Abstract：
:Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expression through the activity of Brg. Genetic ablation of Brg gene in mouse resulted in early embryonic lethality. T cell failed to develop in the thymus when Brg is deleted at DN stage. Using a Brg conditional KO mouse model, we deleted Brg at the DP stage in the thymus. Unexpectedly, T cells developed and matured normally. However, these mice displayed lympho-proliferative syndrome 2-4 months of age with enlarged peripheral lymphoid organs and leukocyte infiltration in non-lymphoid organs. T cells from these mice turned into effector cells producing increased amounts of effector cytokines as early as 4 weeks after birth. Further analysis revealed that the Treg population was specifically affected by Brg deletion. In this mini-review, we will discuss in detail the properties of Tregs controlled by Brg and the potential underlying mechanisms for an unanticipated, specific role of the Brg-containing BAF complex in controlling Treg functions.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Jani A,Chi T,Wan YYdoi
10.1016/j.intimp.2009.01.019subject
Has Abstractpub_date
2009-05-01 00:00:00pages
521-3issue
5eissn
1567-5769issn
1878-1705pii
S1567-5769(09)00047-2journal_volume
9pub_type
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更新日期：2017-03-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析,评审
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更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.intimp.2011.01.007
更新日期：2011-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2002-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2020-02-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章
doi：10.1016/j.intimp.2013.07.005
更新日期：2013-10-01 00:00:00
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