当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.

Suppression of NLRP3 and NF-κB signaling pathways by α-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.

Abstract：

:α-Cyperone is the volatile oil component in Cyperus rotundus L. The previous reports had shown the inhibition of α-Cyperone on NF-κB signaling in LPS-stimulated RAW264.7 cells. However, it is still unclear whether α-Cyperone could suppress inflammatory response in acute lung injury (ALI) induced by LPS. The aim of this study is to investigate the suppression of α-Cyperone on LPS-induced ALI in mice. In this study, we established the LPS-induced ALI model and compared different doses of α-Cyperone with the control group and LPS group. Accordingly, the following indexes would be compared, including lung wet/dry ratio, MPO activity, inflammatory cell number, histopathological changes, levels of inflammatory cytokines, NF-κB and NLRP3 signaling pathways activation. The results demonstrated that α-Cyperone had the effect on reducing the wet/dry ratio and MPO activity. Furthermore, the increase of inflammatory cells and inflammatory cytokines could be inhibited by α-Cyperone. Meanwhile, α-Cyperone could downregulate NF-κB and NLRP3 signaling pathways. Finally, we found α-Cyperone could up-regulate the expression of SIRT1 and SIRT1 inhibitor could reverse the protective effects of α-Cyperone on ALI. In conclusion, α-Cyperone showed the protective effect on LPS-induced ALI in mice by suppressing the NF-κB and NLRP3 signaling pathways, mainly via up-regulating SIRT1. This provides a potential drug for the treatment of LPS-induced ALI.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Liu X,Jin X,Yu D,Liu G

doi

10.1016/j.intimp.2019.105886

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

105886

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(19)31561-9

journal_volume

76

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells.

    abstract：:β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose (HG)-induced glomerular mesangial cells (MCs). MCs were maintained under HG condition...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106556

    authors： Li H,Wang D,Chen Y,Yang M

    更新日期：2020-07-01 00:00:00

  • Biphasic regulation of polymorphonuclear leukocyte spreading by polyphenolic compounds with pyrogallol moieties.

    abstract：:Green tea polyphenols have been reported to have anti-inflammatory activities, although the molecular mechanisms responsible for this effect remain unclear. In the present study, we examined the effect of green tea extract and a variety of polyphenolic compounds on spreading of peripheral blood polymorphonuclear leuko...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.06.003

    authors： Kori S,Namiki H,Suzuki K

    更新日期：2009-09-01 00:00:00

  • The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages.

    abstract：:The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liquid growth was arrested by ≥32 μg/mL and...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.08.023

    authors： Oliveira RA,Azevedo-Ximenes E,Luzzati R,Garcia RC

    更新日期：2010-11-01 00:00:00

  • Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models.

    abstract：:AST2017-01 mainly consists of Rumex crispus and -Cordyceps militaris and has been widely consumed as an herbal medicine or functional food in Korea. Here we investigated the influences of AST2017-01 and its active component, chrysophanol on human mast cell (HMC-1 cell) and human keratinocyte (HaCaT cell)-mediated infl...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.11.019

    authors： Jeong HJ,Kim HY,Kim HM

    更新日期：2018-01-01 00:00:00

  • A non-peptide antagonist unusually selective for the human form of the bradykinin B2 receptor.

    abstract：:Analgesic and anti-inflammatory applications for non-peptide bradykinin (BK) B2 receptor antagonists have been documented in rats. However, very large species differences in affinity were also noted within this class of drugs, making the preclinical development of relevant drugs difficult. Bradyzide is a potent antago...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00180-2

    authors： Marceau F,Fortin JP,Morissette G,Dziadulewicz EK

    更新日期：2003-10-01 00:00:00

  • Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation.

