Adenovirus-mediated transduction with Histone Deacetylase 4 ameliorates disease progression in an osteoarthritis rat model.

abstract：:Cartilage degradation is one of the pathological changes of osteoarthritis (OA), and accumulating evidence suggests an excess of matrix metalloproteinases (MMPs) plays a role in this cartilage breakdown. Here, we investigated the effects of chlorogenic acid (CGA) on the mRNA and protein expression of MMPs in interleuk...

journal_title：International immunopharmacology

authors： Chen WP,Tang JL,Bao JP,Hu PF,Shi ZL,Wu LD

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Using a combination of homologous and heterologous (mouse/human) polyclonal anti-idiotypic Igs and immune Igs in BALB/c mice we have previously reported attenuation of allergic type responses following OVA immunization. We have now investigated attenuation of an inflammatory colitis in C57BL/6 mice receiving...

journal_title：International immunopharmacology

authors： Gorczynski RM,Hoffmann G

更新日期：2020-06-01 00:00:00

abstract：:Bee venom (BV) has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved in BV-induced apoptosis are still uncharacterized in human leukemic cells. In the present study, we report that BV induces apoptosis in leukemic U937 cells through downregulation of E...

journal_title：International immunopharmacology

authors： Moon DO,Park SY,Heo MS,Kim KC,Park C,Ko WS,Choi YH,Kim GY

更新日期：2006-12-05 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE), an the active component of propolis, is known to have anticarcinogenic, antiviral and various biological activities; however, the effect of CAPE on the immunomodulatory activity in vivo remains unknown. We have investigated the effect of CAPE on the immune system in female Balb/c m...

journal_title：International immunopharmacology

authors： Park JH,Lee JK,Kim HS,Chung ST,Eom JH,Kim KA,Chung SJ,Paik SY,Oh HY

更新日期：2004-03-01 00:00:00

abstract：:Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens gamma/delta TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator prot...

journal_title：International immunopharmacology

authors： Szekeres-Bartho J,Barakonyi A,Par G,Polgar B,Palkovics T,Szereday L

更新日期：2001-06-01 00:00:00

abstract：:In the present study, possible role of phosphodiesterase 7 (PDE7) in development and function of cytotoxic T lymphocyte (CTL) was examined using ASB16165, a specific inhibitor for PDE7. ASB16165 inhibited generation of CTL activity in mixed lymphocyte reaction (MLR), in which splenocytes from C57BL/6N mice were stimul...

journal_title：International immunopharmacology

authors： Kadoshima-Yamaoka K,Murakawa M,Goto M,Tanaka Y,Inoue H,Murafuji H,Hayashi Y,Nagahira K,Miura K,Nakatsuka T,Chamoto K,Fukuda Y,Nishimura T

更新日期：2009-01-01 00:00:00

abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

journal_title：International immunopharmacology

authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

更新日期：2008-12-20 00:00:00

abstract：:The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

journal_title：International immunopharmacology

authors： Wei F,Hao Y

更新日期：2020-03-06 00:00:00

abstract：:Silent information regulator 1 (SIRT1) is a type III histone deacetylase that is related to the inhibition of the inflammatory response. The aim of this study was to investigate the regulation of SIRT1 on isoniazid-induced hepatocyte injury and the possible mechanism of histone modification. We found that compared wit...

journal_title：International immunopharmacology

authors： Zhang Y,Li Y,Li J,Li B,Chong Y,Zheng G,Sun S,Feng F

更新日期：2019-02-01 00:00:00

abstract：:The garlic-derived organosulfur compound S-allylmercaptocysteine (SAMC) has been reported to exhibit anti-inflammatory and anti-oxidative activities, whereas its potential therapeutic effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) is unknown. In this study, we focused on exploring the therapeutic e...

journal_title：International immunopharmacology

authors： Mo M,Li S,Dong Z,Li C,Sun Y,Li A,Zhao Z

更新日期：2020-04-01 00:00:00

abstract：:Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme activity have shown chemopreventive activity in carcinogen-induced and transgenic rodent tumor models and clinically for colon cancer. However, the mechanism(s) by which COX-2 inhibitors reduce carcinogenesis remains controversial. We report herein that administr...

