当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Cudratricusxanthone A from Cudrania tricuspidata suppresses pro-inflammatory mediators through expression of anti-inflammatory heme oxygenase-1 in RAW264.7 macrophages.

Cudratricusxanthone A from Cudrania tricuspidata suppresses pro-inflammatory mediators through expression of anti-inflammatory heme oxygenase-1 in RAW264.7 macrophages.

Abstract：

:Cudratricusxanthone A (CTXA), isolated from the roots of Cudrania tricuspidata Bureau (Moraceae) has an isoprenylated xanthone skeleton that is known to exert a variety of biological activities. In the present study, we demonstrated that CTXA inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) expression, and thereby reduced COX-2-derived prostaglandin E2 (PGE(2)) and iNOS-derived NO production in lipopolysaccharide (LPS)-stimulated macrophages. Similarly, CTXA suppressed tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production. Moreover, CTXA inhibited the induced phosphorylation and degradation of IkappaB-alpha as well as the LPS-induced increase in p65 in the nuclear fraction of macrophages. CTXA also induced heme oxygenase-1 (HO-1) expression and increased heme oxygenase (HO) activity in RAW264.7 macrophages. We also demonstrated that the effects of CTXA on LPS-induced PGE(2), NO, TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor tin protoporphyrin, suggesting that CTXA-induced HO-1 expression was partly responsible for the resulting anti-inflammatory effects of the drug. Thus CTXA was shown to be an effective HO-1 inducer, capable of inhibiting macrophage-derived pro-inflammatory mediators.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Jeong GS,Lee DS,Kim YC

doi

10.1016/j.intimp.2008.11.008

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

241-6

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(08)00352-4

journal_volume

9

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis: A systematic review and meta-analysis.

    abstract：OBJECTIVES:Various studies have researched the serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis (AS), but the results were inconclusive. The purpose of this study was to systematically evaluate the correlations between serum levels of these adipokines and AS. METHODS:Electronic ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.intimp.2017.09.029

    authors： Yang J,Zhang X,Ma Y,Wu M,Hu X,Han R,Yuan Y,Wang M,Chen M,Jiang S,Tong J,Xu S,Xu J,Shuai Z,Zou Y,Pan F

    更新日期：2017-11-01 00:00:00

  • Association of platelet-to-lymphocyte ratio with kidney clinicopathologic features and renal outcomes in patients with diabetic kidney disease.

    abstract：BACKGROUND:Growing evidence points to the pivotal role of inflammation in the pathogenesis of diabetic kidney disease (DKD). However, as an inflammation-based prognostic score, the significance of platelet-to-lymphocyte ratio (PLR) in biopsy-proven DKD remains uncertain. Therefore, the current study aimed to evaluate t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2021.107413

    authors： Duan S,Sun L,Zhang C,Wu L,Nie G,Huang Z,Xing C,Zhang B,Yuan Y

    更新日期：2021-01-29 00:00:00

  • S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways.

    abstract：:The garlic-derived organosulfur compound S-allylmercaptocysteine (SAMC) has been reported to exhibit anti-inflammatory and anti-oxidative activities, whereas its potential therapeutic effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) is unknown. In this study, we focused on exploring the therapeutic e...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106273

    authors： Mo M,Li S,Dong Z,Li C,Sun Y,Li A,Zhao Z

    更新日期：2020-04-01 00:00:00

  • Modulation of cytokine and beta-defensin 2 expressions in human gingival fibroblasts infected with Chlamydia pneumoniae.

    abstract：:Human beta-defensin 2 is an antimicrobial peptide that is produced by several epithelial cells after stimulation with micro-organisms and inflammatory mediators. Gram-negative bacteria, which are typically detected in periodontal pockets in periodontitis, elicit a stronger antibacterial peptide response of human beta-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.04.015

    authors： Rizzo A,Paolillo R,Buommino E,Lanza AG,Guida L,Annunziata M,Carratelli CR

    更新日期：2008-09-01 00:00:00

  • 1,25-Dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade.

