Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis.

abstract：BACKGROUND:The pregnant uterine microenvironment is repleted with Toll-like receptors (TLRs), however, their roles of these receptors in establishing tolerance to growing fetus are largely unknown. RESULT:Decidual TLR1, TLR3, TLR4, TLR8 and TLR9 gene expressions were significantly over-expressed in patients of spontan...

journal_title：International immunopharmacology

authors： Kang X,Zhang X,Liu Z,Xu H,Wang T,He L,Zhao A

更新日期：2015-12-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a frequently diagnosed histologic subtype with increasing morbidity and mortality. RalGDS-Like 4 (RGL4) has not been reported to be associated with cancer risk, prognosis, immunotherapy or any other treatments. We perform a bioinformatics analysis on data downloaded from the Cancer Genome...

journal_title：International immunopharmacology

authors： Sun Y,Zhang Y,Ren S,Li X,Yang P,Zhu J,Lin L,Wang Z,Jia Y

更新日期：2020-06-01 00:00:00

abstract：:New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

journal_title：International immunopharmacology

authors： Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

更新日期：2009-11-01 00:00:00

abstract：:Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate...

journal_title：International immunopharmacology

authors： Hao J,Li P,Tian Y,Wang Y,Li S,Wang L,Li S

更新日期：2018-07-01 00:00:00

abstract：:IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear health...

journal_title：International immunopharmacology

authors： Galle P,Jensen L,Andersson C,Cuzzocrea S,Di Paola R,Nicoletti F,Svenson M,Bendtzen K,Thomsen AR,Hansen MB

更新日期：2007-12-15 00:00:00

abstract：:Senescence is an irreversible growth arrest which can be triggered by stresses such as oxidative reaction, telomere shortening, DNA damage, or oncogene signaling. Oxidative stress accelerates vascular endothelial cell senescence, and may promote atherosclerosis in humans. Interleukin-8 (IL-8) has been shown to play an...

journal_title：International immunopharmacology

authors： Shen XH,Xu SJ,Jin CY,Ding F,Zhou YC,Fu GS

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS:A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science D...

journal_title：International immunopharmacology

authors： Yu C,Kang L,Chen J,Zang N

更新日期：2020-09-01 00:00:00

abstract：:The purpose of this study was the combination of curcumin and ovalbumin in free form or encapsulated into PLGA NPs (polylactic co-glycolic acid nanoparticles) to enhance their sublingual immunotherapy (SLIT) efficiency in mouse model of rhinitis allergic. PLGA NPs containing curcumin (CUR), ovalbumin (OVA) or both wer...

journal_title：International immunopharmacology

authors： Shahgordi S,Sankian M,Yazdani Y,Mashayekhi K,Hasan Ayati S,Sadeghi M,Saeidi M,Hashemi M

更新日期：2020-07-01 00:00:00

abstract：:The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also kn...

journal_title：International immunopharmacology

authors： Kumar S,Verma AK,Das M,Dwivedi PD

更新日期：2012-08-01 00:00:00

abstract：:Type-1 immunity has an essential role for our host defenses against cancer and outer pathogens such as bacteria and virus. We demonstrated here that the edible plant extract of Chrysanthemum coronarium L. (C. coronarium) remarkably activates Type-1 immunity in a Toll-like receptor (TLR)2-, TLR4-, and TLR9-dependent ma...

journal_title：International immunopharmacology

authors： Tanaka S,Koizumi S,Masuko K,Makiuchi N,Aoyagi Y,Quivy E,Mitamura R,Kano T,Ohkuri T,Wakita D,Chamoto K,Kitamura H,Nishimura T

更新日期：2011-02-01 00:00:00

abstract：:1,25-dihydroxyvitaminD3 [1,25(OH)2D3] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)2D3 on cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (P...

journal_title：International immunopharmacology

authors： Afsal K,Selvaraj P,Harishankar M

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Many studies have shown that ghrelin can down-regulate inflammatory cytokine expression via the inhibition of NF-κB activity and therefore, its administration to septic patients is considered beneficial. However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2...

journal_title：International immunopharmacology

authors： Peng Z,Zhu Y,Zhang Y,Wilhelmsen K,Jia C,Jin J,Xue Q,Feng X,Zhang F,Yu B

更新日期：2012-08-01 00:00:00

abstract：:Salvinorin A (SA), a neoclerodane diterpene, is isolated from the dried leaves ofSalvia divinorum. SA has traditionally been used treatments for chronic pain diseases. Recent research has demonstrated that SA possesses the anti-inflammatory property. The present study aim to explore the effects and potentialmechanisms...

journal_title：International immunopharmacology

authors： Zeng S,Chen D,Liu G,Wu YX,Gao ZQ,Su Y,Yuan JN,Liu L,Shan JC,Pang QF,Zhu T

