Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.

Abstract:

OBJECTIVE:This meta-analysis was performed to evaluate the efficacy of ulinastatin (UTI) and thymosin α1 (Tα1) based immunomodulatory strategy in sepsis patients. METHODS:A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of sepsis with the combination of ulinastatin and Tα1, compared with placebo, were reviewed. Studies were pooled to relative risk (RR) and weighted mean differences (WMD), with 95% confidence interval (CI). RESULTS:Six trials (enrolling 915 participants) met the inclusion criteria. Compared with placebo, the combination of ulinastatin and Tα1 presented significant effects on 28-day all-cause mortality (RR 0.67; 95% CI 0.57 to 0.80), 90-day all-cause mortality (RR 0.75; 95% CI 0.61 to 0.93), TNF-α (WMD -73.86ng/L; 95% CI -91.00 to -56.73ng/L), IL-6 (WMD -55.04ng/L; 95% CI -61.22 to -48.85ng/L), and duration of mechanical ventilation (WMD -2.26days; 95% CI -2.79 to -1.73days). CONCLUSIONS:Immunomodulatory therapy that combines ulinastatin and Tα1 significantly improves all-cause mortality, inflammatory mediators and duration of mechanical ventilation in subjects with sepsis.

journal_name

Int Immunopharmacol

authors

Han D,Shang W,Wang G,Sun L,Zhang Y,Wen H,Xu L

doi

10.1016/j.intimp.2015.10.026

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

377-382

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(15)30155-7

journal_volume

29

pub_type

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