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Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo.

Abstract：

:Ganoderic acid Me (GA-Me) is a lanostane triterpenoid purified from Ganoderma lucidum mycelia, one of the most widely used herbs for cancer treatment and prevention in east Asia. In the present study, it was demonstrated that GA-Me could inhibit both tumor growth and lung metastasis of Lewis lung carcinoma in C57BL/6 mice. Compared with the control group, Natural Killer (NK) cells activity was significantly enhanced by intraperitoneal administration of GA-Me (28 mg/kg). Results of ELISA assay and RT-PCR showed that the expressions of Interleukin-2 (IL-2) and Interferon-gamma (IFN-gamma) were also increased (p<0.05). Additionally, the expression of Nuclear Factor-kappaB (NF-kappaB) was up-regulated after the treatment of GA-Me, which might be involved in the production of IL-2. In conclusion, the findings of this study implied that GA-Me could effectively inhibit tumor growth and lung metastasis through increasing immune function.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Wang G,Zhao J,Liu J,Huang Y,Zhong JJ,Tang W

doi

10.1016/j.intimp.2007.02.006

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

864-70

issue

6

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(07)00057-4

journal_volume

7

pub_type

杂志文章

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