Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.

abstract：:Cartilage degradation is one of the pathological changes of osteoarthritis (OA), and accumulating evidence suggests an excess of matrix metalloproteinases (MMPs) plays a role in this cartilage breakdown. Here, we investigated the effects of chlorogenic acid (CGA) on the mRNA and protein expression of MMPs in interleuk...

journal_title：International immunopharmacology

authors： Chen WP,Tang JL,Bao JP,Hu PF,Shi ZL,Wu LD

更新日期：2011-01-01 00:00:00

abstract：:Melatonin has anti-oxidant, anti-inflammatory and anti-apoptotic properties. We aimed to investigate the effect of melatonin on the structure and function of mice ovaries following autograft transplantation. NMRI mice were divided into: control, autografted + saline, autografted + melatonin (20 mg/kg/day i.p. injectio...

journal_title：International immunopharmacology

authors： Noori Hassanvand M,Soleimani Mehranjani M,Shojafar E

更新日期：2019-09-01 00:00:00

abstract：:Recombinant immunotoxins are chimeric proteins composed of a targeting peptide that binds to a specific tumor antigen and a toxin protein killing target cells. Recombinant immunotoxin exhibits potent cancer inhibiting effects both in vivo and in vitro. However, the non-specific toxicity causes severe syndromes limitin...

journal_title：International immunopharmacology

authors： Wang J,Han L,Chen J,Xie Y,Jiang H,Zhu J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hepatic ischemia/reperfusion (I/R) injury occurs in different clinical settings as hepatic transplantation, and different types of shock. I/R injury is the main cause of hepatic damage and failure due to the production of reactive oxygen species (ROS) and inflammatory cytokines. Dimethyl fumarate (DMF), an i...

journal_title：International immunopharmacology

authors： Ibrahim SG,El-Emam SZ,Mohamed EA,Abd Ellah MF

更新日期：2020-03-01 00:00:00

abstract：:Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax pathogenesis. The anthrax lethal toxin can trigger NLRP1b inflammasome activation and pyroptosis. Although the underlying mechanism is well understood, the medications targeting the NLRP1b inflammasome are not available in t...

journal_title：International immunopharmacology

authors： Wang J,Yang D,Shen X,Wang J,Liu X,Lin J,Zhong J,Zhao Y,Qi Z

更新日期：2020-08-01 00:00:00

abstract：:Rubi Fructus, a traditional Chinese medicine, was considered as an anti-inflammatory agent in folk medicine. In the present study, we investigated the signalling pathways involved in the anti-inflammatory effects of goshonoside-F5 (GF5), isolated from Rubi Fructus, in peritoneal macrophages and examined its therapeuti...

journal_title：International immunopharmacology

authors： He JM,Chen SC,Li RP,Yuan LX,Bao JM,Guo ML

更新日期：2015-02-01 00:00:00

abstract：:Azithromycin (AZM) is a macrolide antibiotic that exhibits anti-inflammatory activity aside from its antimicrobial effect, a feature that may ameliorate certain inflammatory disorders and prevent graft-versus-host disease in patients receiving stem cell transplantation. In the present study, we investigated the abilit...

journal_title：International immunopharmacology

authors： Lin SJ,Kuo ML,Hsiao HS,Lee PT

更新日期：2016-11-01 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced TLR4-NF-(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism ...

journal_title：International immunopharmacology

authors： Pei Z,Li H,Guo Y,Jin Y,Lin D

更新日期：2010-01-01 00:00:00

abstract：:Streptococcus pyogenes is a common colonizer of the mucosal layers in the mouth, nose, and pharynx but it is also a major Gram-positive human pathogen that causes infections ranging from pharyngitis to severe systemic diseases. The lactobacilli colonize the oral tracts and are known to protect against colonization by ...

journal_title：International immunopharmacology

authors： Rizzo A,Losacco A,Carratelli CR,Domenico MD,Bevilacqua N

更新日期：2013-10-01 00:00:00

abstract：:Compared with freshly isolated peripheral blood natural killer (NK) cells, the YT and NK-92 cell lines are characterized by elevated cytolytic activity. The molecular mechanisms underlying the rapid proliferation and enhanced lytic activity of NK cell lines are poorly understood. Investigation of these cell lines reve...