    abstract：PURPOSE:The molecular mechanism responsible for the immunomodulatory effect of 1,25-dihydroxyvitamin D3 (Vit-D) is still not well elucidated. Unavoidable systemic toxicity of Vit-D has encouraged to develop more potent and less toxic Vit-D analogs, such as 1,25-dihydroxyvitamin D3-3-bromoacetate (BE). Our aim was to ex...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.08.009

    authors： Datta-Mitra A,Mitra A,Ray R,Raychaudhuri SP,Kundu-Raychaudhuri S

    更新日期：2013-11-01 00:00:00

  • S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation.

    abstract：:Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-in...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.026

    authors： Khajevand-Khazaei MR,Azimi S,Sedighnejad L,Salari S,Ghorbanpour A,Baluchnejadmojarad T,Mohseni-Moghaddam P,Khamse S,Roghani M

    更新日期：2019-04-01 00:00:00

  • Immunomodulatory activity of polysaccharides isolated from Strongylocentrotus nudus eggs.

    abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.09.005

    authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

    更新日期：2008-12-20 00:00:00

  • The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease.

    abstract：:Coronary atherosclerotic heart disease (CHD) is currently regarded as a chronic inflammatory disease. The inflammatory cytokine neopterin (NP) is a new predictor of the stable type of atherosclerotic plaque, and this study focused on the relationship between neopterin, Gensini score and high-sensitivity C-reactive pro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.11.013

    authors： Lyu Y,Jiang X,Dai W

    更新日期：2015-02-01 00:00:00

  • Oral immunogenicity of the plant proteinase bromelain.

    abstract：:Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we previously reported that long-term oral exposure to bromelain stim...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.08.007

    authors： Hale LP,Fitzhugh DJ,Staats HF

    更新日期：2006-12-20 00:00:00

  • Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice.

    abstract：:P-glycoprotein (PGP), an ATP-dependent membrane transporter is found in epithelial tissues of the liver, kidneys, intestine and blood-brain barrier. In tumor cells, PGP is often overexpressed and confers multidrug resistance toward cancer chemotherapeutics. It has been previously shown in rats that induction of an inf...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0162-3109(00)00271-x

    authors： Hartmann G,Kim H,Piquette-Miller M

    更新日期：2001-02-01 00:00:00

  • PRDM1 levels are associated with clinical diseases in chronic HBV infection and survival of patients with HBV-related hepatocellular carcinoma.

    abstract：:PR domain zinc finger protein 1 (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor involved in B and T cell responses which are implicated in chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study investigated the association of PRDM1 with clinic...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.012

    authors： Li N,Fan X,Wang X,Deng H,Zhang K,Zhang X,Wang Y,Han Q,Lv Y,Liu Z

    更新日期：2019-08-01 00:00:00

  • TNF-alpha regulates vascular smooth muscle cell responses in genetic hypertension.

    abstract：:Cellular and molecular events in vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated. SHR-derived VSMC showed increased proliferative capacity and MAP kinase levels in comparison with WKY-derived VSMC. Flow cytometry analysis revealed that progre...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.03.010

    authors： Lee SJ,Kim WJ,Moon SK

    更新日期：2009-07-01 00:00:00

  • Immunomodulatory properties of Cumaside.

    abstract：:The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with original glycosides d...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.01.017

    authors： Aminin DL,Pinegin BV,Pichugina LV,Zaporozhets TS,Agafonova IG,Boguslavski VM,Silchenko AS,Avilov SA,Stonik VA

    更新日期：2006-07-01 00:00:00

  • Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice.

    abstract：:Zingerone, one of the active components of ginger, is a phenolic alkanone with antioxidant and anti-inflammatory properties. In the present study, we analyzed the role of zingerone against RAW 264.7 cells and acute lung injury induced by lipopolysaccharide (LPS) in mice. RAW cells or BALB/c mice were pretreated with z...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.12.028

    authors： Xie X,Sun S,Zhong W,Soromou LW,Zhou X,Wei M,Ren Y,Ding Y

    更新日期：2014-03-01 00:00:00

  • IL-7R gene variants are associated with breast cancer susceptibility in Chinese Han women.

