Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.


OBJECTIVE:This meta-analysis was performed to evaluate the efficacy of ulinastatin (UTI) and thymosin α1 (Tα1) based immunomodulatory strategy in sepsis patients. METHODS:A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of sepsis with the combination of ulinastatin and Tα1, compared with placebo, were reviewed. Studies were pooled to relative risk (RR) and weighted mean differences (WMD), with 95% confidence interval (CI). RESULTS:Six trials (enrolling 915 participants) met the inclusion criteria. Compared with placebo, the combination of ulinastatin and Tα1 presented significant effects on 28-day all-cause mortality (RR 0.67; 95% CI 0.57 to 0.80), 90-day all-cause mortality (RR 0.75; 95% CI 0.61 to 0.93), TNF-α (WMD -73.86ng/L; 95% CI -91.00 to -56.73ng/L), IL-6 (WMD -55.04ng/L; 95% CI -61.22 to -48.85ng/L), and duration of mechanical ventilation (WMD -2.26days; 95% CI -2.79 to -1.73days). CONCLUSIONS:Immunomodulatory therapy that combines ulinastatin and Tα1 significantly improves all-cause mortality, inflammatory mediators and duration of mechanical ventilation in subjects with sepsis.


Int Immunopharmacol


Han D,Shang W,Wang G,Sun L,Zhang Y,Wen H,Xu L




Has Abstract


2015-12-01 00:00:00














  • Excessive TLR9 signaling contributes to the pathogenesis of spontaneous abortion through impairment of Treg cell survival by activation of Caspase 8/3.

    abstract:BACKGROUND:The pregnant uterine microenvironment is repleted with Toll-like receptors (TLRs), however, their roles of these receptors in establishing tolerance to growing fetus are largely unknown. RESULT:Decidual TLR1, TLR3, TLR4, TLR8 and TLR9 gene expressions were significantly over-expressed in patients of spontan...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Kang X,Zhang X,Liu Z,Xu H,Wang T,He L,Zhao A

    更新日期:2015-12-01 00:00:00

  • Low expression of RGL4 is associated with a poor prognosis and immune infiltration in lung adenocarcinoma patients.

    abstract::Lung adenocarcinoma (LUAD) is a frequently diagnosed histologic subtype with increasing morbidity and mortality. RalGDS-Like 4 (RGL4) has not been reported to be associated with cancer risk, prognosis, immunotherapy or any other treatments. We perform a bioinformatics analysis on data downloaded from the Cancer Genome...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Sun Y,Zhang Y,Ren S,Li X,Yang P,Zhu J,Lin L,Wang Z,Jia Y

    更新日期:2020-06-01 00:00:00

  • Naloxone can improve the anti-tumor immunity by reducing the CD4+CD25+Foxp3+ regulatory T cells in BALB/c mice.

    abstract::New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

    更新日期:2009-11-01 00:00:00

  • Crosstalk between Toll-like receptor 3 and Notch signaling contributes to CD14+ monocytes activity in enterovirus 71 infected hand, foot, and mouth disease.

    abstract::Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hao J,Li P,Tian Y,Wang Y,Li S,Wang L,Li S

    更新日期:2018-07-01 00:00:00

  • Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation.

    abstract::IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear health...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Galle P,Jensen L,Andersson C,Cuzzocrea S,Di Paola R,Nicoletti F,Svenson M,Bendtzen K,Thomsen AR,Hansen MB

    更新日期:2007-12-15 00:00:00

  • Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation.

    abstract::Senescence is an irreversible growth arrest which can be triggered by stresses such as oxidative reaction, telomere shortening, DNA damage, or oncogene signaling. Oxidative stress accelerates vascular endothelial cell senescence, and may promote atherosclerosis in humans. Interleukin-8 (IL-8) has been shown to play an...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shen XH,Xu SJ,Jin CY,Ding F,Zhou YC,Fu GS

    更新日期:2013-06-01 00:00:00

  • Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis.

