Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.


OBJECTIVE:This meta-analysis was performed to evaluate the efficacy of ulinastatin (UTI) and thymosin α1 (Tα1) based immunomodulatory strategy in sepsis patients. METHODS:A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of sepsis with the combination of ulinastatin and Tα1, compared with placebo, were reviewed. Studies were pooled to relative risk (RR) and weighted mean differences (WMD), with 95% confidence interval (CI). RESULTS:Six trials (enrolling 915 participants) met the inclusion criteria. Compared with placebo, the combination of ulinastatin and Tα1 presented significant effects on 28-day all-cause mortality (RR 0.67; 95% CI 0.57 to 0.80), 90-day all-cause mortality (RR 0.75; 95% CI 0.61 to 0.93), TNF-α (WMD -73.86ng/L; 95% CI -91.00 to -56.73ng/L), IL-6 (WMD -55.04ng/L; 95% CI -61.22 to -48.85ng/L), and duration of mechanical ventilation (WMD -2.26days; 95% CI -2.79 to -1.73days). CONCLUSIONS:Immunomodulatory therapy that combines ulinastatin and Tα1 significantly improves all-cause mortality, inflammatory mediators and duration of mechanical ventilation in subjects with sepsis.


Int Immunopharmacol


Han D,Shang W,Wang G,Sun L,Zhang Y,Wen H,Xu L




Has Abstract


2015-12-01 00:00:00














  • Immunogenicity and protective efficacy of multistage vaccine candidates (Mtb8.4-HspX and HspX-Mtb8.4) against Mycobacterium tuberculosis infection in mice.

    abstract::In this study, Mtb8.4 and HspX, which are expressed at proliferating and dormant stages of Mycobacterium tuberculosis (M. tuberculosis), respectively, were chosen to construct two fusion proteins, Mtb8.4-HspX (8.4H) and HspX-Mtb8.4 (H8.4), and we investigated whether the antigen dose and protein sequential order could...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Liu W,Li J,Niu H,Lin X,Li R,Wang Y,Xin Q,Yu H,Wu Y,Zhu B,Tan J

    更新日期:2017-12-01 00:00:00

  • Carvedilol can attenuate histamine-induced paw edema and formaldehyde-induced arthritis in rats without risk of gastric irritation.

    abstract:BACKGROUND AND AIM:Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Osman AS,Labib DA,Kamel MM

    更新日期:2017-09-01 00:00:00

  • Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.

    abstract::Acute liver injury (ALI) is a dramatic liver disease characterized by large areas of inflammation in the liver. This study aimed to investigate the protective effects of ginsenoside Rg1 (Rg1), a biologically active component in Panax ginseng, on lipopolysaccharide/d-galactosamine (LPS/D-GalN)-induced ALI in mice, and ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Ning C,Gao X,Wang C,Huo X,Liu Z,Sun H,Yang X,Sun P,Ma X,Meng Q,Liu K

    更新日期:2018-08-01 00:00:00

  • Scutellarin suppresses cartilage destruction in osteoarthritis mouse model by inhibiting the NF-κB and PI3K/AKT signaling pathways.

    abstract::Osteoarthritis (OA), a common and severe disease, is predominantly characterized by cartilage destruction, which results in the degeneration of joint surfaces. Nowadays, it is accepted that TNFα plays a critical role in OA. Scutellarin, the main bioactive flavonoid glycoside extracted form Erigeron breviscapus, has be...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang W,Li J,Li F,Peng J,Xu M,Shangguan Y,Li Y,Zhao Y,Qiu C,Qu R,Li W,Zhang C,Zhang T

    更新日期:2019-12-01 00:00:00

  • Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L.

    abstract::Type-1 immunity has an essential role for our host defenses against cancer and outer pathogens such as bacteria and virus. We demonstrated here that the edible plant extract of Chrysanthemum coronarium L. (C. coronarium) remarkably activates Type-1 immunity in a Toll-like receptor (TLR)2-, TLR4-, and TLR9-dependent ma...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Tanaka S,Koizumi S,Masuko K,Makiuchi N,Aoyagi Y,Quivy E,Mitamura R,Kano T,Ohkuri T,Wakita D,Chamoto K,Kitamura H,Nishimura T