journal_title：International immunopharmacology

authors： Liang S,Zhang J,Wei H,Sun R,Tian Z

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:The mechanistic implications of the presence of sympathetic noradrenergic innervation in lymphoid organs in synaptic association with lymphocytes open to the influence of hormonal fluctuations throughout reproductive age in females has not been investigated yet. OBJECTIVES:The aim of the present study is to...

journal_title：International immunopharmacology

authors： Priyanka HP,ThyagaRajan S

更新日期：2013-11-01 00:00:00

abstract：:The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and the possible mechanisms underlying the...

journal_title：International immunopharmacology

authors： Li W,Li H,Mu Q,Zhang H,Yao H,Li J,Niu X

更新日期：2014-10-01 00:00:00

abstract：:We have used a high throughput small molecule screen, using a fission yeast-based assay, to identify novel phosphodiesterase 7 (PDE7) inhibitors. One of the most effective hit compounds was BC12, a barbituric acid-based molecule that exhibits unusually potent immunosuppressive and immunomodulatory actions on T lymphoc...

journal_title：International immunopharmacology

authors： Xu C,Wyman AR,Alaamery MA,Argueta SA,Ivey FD,Meyers JA,Lerner A,Burdo TH,Connolly T,Hoffman CS,Chiles TC

更新日期：2016-09-01 00:00:00

abstract：:Nicotine, the major addictive component of tobacco, is an immunomodulator that impacts on many cells, including immune cells involved in inflammatory processes. Nicotine also induces oxidative damage to the vascular endothelium and accentuates lipid peroxidation, resulting in vascular cell dysfunction. Furthermore, va...

journal_title：International immunopharmacology

authors： Patton GW,Powell DA,Hakki A,Friedman H,Pross S

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Increases in galactose-deficient IgA1 (Gd-IgA1) play a crucial role in the pathogenesis of IgA nephropathy (IgAN), and several recent experiments have shown that microRNAs (miRNAs) are involved in regulating the development and physiological function of the kidney. The aims of this study were to identify miRN...

journal_title：International immunopharmacology

authors： Liu D,Xia M,Liu Y,Tan X,He L,Liu Y,Chen G,Liu H

更新日期：2020-02-29 00:00:00

abstract：:In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammator...

journal_title：International immunopharmacology

authors： Cho IJ,Lee CW,Lee MY,Kang MR,Yun J,Oh SJ,Han SB,Lee K,Park SK,Kim HM,Jung SH,Kang JS

更新日期：2013-08-01 00:00:00

abstract：:B cell activating factor (BAFF), a member of the tumor necrosis factor family, is critical to B cell survival, proliferation, maturation, and immunoglobulin secretion and to T cell activation. In the present study, the full-length cDNA of BAFF from the South African clawed frog (Xenopus laevis, designated xlBAFF) was ...

journal_title：International immunopharmacology

authors： Yang L,Zhou L,Zong X,Cao X,Ji X,Gu W,Zhang S

更新日期：2013-03-01 00:00:00

abstract：:Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor rece...

journal_title：International immunopharmacology

authors： Forni G,Curcio C,Spadaro M,Iliffe J,Quaglino E,Di Carlo E,Musiani P,Lollini PL

更新日期：2003-08-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...

journal_title：International immunopharmacology

authors： Tavakolpour S,Mahmoudi H,Balighi K,Abedini R,Daneshpazhooh M

更新日期：2018-01-01 00:00:00

abstract：:Galectin-9 (Gal-9) is a β-galactoside-binding soluble lectin family member that exerts its primary biological functions via specific glycoconjugate interactions. Gal-9 expression is closely related to tumor occurrence, development, metastasis and prognosis. In transplant immunology, a high level of Gal-9 expression ha...

