Abstract：
:Monocytes recruited and adhering to the inflamed arteries are crucial for atherosclerosis development. Here, we report the role of zinc (Zn2+) homeostasis in monocyte adhesion and recruitment. By comparing the expression levels of Zn2+ transporters between non-adhering and adhering monocytes, we found that the Zn2+ importer ZIP8 was specifically upregulated in monocytes adhering to the aortas ex-vivo. Although the overexpression of ZIP8 increased the absorption of Zn2+, Fe2+ and Cd2+ in monocytes, only Zn2+ supplementation was demonstrated capable of promoting the adhesion of monocytes to endothelial monolayers in vitro. In addition, we confirmed the role of ZIP8-dependent Zn2+ influx in promoting monocyte adhesion to the aortas ex-vivo. More importantly, the enforced expression of ZIP8 increased monocyte adhesion and recruitment to the nascent atherosclerotic lesions in ApoE-/- mice. Overall, our results suggest that the Zn2+ influx in monocytes regulated by ZIP8 is a novel factor determining their adhesion and recruitment to atherosclerotic lesions, and that targeting ZIP8 or Zn2+ homeostasis may represent a novel strategy to interfere these activities.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Cheng G,Chang FJ,You PH,Lin J,Huang XY,Wu HY,Yan L,Deng JZ,You HJ,Sun CFdoi
10.1016/j.intimp.2018.06.018subject
Has Abstractpub_date
2018-09-01 00:00:00pages
203-211eissn
1567-5769issn
1878-1705pii
S1567-5769(18)30269-8journal_volume
62pub_type
杂志文章abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a crucial pathological type of lung cancer. Immune-infiltration of the tumor microenvironment positively associated with overall survival in LUAD. TTC21A is a gene has not reported in cancer, and the mechanism behind it is still unclear. Our study assesses TTC21A role in LUAD, v...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2019.106077
更新日期：2020-01-01 00:00:00
abstract：:Paraquat (PQ) induces acute lung injury (ALI) and immunotoxicity. Apigenin exerts anti-oxidant and anti-inflammatory properties. The purpose of this study was to investigate the possible protective effects of apigenin on PQ-induced ALI and immunotoxicity in mice. Female C57BL/6 mice received a single injection of PQ (...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2018.10.046
更新日期：2018-12-01 00:00:00
abstract：:Ischemia-reperfusion injury is a common early event in kidney transplantation and contributes to a delay in organ function. Acute tubular necrosis, impaired kidney function and organ leukocyte infiltration are the major findings. The therapeutic potential of stem cells has been the focus of recent research as these ce...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2007.08.014
更新日期：2007-12-15 00:00:00
abstract：:The polysaccharide PSPP (purified sweet potato polysaccharide), isolated and purified from the roots of Ipomoea batatas, was found to be a glucan with a molecular weight of 53.2 kDa and specific rotation of +115.0 degrees (ca. 0.80, H(2)O). On the basis of methylation analysis, periodate oxidation, Smith degradation, ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2005.03.012
更新日期：2005-08-01 00:00:00
abstract：:Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals, clinically available pharmacological therapies that can promote repair and prevent visual complications remain limited. We have recently demonstrated that the ace...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2015.04.036
更新日期：2015-11-01 00:00:00
abstract：:With the introduction of biological agents, over the last two decades treatment prospects in many medical fields including Rheumatology have experienced an exciting revolution. The advent of biological therapy for specifically rheumatic diseases has provided more effective control of both the underlying disease, and s...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2015.04.022
更新日期：2015-08-01 00:00:00
abstract：:Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is the fourth commonest female malignancy worldwide. CESC progresses in immune-microenvironment mainly composed of infiltrating immune and stromal cells. Here, we performed an integrated analysis incorporating the expression profiles from the Canc...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.106884
更新日期：2020-11-01 00:00:00
abstract：:The aim of this study was to evaluate the DNA damage in peripheral lymphocytes and the frequencies of CD8+ T cells expressing CD25, CD28 and CD45ro in aged individuals with inverted CD4:CD8 ratio. Blood samples of elderly individuals (aged >65) with normal CD4:CD8 ratio (n = 8) and inverted CD4:CD8 ratio (n = 8) were ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2018.12.060
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS:A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science D...