    更新日期:2011-02-01 00:00:00

  • Correlation of Tc17 cells at early stages after allogeneic hematopoietic stem cell transplantation with acute graft-versus-host disease.

    abstract::Acute graft-versus-host disease (aGVHD) is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, IL-17-producing T cells including Th17 and Tc17 cells have been implicated in immune-related diseases. However, their roles in aGVHD remain uncertain. In the study, we analyzed IL-17-producin...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang L,Zhao P,Song L,Yan F,Shi C,Li Y,Han M,Lan K

    更新日期:2016-12-01 00:00:00

  • A synthetic cyclic peptide derived from Limulus anti-lipopolysaccharide factor neutralizes endotoxin in vitro and in vivo.

    abstract::Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

    更新日期:2008-06-01 00:00:00

  • Association of platelet-to-lymphocyte ratio with kidney clinicopathologic features and renal outcomes in patients with diabetic kidney disease.

    abstract:BACKGROUND:Growing evidence points to the pivotal role of inflammation in the pathogenesis of diabetic kidney disease (DKD). However, as an inflammation-based prognostic score, the significance of platelet-to-lymphocyte ratio (PLR) in biopsy-proven DKD remains uncertain. Therefore, the current study aimed to evaluate t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Duan S,Sun L,Zhang C,Wu L,Nie G,Huang Z,Xing C,Zhang B,Yuan Y

    更新日期:2021-01-29 00:00:00

  • Inflammation research sails through the sea of immunology to reach immunometabolism.

    abstract::Inflammation occurs as a result of acute trauma, invasion of the host by different pathogens, pathogen-associated molecular patterns (PAMPs) or chronic cellular stress generating damage-associated molecular patterns (DAMPs). Thus inflammation may occur under both sterile inflammatory conditions including certain cance...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Kumar V

    更新日期:2019-08-01 00:00:00

  • Morphological and functional analysis of beige (Chèdiak-Higashi syndrome) mouse mast cells with giant granules.

    abstract::Chèdiak-Higashi syndrome is a rare autosomal recessive disease that causes hypopigmentation, recurrent infections, mild coagulation defects and neurological problems. Beige mice carry a mutation in the lysosome trafficking regulator (LYST) gene and display some of the key characteristics of human Chèdiak-Higashi syndr...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Kiyoi T,Liu S,Sahid MNA,Shudou M,Ogasawara M,Mogi M,Maeyama K

    更新日期:2019-04-01 00:00:00

  • Baicalein attenuates pancreatic inflammatory injury through regulating MAPK, STAT 3 and NF-κB activation.

    abstract::Acute pancreatitis (AP) is a common acute abdominal disease with local or systemic inflammatory response, caused by abnormal activation of digestive enzymes. Baicalein has been shown to exert anti-inflammatory effects and to attenuate the pathological changes of AP. The aim of the research was to investigate the effec...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Pu WL,Bai RY,Zhou K,Peng YF,Zhang MY,Hottiger MO,Li WH,Gao XM,Sun LK

    更新日期:2019-07-01 00:00:00

  • Elevated serum levels of M30 and M65 in patients with locally advanced head and neck tumors.

    abstract:BACKGROUND:M30-Apoptosense and M65 ELISAs can detect caspase cleaved and intact forms of cytokeratin 18. As biologic marker of cell death, both assays can be useful to evaluate prognosis and chemotherapy response in the patients with breast, lung, and endometrium cancer. In the present study, we measured serum M30 and ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Ozturk B,Coskun U,Sancak B,Yaman E,Buyukberber S,Benekli M

    更新日期:2009-05-01 00:00:00

  • Chromatin remodeling complex in Treg function.

    abstract::Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Jani A,Chi T,Wan YY

    更新日期:2009-05-01 00:00:00

  • Bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by upregulating microRNA-26a expression.