journal_title：International immunopharmacology

authors： Talmadge JE,Hood KC,Zobel LC,Shafer LR,Coles M,Toth B

更新日期：2007-02-01 00:00:00

abstract：:Bothrops snake venoms contain biologically active components, including L-amino acid oxidases (LAAO) that induce significant leukocyte accumulation at inflammatory sites characterized by early neutrophil infiltration. As it remains unclear how snake venoms modulate neutrophil activation and chemokine production, here ...

journal_title：International immunopharmacology

authors： Pereira-Crott LS,Casare-Ogasawara TM,Ambrosio L,Chaim LFP,de Morais FR,Cintra ACO,Canicoba NC,Tucci LFF,Torqueti MR,Sampaio SV,Marzocchi-Machado CM,Castro FA

更新日期：2020-03-01 00:00:00

abstract：:Proteasome inhibitor bortezomib offers one more option for acute or chronic antibody-mediated rejection after kidney transplantation, but aggravated acute kidney injury (AKI) in some cases early after surgery using bortezomib bring new problem. Here, we evaluated the effects of bortezomib and ONX-0914 on renal tubule ...

journal_title：International immunopharmacology

authors： Zhang XZ,Han F,Ding CG,Dou M,Wang YX,Xue WJ,Ding XM,Zheng J,Xu CX,Tian PX

更新日期：2020-03-03 00:00:00

abstract：OBJECTIVE:Histone deacetylases (HDACs) play an important role in dysregulation of histone acetylation/deacetylation, which is the main driving force of the progression of pulmonary fibrosis. Here we investigated the changes in histone acetylation/deacetylation, and the contribution of specific class I and class II HDAC...

journal_title：International immunopharmacology

authors： Li M,Zheng Y,Yuan H,Liu Y,Wen X

更新日期：2017-11-01 00:00:00

abstract：:Dopamine (DA), an important neurotransmitter, has been reported to play a negative role in tumor progression. DA acts its role via dopamine receptors (DRs), which can be divided into five receptor subtypes (D1R-D5R). Among these receptor subtypes, D2R has been found to inhibit IGF-I-induced gastric cancer cell growth....

journal_title：International immunopharmacology

authors： Huang H,Wu K,Ma J,Du Y,Cao C,Nie Y

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, and have been implicated in the pathogenesis of some autoimmune diseases. Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregu...

journal_title：International immunopharmacology

authors： Zhang XM,Shan NN,Sun M,Wang X,Feng XM,Liu X,Li Y,Yuan D,Ding M

更新日期：2014-03-01 00:00:00

abstract：:Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo and in vitro. However, the non-specific toxicity causes severe syndromes limitin...

journal_title：International immunopharmacology

authors： Wang J,Han L,Chen J,Xie Y,Jiang H,Zhu J

更新日期：2019-01-01 00:00:00

abstract：:Water-soluble acidic polysaccharides from the cell walls of Ulva rigida are mainly composed of disaccharides that contain glucuronic acid and sulphated rhamnose. The structure of disaccharides resembles that of glycosaminoglycans (GAGs) as they both contain glucuronic acid and sulphated sugars. Glycosaminoglycans occu...

journal_title：International immunopharmacology

authors： Leiro JM,Castro R,Arranz JA,Lamas J

更新日期：2007-07-01 00:00:00

abstract：:The potentiation of the immune system in pregnant rats was performed with Complete Freund's Adjuvant [CFA; 20μl, subcutaneous at gestation day (GD) 18] in experimentally-induced hyperthyroidism by Levo-thyroxine (L-T4; 10μg/100g of b.w., intraperitoneal from GD 2 to 17). The potential effects on the fetal neuroendocri...

journal_title：International immunopharmacology

authors： Ahmed RG,Abdel-Latif M,Mahdi EA,El-Nesr KA

更新日期：2015-12-01 00:00:00

abstract：:A considerable fraction of renal transplanted patients is susceptible to humoral rejection. Today well-established therapy regimens are available to control antibody-mediated rejection in the short term. Nevertheless, donor-specific antibodies persist and graft function deteriorates over time. This might be due to ins...

journal_title：International immunopharmacology

authors： Matz M,Lehnert M,Lorkowski C,Fabritius K,Weber UA,Mashreghi MF,Neumayer HH,Budde K

更新日期：2013-04-01 00:00:00

abstract：:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...

