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Low DNA damage in peripheral lymphocytes of healthy elderly individuals with inverted CD4:CD8 ratio.

Abstract：

:The aim of this study was to evaluate the DNA damage in peripheral lymphocytes and the frequencies of CD8+ T cells expressing CD25, CD28 and CD45ro in aged individuals with inverted CD4:CD8 ratio. Blood samples of elderly individuals (aged >65) with normal CD4:CD8 ratio (n = 8) and inverted CD4:CD8 ratio (n = 8) were collected to identify the expression of CD25+, CD28+ and CD45ro+ in CD8+ T cells. DNA damage index was evaluated by the alkaline comet assay which was performed in lymphocytes treated with different concentrations of methyl methanesulfonate (MMS) (control non-treatment, 2 × 10-5 M, 4 × 10-5 M) for 1, 2 or 24 h. Elderly individuals with inverted CD4:CD8 ratio presented low frequency of CD8+ CD28+. Moreover, low DNA damage was observed in lymphocytes of elderly with inverted CD4:CD8 ratio in different doses of MMS. Aged individuals with inverted CD4:CD8 ratio presented lower DNA damage events in peripheral lymphocytes, suggesting a resistance for cell death in T cells of individuals with immune risk profile.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Dorneles GP,Heuser V,de Andrade VM,Vilela TC,da Silva J,Dalberto D,Chies JA,Peres A

doi

10.1016/j.intimp.2018.12.060

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

483-486

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(18)31083-X

journal_volume

67

pub_type

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