TACI-Ig induces immune balance of Th cells in MLN via BLyS/APRIL-receptors signaling in rats with adjuvant-induced arthritis.

abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...

journal_title：International immunopharmacology

authors： Helal MG,Said E

更新日期：2019-05-01 00:00:00

abstract：:Analgesic and anti-inflammatory applications for non-peptide bradykinin (BK) B2 receptor antagonists have been documented in rats. However, very large species differences in affinity were also noted within this class of drugs, making the preclinical development of relevant drugs difficult. Bradyzide is a potent antago...

journal_title：International immunopharmacology

authors： Marceau F,Fortin JP,Morissette G,Dziadulewicz EK

更新日期：2003-10-01 00:00:00

abstract：:Paclitaxel has become one of the most effective and widely used chemotherapeutic agents over the past decades. Although it has shown promise to selectively deplete regulatory T (Treg) cells in our previous study, the underlying molecular mechanism remains to be further elucidated. The present study focused on the effe...

journal_title：International immunopharmacology

authors： Liu N,Zheng Y,Zhu Y,Xiong S,Chu Y

更新日期：2011-02-01 00:00:00

abstract：:Upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. As resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, ...

journal_title：International immunopharmacology

authors： Bi XL,Yang JY,Dong YX,Wang JM,Cui YH,Ikeshima T,Zhao YQ,Wu CF

更新日期：2005-01-01 00:00:00

abstract：:Evidence shows that psychosocial stress exacerbates asthma, but there is little intervention to alleviate negative effects of psychosocial stress on asthma. We investigated the role of icariin in anti-inflammation and anti-anxiety potential in a murine model combined psychosocial stress with allergic exposure. The res...

journal_title：International immunopharmacology

authors： Li B,Duan X,Xu C,Wu J,Liu B,Du Y,Luo Q,Jin H,Gong W,Dong J

更新日期：2014-04-01 00:00:00

abstract：:Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

journal_title：International immunopharmacology

authors： Majdalawieh AF,Fayyad MW

更新日期：2015-09-01 00:00:00

abstract：:Methylglyoxal is a normal metabolite and has the potential to affect a wide variety of cellular processes. In particular, it can act selectively against malignant cells. The study described herein was to investigate whether methylglyoxal can enhance the non-specific immunity of the host against tumor cells. Methylglyo...

journal_title：International immunopharmacology

authors： Bhattacharyya N,Pal A,Patra S,Haldar AK,Roy S,Ray M

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:Growth arrest-specific protein 6 (Gas6) is a vitamin K-dependent protein that plays an important role in the pathogenesis of autoimmune diseases. The purpose of this study was to explore the expression of Gas6 and its effects on autoimmune thyroiditis (AIT). METHOD:A total of 24 male NOD.H-2h4 mice were random...

journal_title：International immunopharmacology

authors： Sun X,Guan H,Peng S,Zhao Y,Zhang L,Wang X,Li C,Shan Z,Teng W

更新日期：2019-08-01 00:00:00

abstract：:This study was aimed to introduce a novel algorithm for determining linear B- and T-cell epitopes from Crimean-Congo haemorrhagic fever virus (CCHFV) antigens. To this end, 387 approved B- and T-cell epitopes, as well as 331 non-epitope peptides from different serotypes of the virus were collected from IEDB database f...

journal_title：International immunopharmacology

authors： Nosrati M,Mohabatkar H,Behbahani M

更新日期：2020-01-01 00:00:00

abstract：:Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Galactose in a ratio o...

journal_title：International immunopharmacology

authors： Bai Y,Zhang P,Chen G,Cao J,Huang T,Chen K

更新日期：2012-04-01 00:00:00

abstract：:To be effective, vaccines against the highly variable HIV-1 must elicit antibodies to a huge number of clinical isolates. For this purpose, new strategies to overcome this variability are needed. We previously reported a useful immunogenic strategy which consists of conjugating multiple antigen peptides (MAPs) to HBsA...

journal_title：International immunopharmacology

authors： Cruz LJ,Cabrales A,Iglesias E,Aguilar JC,González LJ,Reyes O

更新日期：2009-11-01 00:00:00

abstract：:Acute lung injury (ALI) is a severe disease characterized by several inflammatory responses in the lung with high mortality. We applied a mouse model of the pulmonary inflammation induced by the intratracheal instillation of bleomycin which is widely used to induce ALI and fibrosis in animal models. We hypothesized th...