    abstract:OBJECTIVE:Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been widely applied in disease therapies. However, the role of BMSCs-derived exosomes in depression remains obscure. This study aims to explore the mechanism of BMSCs-derived exosomal microRNA-26a (miR-26a) on hippocampal neuronal injury of depr...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Guo H,Huang B,Wang Y,Zhang Y,Ma Q,Ren Y

    更新日期:2020-02-20 00:00:00

  • Isofraxidin ameliorated influenza viral inflammation in rodents via inhibiting platelet aggregation.

    abstract::Platelets have been proved to exacerbate influenza infection and its complications. Inhibition of platelet activation may be a feasible method for preventing severe infection and secondary acute lung injury (ALI). Isofraxidin (IFD) is a natural coumarin isolated from the plants Sarcandra glabra and Siberian ginseng, a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Jin L,Ying ZH,Yu CH,Zhang HH,Yu WY,Wu XN

    更新日期:2020-07-01 00:00:00

  • Melatonin improves the structure and function of autografted mice ovaries through reducing inflammation: A stereological and biochemical analysis.

    abstract::Melatonin has anti-oxidant, anti-inflammatory and anti-apoptotic properties. We aimed to investigate the effect of melatonin on the structure and function of mice ovaries following autograft transplantation. NMRI mice were divided into: control, autografted + saline, autografted + melatonin (20 mg/kg/day i.p. injectio...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Noori Hassanvand M,Soleimani Mehranjani M,Shojafar E

    更新日期:2019-09-01 00:00:00

  • Differential roles of constitutively activated ERK1/2 and NF-kappa B in cytotoxicity and proliferation by human NK cell lines.

    abstract::Compared with freshly isolated peripheral blood natural killer (NK) cells, the YT and NK-92 cell lines are characterized by elevated cytolytic activity. The molecular mechanisms underlying the rapid proliferation and enhanced lytic activity of NK cell lines are poorly understood. Investigation of these cell lines reve...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Liang S,Zhang J,Wei H,Sun R,Tian Z

    更新日期:2005-05-01 00:00:00

  • Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.

    abstract::The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. In...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Luo X,Lin B,Gao Y,Lei X,Wang X,Li Y,Li T

    更新日期:2019-11-01 00:00:00

  • Adenovirus-mediated transduction with Histone Deacetylase 4 ameliorates disease progression in an osteoarthritis rat model.

    abstract:BACKGROUND:Downregulation of histone deacetylase-4 (HDAC4) contributes to cartilage degeneration in osteoarthritis (OA) because it promotes upregulation of runt-related transcription factor-2 (Runx-2) and osteoarthritis-related genes. The effect of HDAC4 upregulation on cartilage damage in OA remains unknown. METHODS:...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Gu XD,Wei L,Li PC,Che XD,Zhao RP,Han PF,Lu JG,Wei XC

    更新日期:2019-10-01 00:00:00

  • Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.

    abstract::Cartilage degradation is the most predominant pathological change during osteoarthritis (OA). Furthermore, accumulating evidence suggests that an excess of matrix metalloproteinase-13 (MMP-13) plays a critical role in the breakdown of cartilage. Here, the effects of Icariin on the expression of MMP-13 in IL-1β-induced...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zeng L,Wang W,Rong XF,Zhong Y,Jia P,Zhou GQ,Li RH

    更新日期:2014-01-01 00:00:00

  • Immunomodulatory activity of analog of muramyl dipeptide and their use as adjunct to chemotherapy of Leishmania donovani in hamster.

    abstract::In search of a potent immunomodulator to be used as an immunoprophylactic agent and as adjunct to chemotherapy against Leishmania infection, two analogs of muramyl dipeptide, viz. N.Ac-norMur-MeVal-D-isoGln (86/448) and N.AcMur-Acc-D-isoGln (89/729) were evaluated for desired activity. Effect of these peptides on cell...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Puri A,Sahai R,Haq W,Zaidi A,Guru PY,Tripathi LM,Srivastava VM

    更新日期:2005-06-01 00:00:00

  • cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts.

