当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.

The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.

Abstract：

:1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1 during treatment with glucocorticoids or the mast cell 'stabilising' drugs ketotifen and nedocromil. 3.Compound 48/80 also stimulated ANX-A1 phosphorylation and release and this was also potentiated by nedocromil. Anti-ANX-A1 neutralising monoclonal antibodies (Mabs) enhanced the release of pro-inflammatory mediators in response to compound 48/80. 4.Nedocromil and ketotifen potently inhibited the release of histamine, PGD2, tryptase and β-hexosaminidase from mast cells challenged with compound 48/80. Anti-ANX-A1 neutralising Mabs prevented the inhibitory effect of these drugs. 5.BMDMCs derived from Anx-A1−/− mice were insensitive to the inhibitory effects of nedocromil or ketotifen but cells retained their sensitivity to the inhibitory action of hu-r-ANX-A1. 6.The fpr2/3 antagonist WRW4 blocked the action of nedocromil on PGD2, but not histamine, release. BMDMCs derived from fpr2/3−/− mice were insensitive to the inhibitory effects of nedocromil on PGD2, but not histamine release. 7.Compound 48/80 stimulated both p38 and JNK phosphorylation in CBDMCs and this was inhibited by nedocromil. Inhibition of p38 phosphorylation was ANX-A1 dependent. 8.We conclude that ANX-A1 is an important regulator of mast cell reactivity to compound 48/80 exerting a negative feedback effect through a mechanism that depends at least partly on the FPR receptor.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Sinniah A,Yazid S,Perretti M,Solito E,Flower RJ

doi

10.1016/j.intimp.2016.01.003

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

87-95

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30004-2

journal_volume

32

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Pinocembrin attenuates allergic airway inflammation via inhibition of NF-κB pathway in mice.

    abstract：:Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mecha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.10.005

    authors： Gu X,Zhang Q,Du Q,Shen H,Zhu Z

    更新日期：2017-12-01 00:00:00

  • Astilbin promotes the induction of regulatory NK1.1- CD4+ NKG2D+ T cells through the PI3K, STAT3, and MAPK signaling pathways.

    abstract：:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whe...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106143

    authors： Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W

    更新日期：2020-04-01 00:00:00

  • Efficacy and safety of dendritic cell vaccines for patients with glioblastoma: A meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:Dendritic cell (DC)-based vaccination has been suggested to be promising for glioblastoma. However, the evidence in randomized controlled trials (RCTs) is inconsistent. We aimed to systematically evaluate the efficacy and safety of DC vaccine for glioblastoma via a meta-analysis of RCTs. METHODS:Related ran...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106336

    authors： Lv L,Huang J,Xi H,Zhou X

    更新日期：2020-06-01 00:00:00

  • Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers.

    abstract：:Hemorrhagic transformation (HT) is a common and serious complication following ischemic stroke, especially after tissue plasminogen activator (t-PA) thrombolysis, which is associated with increased mortality and disability. Due to the unknown mechanisms and targets of HT, there are no effective therapeutic drugs to de...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.107216

    authors： Ma G,Pan Z,Kong L,Du G

    更新日期：2021-01-01 00:00:00

  • Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-gamma.

    abstract：:Human melanoma Colo 679 cells were made resistant to doxorubicin (adriamycin, ADM) by continuous exposure to ascending concentrations of the drug and Colo/ADM80; a variant which grew continuously in the presence of 80 ng/ml of ADM was thus established. Human peripheral blood mononuclear cells (PBMC) produced interfero...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(00)00026-6

    authors： Micallef MJ,Darmanin S,Buhagiar JA,Camilleri-Podesta MT,Yamauchi H,Kurimoto M,Inglott AS,Ellul-Micallef R

    更新日期：2001-02-01 00:00:00

  • Selective impairment of CD4+CD25+Foxp3+ regulatory T cells by paclitaxel is explained by Bcl-2/Bax mediated apoptosis.

    abstract：:Paclitaxel has become one of the most effective and widely used chemotherapeutic agents over the past decades. Although it has shown promise to selectively deplete regulatory T (Treg) cells in our previous study, the underlying molecular mechanism remains to be further elucidated. The present study focused on the effe...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.11.021

    authors： Liu N,Zheng Y,Zhu Y,Xiong S,Chu Y

    更新日期：2011-02-01 00:00:00

  • Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice.

