Immune stimulation improves endocrine and neural fetal outcomes in a model of maternofetal thyrotoxicosis.

abstract：:A lipoteichoic acid-related molecule (OK-PSA) isolated from OK-432, a penicillin-killed Streptococcus pyogenes, is a potent inducer of Th1 cytokines, and elicits anti-cancer effect in tumor-bearing mice. Toll-like receptor (TLR) 4 is a member of the recently identified toll-like receptor family of proteins that has be...

journal_title：International immunopharmacology

authors： Okamoto M,Oshikawa T,Ohe G,Nishikawa H,Furuichi S,Tano T,Moriya Y,Saito M,Sato M

更新日期：2001-09-01 00:00:00

abstract：:We recently designed a series of N-[4-(t-amino-yl)-but-2-yn-1-yl] isoindoline-1,3-diones as anti-inflammatory compounds, called ZM compounds. These ZM compounds were categorized according to the nature of the cyclic amino groups into ZM2, ZM3, ZM4, and ZM5 and were shown to reduce carrageenan-induced inflammation, inh...

journal_title：International immunopharmacology

authors： Matalka KZ,Alfarhoud F,Qinna NA,Mallah EM,Abu-Dayyih WA,Muhi-eldeen ZA

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To illustrate the potential effects and mechanism of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) on fibrosis in sclerodermatous chronic graft-versus-host-disease (cGVHD) models after allogeneic hematopoietic stem cell transplantation. METHODS:We first observed the therapeutic effects...

journal_title：International immunopharmacology

authors： Guo L,Lai P,Wang Y,Huang T,Chen X,Geng S,Huang X,Luo C,Wu S,Ling W,Huang L,Du X,Weng J

更新日期：2020-07-01 00:00:00

abstract：:Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax pathogenesis. The anthrax lethal toxin can trigger NLRP1b inflammasome activation and pyroptosis. Although the underlying mechanism is well understood, the medications targeting the NLRP1b inflammasome are not available in t...

journal_title：International immunopharmacology

authors： Wang J,Yang D,Shen X,Wang J,Liu X,Lin J,Zhong J,Zhao Y,Qi Z

更新日期：2020-08-01 00:00:00

abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...

journal_title：International immunopharmacology

authors： Helal MG,Said E

更新日期：2019-05-01 00:00:00

abstract：:Acute lung injury (ALI) is linked with considerable morbidity and mortality. ALI can be caused by various agents, one of them being sepsis. ALI is characterized by injury to vascular endothelium and alveolar epithelium that results in edema, pulmonary immune cells infiltration and hypoxemia. Neutrophils and T cells pa...

journal_title：International immunopharmacology

authors： Nadeem A,Al-Harbi NO,Ahmad SF,Al-Harbi MM,Alhamed AS,Alfardan AS,Assiri MA,Ibrahim KE,Albassam H

更新日期：2020-06-01 00:00:00

abstract：:Vimang is an aqueous extract of Mangiferia indica L., traditionally used in Cuba as an anti-inflammatory, analgesic and antioxidant. In the present study, we investigated the effects of Vimang and of mangiferin (a C-glucosylxanthone present in the extract) on rat macrophage functions including phagocytic activity and ...

journal_title：International immunopharmacology

authors： García D,Delgado R,Ubeira FM,Leiro J

更新日期：2002-05-01 00:00:00

abstract：:Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to ...

journal_title：International immunopharmacology

authors： Amirshahrokhi K

更新日期：2013-10-01 00:00:00

abstract：:Echinacea plant extract is widely used for the prevention and the treatment of upper respiratory tract infections. However, the active components in the herb, their optimal dosages and their in vivo effects are still undefined. Using male Sprague-Dawley rats (425-475 g), an in vivo study was conducted to examine the i...

journal_title：International immunopharmacology

authors： Goel V,Chang C,Slama JV,Barton R,Bauer R,Gahler R,Basu TK

更新日期：2002-02-01 00:00:00

abstract：:Inflammation and oxidative stress play important roles in the progression of renal damage. The natural polyphenol naringenin is known to exert potent antioxidant and anti-inflammatory effects. In this study, we have investigated the effect of naringenin on kidney dysfunction, fibrosis, endoplasmic reticulum (ER) stres...

