TACI-Ig induces immune balance of Th cells in MLN via BLyS/APRIL-receptors signaling in rats with adjuvant-induced arthritis.

abstract：BACKGROUND:The precision-cut kidney slice (PCKS) model appears to be a useful ex vivo model of renal fibrosis. However, little in-depth molecular investigation on the PCKS model has been performed. Therefore, the aim of this study will be to investigate and validate the molecular validity of this model. METHODS:The PC...

journal_title：International immunopharmacology

authors： Zhang S,Liu Q,Xiao J,Lei J,Liu Y,Xu H,Hong Z

更新日期：2016-05-01 00:00:00

abstract：:Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, has been reported to have a protective effect against lipopolysaccharide (LPS)-induced mastitis. However, the underlying molecular mechanisms are not well understood. The aim of this study was to investigate the molecular mechanisms of e...

journal_title：International immunopharmacology

authors： Yang Z,Zhou E,Wei D,Li D,Wei Z,Zhang W,Zhang X

更新日期：2014-08-01 00:00:00

abstract：:Inflammation is fundamental in osteoarthritis (OA) pathogenesis. Semaphorin 4A (Sema4A) has been implicated in immune-associated diseases, however, its role in OA remains unclear. In this study, we show that Sema4A is upregulated in knee OA articular cartilage as well as in chondrocytes exposed to IL-1β treatment in v...

journal_title：International immunopharmacology

authors： Zhang H,Wei Q,Xiang X,Zhou B,Chen J,Li J,Li Q,Xiong H,Liu F

更新日期：2019-04-01 00:00:00

abstract：:Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) refer to acute and progressive hypoxic respiratory failure caused by non-cardiogenic factors, which is a common condition occurring in critically ill patients with widespread pulmonary inflammation. Use of a single medication or target cannot treat A...

journal_title：International immunopharmacology

authors： Huang Z,Liu H,Zhang X,Wen G,Zhu C,Zhao Y,Niu W,Qin Y,Chen H,Bai C,Liu G

更新日期：2018-10-01 00:00:00

abstract：:In this study, we investigated the preventive effects of curcumin using dextran sulfate sodium (DSS)-induced colitis and the potential role of curcumin in regulation of anti-inflammation through S-nitrosylation. After curcumin treatment for 6days, the body weight and disease activity index of DSS-induced mice was alle...

journal_title：International immunopharmacology

authors： Kao NJ,Hu JY,Wu CS,Kong ZL

更新日期：2016-09-01 00:00:00

abstract：:Glucocorticoids (GC) are frequently used for therapy of various inflammatory lung diseases by either systemic or inhalative application. Because the oral application often has various side effects and because the inhalative application is not as potent, new formulations of GCs are required. We evaluated the effect of ...

journal_title：International immunopharmacology

authors： Frankenberger M,Häussinger K,Ziegler-Heitbrock L

更新日期：2005-02-01 00:00:00

abstract：:Acute lung injury (ALI) is one of the severe complications in patients with traumatic brain injury (TBI), contributing to the high mortality. Ghrelin has protective effects against various inflammatory diseases, but the effects of Ghrelin on TBI-induced ALI and its mechanisms remain unknown. In this study, Ghrelin adm...

journal_title：International immunopharmacology

authors： Shao XF,Li B,Shen J,Wang QF,Chen SS,Jiang XC,Qiang D

更新日期：2020-02-01 00:00:00

abstract：:Sunitinib is a tyrosine kinase inhibitor for many tumors. Inflammation is one of the most important factors in the development of intestinal tumors. Many inflammation-related factors are regulated by tyrosine kinase receptors. It is reasonable to hypothesize that sunitinib can regulate the development of intestinal tu...

journal_title：International immunopharmacology

authors： Chen L,Xu P,Xiao Q,Chen L,Li S,Jian JM,Zhong YB

更新日期：2021-01-01 00:00:00

abstract：:Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals, clinically available pharmacological therapies that can promote repair and prevent visual complications remain limited. We have recently demonstrated that the ace...

