当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice).

Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice).

Abstract：

:Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds and antioxidant activity, when compared with methanol/acetone and ethanol. To study the anti-inflammatory properties of this extract in experimental type 1 diabetes, NOD mice were divided into two groups: the P. alata group, treated with aqueous extract of P. alata Curtis, and a non-treated control group, followed by diabetes expression analysis. The consumption of aqueous extract and water ad libitum lasted 28 weeks. The treated-group presented a decrease in diabetes incidence, a low quantity of infiltrative cells in pancreatic islets and increased glutathione in the kidney and liver (p<0.05), when compared with the diabetic and non-diabetic control-groups. In conclusion, our results suggest that the consumption of aqueous extract of P. alata may be considered a good source of natural antioxidants and compounds found in its composition can act as anti-inflammatory agents, helping in the control of diabetes.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Colomeu TC,Figueiredo D,Cazarin CB,Schumacher NS,Maróstica MR Jr,Meletti LM,Zollner RL

doi

10.1016/j.intimp.2013.11.005

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

106-15

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(13)00413-X

journal_volume

18

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling.

    abstract：BACKGROUND:Astragaloside IV (AS-IV), the major active triterpenoid in Radix Astragali, has shown anti-tumorigenic properties in certain cancers; however, its role in breast cancer remains unclear. The present study investigated the effects of AS-IV on breast cancer in vitro and in vivo and examined the underlying mecha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.10.001

    authors： Jiang K,Lu Q,Li Q,Ji Y,Chen W,Xue X

    更新日期：2017-01-01 00:00:00

  • 2,3,5,6-Tetramethylpyrazine of Ephedra sinica regulates melanogenesis and inflammation in a UVA-induced melanoma/keratinocytes co-culture system.

    abstract：BACKGROUND:2,3,5,6-Tetramethylpyrazine (TMP) is known as a composition of Ephedra sinica and it has been used in the treatment of several disorders such as asthma, heart failure, rhinitis, and urinary incontinence. It has been reported that TMP inhibits melanoma metastasis and suppression angiogenesis by VEGF. OBJECTI...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.11.028

    authors： Yeom GG,Min S,Kim SY

    更新日期：2014-02-01 00:00:00

  • beta-glucan protects against burn-induced oxidative organ damage in rats.

    abstract：:Thermal injury may lead to systemic inflammatory response, and multiple organ failure. Generation of reactive oxygen radicals and lipid peroxidation play important roles in burn-induced remote organ injury. In the present study, we investigated the putative protective effect of local or systemic beta-glucan treatment ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.07.016

    authors： Toklu HZ,Sener G,Jahovic N,Uslu B,Arbak S,Yeğen BC

    更新日期：2006-02-01 00:00:00

  • Combination treatment of low dose Anti-Thymocyte Globulin (ATG), Rituximab and high dose Sirolimus as induction agents in immune-conditioned recipients.

    abstract：UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2006.09.013

    authors： Ravichandran P,Natrajan T,Jaganathan R

    更新日期：2006-12-20 00:00:00

  • Administration of a vaccine composed of dendritic cells pulsed with premalignant oral lesion lysate to mice bearing carcinogen-induced premalignant oral lesions stimulates a protective immune response.

    abstract：:The use of dendritic cell (DC) vaccines as treatment for malignancy is complicated by immune evasion tactics often employed by carcinomas such as head and neck squamous cell carcinoma (HNSCC). The present study aims to determine if an immune response can be elicited by administering a DC vaccine during the premalignan...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.05.004

    authors： De Costa AM,Justis DN,Schuyler CA,Young MR

    更新日期：2012-07-01 00:00:00

  • Neutrophil extracellular traps promote corneal neovascularization-induced by alkali burn.

