Fosfomycin inhibits neutrophil function via a protein kinase C-dependent signaling pathway.

abstract：:Here, we investigated the role of LXRα in capsaicin mediated anti-inflammatory effects. Results revealed that capsaicin inhibits LPS-induced IL-1β, IL-6 and TNF-α production in a time- and dose-dependent manner. Moreover, capsaicin increases LXRα expression through PPARγ pathway. Inhibition of LXRα activation by siRNA...

journal_title：International immunopharmacology

authors： Tang J,Luo K,Li Y,Chen Q,Tang D,Wang D,Xiao J

更新日期：2015-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis and limited methods to predict patient survival. Immune cells infiltrating tumors are known to impact tumor progression. Here, we analyzed the phenotype and function of dendritic cells (DCs), and the frequency of IL-10-producing regulatory B c...

journal_title：International immunopharmacology

authors： Song S,Yuan P,Li P,Wu H,Lu J,Wei W

更新日期：2014-10-01 00:00:00

abstract：:An emerging role is postulated for IL-17-producing thymocytes, which in their majority consist of IL-17-producing CD4(+) cells. For these, a specific role in the immediate defense against infectious pathogens is suggested, independent from the development of an adaptive immune response in the immune periphery. Immune ...

journal_title：International immunopharmacology

authors： Weber A,Zimmermann C,Mausberg AK,Kieseier BC,Hartung HP,Hofstetter HH

更新日期：2013-10-01 00:00:00

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：:The anti-inflammatory, immunomodulatory, and anticancer effects of micheliolide (MCL) isolated from Michelia champaca were previously reported, but its role and underlying mechanisms in relieving liver steatosis remain unclear. Herein, we investigated the effects of MCL on hepatic steatosis using a db/db mouse model a...

journal_title：International immunopharmacology

authors： Zhong J,Gong W,Chen J,Qing Y,Wu S,Li H,Huang C,Chen Y,Wang Y,Xu Z,Liu W,Li H,Long H

更新日期：2018-06-01 00:00:00

abstract：:Over-activation of microglia disrupts the physiological homeostasis of the brain, and induces inflammatory response and other processes which are implicated in neurodegenerative diseases. Therefore, theoretically, suppression of neuroinflammation would slow the progression of neurodegenerative disease. In this study, ...

journal_title：International immunopharmacology

authors： Bao Y,Chen Q,Xie Y,Tao Z,Jin K,Chen S,Bai Y,Yang J,Shan S

更新日期：2019-12-01 00:00:00

abstract：:Human beta-defensin 2 is an antimicrobial peptide that is produced by several epithelial cells after stimulation with micro-organisms and inflammatory mediators. Gram-negative bacteria, which are typically detected in periodontal pockets in periodontitis, elicit a stronger antibacterial peptide response of human beta-...

journal_title：International immunopharmacology

authors： Rizzo A,Paolillo R,Buommino E,Lanza AG,Guida L,Annunziata M,Carratelli CR

更新日期：2008-09-01 00:00:00

abstract：:Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages. In the present study, we show that CHL inhibited IL-1beta production and its mRNA expression in a lipopolysaccharide (LPS)-stimulated murine macrophage cell-line, RAW 264.7. The inhibitory effect...

journal_title：International immunopharmacology

authors： Yun CH,Jeon YJ,Yang Y,Ju HR,Han SH

更新日期：2006-02-01 00:00:00

abstract：:Oral contraceptives (OC) may cause intrahepatic cholestasis or increase a pre-established liver damage. OC effects on hepatic injury biochemical markers remain contradictory and the role of cytokines in those processes is fairly unknown. Two doses, simple or double, of the OC combination ethinylestradiol/norgestrel we...

journal_title：International immunopharmacology

authors： Fernández-Martínez E,Pérez-Soto E,González-Hernández C,Ortiz MI,Pérez-Álvarez V,Muriel P,Shibayama M

更新日期：2014-07-01 00:00:00

abstract：:Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights...