    abstract::Cathepsin K (Cat K) is the major cysteine protease expressed in osteoclast and is thought to play a key role in matrix degradation during bone resorption. It is shown that the intracellular maturation of Cat K was prevented by the cAMP antagonist, Rp-cAMP, and the protein kinase A (PKA) inhibitors of KT5720 and H89. I...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Park YG,Kim YH,Kang SK,Kim CH

    更新日期:2006-06-01 00:00:00

  • Effect of a topical steroid on gene expressions for chemokines in mice with contact hypersensitivity.

    abstract::Effects of a topical corticosteroid drug, diflucortolone valerate, on the mRNA expressions for four CC- and four CXC-chemokines, which have been reported to be associated with recruitment of different kinds of proinflammatory and inflammatory cells, were investigated by RT-PCR in mice with 2,4,6-trinitrochlorobenzene ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Mitsui G,Hirano T,Niwano Y,Mitsui K,Ohara O,Yanagihara S,Kato M

    更新日期:2004-01-01 00:00:00

  • γδ T cells in infection and autoimmunity.

    abstract::Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Hou L,Wang T,Sun J

    更新日期:2015-10-01 00:00:00

  • Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway.

    abstract::Inflammation plays an important role in the pathogenesis of cerebral ischemia. Syringin (SYR) is an active substance isolated from Acanthopanax senticosus plants, and possesses anti-inflammatory and neuroprotective properties. However, its effects on cerebral ischemic injury, as well as the underlying molecular events...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Tan J,Luo J,Meng C,Jiang N,Cao J,Zhao J

    更新日期:2021-01-01 00:00:00

  • Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes.

    abstract::Rheumatoid arthritis is a common autoimmune disease primarily characterized by chronic inflammation, the formation of an invasive pannus, and destruction of the joints. In the present study, we employed real-time PCR and western blot analysis to investigate the role of dulaglutide in human fibroblast-like synoviocytes...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zheng W,Pan H,Wei L,Gao F,Lin X

    更新日期:2019-09-01 00:00:00

  • LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.

    abstract::Hypoxia and the resultant decreases in cerebral blood flow in the perinatal period can lead to neonatal hypoxic-ischemic (HI) brain injury, which can, in turn, cause severe disability or even death. However, the efficacy of current treatment strategies remains limited. Several studies have demonstrated that lipoxin A4...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhu JJ,Yu BY,Fu CC,He MZ,Zhu JH,Chen BW,Zheng YH,Chen SQ,Fu XQ,Li PJ,Lin ZL

    更新日期:2020-12-01 00:00:00

  • Adiponectin inhibits proliferation of vascular endothelial cells induced by Ox-LDL by promoting dephosphorylation of Caveolin-1 and depolymerization of eNOS and up-regulating release of NO.

    abstract::Oxidized low density lipoprotein (ox-LDL) can induce the proliferation and differentiation of endothelial cells, which is one of the important mechanisms of ox-LDL atherosclerosis. Adiponectin is an endogenous bioactive polypeptide secreted by adipocytes, it participates in the metabolism of fat and glucose. It has th...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lu Y,Gao X,Wang R,Sun J,Guo B,Wei R,Jia Y

    更新日期:2019-08-01 00:00:00

  • Progesterone suppresses Aβ42-induced neuroinflammation by enhancing autophagy in astrocytes.

    abstract::Autophagy is an intracellular catabolic mechanism essential for recycling intracellular unfolding protein and eliminating toxic protein aggregates. Several studies have shown that deficient autophagy is implicated in the development of Alzheimer's disease (AD) progression. To date, rapidly emerging evidence suggests t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hong Y,Liu Y,Zhang G,Wu H,Hou Y

    更新日期:2018-01-01 00:00:00

  • Identification of myeloid-derived suppressor cells and T regulatory cells in lung microenvironment after Urethane-induced lung tumor.

    abstract::Tumor growth occurs by the imbalance between cells with effector function and cells with suppressor/regulatory functions. To investigate this scenario we administered the chemical carcinogen Urethane in BALB/c mice and followed these animals during 120 days to observe lung tumor development. In another set of experime...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Rosin FC,Pedregosa JF,de Almeida JS,Bueno V

    更新日期:2011-07-01 00:00:00