journal_title：International immunopharmacology

authors： Chernyavsky AI,Galitovskiy V,Grando SA

更新日期：2015-11-01 00:00:00

abstract：:Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-infla...

journal_title：International immunopharmacology

authors： Funakoshi-Tago M,Ohsawa K,Ishikawa T,Nakamura F,Ueda F,Narukawa Y,Kiuchi F,Tamura H,Tago K,Kasahara T

更新日期：2016-11-01 00:00:00

abstract：:Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

journal_title：International immunopharmacology

authors： Majdalawieh AF,Fayyad MW

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Inhaled corticosteroids (ICS) are generally used to treat patients with chronic obstructive pulmonary disease (COPD) who suffer from repeated exacerbations. Recently, it was reported that ICS treatment increased the risk of pneumonia in COPD patients. But it is controversial.The objective of this paper is to ...

journal_title：International immunopharmacology

authors： Yang M,Du Y,Chen H,Jiang D,Xu Z

更新日期：2019-12-01 00:00:00

abstract：:Autophagy is an intracellular catabolic mechanism essential for recycling intracellular unfolding protein and eliminating toxic protein aggregates. Several studies have shown that deficient autophagy is implicated in the development of Alzheimer's disease (AD) progression. To date, rapidly emerging evidence suggests t...

journal_title：International immunopharmacology

authors： Hong Y,Liu Y,Zhang G,Wu H,Hou Y

更新日期：2018-01-01 00:00:00

abstract：:Despite the use of increasingly specific immunosuppressive therapy, rejection remains the leading cause of death in cardiac transplant patients. Endomyocardial biopsy (EMB) is the gold standard for early detection and monitoring of cardiac transplant rejection. However, this approach is invasive and not suitable for r...

journal_title：International immunopharmacology

authors： Zupan I,Vrtovec B,Breskvar UD,Gabrijelcic T

更新日期：2005-01-01 00:00:00

abstract：:The purpose of this study was to prepare a tetravalent anti-human CD22 recombinant antibody with improved antitumor activity and a half life longer than that of its divalent counterpart. We compared the ability of tetravalent vs. divalent antibody to associate/dissociate to/from CD22-positive Daudi cells, to interact ...

journal_title：International immunopharmacology

authors： Liu XY,Pop LM,Roopenian DC,Ghetie V,Vitetta ES,Smallshaw JE

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:RIF is clinically defined as the failure of good quality embryos to implant into the uterus following at least three cycles of In Vitro Fertilization/Embryo Transfer (IVF/ET). During human pregnancy, a genetically different fetus is allowed to survive within the uterus despite the maternal recognition of fet...

journal_title：International immunopharmacology

authors： Ahmadi M,Abdolmohamadi-Vahid S,Ghaebi M,Dolati S,Abbaspour-Aghdam S,Danaii S,Berjis K,Madadi-Javid R,Nouri Z,Siahmansouri H,Babaloo Z,Nouri M,Yousefi M

更新日期：2019-09-01 00:00:00

abstract：:Human melanoma Colo 679 cells were made resistant to doxorubicin (adriamycin, ADM) by continuous exposure to ascending concentrations of the drug and Colo/ADM80; a variant which grew continuously in the presence of 80 ng/ml of ADM was thus established. Human peripheral blood mononuclear cells (PBMC) produced interfero...

journal_title：International immunopharmacology

authors： Micallef MJ,Darmanin S,Buhagiar JA,Camilleri-Podesta MT,Yamauchi H,Kurimoto M,Inglott AS,Ellul-Micallef R

更新日期：2001-02-01 00:00:00

abstract：:Experimental autoimmune encephalomylitis (EAE), an animal mode of multiple sclerosis (MS), was previously considered that be mediated by Th1 cells. However, a number of recent studies provided strong evidence that T helper cells that produce IL-17 play a dominant role in the pathogenesis of EAE. Curcumin (1,7-Bis 94-h...