journal_title：International immunopharmacology

authors： Helal MG,Said E

更新日期：2019-05-01 00:00:00

abstract：:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...

journal_title：International immunopharmacology

authors： Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

更新日期：2017-10-01 00:00:00

abstract：UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...

journal_title：International immunopharmacology

authors： Ravichandran P,Natrajan T,Jaganathan R

更新日期：2006-12-20 00:00:00

abstract：:The polysaccharide PSPP (purified sweet potato polysaccharide), isolated and purified from the roots of Ipomoea batatas, was found to be a glucan with a molecular weight of 53.2 kDa and specific rotation of +115.0 degrees (ca. 0.80, H(2)O). On the basis of methylation analysis, periodate oxidation, Smith degradation, ...

journal_title：International immunopharmacology

authors： Zhao G,Kan J,Li Z,Chen Z

更新日期：2005-08-01 00:00:00

abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

journal_title：International immunopharmacology

authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Ischaemic stroke is a lethal cerebrovascular disease that occurs worldwide. Astilbin is a natural flavonoid compound with various physiological activities. The purpose of this study was to investigate the neuroprotective effects of Astilbin after cerebral ischaemia reperfusion (I/R) injury. METHODS:The oxyg...

journal_title：International immunopharmacology

authors： Li Y,Wang R,Xue L,Yang Y,Zhi F

更新日期：2020-07-01 00:00:00

abstract：:Chelidonic acid (CA) is known as an inhibitor of the rat brain glutamate decarboxylase. However, the pharmacological effects of CA in allergic reactions have not yet been defined. Here, we show the effects and the mechanism of CA in the ovalbumin (OVA)-sensitized allergic rhinitis (AR) model. CA significantly decrease...

journal_title：International immunopharmacology

authors： Oh HA,Kim HM,Jeong HJ

更新日期：2011-01-01 00:00:00

abstract：:Acute lung injury (ALI) is a complex clinical syndrome with high morbidity and mortality rates. Autophagy is an adaptive process that plays a complex role in ALI. The aim of this study was to investigate the effects of autophagy on lipopolysaccharide (LPS)-induced lung injury by establishing a rat ALI model and to fur...

journal_title：International immunopharmacology

authors： Qin L,Li M,Tan HL,Yang HX,Li SD,Luan ZX,Chen YF,Yang MH

更新日期：2020-01-01 00:00:00

abstract：:Neuroinflammation crucially influences functional recovery after ischemic stroke. Wnt-3a, a novel Wnt protein that specifically promotes Wnt/β-catenin signaling pathway, has been shown to regulate apoptosis and cell proliferation, but how it affects ischemic stroke-induced toxic brain inflammation remains unknown. Usi...

journal_title：International immunopharmacology

authors： Zhang D,Lu Z,Man J,Cui K,Fu X,Yu L,Gao Y,Liao L,Xiao Q,Guo R,Zhang Y,Zhang Z,Liu X,Lu H,Wang J

更新日期：2019-10-01 00:00:00

abstract：:It has been recently reported that nicotine, the addictive component of tobacco, is an important modulator at the level of immune cell apoptosis or programmed cell death. Apoptosis is a process that helps maintain the homeostasis of the vascular endothelium and vascular smooth muscle cells, and alteration of the apopt...

journal_title：International immunopharmacology

authors： Hakki A,Friedman H,Pross S

更新日期：2002-09-01 00:00:00

abstract：:Brucellosis is the most common zoonotic disease worldwide and still there is no vaccine for human use. The commercial animal vaccines also have major problems that limit their use. Therefore, there is a need for an effective Brucella vaccine which is multivalent and produces a good protective immunity with minimal dis...

journal_title：International immunopharmacology

authors： Golshani M,Amani M,Amirzadeh F,Nazeri E,Davar Siadat S,Nejati-Moheimani M,Arsang A,Bouzari S