journal_title：International immunopharmacology

authors： Lu CH,Chen CM,Ma J,Wu CJ,Chen LC,Kuo ML

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The precise role of innate immune responses in the early stage of traumatic spinal cord injury (SCI), especially those mediated by natural killer (NK) cells, is poorly understood. METHODS:The frequency and phenotype of NK cells from traumatic SCI patients and healthy controls were assessed by flow cytometry...

journal_title：International immunopharmacology

authors： Xu L,Zhang Y,Zhang R,Zhang H,Song P,Ma T,Li Y,Wang X,Hou X,Li Q,Xu J,Gao X,Shen C

更新日期：2019-09-01 00:00:00

abstract：:Inflammation plays an important role in the pathogenesis of cerebral ischemia. Syringin (SYR) is an active substance isolated from Acanthopanax senticosus plants, and possesses anti-inflammatory and neuroprotective properties. However, its effects on cerebral ischemic injury, as well as the underlying molecular events...

journal_title：International immunopharmacology

authors： Tan J,Luo J,Meng C,Jiang N,Cao J,Zhao J

更新日期：2021-01-01 00:00:00

abstract：:Regulatory T (Treg) cells play an important role in the pathogenesis of inflammatory bowel disease (IBD). In the present study, we found that a superagonistic CD28-specific monoclonal antibody (supCD28mAb, D665) could preferentially stimulate expansion of CD4+Foxp3+ Treg cells. Foxp3(EGFP) mice were orally administrat...

journal_title：International immunopharmacology

authors： Chen J,Xie L,Toyama S,Hünig T,Takahara S,Li XK,Zhong L

更新日期：2011-05-01 00:00:00

abstract：:Regular bathing in the Blue Lagoon has beneficial effects on psoriasis. Previously, we showed that exopolysaccharides (EPS-Ca) secreted by Cyanobacterium aponinum, a dominating organism in the Blue Lagoon, increased IL-10 secretion by human dendritic cells (DCs). In addition, co-culturing allogeneic CD4+ T cells with ...

journal_title：International immunopharmacology

authors： Gudmundsdottir AB,Brynjolfsdottir A,Olafsdottir ES,Hardardottir I,Freysdottir J

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibili...

journal_title：International immunopharmacology

authors： Wang Z,Wang X,Gao Y,Wang Y,Xu M,Han Q,Zhao X

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Ambient fine particulate matter (PM2.5) could induce lung injury. Aryl hydrocarbon receptor (AhR) is involved in the molecular mechanisms of prooxidative and pro-inflammatory effect of PM2.5. Molecular hydrogen has antioxidant properties. The protective effect and mechanism of hydrogen on PM2.5-induced lung ...

journal_title：International immunopharmacology

authors： Feng S,Duan E,Shi X,Zhang H,Li H,Zhao Y,Chao L,Zhong X,Zhang W,Li R,Yan X

更新日期：2019-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder in which lymphocytic infiltration mediated mainly by pro-inflammatory cytokines. In this study, we examined the effect of combined exercise training on the levels of IFN-γ, IL-4 and IL-17 in the plasma and the supernatant of peripheral blood lymp...

journal_title：International immunopharmacology

authors： Golzari Z,Shabkhiz F,Soudi S,Kordi MR,Hashemi SM

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Increases in galactose-deficient IgA1 (Gd-IgA1) play a crucial role in the pathogenesis of IgA nephropathy (IgAN), and several recent experiments have shown that microRNAs (miRNAs) are involved in regulating the development and physiological function of the kidney. The aims of this study were to identify miRN...

journal_title：International immunopharmacology

authors： Liu D,Xia M,Liu Y,Tan X,He L,Liu Y,Chen G,Liu H

更新日期：2020-02-29 00:00:00

abstract：:In the present study, we investigated that (-)-aptosimon, isolated from flower buds of Daphne genkwa, inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Similarly, (-)-aptosimon suppressed tumor necrosis factor (TNF)-alph...