    abstract：:Acetylcholine (ACh), a classical neurotransmitter, has been shown to be present in various non-neuronal cells, including cells of the eye, such as corneal epithelium and endothelium, and to have widespread physiological effects such as cytoskeleton reorganization, cellular proliferation, differentiation, and apoptosis...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.039

    authors： Słoniecka M,Backman LJ,Danielson P

    更新日期：2015-11-01 00:00:00

  • Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.

    abstract：OBJECTIVE:This meta-analysis was performed to evaluate the efficacy of ulinastatin (UTI) and thymosin α1 (Tα1) based immunomodulatory strategy in sepsis patients. METHODS:A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of sepsis with t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.intimp.2015.10.026

    authors： Han D,Shang W,Wang G,Sun L,Zhang Y,Wen H,Xu L

    更新日期：2015-12-01 00:00:00

  • Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells.

    abstract：:Emerging evidences indicated that NLRP3 inflammasome initiates inflammatory response involved in cardiovascular disease. Nicotinic acid (NA) has been known to possess potential anti-inflammatory property. The aim of this study was to investigate the effect of NA on the activation of NLRP3 inflammasome and the underlyi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.09.003

    authors： Li Y,Yang G,Yang X,Wang W,Zhang J,He Y,Zhang W,Jing T,Lin R

    更新日期：2016-11-01 00:00:00

  • Evaluation of immunosuppression induced by metronidazole in Balb/c mice and human peripheral blood lymphocytes.

    abstract：:The immunomodulatory effect of metronidazole (MTZ), a nitroimidazole drug used as an antiprotozoal and antibacterial agent, was investigated using Balb/c mice and human peripheral blood lymphocytes. For in vivo studies, mice were divided into six groups, six animals per group, group I received vehicle alone while the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.10.018

    authors： Fararjeh M,Mohammad MK,Bustanji Y,Alkhatib H,Abdalla S

    更新日期：2008-02-01 00:00:00

  • Iguratimod (T-614) suppresses RANKL-induced osteoclast differentiation and migration in RAW264.7 cells via NF-κB and MAPK pathways.

    abstract：INTRODUCTION:Iguratimod (T-614) has been confirmed as a highly efficacious and safe novel disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis therapy in China and Japan due to its potent anti-inflammation effect. Here, we investigate the effects of Iguratimod on osteoclast differentiation, migration ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.03.038

    authors： Gan K,Yang L,Xu L,Feng X,Zhang Q,Wang F,Tan W,Zhang M

    更新日期：2016-06-01 00:00:00

  • A higher frequency of peripheral blood activated B cells in patients with non-traumatic osteonecrosis of the femoral head.

    abstract：OBJECTIVES:B cells play important roles in inflammatory diseases. This study was aimed at examining the frequency of different subsets of B cells in patients with non-traumatic osteonecrosis of the femoral head (NONFH). METHODS:The percentages of the different subsets of circulating B cells in 28 patients with steroid...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.02.016

    authors： Zhang H,Xiao F,Liu Y,Zhao D,Shan Y,Jiang Y

    更新日期：2014-05-01 00:00:00

  • Effect of elevated carbon dioxide on bronchial epithelial innate immune receptor response to organic dust from swine confinement barns.

    abstract：:Hypercapnia is known to have immunoregulatory effects within the lung. Cell culture systems demonstrate this in both macrophages and alveolar cell lines, suggesting that the alveoli are affected by changes in CO2 levels. We hypothesized that hypercapnia would also modulate human bronchial epithelial cell immune respon...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.04.031

    authors： Schneberger D,Cloonan D,DeVasure JM,Bailey KL,Romberger DJ,Wyatt TA

    更新日期：2015-07-01 00:00:00

  • Is neuroimmunomodulation a future therapeutic approach for sepsis?

    abstract：:Sepsis is considered as a disease of profoundly and uncontrollably activated innate immune response against bacterial infection or their products. Thus, regulation of innate immune response plays a critical role in controlling exaggerated systemic inflammation responsible for sepsis development. However, treatment of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2009.10.003

    authors： Kumar V,Sharma A

    更新日期：2010-01-01 00:00:00

  • Fosfomycin inhibits neutrophil function via a protein kinase C-dependent signaling pathway.