    abstract：OBJECTIVES:To investigate the effects of neutrophil extracellular traps (NETs) on angiogenesis in vitro and in vivo and the regulatory role of mammalian target of rapamycin (mTOR) activity in it. METHODS:The regulatory role of mTOR in NETs formation was explored. In vitro, human neutrophils were pretreated with rapamy...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106902

    authors： Yuan K,Zheng J,Huang X,Zhang Y,Han Y,Hu R,Jin X

    更新日期：2020-11-01 00:00:00

  • β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells.

    abstract：:β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose (HG)-induced glomerular mesangial cells (MCs). MCs were maintained under HG condition...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106556

    authors： Li H,Wang D,Chen Y,Yang M

    更新日期：2020-07-01 00:00:00

  • Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte.

    abstract：:In the present study, possible role of phosphodiesterase 7 (PDE7) in development and function of cytotoxic T lymphocyte (CTL) was examined using ASB16165, a specific inhibitor for PDE7. ASB16165 inhibited generation of CTL activity in mixed lymphocyte reaction (MLR), in which splenocytes from C57BL/6N mice were stimul...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.10.005

    authors： Kadoshima-Yamaoka K,Murakawa M,Goto M,Tanaka Y,Inoue H,Murafuji H,Hayashi Y,Nagahira K,Miura K,Nakatsuka T,Chamoto K,Fukuda Y,Nishimura T

    更新日期：2009-01-01 00:00:00

  • MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis.

    abstract：OBJECTIVE:Ankylosing spondylitis (AS) is a disease characterized by inflammation of the sacroiliac joint and the attachment point of the spine. This study aimed to investigate the effect of microRNA (miR)-204-targeted GSDMD on fibroblast-like synoviocytes (FLSs) in AS. METHODS:miR-204, GSDMD, pyrolysis-related genes (...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107227

    authors： Gu G,Huo Y,Xu G,Li L,Yu J,Sheng L,Yin Z

    更新日期：2021-02-01 00:00:00

  • Lactobacillus plantarum reduces Streptococcus pyogenes virulence by modulating the IL-17, IL-23 and Toll-like receptor 2/4 expressions in human epithelial cells.

    abstract：:Streptococcus pyogenes is a common colonizer of the mucosal layers in the mouth, nose, and pharynx but it is also a major Gram-positive human pathogen that causes infections ranging from pharyngitis to severe systemic diseases. The lactobacilli colonize the oral tracts and are known to protect against colonization by ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.07.005

    authors： Rizzo A,Losacco A,Carratelli CR,Domenico MD,Bevilacqua N

    更新日期：2013-10-01 00:00:00

  • Total glucosides of paeony (TGP) inhibits the production of inflammatory cytokines in oral lichen planus by suppressing the NF-κB signaling pathway.

    abstract：:Total glucosides of paeony (TGP) is a bioactive compound extracted from paeony roots and has been widely used to ameliorate inflammation in several autoimmune and inflammatory diseases. However, the anti-inflammatory effect of TGP on oral lichen planus (OLP), a chronic inflammatory oral condition characterized by T-ce...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.04.010

    authors： Wang Y,Zhang H,Du G,Wang Y,Cao T,Luo Q,Chen J,Chen F,Tang G

    更新日期：2016-07-01 00:00:00

  • Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2.

    abstract：:While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106258

    authors： Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

    更新日期：2020-04-01 00:00:00

  • Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa.

    abstract：OBJECTIVE:This study aims to select the most effective anti-Rheumatoid Arthritis (RA) component of flavonoids from Daphne genkwa Sieb. et Zucc. by anti-inflammatory and immunomodulatory effects in vitro, and to elucidate the mechanism. METHODS:The anti-inflammatory and immunomodulatory effects of total flavonoids (TF)...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106384

    authors： Sun YW,Bao Y,Yu H,Chen QJ,Lu F,Zhai S,Zhang CF,Li F,Wang CZ,Yuan CS

    更新日期：2020-06-01 00:00:00

  • Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia.

    abstract：:Upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. As resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.08.008

    authors： Bi XL,Yang JY,Dong YX,Wang JM,Cui YH,Ikeshima T,Zhao YQ,Wu CF

    更新日期：2005-01-01 00:00:00

  • A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice.

