Abstract:
:The garlic-derived organosulfur compound S-allylmercaptocysteine (SAMC) has been reported to exhibit anti-inflammatory and anti-oxidative activities, whereas its potential therapeutic effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) is unknown. In this study, we focused on exploring the therapeutic effects of SAMC on LPS-induced ALI mice and the involvement of underlying molecular mechanisms. BalB/c mice were treated with SAMC (10, 30 and 60 mg/kg) or positive control N-acetylcysteine (NAC, 500 mg/kg) by gavage after intratracheal instillation of LPS for 30 min and were sacrificed 24 h after LPS administration. Our results indicate that the treatment with SAMC not only ameliorated the histological changes but also decreased LPS-triggered lung edema. Moreover, SAMC displayed an anti-inflammatory effect through reducing inflammatory cells infiltration, myeloperoxidase (MPO) formation and inhibiting pro-inflammatory cytokines/mediator production including tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX2) via suppressing the activation of nuclear factor-kappaB (NF-κB) signaling pathway. Furthermore, SAMC attenuated oxidative stress evoked by LPS via diminishing malondialdehyde (MDA) formation and reversing glutathione (GSH) and superoxide dismutase (SOD) depletion. Meanwhile, SAMC up-regulated expressions of endogenous antioxidant/detoxifying proteins including heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1(NQO1) through reversing the suppression of Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid-2 related factor 2 (Nrf2) signaling pathway. Our results demonstrate that SAMC effectively attenuated LPS-induced ALI which was largely dependent upon inhibition of inflammation and oxidative stress via NF-κB and Keap1/Nrf2 signaling pathways.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Mo M,Li S,Dong Z,Li C,Sun Y,Li A,Zhao Zdoi
10.1016/j.intimp.2020.106273subject
Has Abstractpub_date
2020-04-01 00:00:00pages
106273eissn
1567-5769issn
1878-1705pii
S1567-5769(19)32662-1journal_volume
81pub_type
杂志文章abstract:OBJECTIVE:Batroxobin is a medicinal preparation extracted from the venom of the Fer-de-Lance snake, and is used to lower blood viscosity, promote blood fibrinogen decomposition, and inhibit thrombosis. This research is to investigate whether batroxobin can improve the survival of random skin flaps in a rat model. MATE...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.04.011
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abstract::High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play important roles in the development of sepsis-induced acute lung injury (ALI). Ketamine is considered to confer protective effects on ALI during sepsis. In this study, we investigated the effects of ketamine on HMG...
journal_title:International immunopharmacology
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abstract:OBJECTIVE:This study aims to select the most effective anti-Rheumatoid Arthritis (RA) component of flavonoids from Daphne genkwa Sieb. et Zucc. by anti-inflammatory and immunomodulatory effects in vitro, and to elucidate the mechanism. METHODS:The anti-inflammatory and immunomodulatory effects of total flavonoids (TF)...
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abstract::B-cell lymphoma remains one of the most refractory tumors, and as such the development of novel treatment approaches, such as antibody-drug conjugates (ADCs), is required. To improve the stability and homogeneity of the ADCs, a humanized anti-CD19 monoclonal antibody (RC58) was developed in the present study. RC58 was...
journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2011.12.001
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
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journal_title:International immunopharmacology
pub_type: 杂志文章
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journal_title:International immunopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2008.11.008
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2005.11.022
更新日期:2006-05-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.06.021
更新日期:2015-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2004.04.011
更新日期:2004-08-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-01-01 00:00:00
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2013.10.023
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journal_title:International immunopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.10.001
更新日期:2017-01-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.06.007
更新日期:2016-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2007.08.022
更新日期:2008-02-01 00:00:00
abstract:UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...
journal_title:International immunopharmacology
pub_type: 临床试验,杂志文章
doi:10.1016/j.intimp.2006.09.013
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abstract::Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads to the activation of diverse cellular mechanisms in the central nervous system to attempt to repair the damaged spinal cord tissue. Higenamine (HG) (1-[(4-hydroxyphenyl) methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-di...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.10.022
更新日期:2014-12-01 00:00:00
abstract::Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease. Interleukin (IL)-10 is one of the most important and best anti-inflammatory cytokines. The objective of this report is to investigate whether IL-10 has any role in protecting ventral mesencephalic (VM) neurons in in vitro model of ne...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.07.017
更新日期:2017-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2010.04.008
更新日期:2010-07-01 00:00:00