当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum.

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum.

Abstract：

:Extracts of leaves of different species of the genus Combretum have been used historically to treat a variety of medicinal problems. However, little is known about the active components conferring therapeutic properties to these extracts. In the present studies, we evaluated biochemical properties and immunomodulatory activity of polysaccharides isolated from the leaves of Combretum racemosum. Water-soluble polysaccharides from leaves of C. racemosum were extracted and fractionated by DEAE-cellulose and Diaion HP-20 to obtain a Diaion-bound fraction, designated Combretum polysaccharide-acidic bound or CP-AB, which was eluted with methanol, and an unbound fraction, designated as CP-AU. Molecular weight determination, sugar analysis, and other physical and chemical characterization of the fractions were performed. Fraction CP-AU (mol. weight 5.0 kDa) contained type II arabinogalactan and had potent immunomodulatory activity, inducing the production of interleukin (IL)-1β, -6, -10, and tumor necrosis factor-α (TNF-α) by human peripheral blood mononuclear cells (PBMC) and MonoMac-6 monocytic cells. Likewise, intraperitoneal administration of CP-AU increased in vivo serum levels of IL-6 and monocyte chemoattractant protein-1 (MCP-1) in mice. CP-AU-induced secretion of TNF-α in PBMC was prevented by Toll-like receptor 4 (TLR4) antagonist LPS-RS. Treatment with CP-AU induced phosphorylation of Akt2, Akt3, GSK-3β, HSP27, mTOR, and all p38 MAPK isoforms (α, β, δ, and γ), as well as stimulation of AP-1/NF-κB transcriptional activity. In addition, CP-AU effectively agglutinated erythrocytes from several species, including human, mouse, and rabbit. In contrast, fraction CP-AB was inactive in all biological tests, including cytokine production and hemagglutination. These data suggest that at least part of the beneficial therapeutic effects reported for the water extracts of leaves from C. racemosum are due to modulation of leukocyte functions.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Schepetkin IA,Kouakou K,Yapi A,Kirpotina LN,Jutila MA,Quinn MT

doi

10.1016/j.intimp.2013.01.015

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

628-37

issue

3

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(13)00031-3

journal_volume

15

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway.

    abstract：:This report sought to establish the mechanistic role of sirtuin-1 (Sirt1), a NAD+-dependent deacetylase in the modulation of primary biliary cholangitis (PBC) pathogenesis. 64 PBC patients (diagnosed based on practice guidelines for American Association for the Study of Liver Diseases) and 60 healthy controls were inc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106386

    authors： Li Y,Xi Y,Tao G,Xu G,Yang Z,Fu X,Liang Y,Qian J,Cui Y,Jiang T

    更新日期：2020-06-01 00:00:00

  • Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague-Dawley rats.

    abstract：:Cisplatin is a widely used antineoplastic drug, but its clinical usefulness is limited due to dose dependent nephrotoxicity. Nordihydroguaiaretic acid (NDGA) is a natural compound with broad pharmacological properties like antioxidant, anti-inflammatory and anticancer activity. The present study was undertaken to eval...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.07.016

    authors： Mundhe NA,Kumar P,Ahmed S,Jamdade V,Mundhe S,Lahkar M

    更新日期：2015-09-01 00:00:00

  • Dendritic cells transfected with indoleamine 2,3-dioxygenase gene suppressed acute rejection of cardiac allograft.

    abstract：BACKGROUND:Immunomodulation by indoleamine 2,3-dioxygenase (IDO) has been documented in many studies yet its underlying mechanisms remain undefined, especially in solid organ transplantation. Recent research demonstrated that the active expression of IDO in dendritic cells (DCs) regulates immune reaction. This study as...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.03.048

    authors： Li C,Liu T,Zhao N,Zhu L,Wang P,Dai X

    更新日期：2016-07-01 00:00:00

  • FK506 ameliorates renal injury in early experimental diabetic rats induced by streptozotocin.

    abstract：:Calcineurin (CaN) plays an important role in glomerular hypertrophy and extracellular matrix accumulation in early diabetic nephropathy. Cyclosporine (CSA), a CaN inhibitor, has been shown to reduce renal injury in streptozotocin-induced diabetic rats. We examined whether FK506, which immunosuppressive action was 10-1...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.05.023

    authors： Qi XM,Wu YG,Liang C,Zhang P,Dong J,Ren KJ,Zhang W,Fang F,Shen JJ

    更新日期：2011-10-01 00:00:00

  • A higher frequency of peripheral blood activated B cells in patients with non-traumatic osteonecrosis of the femoral head.

