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Myricetin inhibits IL-1beta-induced inflammatory mediators in SW982 human synovial sarcoma cells.

Abstract：

:Rheumatoid arthritis (RA) synovial fibroblasts produce inflammatory mediators, which destruct cartilage and bone in RA joint. The aim of this study is to investigate the effect of myricetin on inflammatory cytokine/matrix metalloproteinase (MMP) production and mitogen-activated protein kinases (MAPKs) in IL-1beta-stimulated SW982 synovial cells. Myricetin significantly decreased IL-1beta-induced production of IL-6 and MMP-1 in synovial cells. Moreover, myricetin diminished the phosphorylation of Jun NH2-terminal kinase (JNK) and p38 MAPK. These results suggest that myricetin reduces the production of MMP and IL-6 in SW982 cells by inhibiting MAPKs (JNK and p38).

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Lee YS,Choi EM

doi

10.1016/j.intimp.2010.04.010

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

812-4

issue

7

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(10)00124-4

journal_volume

10

pub_type

杂志文章

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