journal_title：International immunopharmacology

authors： Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

更新日期：2017-10-01 00:00:00

abstract：:Recent studies on the immunosuppressive effects of ultraviolet radiation (UVR) and the related resistance to infections in rodents and humans are presented. The waveband dependency of trans-to-cis isomerisation of urocanic acid in the stratum corneum and the role of DNA damage in UVR-induced erythema and immunosuppres...

journal_title：International immunopharmacology

authors： Termorshuizen F,Garssen J,Norval M,Koulu L,Laihia J,Leino L,Jansen CT,De Gruijl F,Gibbs NK,De Simone C,Van Loveren H

更新日期：2002-02-01 00:00:00

abstract：:Oxidized low density lipoprotein (ox-LDL) can induce the proliferation and differentiation of endothelial cells, which is one of the important mechanisms of ox-LDL atherosclerosis. Adiponectin is an endogenous bioactive polypeptide secreted by adipocytes, it participates in the metabolism of fat and glucose. It has th...

journal_title：International immunopharmacology

authors： Lu Y,Gao X,Wang R,Sun J,Guo B,Wei R,Jia Y

更新日期：2019-08-01 00:00:00

abstract：:Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads to the activation of diverse cellular mechanisms in the central nervous system to attempt to repair the damaged spinal cord tissue. Higenamine (HG) (1-[(4-hydroxyphenyl) methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-di...

journal_title：International immunopharmacology

authors： Zhang Z,Li M,Wang Y,Wu J,Li J

更新日期：2014-12-01 00:00:00

abstract：:Effects of a topical corticosteroid drug, diflucortolone valerate, on the mRNA expressions for four CC- and four CXC-chemokines, which have been reported to be associated with recruitment of different kinds of proinflammatory and inflammatory cells, were investigated by RT-PCR in mice with 2,4,6-trinitrochlorobenzene ...

journal_title：International immunopharmacology

authors： Mitsui G,Hirano T,Niwano Y,Mitsui K,Ohara O,Yanagihara S,Kato M

更新日期：2004-01-01 00:00:00

abstract：:We recently designed a series of N-[4-(t-amino-yl)-but-2-yn-1-yl] isoindoline-1,3-diones as anti-inflammatory compounds, called ZM compounds. These ZM compounds were categorized according to the nature of the cyclic amino groups into ZM2, ZM3, ZM4, and ZM5 and were shown to reduce carrageenan-induced inflammation, inh...

journal_title：International immunopharmacology

authors： Matalka KZ,Alfarhoud F,Qinna NA,Mallah EM,Abu-Dayyih WA,Muhi-eldeen ZA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:New emergence of immunotherapy has significantly improved clinical outcome of melanoma patients with advanced and metastatic diseases. We aimed to develop a gene signature based on the expression of PD-1/PD-L1 signaling pathway genes to predict prognosis and immunotherapy response in melanoma patients. METH...

journal_title：International immunopharmacology

authors： Tian M,Yang J,Han J,He J,Liao W

更新日期：2020-10-01 00:00:00

abstract：:Aseptic periprosthetic osteolysis is a complication induced by wear particles after hip joint replacement, which shortens the service life of prostheses. Although many methods have been applied to prevent this complication, the results were not always successful. In the present study, we explored the prophylactic effe...

journal_title：International immunopharmacology

authors： Zhao S,Yan L,Li X,Zhang Z,Sun Y,Wang J

更新日期：2017-06-01 00:00:00

abstract：:Astilbin (AST), a dihydro-flavonol glycoside, is a major bioactive ingredient in Astilbe thunbergii, Engelhardia roxburghiana, Smilax corbularia and Erythroxylum gonocladum, and has been shown to have anti-inflammatory, antioxidative and neuroprotective effects, suggesting potential therapeutic value in the treatment ...

journal_title：International immunopharmacology

authors： Zhu YL,Sun MF,Jia XB,Cheng K,Xu YD,Zhou ZL,Zhang PH,Qiao CM,Cui C,Chen X,Yang XS,Shen YQ

更新日期：2019-01-01 00:00:00

abstract：:It is generally accepted that the appropriate boost of early immune response will control viral replications and limit the immune-mediated pathology in viral hepatitis. However, poor immunity results in viral persistence, chronic inflammation and finally liver cirrhosis and carcinoma. As a peripheral non-lymphoid orga...

journal_title：International immunopharmacology

authors： Liang Y,Kwota Z,Sun J

更新日期：2016-10-01 00:00:00