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Primary immunosuppression with tacrolimus after liver transplantation: 12-years follow-up.

Abstract：

:The early safety and efficacy of tacrolimus after liver transplantation has been shown in two multicenter trials. Herein, we report our single-center long-term follow-up of a randomized controlled trial. As part of a European multicenter trial, 121 patients entered the study at our institution and were randomly assigned to receive either tacrolimus and steroids (n=61) or a quadruple protocol (n=60) using ciclosporin A, steroids, azathioprine, and antithymocyte globulin (ATG). Twelve-year figures of patient survival were 74% in the tacrolimus group and 66% in the cyclosporine-based group. Graft survival after 12 years was 69% in the tacrolimus group compared to 56% in the cyclosporin-based group (not significant, p=0.15). The total rate of graft loss and retransplantation decreased significantly in the tacrolimus arm (p<0.05). De novo malignancies increased significantly in the ciclosporin-based group and dominated as single cause of death beyond 5 years posttransplant. The use of tacrolimus after liver transplantation resulted in a decreased rate of graft loss over the long-term. An increased number of de novo malignancies in the ciclosporin-based group may be attributable to the use of ATG as induction therapy.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Jonas S,Neuhaus R,Junge G,Klupp J,Theruvat T,Langrehr JM,Settmacher U,Neuhaus P

doi

10.1016/j.intimp.2004.09.014

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

125-8

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(04)00299-1

journal_volume

5

pub_type

临床试验,杂志文章,随机对照试验

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