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MiR-130b attenuates vascular inflammation via negatively regulating tumor progression locus 2 (Tpl2) expression.

Abstract：

:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (HUVECs) after lipopolysaccharides (LPS) treatment. Forced expression of miR-130b inhibited the LPS-induced activation of extracellular signal-regulated kinase (ERK) and the inflammatory genes expression, such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α). Furthermore, we identified that tumor progression locus 2 (Tpl2) is a direct target of miR-130b. Finally, in vivo overexpression of miR-130b via miR-130b agomir attenuates acute lung vascular inflammation in the LPS-induced sepsis mouse model. Taken together, our data demonstrated that miR-130b represses vascular inflammation via targeting Tpl2, suggesting that miR-130b mimics might be a promising therapeutic strategy for treatment of vascular inflammatory diseases.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

doi

10.1016/j.intimp.2017.07.020

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

9-16

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(17)30287-4

journal_volume

51

pub_type

杂志文章

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