology due to its remarkable distribution in mammal organisms and capacity to play a modulatory role on several physiological systems, including modulation of immunity. Many studies have shown that administration of cannabinoids causes inhibitory...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.12.017

    authors： Ribeiro A,Ferraz-de-Paula V,Pinheiro ML,Sakai M,Costa-Pinto FA,Palermo-Neto J

    更新日期：2010-04-01 00:00:00

  • Isolation and purification of immune cells from the liver.

    abstract：:Isolating and purifying liver immune cells are crucial for observing the changes in intrahepatic immune responses during the development of liver diseases and exploring the potential immunological mechanisms. Therefore, the aim of this study was to provide an optimal protocol for isolating immune cells with a high yie...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106632

    authors： Shi W,Wang Y,Zhang C,Jin H,Zeng Z,Wei L,Tian Y,Zhang D,Sun G

    更新日期：2020-08-01 00:00:00

  • Association of ophthalmic complications in patients with sulfur mustard induced mild ocular complications and serum soluble adhesion molecules: Sardasht-Iran Cohort Study.

    abstract：:The aim of this study was to evaluate possible association between ophthalmic complications in sulfur mustard (SM) exposed patients with mild ocular injuries and serum soluble adhesion molecules. Serum levels of sICAM-1, sL-selectin, sP-selectin and sE-selectin in 367 SM-exposed individuals with or without eye injurie...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.12.014

    authors： Ghasemi H,Yaraee R,Hassan ZM,Faghihzadeh S,Soroush MR,Pourfarzam S,Ebtekar M,Babaei M,Moaiedmohseni S,Naghizadeh MM,Askari N,Ghazanfari T

    更新日期：2013-11-01 00:00:00

  • Long-term intake of Korean red ginseng in HIV-1-infected patients: development of resistance mutation to zidovudine is delayed.

    abstract：:We have observed that CD4+ T cell counts in human immunodeficiency virus (HIV)-1-infected patients treated with only Korean red ginseng (KRG) are maintained or even increased for a prolonged period. In the present study, we investigated whether the development of resistance mutations in reverse transcriptase (RT) to z...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1567-5769(01)00061-3

    authors： Cho YK,Sung H,Lee HJ,Joo CH,Cho GJ

    更新日期：2001-07-01 00:00:00

  • Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

    abstract：:Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.03.015

    authors： Yoon TJ,Lee SJ,Kim EY,Cho EH,Kang TB,Yu KW,Suh HJ

    更新日期：2013-04-01 00:00:00

  • Inhibitory effects of eicosapentaenoic acid on lipopolysaccharide-induced activation in BV2 microglia.

    abstract：:Upon activation, microglia release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. The anti-inflammatory properties of eicosapentaenoic acid (EPA) have been known, however, the effects responsible for lipopolysaccharide (LPS)-indu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.10.001

    authors： Moon DO,Kim KC,Jin CY,Han MH,Park C,Lee KJ,Park YM,Choi YH,Kim GY

    更新日期：2007-02-01 00:00:00

  • Malondialdehyde-acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions.

    abstract：OBJECTIVE:To compare anti-malondialdehyde-acetaldehyde (MAA) antibody concentrations between rheumatoid arthritis (RA) patients and healthy and rheumatic disease controls. METHODS:Anti-MAA antibody (IgA, IgM, IgG) was measured using ELISA and banked serum from patients with RA (n = 284), osteoarthritis (OA, n = 330), ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.01.022

    authors： Mikuls TR,Duryee MJ,England BR,Anderson DR,Hearth-Holmes M,Su K,Michaud K,Payne JB,Sayles H,Hunter C,McGowan JD,Klassen LW,Thiele GM

    更新日期：2018-03-01 00:00:00

  • Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation.

    abstract：:Acetylcholine (ACh), a classical neurotransmitter, has been shown to be present in various non-neuronal cells, including cells of the eye, such as corneal epithelium and endothelium, and to have widespread physiological effects such as cytoskeleton reorganization, cellular proliferation, differentiation, and apoptosis...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.039

    authors： Słoniecka M,Backman LJ,Danielson P

    更新日期：2015-11-01 00:00:00

  • Protective effects of Clematichinenoside AR against inflammation and cytotoxicity induced by human tumor necrosis factor-α.

    abstract：:Clematichinenoside AR (AR), a major active ingredient extracted from traditional Chinese herb Clematis chinensis Osbeck, has been demonstrated to possess anti-inflammatory and immune-modulatory activities in the treatment of experimental rheumatoid arthritis (RA). The therapeutic potential of AR was supposed to be clo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.010

    authors： Xiong Y,Ma Y,Kodithuwakku ND,Fang W,Liu L,Li F,Hu Y,Li Y

    更新日期：2019-10-01 00:00:00

  • Tauroursodeoxycholate improves 2,4,6-trinitrobenzenesulfonic acid-induced experimental acute ulcerative colitis in mice.

