Abstract:
UNLABELLED:The mechanistic implications of the presence of sympathetic noradrenergic innervation in lymphoid organs in synaptic association with lymphocytes open to the influence of hormonal fluctuations throughout reproductive age in females has not been investigated yet. OBJECTIVES:The aim of the present study is to investigate the role of alpha-adrenoceptors (α-ARs) and estrogen in modulating immune responses in the spleen through intracellular signaling targets such as ERK 1/2, CREB, Akt, NF-κB. METHODS:Splenocytes from young Sprague-Dawley rats were incubated with α1- and α2- AR specific agonists, phenylephrine and clonidine, without and with 17b-estradiol or specific antagonists prazosin and idazoxan to examine their effects on proliferation, cytokine production, nitric oxide production, and intracellular signaling molecules. RESULTS:α1-AR stimulation inhibited lymphocyte proliferation and IFN-g production and enhanced IL-2, p-ERK and p-CREB expression. Co-stimulation using estrogen enhanced cytokine production and suppressed p-Akt expression. α1-AR blockade reversed agonist-induced IL-2 production alone. α2-AR stimulation inhibited lymphocyte proliferation, p-ERK and p-CREB expression, and increased p-NF-kB and p-Akt expression. Co-stimulation with estrogen increased IL-2 and suppressed p-CREB expression. α2-AR Idazoxan prevented IL-2 production in the absence and presence of estrogen, and reversed clonidine-induced increase in NO production and p-ERK and p-Akt expression in the presence of estrogen. CONCLUSIONS:These results suggest that the cell-mediated immune responses are selectively modulated depending upon the subtypes of α-AR and further, these effects are differentially regulated in the presence of estrogen mediated through selective alteration in the intracellular signaling pathways involving ERK, CREB, Akt, and NF-κB.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Priyanka HP,ThyagaRajan Sdoi
10.1016/j.intimp.2013.08.020subject
Has Abstractpub_date
2013-11-01 00:00:00pages
774-84issue
3eissn
1567-5769issn
1878-1705pii
S1567-5769(13)00341-Xjournal_volume
17pub_type
杂志文章abstract::It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a factor regulating the pathological process of the diseases, substances that regulate macrophage growth or...
journal_title:International immunopharmacology
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doi:10.1016/s1567-5769(01)00126-6
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abstract::This report sought to establish the mechanistic role of sirtuin-1 (Sirt1), a NAD+-dependent deacetylase in the modulation of primary biliary cholangitis (PBC) pathogenesis. 64 PBC patients (diagnosed based on practice guidelines for American Association for the Study of Liver Diseases) and 60 healthy controls were inc...
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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abstract::Allergic diseases are caused by the immune system's response to innocent antigens called allergens. Recent decades have seen a significant increase in the prevalence of allergic diseases worldwide, which has imposed various socio-economic effects in different countries. Various factors, including genetic factors, indu...
journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
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abstract::In the present study, antigenic cross-reactivity of OMPs was investigated in several species of bacterial pathogens. Heterogeneous mouse or fish antisera were used to ascertain OMPs with cross-reactivity and cluster analysis was performed to analyze the distribution of cross-antigenic OMPs in diverse bacterial strains...
journal_title:International immunopharmacology
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更新日期:2005-07-01 00:00:00
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2009.10.016
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abstract::Lung cancer is the major cause of cancer-related mortality and is a growing economic burden worldwide. Chemoprevention has emerged as a very effective preventive measure against carcinogenesis and several bioactive compounds in diet have shown their cancer curative potential on lung cancer. Naringenin (NRG), a predomi...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.11.036
更新日期:2016-01-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.10.024
更新日期:2015-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.10.022
更新日期:2014-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.04.018
更新日期:2019-07-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.04.053
更新日期:2019-08-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2010.09.021
更新日期:2011-01-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2005.09.006
更新日期:2006-03-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
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journal_title:International immunopharmacology
pub_type: 临床试验,杂志文章
doi:10.1016/j.intimp.2007.03.006
更新日期:2007-08-01 00:00:00
abstract::In our previous study, we demonstrated that sesamolin can increase the level of cancer cell susceptibility to natural killer (NK) cell mediated cytolysis when it treats cancer cells. The present study attempted to demonstrate the direct influence of sesamolin on NK cells. To achieve the study goal, an NK cell (NK-92MI...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2018.08.027
更新日期:2018-11-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2012.08.021
更新日期:2012-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.02.046
更新日期:2019-05-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.04.010
更新日期:2019-10-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2012.05.008
更新日期:2012-08-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/s1567-5769(02)00253-9
更新日期:2003-02-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.105810
更新日期:2019-10-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2020.106658
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Diallyl Trisulfide (DATS) is an organosulfur compound extracted from garlic bulb, and exerts cardioprotective, anti-inflammatory, antioxidant, antimicrobial and anticancer effects. But its role in the pathogenesis of rheumatoid arthritis (RA) is unknown. Here we explored the influence of DATS on human fibrob...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.03.024
更新日期:2019-06-01 00:00:00