    abstract：OBJECTIVES:B cells play important roles in inflammatory diseases. This study was aimed at examining the frequency of different subsets of B cells in patients with non-traumatic osteonecrosis of the femoral head (NONFH). METHODS:The percentages of the different subsets of circulating B cells in 28 patients with steroid...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.02.016

    authors： Zhang H,Xiao F,Liu Y,Zhao D,Shan Y,Jiang Y

    更新日期：2014-05-01 00:00:00

  • Chromatin remodeling complex in Treg function.

    abstract：:Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2009.01.019

    authors： Jani A,Chi T,Wan YY

    更新日期：2009-05-01 00:00:00

  • Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.

    abstract：:Thymoquinone is an antioxidant phytochemical that has been shown to inhibit neuroinflammation. However, little is known about the potential roles of intracellular antioxidant signalling pathways in its anti-inflammatory activity. The objective of this study was to elucidate the roles played by activation of the Nrf2/A...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.04.018

    authors： Velagapudi R,Kumar A,Bhatia HS,El-Bakoush A,Lepiarz I,Fiebich BL,Olajide OA

    更新日期：2017-07-01 00:00:00

  • Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters.

    abstract：:Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.07.016

    authors： Inoue K,Koike E,Takano H

    更新日期：2010-11-01 00:00:00

  • Combination treatment of low dose Anti-Thymocyte Globulin (ATG), Rituximab and high dose Sirolimus as induction agents in immune-conditioned recipients.

    abstract：UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2006.09.013

    authors： Ravichandran P,Natrajan T,Jaganathan R

    更新日期：2006-12-20 00:00:00

  • Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils.

    abstract：:Antipsychotic drugs (APDs) that bind mainly to the dopamine D2 receptor or the type II 5-HT receptor have been used to ease the symptoms of schizophrenia. Several studies have reported that APDs can also regulate the immune response. Dendritic cells (DCs) are the major antigen-presenting cells in the immune system. DC...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.11.011

    authors： Chen ML,Tsai TC,Wang LK,Lin YY,Tsai YM,Lee MC,Tsai FM

    更新日期：2012-01-01 00:00:00

  • Taishan Pinus massoniana pollen polysaccharides promote immune responses of recombinant Bordetella avium ompA in BALB/c mice.

    abstract：:To study the effects of Taishan Pinus massoniana pollen polysaccharides (TPPPS) on Bordetella avium outer membrane protein A (ompA) recombinant protein vaccine, ompA was expressed, confirmed by Western blotting and mixed with TPPPS. Female BALB/c mice were randomly divided into six groups (I-VI). Groups I, II, and III...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.09.008

    authors： Zhao X,Liang M,Yang P,Guo F,Pan D,Huang X,Li Y,Wu C,Qu T,Zhu R

    更新日期：2013-11-01 00:00:00

  • Digitalis inhibits and furosemide does not change the in vitro phagocytic function of neutrophils of healthy subjects.

    abstract：:This work evaluated the in vitro influence of digitalis and furosemide on the phagocytic function of neutrophils of healthy individuals. Phagocytosis of Saccharomyces cerevisiae by peripheral blood neutrophils of 20 healthy individuals was assessed in the absence or presence of deslanoside or furosemide. The Wilcoxon ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(03)00142-5

    authors： Muniz-Junqueira MI,Mota LM,Aires RB,Junqueira LF Jr

    更新日期：2003-10-01 00:00:00

  • Inductive immune responses in the Japanese pufferfish (Takifugu rubripes) treated with recombinant IFN-γ, IFN-γrel, IL-4/13A and IL-4/13B.

    abstract：:Immune regulation in response to recombinant cytokines (Th1- and Th2-types) is poorly understood in fish. Therefore, we synthesized and purified the Japanese pufferfish, (Takifugu rubripes) recombinant cytokines, namely interferon-gamma (IFN-γ), IFN-γrel, interleukin (IL)-4/13A and IL-4/13B, and then administered by i...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.12.005

    authors： Biswas G,Nagamine R,Hikima J,Sakai M,Kono T

    更新日期：2016-02-01 00:00:00

  • Isolation of functional autologous collagen-II specific IL-10 producing Tr1 cell clones from rheumatoid arthritis blood.