    abstract:BACKGROUND:There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS:A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science D...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,meta分析


    authors: Yu C,Kang L,Chen J,Zang N

    更新日期:2020-09-01 00:00:00

  • Immune responses modulation by curcumin and allergen encapsulated into PLGA nanoparticles in mice model of rhinitis allergic through sublingual immunotherapy.

    abstract::The purpose of this study was the combination of curcumin and ovalbumin in free form or encapsulated into PLGA NPs (polylactic co-glycolic acid nanoparticles) to enhance their sublingual immunotherapy (SLIT) efficiency in mouse model of rhinitis allergic. PLGA NPs containing curcumin (CUR), ovalbumin (OVA) or both wer...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shahgordi S,Sankian M,Yazdani Y,Mashayekhi K,Hasan Ayati S,Sadeghi M,Saeidi M,Hashemi M

    更新日期:2020-07-01 00:00:00

  • Molecular mechanisms of IgE mediated food allergy.

    abstract::The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also kn...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Kumar S,Verma AK,Das M,Dwivedi PD

    更新日期:2012-08-01 00:00:00

  • Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L.

    abstract::Type-1 immunity has an essential role for our host defenses against cancer and outer pathogens such as bacteria and virus. We demonstrated here that the edible plant extract of Chrysanthemum coronarium L. (C. coronarium) remarkably activates Type-1 immunity in a Toll-like receptor (TLR)2-, TLR4-, and TLR9-dependent ma...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Tanaka S,Koizumi S,Masuko K,Makiuchi N,Aoyagi Y,Quivy E,Mitamura R,Kano T,Ohkuri T,Wakita D,Chamoto K,Kitamura H,Nishimura T

    更新日期:2011-02-01 00:00:00

  • 1, 25-dihydroxyvitamin D3 downregulates cytotoxic effector response in pulmonary tuberculosis.

    abstract::1,25-dihydroxyvitaminD3 [1,25(OH)2D3] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)2D3 on cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (P...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Afsal K,Selvaraj P,Harishankar M

    更新日期:2018-09-01 00:00:00

  • Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-κB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture.

    abstract:BACKGROUND:Many studies have shown that ghrelin can down-regulate inflammatory cytokine expression via the inhibition of NF-κB activity and therefore, its administration to septic patients is considered beneficial. However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Peng Z,Zhu Y,Zhang Y,Wilhelmsen K,Jia C,Jin J,Xue Q,Feng X,Zhang F,Yu B

    更新日期:2012-08-01 00:00:00

  • Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.

    abstract::Salvinorin A (SA), a neoclerodane diterpene, is isolated from the dried leaves ofSalvia divinorum. SA has traditionally been used treatments for chronic pain diseases. Recent research has demonstrated that SA possesses the anti-inflammatory property. The present study aim to explore the effects and potentialmechanisms...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zeng S,Chen D,Liu G,Wu YX,Gao ZQ,Su Y,Yuan JN,Liu L,Shan JC,Pang QF,Zhu T

    更新日期:2021-01-01 00:00:00

  • Analysis of cytokine release assay data using machine learning approaches.

    abstract::The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Xiong F,Janko M,Walker M,Makropoulos D,Weinstock D,Kam M,Hrebien L

    更新日期:2014-10-01 00:00:00

  • Albizia lebbeck suppresses histamine signaling by the inhibition of histamine H1 receptor and histidine decarboxylase gene transcriptions.

    abstract::Histamine plays major roles in allergic diseases and its action is mediated mainly by histamine H(1) receptor (H1R). We have demonstrated that histamine signaling-related H1R and histidine decarboxylase (HDC) genes are allergic diseases sensitive genes and their expression level affects severity of the allergic sympto...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Nurul IM,Mizuguchi H,Shahriar M,Venkatesh P,Maeyama K,Mukherjee PK,Hattori M,Choudhuri MS,Takeda N,Fukui H

    更新日期:2011-11-01 00:00:00

  • Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review.

    abstract::Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Majdalawieh AF,Fayyad MW

    更新日期:2015-09-01 00:00:00

  • Long non-coding RNA PVT1 promote LPS-induced septic acute kidney injury by regulating TNFα and JNK/NF-κB pathways in HK-2 cells.