    abstract：BACKGROUND:Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibili...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106756

    authors： Wang Z,Wang X,Gao Y,Wang Y,Xu M,Han Q,Zhao X

    更新日期：2020-09-01 00:00:00

  • The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells.

    abstract：:The mycotoxin, citrinin (CTN), is a secondary metabolite of the fermented products of Monascus. The mycotoxin can either suppress or stimulate immune responses. In the present study, the immunomodulatory role of CTN in nitric oxide (NO) production, a proinflammatory mediator in the process of inflammation, was investi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.09.017

    authors： Liu BH,Chi JY,Hsiao YW,Tsai KD,Lee YJ,Lin CC,Hsu SC,Yang SM,Lin TH

    更新日期：2010-12-01 00:00:00

  • Role of Fas/Fas ligand-mediated apoptosis in murine contact hypersensitivity.

    abstract：:Apoptosis plays an important role in immune responses, but little is known about its involvement in contact hypersensitivity (CH). In this study, we have investigated the role of Fas/Fas ligand (FasL)-mediated apoptosis in the pathogenesis of CH. Mice were sensitized by one topical application of 100 microl of 3% oxaz...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00081-X

    authors： Xu B,Bulfone-Paus S,Aoyama K,Yu S,Huang P,Morimoto K,Matsushita T,Takeuchi T

    更新日期：2003-07-01 00:00:00

  • C1q/TNF-related protein-9 attenuates atherosclerosis through AMPK-NLRP3 inflammasome singling pathway.

    abstract：BACKGROUNDS:C1q tumor necrosis factor-related protein 9 (CTRP9) has been suggested to exert an atheroprotective effect by modulating the inflammation, foam cell formation, endothelia and smooth muscle cell function via Adenosine Monophosphate Activated Protein Kinase (AMPK) pathway. On the other hand, the NLR Family Py...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105934

    authors： Zhang H,Gong X,Ni S,Wang Y,Zhu L,Ji N

    更新日期：2019-12-01 00:00:00

  • Mechanism of action of disease modifying anti-rheumatic agent, gold sodium thiomalate (GSTM).

    abstract：:GSTM has been used for long in the treatment of rheumatoid arthritis (RA). However, its mechanism of action is still poorly understood. In the last decade, tumor necrosis factor-alpha (TNF-alpha) has emerged as the major pro-inflammatory cytokine in the pathogenesis of RA. We studied the effect of GSTM on spontaneous ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00050-9

    authors： Mangalam AK,Aggarwal A,Naik S

    更新日期：2001-06-01 00:00:00

  • Effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in mice.

    abstract：:We studied the effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in ICR mice. Propolis granular A.P.C dose-related inhibited scratching behavior induced by compound 48/80 and significant inhibition were observed at 1000 mg/kg. However, histamine-induced scratching behavior was...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.06.007

    authors： Shinmei Y,Hossen MA,Okihara K,Sugimoto H,Yamada H,Kamei C

    更新日期：2004-10-01 00:00:00

  • Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.

    abstract：OBJECTIVE:This meta-analysis was performed to evaluate the efficacy of ulinastatin (UTI) and thymosin α1 (Tα1) based immunomodulatory strategy in sepsis patients. METHODS:A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of sepsis with t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.intimp.2015.10.026

    authors： Han D,Shang W,Wang G,Sun L,Zhang Y,Wen H,Xu L

    更新日期：2015-12-01 00:00:00

  • Chloroquine attenuates paraquat-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis.

    abstract：:Paraquat is one of the most extensively used herbicides and has high toxicity for humans and animals. However, there is no effective treatment for paraquat poisoning. The aim of the present study was to evaluate the effects of chloroquine on paraquat-induced lung injury in mice. Mice received a single intraperitoneal ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.02.020

    authors： Shen H,Wu N,Wang Y,Zhao H,Zhang L,Li T,Zhao M

    更新日期：2017-05-01 00:00:00

  • Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE2 release from peritoneal macrophages.