    abstract：:IL-10 producing regulatory type 1 (Tr1) cells represents a subpopulation of CD4+ regulatory cells able to prevent in vitro bystander T-cell proliferation and to inhibit a wide range of inflammatory diseases in mice. Our aim was to evaluate the frequency and function of joint specific Tr1 cells in the peripheral blood ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.03.001

    authors： Brun V,Neveu V,Pers YM,Fabre S,Quatannens B,Bastian H,Clerget-Chossat N,Jorgensen C,Foussat A

    更新日期：2011-08-01 00:00:00

  • New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation.

    abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as poten...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.02.011

    authors： Santos LAMD,Rodrigues GB,Mota FVB,França MER,de Souza Barbosa KP,Oliveira WH,Rocha SWS,Lós DB,Silva AKS,Silva TGD,Peixoto CA

    更新日期：2018-04-01 00:00:00

  • Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells.

    abstract：:Phospholipase C (PLC)gamma and phospholipase D (PLD) play pivotal roles in the signal transduction required for various cellular responses, including cell proliferation and differentiation. Dendritic cells (DCs), which are professional antigen-presenting cells, can be generated from human monocytes by stimulating the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.04.001

    authors： Kang HK,Lee HY,Lee YN,Jo EJ,Kim JI,Kim GY,Park YM,Min DS,Yano A,Kwak JY,Bae YS

    更新日期：2004-07-01 00:00:00

  • The role of kinins in the proliferation of fibroblast primed with TNF in scratch wound assay: Kinins and cell proliferation.

    abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.036

    authors： França AJVBDV,De Faveri R,Nunes R,Steimbach VMB,Santin JR,Quintão NLM

    更新日期：2018-12-01 00:00:00

  • Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.

    abstract：:Acute liver injury (ALI) is a dramatic liver disease characterized by large areas of inflammation in the liver. This study aimed to investigate the protective effects of ginsenoside Rg1 (Rg1), a biologically active component in Panax ginseng, on lipopolysaccharide/d-galactosamine (LPS/D-GalN)-induced ALI in mice, and ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.06.008

    authors： Ning C,Gao X,Wang C,Huo X,Liu Z,Sun H,Yang X,Sun P,Ma X,Meng Q,Liu K

    更新日期：2018-08-01 00:00:00

  • Mechanism of miRNA-based Aconitum leucostomum Worosch. Monomer inhibition of bone marrow-derived dendritic cell maturation.

    abstract：:Delvestidine (DLTD) is a monomeric compound isolated from Aconitum leucostomum Worosch, a widely used medicine for local treatment of rheumatoid arthritis (RA). Studies have shown that Aconitum leucostomum Worosch. can inhibit maturation of bone marrow-derived dendritic cells (BMDCs). Further, microRNAs (miRNAs) have ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106791

    authors： Wang YY,Liu HZ,Cao M,Wang XL,Cong S,Sun J,Jia BT,Ta-Bu-Shi NE,Bian YH,Luo L

    更新日期：2020-11-01 00:00:00

  • Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.

    abstract：:We previously reported that abnormally down-regulated protein kinase C (PKC) activity is responsible for the impaired cellular function of natural killer cells and polymorphonuclear cells (PMNs), and the giant granule formation in fibroblasts in the beige mouse, an animal model of Chediak-Higashi syndrome. Here, we ex...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.03.004

    authors： Morimoto M,Tanabe F,Kasai H,Ito M

    更新日期：2007-07-01 00:00:00

  • Immunotherapeutic effects of cytokine-induced killer cells combined with CCL21/IL15 armed oncolytic adenovirus in TERT-positive tumor cells.

    abstract：:The effective antitumor immune responses are dependent on coordinate interaction of various effector cells. Thus, the combination of adoptive immunotherapy and target gene therapy is capable of efficiently generating a productive antitumor immune response. We investigated whether combination of cytokine-induced killer...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.06.028

    authors： Ye JF,Lin YQ,Yu XH,Liu MY,Li Y

    更新日期：2016-09-01 00:00:00

  • Successful treatment of collagen-induced arthritis in non-human primates by chimeric anti-osteopontin antibody.

    abstract：:The presence of thrombin-cleaved form of osteopontin well correlated with various inflammatory disease activities in not only rodents, but also humans. We previously demonstrated that the blocking of the interaction of a cryptic epitope within osteopontin, which is exposed by thrombin cleavage, with its integrins by s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.06.009

    authors： Yamamoto N,Nakashima T,Torikai M,Naruse T,Morimoto J,Kon S,Sakai F,Uede T