    abstract：:Caffeic acid phenethyl ester (CAPE), an the active component of propolis, is known to have anticarcinogenic, antiviral and various biological activities; however, the effect of CAPE on the immunomodulatory activity in vivo remains unknown. We have investigated the effect of CAPE on the immune system in female Balb/c m...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.01.013

    authors： Park JH,Lee JK,Kim HS,Chung ST,Eom JH,Kim KA,Chung SJ,Paik SY,Oh HY

    更新日期：2004-03-01 00:00:00

  • Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice.

    abstract：:MOTS-c (mitochondrial open-reading-frame of the twelve S rRNA-c), a mitochondrial-derived 16-amino acid peptide, targets the methionine-folate cycle, increases 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) levels, and eventually activates AMP-activated protein kinase (AMPK). AMPK activation can attenuate neutr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106174

    authors： Xinqiang Y,Quan C,Yuanyuan J,Hanmei X

    更新日期：2020-03-01 00:00:00

  • Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice.

    abstract：:Zingerone, one of the active components of ginger, is a phenolic alkanone with antioxidant and anti-inflammatory properties. In the present study, we analyzed the role of zingerone against RAW 264.7 cells and acute lung injury induced by lipopolysaccharide (LPS) in mice. RAW cells or BALB/c mice were pretreated with z...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.12.028

    authors： Xie X,Sun S,Zhong W,Soromou LW,Zhou X,Wei M,Ren Y,Ding Y

    更新日期：2014-03-01 00:00:00

  • Role of Fas/Fas ligand-mediated apoptosis in murine contact hypersensitivity.

    abstract：:Apoptosis plays an important role in immune responses, but little is known about its involvement in contact hypersensitivity (CH). In this study, we have investigated the role of Fas/Fas ligand (FasL)-mediated apoptosis in the pathogenesis of CH. Mice were sensitized by one topical application of 100 microl of 3% oxaz...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00081-X

    authors： Xu B,Bulfone-Paus S,Aoyama K,Yu S,Huang P,Morimoto K,Matsushita T,Takeuchi T

    更新日期：2003-07-01 00:00:00

  • Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma.

    abstract：:Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II antagonized the bradykinin receptor more potently than any of the other flavonoids derived from this plant. Here, we were investigated its thera...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.01.010

    authors： Jang HY,Ahn KS,Park MJ,Kwon OK,Lee HK,Oh SR

    更新日期：2012-04-01 00:00:00

  • Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients.

    abstract：BACKGROUND:Regulatory T cells (Tregs) are thought to play a modulatory role in immune responses and to improve outcomes after ischemic stroke. Thus, various strategies for increasing Tregs in animal models of ischemic stroke have yielded successful results. The aim of this study was to examine the potential effect of p...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.04.043

    authors： Noh MY,Lee WM,Lee SJ,Kim HY,Kim SH,Kim YS

    更新日期：2018-07-01 00:00:00

  • Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-α and IL-1β release and augmentation of IL-10 production.

    abstract：:Lipopolysaccharide (LPS) plays an important role in Gram-negative bacteria-induced sepsis and multiple organ dysfunction syndrome, which are still the leading cause of high mortality in intensive care units. Although paeoniflorin (Pae) has reportedly exhibited anti-inflammatory effect and protection against immunologi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.11.012

    authors： Cao W,Zhang W,Liu J,Wang Y,Peng X,Lu D,Qi R,Wang Y,Wang H

    更新日期：2011-02-01 00:00:00

  • Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression.

    abstract：:Lung cancer is the major cause of cancer-related mortality and is a growing economic burden worldwide. Chemoprevention has emerged as a very effective preventive measure against carcinogenesis and several bioactive compounds in diet have shown their cancer curative potential on lung cancer. Naringenin (NRG), a predomi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.11.036

    authors： Bodduluru LN,Kasala ER,Madhana RM,Barua CC,Hussain MI,Haloi P,Borah P

    更新日期：2016-01-01 00:00:00

  • Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation.

    abstract：:We investigated the anti-inflammatory effects of sauchinone, a lignan isolated from Saururus chinensis, and the underlying mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. To assess the effects of sauchinone on LPS-induced macrophages activation, we measured the production of tumor necrosis factor (TNF...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.06.001

    authors： Bae HB,Li M,Son JK,Seo CS,Chung SH,Kim SJ,Jeong CW,Lee HG,Kim W,Park HC,Kwak SH