    abstract：:Isoflavones, which are phytoestrogens present in large quantities in soy and soy-derived products, have estrogenic activity, inhibit protein tyrosine kinase, and exert other effects in the human body. Thus, the recent spread of soy consumption in Western populations emphasizes the need to more fully understand the pot...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.04.011

    authors： Zhao JH,Sun SJ,Horiguchi H,Arao Y,Kanamori N,Kikuchi A,Oguma E,Kayama F

    更新日期：2005-10-01 00:00:00

  • Recombinant expression of human mannan-binding lectin.

    abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(00)00052-7

    authors： Vorup-Jensen T,Sørensen ES,Jensen UB,Schwaeble W,Kawasaki T,Ma Y,Uemura K,Wakamiya N,Suzuki Y,Jensen TG,Takahashi K,Ezekowitz RA,Thiel S,Jensenius JC

    更新日期：2001-04-01 00:00:00

  • Activation of macrophages and lymphocytes by methylglyoxal against tumor cells in the host.

    abstract：:Methylglyoxal is a normal metabolite and has the potential to affect a wide variety of cellular processes. In particular, it can act selectively against malignant cells. The study described herein was to investigate whether methylglyoxal can enhance the non-specific immunity of the host against tumor cells. Methylglyo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.06.005

    authors： Bhattacharyya N,Pal A,Patra S,Haldar AK,Roy S,Ray M

    更新日期：2008-11-01 00:00:00

  • PRDM1 levels are associated with clinical diseases in chronic HBV infection and survival of patients with HBV-related hepatocellular carcinoma.

    abstract：:PR domain zinc finger protein 1 (PRDM1)/B lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor involved in B and T cell responses which are implicated in chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study investigated the association of PRDM1 with clinic...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.012

    authors： Li N,Fan X,Wang X,Deng H,Zhang K,Zhang X,Wang Y,Han Q,Lv Y,Liu Z

    更新日期：2019-08-01 00:00:00

  • (E)-1-(4-ethoxyphenyl)-3-(4-nitrophenyl)-prop-2-en-1-one suppresses LPS-induced inflammatory response through inhibition of NF-κB signaling pathway.

    abstract：:Flavonoids are a class of compounds that exist in nature with the structure of 2-phenyl-chromone. In Chinese traditional medicine, herbal drugs containing flavonoids are widely used for the treatment of inflammation, cardiovascular disease, tumor and so on. In this study, we investigated the anti-inflammatory effect a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.024

    authors： Xu J,Jia YY,Chen SR,Ye JT,Bu XZ,Hu Y,Ma YZ,Guo JL,Liu PQ

    更新日期：2013-04-01 00:00:00

  • Isolation and purification of immune cells from the liver.

    abstract：:Isolating and purifying liver immune cells are crucial for observing the changes in intrahepatic immune responses during the development of liver diseases and exploring the potential immunological mechanisms. Therefore, the aim of this study was to provide an optimal protocol for isolating immune cells with a high yie...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106632

    authors： Shi W,Wang Y,Zhang C,Jin H,Zeng Z,Wei L,Tian Y,Zhang D,Sun G

    更新日期：2020-08-01 00:00:00

  • Extracellular vesicles derived from mesenchymal stem cells prevent skin fibrosis in the cGVHD mouse model by suppressing the activation of macrophages and B cells immune response.

    abstract：OBJECTIVE:To illustrate the potential effects and mechanism of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) on fibrosis in sclerodermatous chronic graft-versus-host-disease (cGVHD) models after allogeneic hematopoietic stem cell transplantation. METHODS:We first observed the therapeutic effects...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106541

    authors： Guo L,Lai P,Wang Y,Huang T,Chen X,Geng S,Huang X,Luo C,Wu S,Ling W,Huang L,Du X,Weng J

    更新日期：2020-07-01 00:00:00

  • Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation.