    abstract::This study aimed to investigate the effect and underlying mechanism of long non-coding RNA plasmacytoma variant translocation 1 (PVT1) in lipopolysaccharide (LPS)-induced inflammation injury in HK-2 cells. We established LPS-induced septic acute kidney injury (AKI) model in HK-2 cells. LPS-induced HK-2 cells were tran...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Huang W,Lan X,Li X,Wang D,Sun Y,Wang Q,Gao H,Yu K

    更新日期:2017-06-01 00:00:00

  • Adenovirus-mediated transduction with Histone Deacetylase 4 ameliorates disease progression in an osteoarthritis rat model.

    abstract:BACKGROUND:Downregulation of histone deacetylase-4 (HDAC4) contributes to cartilage degeneration in osteoarthritis (OA) because it promotes upregulation of runt-related transcription factor-2 (Runx-2) and osteoarthritis-related genes. The effect of HDAC4 upregulation on cartilage damage in OA remains unknown. METHODS:...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Gu XD,Wei L,Li PC,Che XD,Zhao RP,Han PF,Lu JG,Wei XC

    更新日期:2019-10-01 00:00:00

  • Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

    abstract::Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

    更新日期:2020-12-01 00:00:00

  • Genipin inhibits the inflammatory response of rat brain microglial cells.

    abstract::Microglia are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and n...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Nam KN,Choi YS,Jung HJ,Park GH,Park JM,Moon SK,Cho KH,Kang C,Kang I,Oh MS,Lee EH

    更新日期:2010-04-01 00:00:00

  • TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation.

    abstract::The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wei F,Hao Y

    更新日期:2020-03-06 00:00:00

  • Anti-brain cholinergic auto antibodies from primary Sjögren syndrome sera modify simultaneously cerebral nitric oxide and prostaglandin biosynthesis.

    abstract::The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, nitric oxide synthase (NOS) activity was measured in cerebral frontal cortex slices by produ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Orman B,Sterin-Borda L,De Couto Pita A,Reina S,Borda E

    更新日期:2007-12-05 00:00:00

  • Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats.

    abstract::Echinacea plant extract is widely used for the prevention and the treatment of upper respiratory tract infections. However, the active components in the herb, their optimal dosages and their in vivo effects are still undefined. Using male Sprague-Dawley rats (425-475 g), an in vivo study was conducted to examine the i...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Goel V,Chang C,Slama JV,Barton R,Bauer R,Gahler R,Basu TK

    更新日期:2002-02-01 00:00:00

  • γδ T cells in infection and autoimmunity.

    abstract::Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Hou L,Wang T,Sun J

    更新日期:2015-10-01 00:00:00

  • Preventive effect of Diallyl Trisulfide on cutaneous toxicities induced by EGFR inhibitor.

    abstract::Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Liu Y,Jiang X,Gu Y,Chen Y

    更新日期:2019-04-01 00:00:00

  • Tissue-resident dendritic cells and diseases involving dendritic cell malfunction.

    abstract::Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident popula...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Chen K,Wang JM,Yuan R,Yi X,Li L,Gong W,Yang T,Li L,Su S

    更新日期:2016-05-01 00:00:00

  • Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-gamma.

    abstract::Human melanoma Colo 679 cells were made resistant to doxorubicin (adriamycin, ADM) by continuous exposure to ascending concentrations of the drug and Colo/ADM80; a variant which grew continuously in the presence of 80 ng/ml of ADM was thus established. Human peripheral blood mononuclear cells (PBMC) produced interfero...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Micallef MJ,Darmanin S,Buhagiar JA,Camilleri-Podesta MT,Yamauchi H,Kurimoto M,Inglott AS,Ellul-Micallef R

    更新日期:2001-02-01 00:00:00

  • Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.

    abstract::Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

    更新日期:2014-08-01 00:00:00

  • Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice.

    abstract::Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Amirshahrokhi K

    更新日期:2013-10-01 00:00:00

  • Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2.

    abstract::While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

    更新日期:2020-04-01 00:00:00