    更新日期：2010-09-01 00:00:00

  • DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner.

    abstract：:Endotoxin can stimulate inflammatory cytokine release from monocytes/macrophages and result in septic shock. Glycyrrhetinic acid (GA), the main bioactive component of licorice, possesses substantial anti-inflammatory activity. Here, we explored effect of 11-deoxy-18α-glycyrrhetinic acid-30-ethyl ester (DGAEE), a newly...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.09.025

    authors： Luo J,Liu M,Wu X,Dou Y,Xia Y,Dai Y,Wei Z

    更新日期：2015-12-01 00:00:00

  • Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage.

    abstract：:Intracerebral hemorrhage (ICH) from blood vessel rupture results in parenchymal hematoma formation and neuroinflammation, ultimately leading to neurodegeneration. Several lines of evidence suggest that the severity of ICH-induced neural damage is exacerbated by infiltration of T-cells, monocytes, and especially neutro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106678

    authors： Hijioka M,Futokoro R,Ohto-Nakanishi T,Nakanishi H,Katsuki H,Kitamura Y

    更新日期：2020-08-01 00:00:00

  • Andrographolide sulfonate reduces mortality in Enterovirus 71 infected mice by modulating immunity.

    abstract：:Outbreaks of hand, foot and mouth disease (HFMD), which is caused by Enterovirus 71 (EV71), have erupted in recent years. Andrographolide sulfonate (Trade name: Xiyanping injection) has been recommended to treat severe HFMD in China because of its conventional antithermic and antitoxic activities, but its actual mecha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.11.042

    authors： Li M,Yang X,Guan C,Wen T,Duan Y,Zhang W,Li X,Wang Y,Zhao Z,Liu S

    更新日期：2018-02-01 00:00:00

  • Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation.

    abstract：:We assessed the effects of Zizyphus lotus L. (Desf.) polyphenols (ZLP) on T-cell signaling and proliferation. Our results showed that ZLP exerted no effect on the increases in intracellular free calcium concentrations, [Ca(2+)]i, in human Jurkat T-cells. However, ZLP modulated the thapsigargin-induced increases in [Ca...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.11.013

    authors： Abdoul-Azize S,Bendahmane M,Hichami A,Dramane G,Simonin AM,Benammar C,Sadou H,Akpona S,El Boustani ES,Khan NA

    更新日期：2013-02-01 00:00:00

  • Dopamine D2 receptor suppresses gastric cancer cell invasion and migration via inhibition of EGFR/AKT/MMP-13 pathway.

    abstract：:Dopamine (DA), an important neurotransmitter, has been reported to play a negative role in tumor progression. DA acts its role via dopamine receptors (DRs), which can be divided into five receptor subtypes (D1R-D5R). Among these receptor subtypes, D2R has been found to inhibit IGF-I-induced gastric cancer cell growth....

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.07.002

    authors： Huang H,Wu K,Ma J,Du Y,Cao C,Nie Y

    更新日期：2016-10-01 00:00:00

  • Mechanistic exploration of AhR-mediated host protection against Streptococcus pneumoniae infection.

    abstract：:Streptococcus pneumoniae is a primary cause of invasive bacterial infection and pneumonia and is one of the leading causes of death worldwide. In prior studies we showed that pre-treating mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent agonist of the aryl hydrocarbon receptor (AhR), protects against S. ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.05.008

    authors： Wang T,Wyrick KL,Pecka MR,Wills TB,Vorderstrasse BA

    更新日期：2012-08-01 00:00:00

  • (E)-1-(4-ethoxyphenyl)-3-(4-nitrophenyl)-prop-2-en-1-one suppresses LPS-induced inflammatory response through inhibition of NF-κB signaling pathway.

    abstract：:Flavonoids are a class of compounds that exist in nature with the structure of 2-phenyl-chromone. In Chinese traditional medicine, herbal drugs containing flavonoids are widely used for the treatment of inflammation, cardiovascular disease, tumor and so on. In this study, we investigated the anti-inflammatory effect a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.024

    authors： Xu J,Jia YY,Chen SR,Ye JT,Bu XZ,Hu Y,Ma YZ,Guo JL,Liu PQ

    更新日期：2013-04-01 00:00:00

  • Chikusetsusaponin V attenuates lipopolysaccharide-induced acute lung injury in mice by modulation of the NF-κB and LXRα.