    更新日期：2007-11-01 00:00:00

  • The fungal metabolite, citrinin, inhibits lipopolysaccharide/interferon-γ-induced nitric oxide production in glomerular mesangial cells.

    abstract：:The mycotoxin, citrinin (CTN), is a secondary metabolite of the fermented products of Monascus. The mycotoxin can either suppress or stimulate immune responses. In the present study, the immunomodulatory role of CTN in nitric oxide (NO) production, a proinflammatory mediator in the process of inflammation, was investi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.09.017

    authors： Liu BH,Chi JY,Hsiao YW,Tsai KD,Lee YJ,Lin CC,Hsu SC,Yang SM,Lin TH

    更新日期：2010-12-01 00:00:00

  • Neutralizing antibody production against Rebif® and ReciGen® in Relapsing-Remitting Multiple Sclerosis (RRMS) patients and its association with patient's disability.

    abstract：INTRODUCTION:Human recombinant interferon beta (IFN-β) is one of the first line treatments for Relapsing-Remitting Multiple Sclerosis (RRMS). However, the production of neutralizing antibodies (NAb) can impair its function. The aim of this study was to investigate the production of neutralizing antibodies against Rebif...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2018.06.032

    authors： Shokrollahi Barough M,Ashtari F,Sadat Akhavi M,Asghari N,Mosayebi G,Mirmohammadkhani M,Kokhaei N,Bahraminia F,Ajami A,Kokhaei P

    更新日期：2018-09-01 00:00:00

  • Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

    abstract：:Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107026

    authors： Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

    更新日期：2020-12-01 00:00:00

  • Dietary quercetin combining intratumoral doxorubicin injection synergistically induces rejection of established breast cancer in mice.

    abstract：:Dietary ingredients can decrease the risk of a variety of human cancers. Quercetin (3,3',4',5,7-pentahydroxyflavone) has a long history of consumption as part of the normal human diet and is able to induce growth inhibition in multiple cancer cells. In an attempt to generate more potent therapeutic effect for breast c...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.04.018

    authors： Du G,Lin H,Yang Y,Zhang S,Wu X,Wang M,Ji L,Lu L,Yu L,Han G

    更新日期：2010-07-01 00:00:00

  • Cannabinoid receptor 2 promotes the intracellular degradation of HMGB1 via the autophagy-lysosome pathway in macrophage.

    abstract：:High mobility group box 1 (HMGB1) is a late phase inflammatory mediator in many inflammatory diseases. Extracellular HMGB1 could bind to many membrane receptors to activate downstream signaling molecules and promote inflammation resulting in cell and tissue damage. In our previous work, we found cannabinoid receptor Ⅱ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106007

    authors： Zhou H,Du R,Li G,Bai Z,Ma J,Mao C,Wang J,Gui H

    更新日期：2020-01-01 00:00:00

  • Crosstalk between Toll-like receptor 3 and Notch signaling contributes to CD14+ monocytes activity in enterovirus 71 infected hand, foot, and mouth disease.

    abstract：:Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.04.031

    authors： Hao J,Li P,Tian Y,Wang Y,Li S,Wang L,Li S

    更新日期：2018-07-01 00:00:00

  • Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo.

    abstract：:Ganoderic acid Me (GA-Me) is a lanostane triterpenoid purified from Ganoderma lucidum mycelia, one of the most widely used herbs for cancer treatment and prevention in east Asia. In the present study, it was demonstrated that GA-Me could inhibit both tumor growth and lung metastasis of Lewis lung carcinoma in C57BL/6 ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.02.006

    authors： Wang G,Zhao J,Liu J,Huang Y,Zhong JJ,Tang W

    更新日期：2007-06-01 00:00:00

  • Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation.

    abstract：:Acute graft-versus-host disease (aGVHD) is a major complication following transplantation, limiting the success of this therapy. Chitinase 3-like-1 (CHI3L1), a member of the glycosyl hydrolase 18 family, plays a critical role in bacterial infections, allergic disease and a variety of malignancies. Here, we investigate...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.03.010

    authors： Li Z,Gu J,Liu J,Zhu Q,Lu H,Lu Y,Rao J,Lu L,Wang X

    更新日期：2017-05-01 00:00:00