    abstract：:Ulcerative colitis is a chronic nonspecific inflammatory disease of unknown cause. The aim of this study was to evaluate the anti-inflammatory effect of tauroursodeoxycholate in 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in mice. After the induction of colitis for 24h, the mice were administrate...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.04.037

    authors： Yang Y,He J,Suo Y,Zheng Z,Wang J,Lv L,Huo C,Wang Z,Li J,Sun W,Zhang Y

    更新日期：2016-07-01 00:00:00

  • Analysis of cytokine release assay data using machine learning approaches.

    abstract：:The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.07.024

    authors： Xiong F,Janko M,Walker M,Makropoulos D,Weinstock D,Kam M,Hrebien L

    更新日期：2014-10-01 00:00:00

  • Increased Galectin-9 expression, a prognostic biomarker of aGVHD, regulates the immune response through the Galectin-9 induced MDSC pathway after allogeneic hematopoietic stem cell transplantation.

    abstract：:Galectin-9 (Gal-9) is a β-galactoside-binding soluble lectin family member that exerts its primary biological functions via specific glycoconjugate interactions. Gal-9 expression is closely related to tumor occurrence, development, metastasis and prognosis. In transplant immunology, a high level of Gal-9 expression ha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106929

    authors： Yin J,Li L,Wang C,Zhang Y

    更新日期：2020-11-01 00:00:00

  • Inhaled corticosteroids and risk of pneumonia in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials.

    abstract：OBJECTIVE:Inhaled corticosteroids (ICS) are generally used to treat patients with chronic obstructive pulmonary disease (COPD) who suffer from repeated exacerbations. Recently, it was reported that ICS treatment increased the risk of pneumonia in COPD patients. But it is controversial.The objective of this paper is to ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.intimp.2019.105950

    authors： Yang M,Du Y,Chen H,Jiang D,Xu Z

    更新日期：2019-12-01 00:00:00

  • Morphological and functional analysis of beige (Chèdiak-Higashi syndrome) mouse mast cells with giant granules.

    abstract：:Chèdiak-Higashi syndrome is a rare autosomal recessive disease that causes hypopigmentation, recurrent infections, mild coagulation defects and neurological problems. Beige mice carry a mutation in the lysosome trafficking regulator (LYST) gene and display some of the key characteristics of human Chèdiak-Higashi syndr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.053

    authors： Kiyoi T,Liu S,Sahid MNA,Shudou M,Ogasawara M,Mogi M,Maeyama K

    更新日期：2019-04-01 00:00:00

  • Platycodin D attenuates acute lung injury by suppressing apoptosis and inflammation in vivo and in vitro.

    abstract：:Platycodin D (PLD) is the major triterpene saponin in the root of Platycodon grandiflorum (Jacq.) with various pharmacological activities. The purpose of the present study was to evaluate the protective effects and possible mechanisms of PLD on acute lung injury (ALI) both in vivo and in vitro. In vivo, we used two AL...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.005

    authors： Tao W,Su Q,Wang H,Guo S,Chen Y,Duan J,Wang S

    更新日期：2015-07-01 00:00:00

  • Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review.

    abstract：:Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.06.023

    authors： Majdalawieh AF,Fayyad MW

    更新日期：2015-09-01 00:00:00

  • Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells.

    abstract：:Mast cells play a critical role in allergic diseases. Therefore, development of new therapeutic agents that suppresses the activation of mast cells may help prevent or treat allergic diseases. Here, we investigated the anti-allergic effects of 4-chloro-cinnamaldehyde and 4-trifluoro-cinnamaldehyde in RBL-2H3 cells. β-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.06.018

    authors： Ahn S,Kim E,Lee K,Lee DC

    更新日期：2016-09-01 00:00:00

  • GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

    abstract：:Chronic cold stress has long-term dramatic effects on the animal immune and neuroendocrine systems. As one of the important regions of the brain, the hippocampus is the main region involved in response to stressors. Nevertheless, the impact to the hippocampus following cold exposure and the underlying mechanism involv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106908

    authors： Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

    更新日期：2020-12-01 00:00:00

  • Dietary quercetin combining intratumoral doxorubicin injection synergistically induces rejection of established breast cancer in mice.

    abstract：:Dietary ingredients can decrease the risk of a variety of human cancers. Quercetin (3,3',4',5,7-pentahydroxyflavone) has a long history of consumption as part of the normal human diet and is able to induce growth inhibition in multiple cancer cells. In an attempt to generate more potent therapeutic effect for breast c...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.04.018

    authors： Du G,Lin H,Yang Y,Zhang S,Wu X,Wang M,Ji L,Lu L,Yu L,Han G

    更新日期：2010-07-01 00:00:00

  • Gamma irradiation enhanced Tollip-mediated anti-inflammatory action through structural modification of quercetin in lipopolysaccharide-stimulated macrophages.