    abstract：:Acute lung injury (ALI) is an excessive and uncontrolled inflammatory response in lung, of which remains the leading cause of morbidity and mortality in worldwide. Chikusetsusaponin V (CsV), a bioactive compounds derived from Panacis Japonica, has been reported to have anti-inflammatory effects. However, it is still u...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.02.023

    authors： Su K,Zhang G,Zhang X,Jiang W

    更新日期：2019-05-01 00:00:00

  • GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

    abstract：:Chronic cold stress has long-term dramatic effects on the animal immune and neuroendocrine systems. As one of the important regions of the brain, the hippocampus is the main region involved in response to stressors. Nevertheless, the impact to the hippocampus following cold exposure and the underlying mechanism involv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106908

    authors： Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

    更新日期：2020-12-01 00:00:00

  • Herpesviral Fcgamma receptors: culprits attenuating antiviral IgG?

    abstract：:Production of IgG in response to virus infection is central to antiviral immune effector functions and a hallmark of B cell memory. Antiviral antibodies (Abs) recognising viral glycoproteins or protein antigen displayed on the surface of virions or virus-infected cells are crucial in rendering the virus noninfectious ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.05.020

    authors： Budt M,Reinhard H,Bigl A,Hengel H

    更新日期：2004-09-01 00:00:00

  • Gene expression profile of human peripheral blood mononuclear cells induced by Staphylococcus aureus lipoteichoic acid.

    abstract：:Lipoteichoic acid (LTA) is a major virulence factor of Gram-positive bacteria including Staphylococcus aureus. Despite its pivotal role in causing sepsis, the systemic immune responses to LTA in human cells are poorly understood. Here, we produced highly-pure and structurally-intact LTA from S. aureus and examined the...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.05.010

    authors： Kang SS,Kim HJ,Jang MS,Moon S,In Lee S,Jeon JH,Baik JE,Park OJ,Son YM,Kim GR,Joo D,Kim H,Han JY,Yun CH,Han SH

    更新日期：2012-08-01 00:00:00

  • IL-7R gene variants are associated with breast cancer susceptibility in Chinese Han women.

    abstract：BACKGROUND:Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibili...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106756

    authors： Wang Z,Wang X,Gao Y,Wang Y,Xu M,Han Q,Zhao X

    更新日期：2020-09-01 00:00:00

  • Pseudomonas aeruginosa promotes autophagy to suppress macrophage-mediated bacterial eradication.

    abstract：OBJECTIVES:To explore the role of autophagy on macrophage-mediated phagocytosis and intracellular killing of Pseudomonas aeruginosa (PA), a common extracellular bacterium which often causes various opportunistic infections. METHODS:Macrophages were infected with PA or stimulated with zymosan bioparticles. Autophagy wa...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.04.044

    authors： Wu Y,Li D,Wang Y,Chen K,Yang K,Huang X,Zhang Y,Wu M

    更新日期：2016-09-01 00:00:00

  • Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients.

    abstract：INTRODUCTION:Sulfur mustard (SM) intoxication produces local and systemic changes in the human body. In this study, the relationship between tear and serum matrix metalloproteinase (MMP)-9 and serum tissue inhibitors of metalloproteinases (TIMPs) are assessed in serious eye-injured SM-exposed casualties. METHODS:A gro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105812

    authors： Ghasemi H,Yaraee R,Faghihzadeh S,Ghassemi-Broumand M,Mahmoudi M,Babaei M,Naderi M,Safavi M,Ghazanfari Z,Rastin M,Zamani S,Tabasi N,Faghihzadeh E,Gharebaghi R,Hassan ZM,Mirsharif ES,Ghazanfari T

    更新日期：2019-12-01 00:00:00

  • Association of cytokine gene polymorphisms and the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone.

    abstract：:Immunosuppressive drugs are widely used in the therapy of autoimmune disorders to suppress autoreactive T cells. The immune system is regulated by the release of cytokines. Cytokine are potent immunomodulatory molecules that act as mediators of inflammation and the immune response. Primarily secreted by T cell and mac...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.08.019

    authors： Pawlik A,Baskiewicz-Masiuk M,Machalinski B,Gawronska-Szklarz B

    更新日期：2006-03-01 00:00:00