更新日期：2020-07-01 00:00:00

abstract：:The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFalpha, IL-1beta, and NO thus enabling the understanding of the key signaling events involved. ...

journal_title：International immunopharmacology

authors： Gayathri B,Manjula N,Vinaykumar KS,Lakshmi BS,Balakrishnan A

更新日期：2007-04-01 00:00:00

abstract：:Melatonin has anti-oxidant, anti-inflammatory and anti-apoptotic properties. We aimed to investigate the effect of melatonin on the structure and function of mice ovaries following autograft transplantation. NMRI mice were divided into: control, autografted + saline, autografted + melatonin (20 mg/kg/day i.p. injectio...

journal_title：International immunopharmacology

authors： Noori Hassanvand M,Soleimani Mehranjani M,Shojafar E

更新日期：2019-09-01 00:00:00

abstract：:The immune system is the body's natural defense system against invading pathogens. It protects the body from infection and works to communicate an individual's well-being through a complex network of interconnected cells and cytokines. This system is an associated host defense. An uncontrolled immune system has the po...

journal_title：International immunopharmacology

authors： Szablewski L

更新日期：2014-09-01 00:00:00

abstract：:Our group recently reported the strong anti-inflammatory effects of geniposide (Gen), a bioactive iridoid glucoside derived from gardenia jasminoides, in a mouse acute lung injury model. Herein, we hypothesized that Gen might also have potential therapeutic benefits in treatment of asthma, which was tested in a mouse ...

journal_title：International immunopharmacology

authors： Deng Y,Guan M,Xie X,Yang X,Xiang H,Li H,Zou L,Wei J,Wang D,Deng X

更新日期：2013-11-01 00:00:00

abstract：:The immunomodulatory effect of metronidazole (MTZ), a nitroimidazole drug used as an antiprotozoal and antibacterial agent, was investigated using Balb/c mice and human peripheral blood lymphocytes. For in vivo studies, mice were divided into six groups, six animals per group, group I received vehicle alone while the ...

journal_title：International immunopharmacology

authors： Fararjeh M,Mohammad MK,Bustanji Y,Alkhatib H,Abdalla S

更新日期：2008-02-01 00:00:00

abstract：:Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural e...

journal_title：International immunopharmacology

authors： Li Z,Ji H,Song X,Hu J,Han N,Chen N

更新日期：2014-05-01 00:00:00

abstract：:Lung cancer is the leading reason of cancer-related death from cancer globally for both men and women. Recently, tumor immune heterogeneity has been implicated in cancer clinical outcome. However, this prognostic significance of immune cell types in lung squamous cell carcinoma (LUSC) is unclear and should be systemat...

journal_title：International immunopharmacology

authors： Xu F,Zhang H,Chen J,Lin L,Chen Y

更新日期：2020-04-01 00:00:00

abstract：:Anemoside B4 (B4) is a compound extracted from Pulsatilla chinensis(P. chinensis). Pharmacological studies have proved that it has certain anti-inflammatory activity. Acute ulcerative colitis (ulcerative colitis) is a non-specific inflammatory disease whose pathogenesis is not completely known, and there is no effecti...

journal_title：International immunopharmacology

authors： Ma H,Zhou M,Duan W,Chen L,Wang L,Liu P

更新日期：2020-10-01 00:00:00

abstract：:As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR) could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain immune homeostasis. The unbalance of TFR and TFH cells could result in abnormal germinal center responses and contribute to pathogenesi...

journal_title：International immunopharmacology

authors： Liu C,Wang D,Song Y,Lu S,Zhao J,Wang H

更新日期：2018-03-01 00:00:00

abstract：:With the introduction of biological agents, over the last two decades treatment prospects in many medical fields including Rheumatology have experienced an exciting revolution. The advent of biological therapy for specifically rheumatic diseases has provided more effective control of both the underlying disease, and s...

journal_title：International immunopharmacology

authors： Lie G,Sciascia S,Cuadrado MJ

更新日期：2015-08-01 00:00:00