journal_title：International immunopharmacology

authors： Xie L,Li XK,Funeshima-Fuji N,Kimura H,Matsumoto Y,Isaka Y,Takahara S

更新日期：2009-05-01 00:00:00

abstract：:Amaranthus spinosus Linn. (thorny amaranth), a plant that grows in the wild fields of Taiwan, is extensively used in Chinese traditional medicine to treat diabetes. There have been no published studies on the immunological effects of A. spinosus. To determine whether A. spinosus has immuno-modulatory effects and clari...

journal_title：International immunopharmacology

authors： Lin BF,Chiang BL,Lin JY

更新日期：2005-04-01 00:00:00

abstract：:In sequential studies, we compared immune reconstitution following high-dose chemotherapy (HDT) and stem cell transplantation (SCT) using intact mobilized peripheral blood stem cell (PSC) in intermediate grade non-Hodgkin's lymphoma (NHL) patients and CD34(+), lineage-negative (Lin(-)), Thy-1(lo) (CD34(+)Lin(-)Thy-1(l...

journal_title：International immunopharmacology

authors： Singh RK,Varney ML,Leutzinger C,Vose JM,Bierman PJ,Buyukberber S,Ino K,Loh K,Nichols C,Inwards D,Rifkin R,Talmadge JE

更新日期：2007-08-01 00:00:00

abstract：:Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

journal_title：International immunopharmacology

authors： Sahu KK,Pandey RS

更新日期：2016-10-01 00:00:00

abstract：:The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFalpha, IL-1beta, and NO thus enabling the understanding of the key signaling events involved. ...

journal_title：International immunopharmacology

authors： Gayathri B,Manjula N,Vinaykumar KS,Lakshmi BS,Balakrishnan A

更新日期：2007-04-01 00:00:00

abstract：:The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. Int. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins as a function of pH, temperature and denaturants has been examine...

journal_title：International immunopharmacology

authors： Clement F,Venkatesh YP

更新日期：2010-10-01 00:00:00

abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...

journal_title：International immunopharmacology

authors： Helal MG,Said E

更新日期：2019-05-01 00:00:00

abstract：:Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

journal_title：International immunopharmacology

authors： Zhang S,Bai X,Shan F

更新日期：2020-03-01 00:00:00

abstract：:The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also kn...

journal_title：International immunopharmacology

authors： Kumar S,Verma AK,Das M,Dwivedi PD

更新日期：2012-08-01 00:00:00

abstract：:The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...

journal_title：International immunopharmacology

authors： Xiong F,Janko M,Walker M,Makropoulos D,Weinstock D,Kam M,Hrebien L

更新日期：2014-10-01 00:00:00

abstract：:The present study was conducted to determine if selected events in glucocorticoid receptor (GR) signaling that have been identified using mostly in vitro approaches with synthetic glucocorticoids also occur in mature T cells exposed to relevant levels of corticosterone in vivo. In contrast to effects reported in vitro...

journal_title：International immunopharmacology

authors： Pruett SB,Fan R,Zheng Q

更新日期：2003-01-01 00:00:00

abstract：:Anti-citrullinated protein antibodies (ACPAs) are a key serological marker of rheumatoid arthritis (RA). To investigate whether miR-let7a downregulated ACPA-induced macrophage activation and arthritis, miR-let7a levels were assessed in the synovial fluid from patients with RA or osteoarthritis (OA). In addition, expre...

journal_title：International immunopharmacology

authors： Zhu W,Yu J,Qiu S,Liu H,Wang Y,Xu X,Shao L,Zhu L,Jiao Y,Liu F,Zhu X

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To investigate the effect of miR-200c/PAI-2 on macrophage polarization into M2-type TAMs in TNBC. METHODS AND MATERIALS:PAI-2 expression in MDA-MB-231con, MDA-MB-231miR-200ab and MDA-MB-231miR-200c breast cancer cells was evaluated by RT-PCR and immunofluorescence (IF), while the expression of the TAM marker F...

journal_title：International immunopharmacology

authors： Meng Z,Zhang R,Wang Y,Zhu G,Jin T,Li C,Zhang S

更新日期：2020-04-01 00:00:00