更新日期：2021-01-01 00:00:00

abstract：:The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...

journal_title：International immunopharmacology

authors： Xiong F,Janko M,Walker M,Makropoulos D,Weinstock D,Kam M,Hrebien L

更新日期：2014-10-01 00:00:00

abstract：:Histamine plays major roles in allergic diseases and its action is mediated mainly by histamine H(1) receptor (H1R). We have demonstrated that histamine signaling-related H1R and histidine decarboxylase (HDC) genes are allergic diseases sensitive genes and their expression level affects severity of the allergic sympto...

journal_title：International immunopharmacology

authors： Nurul IM,Mizuguchi H,Shahriar M,Venkatesh P,Maeyama K,Mukherjee PK,Hattori M,Choudhuri MS,Takeda N,Fukui H

更新日期：2011-11-01 00:00:00

abstract：:Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

journal_title：International immunopharmacology

authors： Majdalawieh AF,Fayyad MW

更新日期：2015-09-01 00:00:00

abstract：:This study aimed to investigate the effect and underlying mechanism of long non-coding RNA plasmacytoma variant translocation 1 (PVT1) in lipopolysaccharide (LPS)-induced inflammation injury in HK-2 cells. We established LPS-induced septic acute kidney injury (AKI) model in HK-2 cells. LPS-induced HK-2 cells were tran...

journal_title：International immunopharmacology

authors： Huang W,Lan X,Li X,Wang D,Sun Y,Wang Q,Gao H,Yu K

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Downregulation of histone deacetylase-4 (HDAC4) contributes to cartilage degeneration in osteoarthritis (OA) because it promotes upregulation of runt-related transcription factor-2 (Runx-2) and osteoarthritis-related genes. The effect of HDAC4 upregulation on cartilage damage in OA remains unknown. METHODS:...

journal_title：International immunopharmacology

authors： Gu XD,Wei L,Li PC,Che XD,Zhao RP,Han PF,Lu JG,Wei XC

更新日期：2019-10-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

journal_title：International immunopharmacology

authors： Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

更新日期：2020-12-01 00:00:00

abstract：:Microglia are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). Under pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory and n...

journal_title：International immunopharmacology

authors： Nam KN,Choi YS,Jung HJ,Park GH,Park JM,Moon SK,Cho KH,Kang C,Kang I,Oh MS,Lee EH

更新日期：2010-04-01 00:00:00

abstract：:The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

journal_title：International immunopharmacology

authors： Wei F,Hao Y

更新日期：2020-03-06 00:00:00

abstract：:The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, nitric oxide synthase (NOS) activity was measured in cerebral frontal cortex slices by produ...

journal_title：International immunopharmacology

authors： Orman B,Sterin-Borda L,De Couto Pita A,Reina S,Borda E

更新日期：2007-12-05 00:00:00

abstract：:Echinacea plant extract is widely used for the prevention and the treatment of upper respiratory tract infections. However, the active components in the herb, their optimal dosages and their in vivo effects are still undefined. Using male Sprague-Dawley rats (425-475 g), an in vivo study was conducted to examine the i...

journal_title：International immunopharmacology

authors： Goel V,Chang C,Slama JV,Barton R,Bauer R,Gahler R,Basu TK

更新日期：2002-02-01 00:00:00

abstract：:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

journal_title：International immunopharmacology

authors： Hou L,Wang T,Sun J

更新日期：2015-10-01 00:00:00

abstract：:Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...

journal_title：International immunopharmacology

authors： Liu Y,Jiang X,Gu Y,Chen Y

更新日期：2019-04-01 00:00:00

abstract：:Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident popula...

journal_title：International immunopharmacology

authors： Chen K,Wang JM,Yuan R,Yi X,Li L,Gong W,Yang T,Li L,Su S

更新日期：2016-05-01 00:00:00

abstract：:Human melanoma Colo 679 cells were made resistant to doxorubicin (adriamycin, ADM) by continuous exposure to ascending concentrations of the drug and Colo/ADM80; a variant which grew continuously in the presence of 80 ng/ml of ADM was thus established. Human peripheral blood mononuclear cells (PBMC) produced interfero...

journal_title：International immunopharmacology

authors： Micallef MJ,Darmanin S,Buhagiar JA,Camilleri-Podesta MT,Yamauchi H,Kurimoto M,Inglott AS,Ellul-Micallef R

更新日期：2001-02-01 00:00:00

abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

journal_title：International immunopharmacology

authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

更新日期：2014-08-01 00:00:00

abstract：:Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to ...

journal_title：International immunopharmacology

authors： Amirshahrokhi K

更新日期：2013-10-01 00:00:00

abstract：:While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of ...

journal_title：International immunopharmacology

authors： Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

更新日期：2020-04-01 00:00:00