    abstract：:The changes in molecular structure and anti-inflammatory action of a gamma-irradiated quercetin were examined. Quercetin was gamma-irradiated at doses of 0, 15, 30, 50, 100 and 150kGy, which induced new radiolytic peaks (the highest radiolytic peak at a dose of 30kGy). Treatment of intact- and gamma-irradiated quercet...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.11.030

    authors： Byun EB,Jang BS,Kim HM,Yang MS,Sung NY,Byun EH

    更新日期：2017-01-01 00:00:00

  • Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

    abstract：:Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effec...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.018

    authors： Pu WL,Bai RY,Zhou K,Peng YF,Zhang MY,Hottiger MO,Li WH,Gao XM,Sun LK

    更新日期：2019-07-01 00:00:00

  • Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models.

    abstract：:Due to the broad anti-inflammatory and immunomodulatory actions of phosphodiesterase (PDE) 4 inhibitors, it has been proposed that PDE4 inhibitors might be efficacious for skin disorders such as atopic dermatitis. KF66490 is a newly developed PDE4 inhibitor that inhibits PDE4B (IC(50)=220 nM) and the production of tum...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.09.011

    authors： Harada D,Takada C,Nosaka Y,Takashima Y,Kobayashi K,Takaba K,Manabe H

    更新日期：2009-01-01 00:00:00

  • Dietary garlic (Allium sativum) lectins, ASA I and ASA II, are highly stable and immunogenic.

    abstract：:The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. Int. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins as a function of pH, temperature and denaturants has been examine...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.022

    authors： Clement F,Venkatesh YP

    更新日期：2010-10-01 00:00:00

  • β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells.

    abstract：:β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose (HG)-induced glomerular mesangial cells (MCs). MCs were maintained under HG condition...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106556

    authors： Li H,Wang D,Chen Y,Yang M

    更新日期：2020-07-01 00:00:00

  • A review on the effect of COVID-19 in type 2 asthma and its management.

    abstract：BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.107309

    authors： Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

    更新日期：2021-02-01 00:00:00

  • Anti-nicotine vaccines: Comparison of adjuvanted CRM197 and Qb-VLP conjugate formulations for immunogenicity and function in non-human primates.

    abstract：:Anti-nicotine vaccines comprise nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). Unfortunately, those tested clinically have failed to improve overall long term quit rates. We had shown in mice that carrier, hapten, linker, hapten load (number of haptens per carrier molecule), aggregation and ad...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.09.012

    authors： McCluskie MJ,Thorn J,Gervais DP,Stead DR,Zhang N,Benoit M,Cartier J,Kim IJ,Bhattacharya K,Finneman JI,Merson JR,Davis HL

    更新日期：2015-12-01 00:00:00

  • Immunomodulatory properties of Cumaside.

    abstract：:The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with original glycosides d...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.01.017

    authors： Aminin DL,Pinegin BV,Pichugina LV,Zaporozhets TS,Agafonova IG,Boguslavski VM,Silchenko AS,Avilov SA,Stonik VA

    更新日期：2006-07-01 00:00:00

  • Evaluation of the efficacy and safety of β-d-mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial.

    abstract：OBJECTIVE:To evaluate the efficacy, safety and tolerability of β-d-mannuronic acid (M2000) in the treatment of ankylosing spondylitis (AS). METHODS:The study was a 12-week randomized, double-blind, placebo-controlled, phase I/II clinical trial with 3 treatment arms: placebo, β-d-mannuronic acid and naproxen. Patients ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2017.11.003

    authors： Fattahi MJ,Jamshidi AR,Mahmoudi M,Vojdanian M,Yekaninejad MS,Jafarnezhad-Ansariha F,Ahmadi H,Rehm BHA,Matsuo H,Cuzzocrea S,Hosseini M,Hashemi SN,Aghazadeh Z,Mirshafiey A

    更新日期：2018-01-01 00:00:00

  • The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE.

    abstract：:Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE), with unclear etiopathogenesis. We evaluated the role of macrophage migration inhibitory factor (MIF), which has been implicated in idiopathic pulmonary hypertension (PH), in SLE-associated PAH. Circulating MIF was mea...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105874

    authors： Huang H,Chen D,Pu J,Yuan A,Fu Q,Li J,Leng L,Bucala R,Ye S,Lu L

    更新日期：2019-11-01 00:00:00

  • Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry.

    abstract：:A procedure was developed for the determination of low levels of the anthraquinones aloe-emodin and aloin A (barbalin) in aloe products based on gas chromatography/mass spectrometry (GC/MS) of the trimethyl silyl (TMS) derivatives of these analytes in the presence of Chrysophanol used as internal standard. The method ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.07.005

    authors： ElSohly MA,Gul W,Murphy TP

    更新日期：2004-12-20 00:00:00