journal_title：International immunopharmacology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Suzuki K,Nakamura M,Ueno K,Watanabe K

更新日期：2015-09-01 00:00:00

abstract：:The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors ...

journal_title：International immunopharmacology

authors： Momose I,Kawada M

更新日期：2016-08-01 00:00:00

abstract：:Extracellular adenosine triphosphate (ATP) is sequentially dephosphorylated by two ectoenzymes: CD39/nucleotidase triphosphate dephosphorylase (ENTPD) and CD73/5'-ectonucleotidase (5'-NT). Adenosine, its notable metabolite, may elicit potent anti-inflammatory responses. We examined whether the CD39-adenosinergic axis ...

journal_title：International immunopharmacology

authors： Nemoto E,Gotoh K,Tsuchiya M,Sakisaka Y,Shimauchi H

更新日期：2013-11-01 00:00:00

abstract：:Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural e...

journal_title：International immunopharmacology

authors： Li Z,Ji H,Song X,Hu J,Han N,Chen N

更新日期：2014-05-01 00:00:00

abstract：:Chronic inflammation is a major contributing factor in the pathogenesis of many diseases. Natural product berberine (BBR) exhibits potent anti-inflammatory effect in vitro and in vivo, while the underlying mechanisms remain elusive. Sirt1, a NAD+-dependent protein deacetylase, was recently found to play an important r...

journal_title：International immunopharmacology

authors： Zhang H,Shan Y,Wu Y,Xu C,Yu X,Zhao J,Yan J,Shang W

更新日期：2017-11-01 00:00:00

abstract：:Dermonecrotic toxin (DNT) produced by Bordetella bronchiseptica (B. bronchiseptica) can cause clinical turbinate atrophy in swine and induce dermonecrotic lesions in model mice. We know that the N-terminal of DNT molecule contains the receptor-binding domain, which facilitates binding to the target cells. However, we ...

journal_title：International immunopharmacology

authors： Wang C,Liu L,Zhang Z,Yan Z,Yu C,Shao M,Jiang X,Chi S,Wei K,Zhu R

更新日期：2015-10-01 00:00:00

abstract：:New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

journal_title：International immunopharmacology

authors： Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

更新日期：2009-11-01 00:00:00

abstract：:B1 kinin receptor (B1R) is up-regulated by endotoxins and thus may represent a therapeutic target in sepsis. We investigated the expression and role of B1R and B2R in the acute phase of lipopolysaccharide (LPS)-induced endotoxin shock in C57BL/6 mice (WT) and B1R and B2R knock out mice (B1KO, B2KO). B1R mRNA was enhan...

journal_title：International immunopharmacology

authors： Seguin T,Buleon M,Destrube M,Ranera MT,Couture R,Girolami JP,Tack I

更新日期：2008-02-01 00:00:00

abstract：:Galectin-9 (Gal-9) is a β-galactoside-binding soluble lectin family member that exerts its primary biological functions via specific glycoconjugate interactions. Gal-9 expression is closely related to tumor occurrence, development, metastasis and prognosis. In transplant immunology, a high level of Gal-9 expression ha...

journal_title：International immunopharmacology

authors： Yin J,Li L,Wang C,Zhang Y

更新日期：2020-11-01 00:00:00

abstract：:Atractylodin (ACD) possesses versatile biological and pharmacological activities, including antibacterial, anti-inflammatory and hepatoprotective properties. However, the protective effects of ACD on lipopolysaccharide (LPS) and d-galactosamine (GalN)-induced acute liver failure (ALF) as well as the underlying molecul...

journal_title：International immunopharmacology

authors： Lyu Z,Ji X,Chen G,An B

更新日期：2019-07-01 00:00:00

abstract：:As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR) could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain immune homeostasis. The unbalance of TFR and TFH cells could result in abnormal germinal center responses and contribute to pathogenesi...

journal_title：International immunopharmacology

authors： Liu C,Wang D,Song Y,Lu S,Zhao J,Wang H

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibili...

journal_title：International immunopharmacology

authors： Wang Z,Wang X,Gao Y,Wang Y,Xu M,Han Q,Zhao X

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Recent studies have revealed the significant roles of immune-related long noncoding RNAs (lncRNAs) in cancer development and progression. The identification of biomarkers that contribute to early detection and risk stratification provides significant benefits for bladder cancer (BC) patients. The current stu...

