当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells.

Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells.

Abstract：

:Chronic inflammation is a major contributing factor in the pathogenesis of many diseases. Natural product berberine (BBR) exhibits potent anti-inflammatory effect in vitro and in vivo, while the underlying mechanisms remain elusive. Sirt1, a NAD+-dependent protein deacetylase, was recently found to play an important role in modulating the development and progression of inflammation. Thus, we speculate that Sirt1 might mediate the inhibitory effect of BBR on inflammation. In LPS-stimulated RAW264.7 macrophages, BBR treatment significantly downregulated the expression of proinflammatory cytokines such as MCP-1, IL-6 and TNF-α. Importantly, BBR potently reversed LPS-induced down-regulation of Sirt1. Consistently, the inhibitory effects of BBR on proinflammatory cytokines expression was largely abrogated by Sirt1 inhibition either by EX527, a Sirt1 inhibitor or Sirt1 siRNA. Further mechanistic studies revealed that BBR-induced inhibition of NF-κB is Sirt1-dependent, as either pharmacologically or genetically inactivating Sirt1 enhanced the IκΒα degradation, IKK phosphorylation, NF-κB p65 acetylation and DNA-binding activity. Taken together, our results provide the first evidence that BBR potently suppressed inflammatory responses in macrophages through inhibition of NF-κB signaling via Sirt1-dependent mechanisms.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhang H,Shan Y,Wu Y,Xu C,Yu X,Zhao J,Yan J,Shang W

doi

10.1016/j.intimp.2017.08.032

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

93-100

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(17)30339-9

journal_volume

52

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Thalidomide induce response in patients with corticosteroid-resistant or relapsed ITP by upregulating Neuropilin-1 expression.

    abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated acquired autoimmune hemorrhagic disease. About one-third of patients are unresponsive to first-line therapies. Thalidomide (THD) as an immunomodulatory agent is now used to treat several autoimmune disorders. Therefore, we assessed the safety and efficacy o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.041

    authors： Yang ZG,Wen RT,Zhang YM,Wu GC,Chen WJ,Wang YF,Weng ZY,Wen SS,Zhang XJ,Guan MH

    更新日期：2019-07-01 00:00:00

  • Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation.

    abstract：:Bradykinin-related peptides, the kinins, are blood-derived peptides that stimulate 2 G protein-coupled receptors, the B1 and B2 receptors (B1R, B2R). The pharmacologic and molecular identities of these 2 receptor subtypes will be succinctly reviewed herein, with emphasis on drug development, receptor expression, signa...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106305

    authors： Marceau F,Bachelard H,Bouthillier J,Fortin JP,Morissette G,Bawolak MT,Charest-Morin X,Gera L

    更新日期：2020-02-24 00:00:00

  • New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation.

    abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as poten...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.02.011

    authors： Santos LAMD,Rodrigues GB,Mota FVB,França MER,de Souza Barbosa KP,Oliveira WH,Rocha SWS,Lós DB,Silva AKS,Silva TGD,Peixoto CA

    更新日期：2018-04-01 00:00:00

  • Association of ophthalmic complications in patients with sulfur mustard induced mild ocular complications and serum soluble adhesion molecules: Sardasht-Iran Cohort Study.

    abstract：:The aim of this study was to evaluate possible association between ophthalmic complications in sulfur mustard (SM) exposed patients with mild ocular injuries and serum soluble adhesion molecules. Serum levels of sICAM-1, sL-selectin, sP-selectin and sE-selectin in 367 SM-exposed individuals with or without eye injurie...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.12.014

    authors： Ghasemi H,Yaraee R,Hassan ZM,Faghihzadeh S,Soroush MR,Pourfarzam S,Ebtekar M,Babaei M,Moaiedmohseni S,Naghizadeh MM,Askari N,Ghazanfari T

    更新日期：2013-11-01 00:00:00

  • Magnolol prevents ossified tendinopathy by inhibiting PGE2-induced osteogenic differentiation of TDSCs.

    abstract：:Magnolol is a compound that is extracted from magnolia, is used in Chinese medicine and is a type of lignan. Magnolol has various anti-inflammation, anti-proliferation and pro-autophagy effects. Ossified tendinopathy affects many athletes and people with repetitive tendon injuries. Ossified tendinopathy is a tremendou...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.02.010

    authors： Zhou W,Lin X,Chu J,Jiang T,Zhao H,Yan B,Zhang Z

    更新日期：2019-05-01 00:00:00

  • Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes.