journal_title：International immunopharmacology

authors： Lee MY,Park BY,Kwon OK,Yuk JE,Oh SR,Kim HS,Lee HK,Ahn KS

更新日期：2009-07-01 00:00:00

abstract：:The objective of the present study was to compare the host's immune responses between unresponsive and responsive patients with anthroponotic cutaneous leishmaniasis (ACL) treated by meglumine antimoniate. A case-control study was carried out in an endemic focus in Iran. Blood samples were taken from patients and peri...

journal_title：International immunopharmacology

authors： Bamorovat M,Sharifi I,Aflatoonian MR,Sadeghi B,Shafiian A,Oliaee RT,Keyhani A,Afshar AA,Khosravi A,Mostafavi M,Parizi MH,Khatami M,Arefinia N

更新日期：2019-04-01 00:00:00

abstract：:The endocannabinoid system has become a topic of great interest in pharmacology due to its remarkable distribution in mammal organisms and capacity to play a modulatory role on several physiological systems, including modulation of immunity. Many studies have shown that administration of cannabinoids causes inhibitory...

journal_title：International immunopharmacology

authors： Ribeiro A,Ferraz-de-Paula V,Pinheiro ML,Sakai M,Costa-Pinto FA,Palermo-Neto J

更新日期：2010-04-01 00:00:00

abstract：:Endometriosis is a gynecologic disorder characterized by the ectopic growth of misplaced endometrial cells. Moreover, immunological abnormalities of cell-mediated and humoral immunity may be associated with the pathogenesis of endometriosis. The effects of peritoneal fluid (PF) from endometriosis patients on the expre...

journal_title：International immunopharmacology

authors： Lee KS,Baek DW,Kim KH,Shin BS,Lee DH,Kim JW,Hong YS,Bae YS,Kwak JY

更新日期：2005-11-01 00:00:00

abstract：:Astragalus mongholicus polysaccharides(ASP) isolated from one of the Chinese herbs-A. mongholicus which are known to have a variety of immunomodulatory activity. However, little is known about their immunomodulatory effects on murine bone marrow (BM)-derived dendritic cells (DC). DC are professional antigen presenting...

journal_title：International immunopharmacology

authors： Shao P,Zhao LH,Zhi-Chen,Pan JP

更新日期：2006-07-01 00:00:00

abstract：:An emerging role is postulated for IL-17-producing thymocytes, which in their majority consist of IL-17-producing CD4(+) cells. For these, a specific role in the immediate defense against infectious pathogens is suggested, independent from the development of an adaptive immune response in the immune periphery. Immune ...

journal_title：International immunopharmacology

authors： Weber A,Zimmermann C,Mausberg AK,Kieseier BC,Hartung HP,Hofstetter HH

更新日期：2013-10-01 00:00:00

abstract：:Members of the tumor necrosis factor (TNF) family play key roles in the regulation of inflammation, immune responses and tissue homeostasis. Here we describe the identification of the Japanese sea perch (Lateolabrax japonicus) homologue of mammalian B cell activating factor of the TNF family (BAFF/BLyS) (designated Lj...

journal_title：International immunopharmacology

authors： Cui XW,Li JF,Xiao W,Xuan Y,Tian AY,Xu XZ,Zhang SQ

更新日期：2012-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide. The PD-1/PD-L1 interaction plays important roles in cancer immunology, and expression of PD-L1 has been discovered in NSCLC tumor cells. Since follicular helper T (Tfh) cells have characteristic high PD-1 expression,...

journal_title：International immunopharmacology

authors： Ma QY,Huang DY,Zhang HJ,Chen J,Miller W,Chen XF

更新日期：2016-12-01 00:00:00

abstract：:Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells (VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria cocos polysaccharides (PCP) has been shown to possess anti-inflammatory, antitumor and anti-oxidative properties. In this study we explored ...

journal_title：International immunopharmacology

authors： Zhao J,Niu X,Yu J,Xiao X,Li W,Zang L,Hu Z,Siu-Po Ip P,Li W

更新日期：2020-03-01 00:00:00

abstract：:Paeonia lactiflora Pallas, also named Chinese Paeony, is a Chinese herb. A decoction of its root has been used to treat painful or inflammatory disorders in traditional Chinese medicine. A water/ethanol extract of Radix Paeoniae is known as total glycosides of paeony (TGP), of which paeoniflorin is the major active co...

journal_title：International immunopharmacology

authors： Zhang W,Dai SM

更新日期：2012-09-01 00:00:00