    abstract：:We investigated effects of fosfomycin (FOM) on neutrophil function, specifically the oxidative burst and adhesion molecule expression (CD11b/CD18, or MAC-1) using flow cytometry assay. Preincubation of polymorphonuclear leukocytes (PMNL) with FOM from 1 to 100 microg/ml prior to stimulation by phorbol 12-myristate 13-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00194-1

    authors： Hamada M,Honda J,Yoshimuta T,Fumimori T,Okamoto M,Aizawa H

    更新日期：2002-03-01 00:00:00

  • Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.

    abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.05.012

    authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

    更新日期：2014-08-01 00:00:00

  • Upregulation of bacterial-specific Th1 and Th17 responses that are enriched in CXCR5+CD4+ T cells in non-small cell lung cancer.

    abstract：:The microbial community in the mucosal surfaces is involved in the development of human cancers, including gastric cancer and colorectal cancer. The respiratory tract in the lung also hosts a distinctive microbial community, but the correlation between this community and lung cancer is largely unknown. Here, we examin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.09.024

    authors： Ma QY,Huang DY,Zhang HJ,Wang S,Chen XF

    更新日期：2017-11-01 00:00:00

  • γδ T cells in infection and autoimmunity.

    abstract：:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.03.038

    authors： Hou L,Wang T,Sun J

    更新日期：2015-10-01 00:00:00

  • Combined treatment with colchicine and Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.) attenuates Behcet's disease-like symptoms in mice and influences the expressions of cytokines.

    abstract：:Herbal medicine, Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.), was administered to mice with Behcet's disease (BD)-like symptoms induced by herpes simplex virus (HSV). BD is a chronic recurrent inflammatory disease. Herba Taraxaci (6 mg) was administered alone or in combination with 2 microg of colchicine to BD-l...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00071-7

    authors： Sohn S,Bang D,Lee SI,Kim YA,Lee ES,Ha JY,Kim JH,Choi SY,Lee S

    更新日期：2003-05-01 00:00:00

  • Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK.

    abstract：:Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.04.002

    authors： Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

    更新日期：2017-06-01 00:00:00

  • Sesamolin affects both natural killer cells and cancer cells in order to create an optimal environment for cancer cell sensitization.

    abstract：:In our previous study, we demonstrated that sesamolin can increase the level of cancer cell susceptibility to natural killer (NK) cell mediated cytolysis when it treats cancer cells. The present study attempted to demonstrate the direct influence of sesamolin on NK cells. To achieve the study goal, an NK cell (NK-92MI...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.08.027

    authors： Lee SE,Lee JK

    更新日期：2018-11-01 00:00:00

  • Maturation of dendritic cells induced by Candida beta-D-glucan.

    abstract：:We investigated whether Candida beta-D-glucan (CSBG) alters the maturation of dendritic cells (DCs). DC phenotypes were analyzed using FACScan. The expression of surface molecules, including major histocompatibility complex (MHC) classes I and II, as well as CD80 and CD86, increased on DCs that were stimulated with li...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00084-x

    authors： Kikuchi T,Ohno N,Ohno T

    更新日期：2002-09-01 00:00:00

  • Elevated serum levels of M30 and M65 in patients with locally advanced head and neck tumors.

    abstract：BACKGROUND:M30-Apoptosense and M65 ELISAs can detect caspase cleaved and intact forms of cytokeratin 18. As biologic marker of cell death, both assays can be useful to evaluate prognosis and chemotherapy response in the patients with breast, lung, and endometrium cancer. In the present study, we measured serum M30 and ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.02.004

    authors： Ozturk B,Coskun U,Sancak B,Yaman E,Buyukberber S,Benekli M

    更新日期：2009-05-01 00:00:00

  • Peltophorum dubium and soybean Kunitz-type trypsin inhibitors induce human Jurkat cell apoptosis.