    abstract：OBJECTIVE:To evaluate the anti-inflammatory potential of ICT in LPS stimulated human innate immune cells. BACKGROUND:3, 5, 7-Trihydroxy-4'-methoxy-8-(3-hydroxy-3- methylbutyl)-flavone (ICT) is a novel derivative of icariin, the major active ingredient of Herba Epimedii, an herb used in traditional Chinese medicine. We...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.10.015

    authors： Wu J,Zhou J,Chen X,Fortenbery N,Eksioglu EA,Wei S,Dong J

    更新日期：2012-01-01 00:00:00

  • Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor.

    abstract：:Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.023

    authors： Liu Y,Jiang X,Gu Y,Chen Y

    更新日期：2019-04-01 00:00:00

  • Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives.

    abstract：:Plasma osteopontin (OPN) levels are elevated in tuberculosis patients and may involve granuloma formation. New inhibitors using brefelamide, an aromatic amide isolated from Dictyostelium cellular slime molds that may inhibit OPN transcription in A549 cells at 1 μM concentration, were synthesized as compounds C, D, and...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105831

    authors： Bai G,Matsuba T,Kikuchi H,Chagan-Yasutan H,Motoda H,Ozuru R,Yamada O,Oshima Y,Hattori T

    更新日期：2019-10-01 00:00:00

  • Tumor associated macrophages in the molecular pathogenesis of ovarian cancer.

    abstract：:The tumor microenvironment is a critical factor that enhances cancer progression, drug resistance, and failure of therapeutic approaches. Several cellular and non-cellular factors are involved in cancer promotion. Among the several cell populations in the tumor microenvironment, macrophages, as one of the most abundan...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106471

    authors： Yousefzadeh Y,Hallaj S,Baghi Moornani M,Asghary A,Azizi G,Hojjat-Farsangi M,Ghalamfarsa G,Jadidi-Niaragh F

    更新日期：2020-07-01 00:00:00

  • Characterization and immunostimulatory activity of an (1-->6)-a-D-glucan from the root of Ipomoea batatas.

    abstract：:The polysaccharide PSPP (purified sweet potato polysaccharide), isolated and purified from the roots of Ipomoea batatas, was found to be a glucan with a molecular weight of 53.2 kDa and specific rotation of +115.0 degrees (ca. 0.80, H(2)O). On the basis of methylation analysis, periodate oxidation, Smith degradation, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.03.012

    authors： Zhao G,Kan J,Li Z,Chen Z

    更新日期：2005-08-01 00:00:00

  • Selective impairment of CD4+CD25+Foxp3+ regulatory T cells by paclitaxel is explained by Bcl-2/Bax mediated apoptosis.

    abstract：:Paclitaxel has become one of the most effective and widely used chemotherapeutic agents over the past decades. Although it has shown promise to selectively deplete regulatory T (Treg) cells in our previous study, the underlying molecular mechanism remains to be further elucidated. The present study focused on the effe...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.11.021

    authors： Liu N,Zheng Y,Zhu Y,Xiong S,Chu Y

    更新日期：2011-02-01 00:00:00

  • Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

    abstract：:Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effec...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.018

    authors： Pu WL,Bai RY,Zhou K,Peng YF,Zhang MY,Hottiger MO,Li WH,Gao XM,Sun LK

    更新日期：2019-07-01 00:00:00

  • Neutrophil extracellular traps promote corneal neovascularization-induced by alkali burn.

    abstract：OBJECTIVES:To investigate the effects of neutrophil extracellular traps (NETs) on angiogenesis in vitro and in vivo and the regulatory role of mammalian target of rapamycin (mTOR) activity in it. METHODS:The regulatory role of mTOR in NETs formation was explored. In vitro, human neutrophils were pretreated with rapamy...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106902

    authors： Yuan K,Zheng J,Huang X,Zhang Y,Han Y,Hu R,Jin X

    更新日期：2020-11-01 00:00:00

  • Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system.

    abstract：:The plasma kallikrein/kinin system that consists of the proteins factor XII, prekallikrein, and high molecular weight kininogen was first recognized as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces. Although surface-activated contact activation occurs in vivo wh...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2007.08.022

    authors： Schmaier AH

    更新日期：2008-02-01 00:00:00

  • Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling.

