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Regulatory functions of γδ T cells.

Abstract：

:γδ T cells account for approximately 5% of peripheral blood T cells but are more abundant in mucosal tissue. Based on the recognized ligands and their general lack of MHC restriction, γδ T cells are considered as unconventional T cells that link innate and adaptive immunity. γδ T cells produce a diverse range of cytokines, exert cytotoxic effector function, can act as antigen-presenting cells, and display regulatory activity. Here we review the current knowledge on the regulatory functions of murine and human γδ T cells. Some γδ T cells produce inhibitory cytokines such as transforming growth factor-β but γδ T cells can utilize additional regulatory mechanisms. By subverting regulatory T cells (Treg) through induction of Treg apoptosis or cytokine-dependent reversal of Treg activity, however, γδ T cells can also enhance effector T cell activity and thereby contribute to autoimmunity. A more precise understanding of the plasticity of regulatory γδ T cells is required to specifically identify strategies for intentional modulation of their beneficial or detrimental regulatory activity.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Kabelitz D,Peters C,Wesch D,Oberg HH

doi

10.1016/j.intimp.2013.01.022

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

382-7

issue

3

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(13)00039-8

journal_volume

16

pub_type

杂志文章,评审

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