journal_title：International immunopharmacology

authors： Wang J,Shen C,Dong D,Zhong X,Wang Y,Yang X

更新日期：2021-01-01 00:00:00

abstract：:Inflammatory/pro-resorptive cytokines and chemokines form part of a complex inter-dependent network and may be influenced by vitamin D. We investigated their inter-relationship and the effect of a loading dose of vitamin D. We measured plasma concentrations of an array of cytokines including tumour necrosis factor-alp...

journal_title：International immunopharmacology

authors： Karim Y,Turner C,Dalton N,Roplekar R,Sankaralingam A,Ewang M,Fogelman I,Hampson G

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Immunomodulation by indoleamine 2,3-dioxygenase (IDO) has been documented in many studies yet its underlying mechanisms remain undefined, especially in solid organ transplantation. Recent research demonstrated that the active expression of IDO in dendritic cells (DCs) regulates immune reaction. This study as...

journal_title：International immunopharmacology

authors： Li C,Liu T,Zhao N,Zhu L,Wang P,Dai X

更新日期：2016-07-01 00:00:00

abstract：:Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) refer to acute and progressive hypoxic respiratory failure caused by non-cardiogenic factors, which is a common condition occurring in critically ill patients with widespread pulmonary inflammation. Use of a single medication or target cannot treat A...

journal_title：International immunopharmacology

authors： Huang Z,Liu H,Zhang X,Wen G,Zhu C,Zhao Y,Niu W,Qin Y,Chen H,Bai C,Liu G

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Sulfur mustard (SM) intoxication produces local and systemic changes in the human body. In this study, the relationship between tear and serum matrix metalloproteinase (MMP)-9 and serum tissue inhibitors of metalloproteinases (TIMPs) are assessed in serious eye-injured SM-exposed casualties. METHODS:A gro...

journal_title：International immunopharmacology

authors： Ghasemi H,Yaraee R,Faghihzadeh S,Ghassemi-Broumand M,Mahmoudi M,Babaei M,Naderi M,Safavi M,Ghazanfari Z,Rastin M,Zamani S,Tabasi N,Faghihzadeh E,Gharebaghi R,Hassan ZM,Mirsharif ES,Ghazanfari T

更新日期：2019-12-01 00:00:00

abstract：:It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a factor regulating the pathological process of the diseases, substances that regulate macrophage growth or...

journal_title：International immunopharmacology

authors： Yui S,Ubukata K,Hodono K,Kitahara M,Mimaki Y,Kuroda M,Sashida Y,Yamazaki M

更新日期：2001-10-01 00:00:00

abstract：:Problem due to disc degeneration is frequently found in the aging population. However, severe pain and accompanying end plate inflammation is only found in a small subset of patients, who can be of a younger age than most people with severe disc degeneration, with no apparent cause. We hypothesized that deficiencies i...

journal_title：International immunopharmacology

authors： Xu C,Zhang M,Li K,Ni M,Bai Y,Zhang J,Song X,Wang J

更新日期：2019-05-01 00:00:00

abstract：:Mast cells play a critical role during the development of an allergic response. Upon activation by an antigen and IgE, via FcεRI receptors, mast cells release histamine and other mediators that initiate and propagate immediate hypersensitivity reactions. Mast cells also secrete cytokines that regulate the immune respo...

journal_title：International immunopharmacology

authors： de Souza Santos M,Jonis Andrioli W,Freire de Morais Del Lama MP,Kenupp Bastos J,Nanayakkara NP,Zumstein Georgetto Naal RM

更新日期：2013-03-01 00:00:00

abstract：:To study the effects of Taishan Pinus massoniana pollen polysaccharides (TPPPS) on Bordetella avium outer membrane protein A (ompA) recombinant protein vaccine, ompA was expressed, confirmed by Western blotting and mixed with TPPPS. Female BALB/c mice were randomly divided into six groups (I-VI). Groups I, II, and III...

journal_title：International immunopharmacology

authors： Zhao X,Liang M,Yang P,Guo F,Pan D,Huang X,Li Y,Wu C,Qu T,Zhu R

更新日期：2013-11-01 00:00:00