    abstract：:The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and the possible mechanisms underlying the...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.07.017

    authors： Li W,Li H,Mu Q,Zhang H,Yao H,Li J,Niu X

    更新日期：2014-10-01 00:00:00

  • Diallyl Trisulfide can induce fibroblast-like synovial apoptosis and has a therapeutic effect on collagen-induced arthritis in mice via blocking NF-κB and Wnt pathways.

    abstract：BACKGROUND:Diallyl Trisulfide (DATS) is an organosulfur compound extracted from garlic bulb, and exerts cardioprotective, anti-inflammatory, antioxidant, antimicrobial and anticancer effects. But its role in the pathogenesis of rheumatoid arthritis (RA) is unknown. Here we explored the influence of DATS on human fibrob...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.03.024

    authors： Liang JJ,Li HR,Chen Y,Zhang C,Chen DG,Liang ZC,Shi YQ,Zhang LL,Xin L,Zhao DB

    更新日期：2019-06-01 00:00:00

  • American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain.

    abstract：:Inflammatory bowel disease (IBD) is a significant public health problem in the United States. Abdominal pain is a major complaint among individuals with IBD. Successful IBD management not only controls enteric inflammation, but also reduces abdominal discomfort. Recently, increased attention has been focused on altern...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.005

    authors： Wang CZ,Yao H,Zhang CF,Chen L,Wan JY,Huang WH,Zeng J,Zhang QH,Liu Z,Yuan J,Bi Y,Sava-Segal C,Du W,Xu M,Yuan CS

    更新日期：2018-11-01 00:00:00

  • Higenamine promotes M2 macrophage activation and reduces Hmgb1 production through HO-1 induction in a murine model of spinal cord injury.

    abstract：:Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads to the activation of diverse cellular mechanisms in the central nervous system to attempt to repair the damaged spinal cord tissue. Higenamine (HG) (1-[(4-hydroxyphenyl) methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-di...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.10.022

    authors： Zhang Z,Li M,Wang Y,Wu J,Li J

    更新日期：2014-12-01 00:00:00

  • Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock.

    abstract：:Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.07.006

    authors： Cruz EA,Da-Silva SA,Muzitano MF,Silva PM,Costa SS,Rossi-Bergmann B

    更新日期：2008-12-10 00:00:00

  • Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension.

    abstract：:Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and seru...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106789

    authors： Zhong Y,Tang R,Lu Y,Wang W,Xiao C,Meng T,Ao X,Li X,Peng L,Kwadwo Nuro-Gyina P,Zhou Q

    更新日期：2020-10-01 00:00:00

  • Virulizin, a novel immunotherapy agent, stimulates TNFalpha expression in monocytes/macrophages in vitro and in vivo.

    abstract：:Virulizin, a novel biological response modifier, has demonstrated broad antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cancer and prostate cancer. Previous studies have demonstrated a significant role of macrophages and NK cells in the anti...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.06.001

    authors： Li H,Cao MY,Lee Y,Benatar T,Lee V,Feng N,Gu X,Liu P,Jin H,Wang M,Der S,Lightfoot J,Wright JA,Young AH

    更新日期：2007-10-01 00:00:00

  • Malondialdehyde-acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions.

    abstract：OBJECTIVE:To compare anti-malondialdehyde-acetaldehyde (MAA) antibody concentrations between rheumatoid arthritis (RA) patients and healthy and rheumatic disease controls. METHODS:Anti-MAA antibody (IgA, IgM, IgG) was measured using ELISA and banked serum from patients with RA (n = 284), osteoarthritis (OA, n = 330), ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.01.022

    authors： Mikuls TR,Duryee MJ,England BR,Anderson DR,Hearth-Holmes M,Su K,Michaud K,Payne JB,Sayles H,Hunter C,McGowan JD,Klassen LW,Thiele GM

    更新日期：2018-03-01 00:00:00