Abstract:
:Chelidonic acid (CA) is known as an inhibitor of the rat brain glutamate decarboxylase. However, the pharmacological effects of CA in allergic reactions have not yet been defined. Here, we show the effects and the mechanism of CA in the ovalbumin (OVA)-sensitized allergic rhinitis (AR) model. CA significantly decreased the number of nasal/ear rubs and increment of IgE levels in the AR mice. The level of interferon-γ was enhanced while the level of IL-4 was reduced on the spleen tissue of the CA-administered AR mice. Expressions of IL-1β and cyclooxygenase-2 were inhibited by CA administration in the nasal mucosa tissues. Infiltration of eosinophils and mast cells was decreased in the CA-administered AR mice. Furthermore, CA decreased the caspase-1 activity in the same nasal mucosa tissue and human mast cell line, HMC-1. Our results indicate that CA may attenuate allergic reaction by inhibition of caspase-1 activity.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Oh HA,Kim HM,Jeong HJdoi
10.1016/j.intimp.2010.10.002subject
Has Abstractpub_date
2011-01-01 00:00:00pages
39-45issue
1eissn
1567-5769issn
1878-1705pii
S1567-5769(10)00315-2journal_volume
11pub_type
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