    abstract：:We investigated the anti-inflammatory effects of sauchinone, a lignan isolated from Saururus chinensis, and the underlying mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. To assess the effects of sauchinone on LPS-induced macrophages activation, we measured the production of tumor necrosis factor (TNF...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.001

    authors： Bae HB,Li M,Son JK,Seo CS,Chung SH,Kim SJ,Jeong CW,Lee HG,Kim W,Park HC,Kwak SH

    更新日期：2010-09-01 00:00:00

  • Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis.

    abstract：BACKGROUND:Triptolide, the principal active ingredient in the extract of Chinese herb Tripterygium wilfordii Hook , has both anti-inflammatory and immunomodulatory activities. However, the potential therapeutic role of triptolide in IBD was still unknown. Interleukin-10 deficient mice, a well characterized experimental...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.08.019

    authors： Wei X,Gong J,Zhu J,Niu L,Zhu W,Li N,Li J

    更新日期：2008-12-20 00:00:00

  • Evaluation of immunosuppression induced by metronidazole in Balb/c mice and human peripheral blood lymphocytes.

    abstract：:The immunomodulatory effect of metronidazole (MTZ), a nitroimidazole drug used as an antiprotozoal and antibacterial agent, was investigated using Balb/c mice and human peripheral blood lymphocytes. For in vivo studies, mice were divided into six groups, six animals per group, group I received vehicle alone while the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.10.018

    authors： Fararjeh M,Mohammad MK,Bustanji Y,Alkhatib H,Abdalla S

    更新日期：2008-02-01 00:00:00

  • IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B/S100A9-mediated pathway.

    abstract：:Rheumatoid arthritis (RA) is an inflammatory disease with symmetric polyarthritis. IL-6 and NLRP3 inflammasome in macrophages contribute to the pathogenesis of RA. This study aimed to investigate the relationship between IL-6 and the NLRP3 inflammasome in RA. Here, we found that IL-6 inhibition reduced NLRP3 inflammas...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106985

    authors： Wang H,Wang Z,Wang L,Sun L,Liu W,Li Q,Wang J

    更新日期：2020-11-01 00:00:00

  • Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.

    abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.05.012

    authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

    更新日期：2014-08-01 00:00:00

  • TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model.

    abstract：:Angiogenesis plays a crucial role at the early stage of tumorigenesis and tumor progression. A suitable model will be useful not only for the clarification of the underlying molecular mechanisms, but also for high-throughput identification of novel anti-angiogenesis compounds. Here, we established a zebrafish model fo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.12.002

    authors： Yang XJ,Chen GL,Yu SC,Xu C,Xin YH,Li TT,Shi Y,Gu A,Duan JJ,Qian C,Cui YH,Zhang X,Bian XW

    更新日期：2013-02-01 00:00:00

  • Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide.

    abstract：:The objective of this study was to define the role of complement activation in the acute and transient toxicities associated with administration of phosphorothioate oligonucleotides in monkeys. In the absence of complement inhibitor, complement activation blocker-2 (CAB-2), i.v. infusion of 20 mg/kg ISIS 2302 produced...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00142-x

    authors： Henry SP,Beattie G,Yeh G,Chappel A,Giclas P,Mortari A,Jagels MA,Kornbrust DJ,Levin AA

    更新日期：2002-11-01 00:00:00

  • Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage.

    abstract：:Lipopolysaccharide (LPS)-induced TLR4-NF-(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.09.020

    authors： Pei Z,Li H,Guo Y,Jin Y,Lin D

    更新日期：2010-01-01 00:00:00

  • Role of immune system in type 1 diabetes mellitus pathogenesis.

    abstract：:The immune system is the body's natural defense system against invading pathogens. It protects the body from infection and works to communicate an individual's well-being through a complex network of interconnected cells and cytokines. This system is an associated host defense. An uncontrolled immune system has the po...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2014.06.033

    authors： Szablewski L

    更新日期：2014-09-01 00:00:00