    abstract：:Andrographolide (AG), an ingredient extracted from traditional Chinese herbal medicine Andrographis paniculata, has been demonstrated to have potent anti-inflammatory and anti-oxidative stress properties. The purpose of this study was to investigate whether and how AG attenuated CSE-induced mitochondrial dysfunction, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106230

    authors： Zhang XF,Ding MJ,Cheng C,Zhang Y,Xiang SY,Lu J,Liu ZB

    更新日期：2020-04-01 00:00:00

  • Beneficial effects of chelidonic acid on a model of allergic rhinitis.

    abstract：:Chelidonic acid (CA) is known as an inhibitor of the rat brain glutamate decarboxylase. However, the pharmacological effects of CA in allergic reactions have not yet been defined. Here, we show the effects and the mechanism of CA in the ovalbumin (OVA)-sensitized allergic rhinitis (AR) model. CA significantly decrease...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.10.002

    authors： Oh HA,Kim HM,Jeong HJ

    更新日期：2011-01-01 00:00:00

  • Micheliolide alleviates hepatic steatosis in db/db mice by inhibiting inflammation and promoting autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR signaling.

    abstract：:The anti-inflammatory, immunomodulatory, and anticancer effects of micheliolide (MCL) isolated from Michelia champaca were previously reported, but its role and underlying mechanisms in relieving liver steatosis remain unclear. Herein, we investigated the effects of MCL on hepatic steatosis using a db/db mouse model a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.03.036

    authors： Zhong J,Gong W,Chen J,Qing Y,Wu S,Li H,Huang C,Chen Y,Wang Y,Xu Z,Liu W,Li H,Long H

    更新日期：2018-06-01 00:00:00

  • Reduction of non-specific toxicity of immunotoxin by intein mediated reconstitution on target cells.

    abstract：:Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo and in vitro. However, the non-specific toxicity causes severe syndromes limitin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.11.039

    authors： Wang J,Han L,Chen J,Xie Y,Jiang H,Zhu J

    更新日期：2019-01-01 00:00:00

  • TACI-Ig induces immune balance of Th cells in MLN via BLyS/APRIL-receptors signaling in rats with adjuvant-induced arthritis.

    abstract：:The transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig), a recombinant fusion protein that modulates B and T cells activation by binding and neutralizing B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), has been shown to have a therapeutic...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.09.014

    authors： Qin Q,Chang Y,Wang D,Wu Y,Zhang LL,Wei W

    更新日期：2011-12-01 00:00:00

  • Effects of hydroxyethyl starch (130 kD) on brain inflammatory response and outcome during normotensive sepsis.

    abstract：BACKGROUND:During sepsis, the dysfunction of blood-brain barrier (BBB) was mediated by inflammation and subsequently caused sepsis-associated encephalopathy. Hydroxyethyl starch (HES, 130/0.4) is most widely used for volume replacement to maintain or improve tissue perfusion in patients with sepsis, trauma, and shock. ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.04.020

    authors： Feng X,Zhang F,Dong R,Wang H,Liu J,Liu X,Li W,Yao J,Xu J,Yu B

    更新日期：2010-08-01 00:00:00

  • Gypsophila elegans isoorientin attenuates CCl₄-induced hepatic fibrosis in rats via modulation of NF-κB and TGF-β1/Smad signaling pathways.

    abstract：:The hepatoprotective effect of Gypsophila elegans isoorientin (GEI) was evaluated using a hepatic fibrosis model induced by CCl4 in rats. The results revealed that GEI significantly prevented CCl4-induced liver injury and fibrosis, as evidenced by the attenuation of histopathological changes, the decrease in serum ami...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.06.021

    authors： Lin X,Chen Y,Lv S,Tan S,Zhang S,Huang R,Zhuo L,Liang S,Lu Z,Huang Q

    更新日期：2015-09-01 00:00:00

  • Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes.

    abstract：:Regular bathing in the Blue Lagoon has beneficial effects on psoriasis. Previously, we showed that exopolysaccharides (EPS-Ca) secreted by Cyanobacterium aponinum, a dominating organism in the Blue Lagoon, increased IL-10 secretion by human dendritic cells (DCs). In addition, co-culturing allogeneic CD4+ T cells with ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.044

    authors： Gudmundsdottir AB,Brynjolfsdottir A,Olafsdottir ES,Hardardottir I,Freysdottir J

