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Sesamolin affects both natural killer cells and cancer cells in order to create an optimal environment for cancer cell sensitization.

Abstract：

:In our previous study, we demonstrated that sesamolin can increase the level of cancer cell susceptibility to natural killer (NK) cell mediated cytolysis when it treats cancer cells. The present study attempted to demonstrate the direct influence of sesamolin on NK cells. To achieve the study goal, an NK cell (NK-92MI) or Raji cell was treated with sesamolin for use in the analysis of the cytolytic activity of NK cells. When NK-92MI cells were treated with sesamolin, the cytolysis activities of NK cells increased depending on the concentration of sesamolin. However, the highest cytolytic activity of NK cells was observed when Raji and NK-92MI cells were treated with sesamolin at 20 μg/mL and 40 μg/mL, respectively. Sesamolin also increased the expression of the degranulation marker, CD107a, on the surface of NK cells and the production of immune-activation cytokine, IFN-γ, from NK cells. The effects of sesamolin on NK cells were reproduced in the naïve NK cells. We found that sesamolin effects are triggered by the result of phosphorylation of the p38, ERK1/2 and JNK pathways in NK cells. Taken together, this study proved that NK cell activity can be increased by the stimulation of sesamolin on NK cells as well as cancer cells.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Lee SE,Lee JK

doi

10.1016/j.intimp.2018.08.027

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

16-23

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(18)30441-7

journal_volume

64

pub_type

杂志文章

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