journal_title：International immunopharmacology

authors： Yin J,Li L,Wang C,Zhang Y

更新日期：2020-11-01 00:00:00

abstract：:Cutaneous toxicities are the commonest side effects in patients with cancer treated using epidermal growth factor receptor inhibitors such as erlotinib. For patients with such toxicities, there is a lack of safe, effective pharmacological agents. Here we established a skin toxicity model and investigated the preventiv...

journal_title：International immunopharmacology

authors： Liu Y,Jiang X,Gu Y,Chen Y

更新日期：2019-04-01 00:00:00

abstract：:Current evidence indicates that semicarbazide-sensitive amine oxidase (SSAO) substrates possess insulin-mimic effect, which was thought to play an anti-inflammatory role. The purpose of the present study was to determine whether SSAO substrates benzylamine (BZA) and methylamine (MA) attenuate inflammatory response ind...

journal_title：International immunopharmacology

authors： Lin Z,Li H,Luo H,Zhang Y,Luo W

更新日期：2011-08-01 00:00:00

abstract：:Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mecha...

journal_title：International immunopharmacology

authors： Gu X,Zhang Q,Du Q,Shen H,Zhu Z

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Histone deacetylases (HDACs) play an important role in dysregulation of histone acetylation/deacetylation, which is the main driving force of the progression of pulmonary fibrosis. Here we investigated the changes in histone acetylation/deacetylation, and the contribution of specific class I and class II HDAC...

journal_title：International immunopharmacology

authors： Li M,Zheng Y,Yuan H,Liu Y,Wen X

更新日期：2017-11-01 00:00:00

abstract：:This study aims to explore the protective effects and mechanisms of ulinastatin (UTI), which is a urinary trypsin inhibitor, of the renal interstitial fibrosis of rats subjected to unilateral ureteral obstruction (UUO). A total of 36 male Wistar rats were divided in random into three groups, namely, the sham operation...

journal_title：International immunopharmacology

authors： Ning XH,Ge XF,Cui Y,An HX

更新日期：2013-02-01 00:00:00

abstract：:Cyclosporine A (CsA) is the first immunosuppressant universally used in allotransplantation. However, it has been demonstrated that this drug produces side effects in several organs, particularly in the kidney and in the heart. Since the immunosuppressive therapy induces myocardial toxicity, the aim of this study was ...

journal_title：International immunopharmacology

authors： Bianchi R,Rodella L,Rezzani R

更新日期：2003-03-01 00:00:00

abstract：:Probiotics, defined as live microbial food supplements which improve the health of the host, have obtained increasing medical importance. In the intestine they may prevent the overgrowth of pathogenic bacteria, increase the resistance of the gut to invasion by pathogens and ameliorate disease processes by inducting th...

journal_title：International immunopharmacology

authors： Paolillo R,Romano Carratelli C,Sorrentino S,Mazzola N,Rizzo A

更新日期：2009-10-01 00:00:00

abstract：:The immunomodulatory properties of mannose-binding lectins ConBr (Canavalia brasiliensis) and CFL (Cratylia argentea) were investigated comparatively in a model of Salmonella infection. The lectins were intraperitoneally (i.p.) administered to mice daily for three days before the bacterial challenge with Salmonella en...

journal_title：International immunopharmacology

authors： Silva AF,Matos MP,Ralph MT,Silva DL,de Alencar NM,Ramos MV,Lima-Filho JV

更新日期：2016-02-01 00:00:00

abstract：:Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen ...

journal_title：International immunopharmacology

authors： Ishii M,Koyama A,Iseki H,Narumi H,Yokoyama N,Kojima N

更新日期：2010-09-01 00:00:00

abstract：:Previously, we reported that oral administration of madecassoside, the main active triterpene in Centella asiatica L., exerted anti-arthritis effect by inducing the generation of regulatory T (Treg) cells in small intestine. This study investigates the action site and mechanism of madecassoside to induce Treg cells. I...

journal_title：International immunopharmacology

authors： Qiao S,Lian X,Yue M,Zhang Q,Wei Z,Chen L,Xia Y,Dai Y

更新日期：2020-12-01 00:00:00