journal_title：International immunopharmacology
pub_type： 杂志文章,meta分析
doi：10.1016/j.intimp.2020.106740
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:We examined the effects of the immunosuppressive neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) on rat endotoxin-induced uveitis, and to measure the expression of inflammatory cytokines and chemokines with and without the alpha-MSH treatment over the course of the disease. METHODS:We injected Le...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2004.04.011
更新日期：2004-08-01 00:00:00
abstract：:Innate immune cells have evolved to sense microbial pathogens through pattern recognition receptors (PRRs), which interact with conserved pathogen-associated molecular patterns (PAMPs) to convey microbial information into immune cell signaling and activation events. PRRs also recognize endogenous damage-associated mol...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2011.05.002
更新日期：2011-10-01 00:00:00
abstract：:Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads to the activation of diverse cellular mechanisms in the central nervous system to attempt to repair the damaged spinal cord tissue. Higenamine (HG) (1-[(4-hydroxyphenyl) methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-di...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.10.022
更新日期：2014-12-01 00:00:00
abstract：:The present study was conducted to determine if selected events in glucocorticoid receptor (GR) signaling that have been identified using mostly in vitro approaches with synthetic glucocorticoids also occur in mature T cells exposed to relevant levels of corticosterone in vivo. In contrast to effects reported in vitro...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(02)00081-4
更新日期：2003-01-01 00:00:00
abstract：:Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, having it shown anti-inflammatory activity. We evaluated A. esculentus lectin (AEL) efficacy in reducing zymosan-induce...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2016.06.012
更新日期：2016-09-01 00:00:00
abstract：:The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liquid growth was arrested by ≥32 μg/mL and...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2010.08.023
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Recent studies have revealed the significant roles of immune-related long noncoding RNAs (lncRNAs) in cancer development and progression. The identification of biomarkers that contribute to early detection and risk stratification provides significant benefits for bladder cancer (BC) patients. The current stu...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.107146
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Allergic rhinitis (AR) is characterized by a Th2 polarized immune response and soluble HLA (sHLA) molecules play an immunomodulatory role in this response. Previously, it has been reported that these molecules are increased in sera of patients with pollen-induced allergic rhinitis studied outside the pollen ...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2009.04.014
更新日期：2009-08-01 00:00:00
abstract：:The tumor microenvironment is a critical factor that enhances cancer progression, drug resistance, and failure of therapeutic approaches. Several cellular and non-cellular factors are involved in cancer promotion. Among the several cell populations in the tumor microenvironment, macrophages, as one of the most abundan...
journal_title：International immunopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.intimp.2020.106471
更新日期：2020-07-01 00:00:00
abstract：:To be effective, vaccines against the highly variable HIV-1 must elicit antibodies to a huge number of clinical isolates. For this purpose, new strategies to overcome this variability are needed. We previously reported a useful immunogenic strategy which consists of conjugating multiple antigen peptides (MAPs) to HBsA...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2009.08.026
更新日期：2009-11-01 00:00:00
abstract：:Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet. In the present study, non-cytotoxic level of ampelopsin sign...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2011.12.001
更新日期：2012-01-01 00:00:00
abstract：:Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evalu...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2016.04.002
更新日期：2016-06-01 00:00:00
abstract：:Oral contraceptives (OC) may cause intrahepatic cholestasis or increase a pre-established liver damage. OC effects on hepatic injury biochemical markers remain contradictory and the role of cytokines in those processes is fairly unknown. Two doses, simple or double, of the OC combination ethinylestradiol/norgestrel we...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2014.03.022
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Neuroinflammation in the spinal cord following acute brachial plexus injury (BPI) remains a vital cause that leads to motor dysfunction and neuropathic pain. In this study, we aim to explore the role of long non-coding RNA JHDM1D antisense 1 (JHDM1D-AS1) in mediating BPI-induced neuroinflammation and neurona...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.106962
更新日期：2020-12-01 00:00:00
abstract：:Previous studies have suggested that stearoyl lysophosphatidlycholine (LPC) protects against lethal experimental sepsis by inhibiting lipopolysaccharide (LPS)-induced extracellular release of high-mobility group box 1 (HMGB1). However, limited information exists on the mechanism by which stearoyl-LPC suppresses the ex...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2015.07.010
更新日期：2015-09-01 00:00:00
abstract：:Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1β (IL-1β) induced express...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.106612
更新日期：2020-08-01 00:00:00
abstract：:Azithromycin is a potent agent that prevents airway remodeling. In this study, we hypothesized that azithromycin (35 mg/kg orally) alleviated airway remodeling through suppression of epithelial-to-mesenchymal transition (EMT) via downregulation of transforming growth factor-beta 1 (TGF-β1)/receptor for activated C-kin...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2018.03.016
更新日期：2018-05-01 00:00:00
abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/s1567-5769(00)00052-7
更新日期：2001-04-01 00:00:00
abstract：:Acute lung injury (ALI) is linked with considerable morbidity and mortality. ALI can be caused by various agents, one of them being sepsis. ALI is characterized by injury to vascular endothelium and alveolar epithelium that results in edema, pulmonary immune cells infiltration and hypoxemia. Neutrophils and T cells pa...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.106369
更新日期：2020-06-01 00:00:00
abstract：:Extracts of leaves of different species of the genus Combretum have been used historically to treat a variety of medicinal problems. However, little is known about the active components conferring therapeutic properties to these extracts. In the present studies, we evaluated biochemical properties and immunomodulatory...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2013.01.015
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Spontaneous abortion is a common disease in human pregnancy. Increasing evidence suggests that proper function of trophoblasts and immune balance of the maternal-fetal interface are crucial for successful pregnancy. Macrophages are involved in the maternal-fetal immune microenvironment. However, mechanisms a...
journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2020.106981
更新日期：2020-11-01 00:00:00