    更新日期：2019-04-01 00:00:00

  • Upregulation of JHDM1D-AS1 alleviates neuroinflammation and neuronal injury via targeting miR-101-3p-DUSP1 in spinal cord after brachial plexus injury.

    abstract：BACKGROUND:Neuroinflammation in the spinal cord following acute brachial plexus injury (BPI) remains a vital cause that leads to motor dysfunction and neuropathic pain. In this study, we aim to explore the role of long non-coding RNA JHDM1D antisense 1 (JHDM1D-AS1) in mediating BPI-induced neuroinflammation and neurona...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106962

    authors： Liu LP,Zhang J,Pu B,Li WQ,Wang YS

    更新日期：2020-12-01 00:00:00

  • Different roles of IL-15 from IL-2 in differentiation and activation of human CD3+CD56+ NKT-like cells from cord blood in long term culture.

    abstract：:The abundantly available source of stem cells and the low incidence of graft-versus-host disease (GVHD) made cord blood an attractive alternative source of hematopoietic stem cells for transplantation. Besides T cell and NK cell, NKT cell played an important role in low incidence of GVHD during allogeneic transplantat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.02.011

    authors： Wang Y,Zheng X,Wei H,Sun R,Tian Z

    更新日期：2008-06-01 00:00:00

  • Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh.

    abstract：:Water-soluble acidic polysaccharides from the cell walls of Ulva rigida are mainly composed of disaccharides that contain glucuronic acid and sulphated rhamnose. The structure of disaccharides resembles that of glycosaminoglycans (GAGs) as they both contain glucuronic acid and sulphated sugars. Glycosaminoglycans occu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.02.007

    authors： Leiro JM,Castro R,Arranz JA,Lamas J

    更新日期：2007-07-01 00:00:00

  • Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells.

    abstract：:Glucocorticoids (GCs) have been considered to regulate immune cell systems through induction of apoptosis in thymocytes and mature peripheral-blood lymphocytes. Here we report that apoptosis induced by cortisol in mitogen-activated peripheral-blood mononuclear cells (PBMC) is suppressed by cortisone, an oxidized metab...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00135-7

    authors： Hirano T,Horigome A,Takatani M,Oka K

    更新日期：2001-11-01 00:00:00

  • The mechanisms on apoptosis by inhibiting VEGF expression in human breast cancer cells.

    abstract：:This study investigated apoptotic mechanisms of down-expression vascular endothelial growth factor (VEGF) by short interfering RNA (siRNA) in human breast cancer MCF-7 cells. Human breast cancer cells were evaluated for the expression of VEGF and VEGF receptor 2 (VEGFR-2). siRNA targeting VEGF mRNA were chemically syn...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.11.020

    authors： Ge YL,Zhang X,Zhang JY,Hou L,Tian RH

    更新日期：2009-04-01 00:00:00

  • Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657.

    abstract：:Endothelial cells play an important role in inflammatory diseases like rheumatoid arthritis by recruitment of inflammatory cells. The cytokines TNF-alpha and IL-1beta are major inducers of endothelial cell activation and are stimulators of inflammatory signal transduction pathway involving p38 MAPK (mitogen-activated ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.03.005

    authors： Westra J,Kułdo JM,van Rijswijk MH,Molema G,Limburg PC

    更新日期：2005-07-01 00:00:00

  • Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice.

    abstract：:Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.003

    authors： Ishii M,Koyama A,Iseki H,Narumi H,Yokoyama N,Kojima N

    更新日期：2010-09-01 00:00:00

  • Elevated plasma BDNF levels are correlated with NK cell activation in patients with traumatic spinal cord injury.

    abstract：BACKGROUND:The precise role of innate immune responses in the early stage of traumatic spinal cord injury (SCI), especially those mediated by natural killer (NK) cells, is poorly understood. METHODS:The frequency and phenotype of NK cells from traumatic SCI patients and healthy controls were assessed by flow cytometry...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105722

    authors： Xu L,Zhang Y,Zhang R,Zhang H,Song P,Ma T,Li Y,Wang X,Hou X,Li Q,Xu J,Gao X,Shen C

    更新日期：2019-09-01 00:00:00