    abstract：:Plants constitute an important source of compounds which can induce apoptosis in a variety of cells. Previously, we reported the isolation of a trypsin inhibitor from Peltophorum dubium seeds (PDTI). This inhibitor, as well as soybean trypsin inhibitor (SBTI), both belonging to the Kunitz family, have lectin-like prop...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.01.002

    authors： Troncoso MF,Biron VA,Longhi SA,Retegui LA,Wolfenstein-Todel C

    更新日期：2007-05-01 00:00:00

  • Correlation of Tc17 cells at early stages after allogeneic hematopoietic stem cell transplantation with acute graft-versus-host disease.

    abstract：:Acute graft-versus-host disease (aGVHD) is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, IL-17-producing T cells including Th17 and Tc17 cells have been implicated in immune-related diseases. However, their roles in aGVHD remain uncertain. In the study, we analyzed IL-17-producin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.11.003

    authors： Wang L,Zhao P,Song L,Yan F,Shi C,Li Y,Han M,Lan K

    更新日期：2016-12-01 00:00:00

  • Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation.

    abstract：:Acute graft-versus-host disease (aGVHD) is a major complication following transplantation, limiting the success of this therapy. Chitinase 3-like-1 (CHI3L1), a member of the glycosyl hydrolase 18 family, plays a critical role in bacterial infections, allergic disease and a variety of malignancies. Here, we investigate...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.03.010

    authors： Li Z,Gu J,Liu J,Zhu Q,Lu H,Lu Y,Rao J,Lu L,Wang X

    更新日期：2017-05-01 00:00:00

  • Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system.

    abstract：:The plasma kallikrein/kinin system that consists of the proteins factor XII, prekallikrein, and high molecular weight kininogen was first recognized as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces. Although surface-activated contact activation occurs in vivo wh...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2007.08.022

    authors： Schmaier AH

    更新日期：2008-02-01 00:00:00

  • Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models.

    abstract：:Due to the broad anti-inflammatory and immunomodulatory actions of phosphodiesterase (PDE) 4 inhibitors, it has been proposed that PDE4 inhibitors might be efficacious for skin disorders such as atopic dermatitis. KF66490 is a newly developed PDE4 inhibitor that inhibits PDE4B (IC(50)=220 nM) and the production of tum...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.09.011

    authors： Harada D,Takada C,Nosaka Y,Takashima Y,Kobayashi K,Takaba K,Manabe H

    更新日期：2009-01-01 00:00:00

  • Dietary garlic (Allium sativum) lectins, ASA I and ASA II, are highly stable and immunogenic.

    abstract：:The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. Int. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins as a function of pH, temperature and denaturants has been examine...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.022

    authors： Clement F,Venkatesh YP

    更新日期：2010-10-01 00:00:00

  • Therapeutic drug monitoring and safety of voriconazole in elderly patients.

    abstract：BACKGROUND:Data on therapeutic drug monitoring of voriconazole in elderly patients are limited. Impaired liver function and an inflammatory state in elderly individuals are hypothesized to impact the voriconazole serum level. METHODS:A total of 166 adult patients (317 trough concentrations) who underwent voriconazole ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106078

    authors： Cheng L,Xiang R,Liu F,Li Y,Chen H,Yao P,Sun F,Xia P

    更新日期：2020-01-01 00:00:00

  • Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression.

    abstract：:Lung cancer is the major cause of cancer-related mortality and is a growing economic burden worldwide. Chemoprevention has emerged as a very effective preventive measure against carcinogenesis and several bioactive compounds in diet have shown their cancer curative potential on lung cancer. Naringenin (NRG), a predomi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.11.036

    authors： Bodduluru LN,Kasala ER,Madhana RM,Barua CC,Hussain MI,Haloi P,Borah P

    更新日期：2016-01-01 00:00:00