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Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice.

Abstract：

:Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to evaluate the anti-inflammatory and anti-fibrotic effect of thalidomide on PQ-induced lung damage in a mouse model. Mice were injected with a single dose of PQ (20mg/kg, i.p.), and treated with thalidomide (25 and 50mg/kg/day, i.p.) for six days. Lung tissues were dissected six days after PQ injection. The results showed that thalidomide ameliorated the biochemical and histological lung alterations induced by PQ. Thalidomide decreased production of inflammatory and fibrogenic cytokine tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and transforming growth factor (TGF)-β1. In addition thalidomide reduced myeloperoxidase (MPO), nitric oxide (NO), and hydroxyproline content in lung tissue. Taken together, the results of this study suggest that thalidomide might be a valuable therapeutic drug in preventing the progression of PQ-induced pulmonary injury.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Amirshahrokhi K

doi

10.1016/j.intimp.2013.06.005

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

210-5

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(13)00246-4

journal_volume

17

pub_type

杂志文章

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