Abstract:
:Methylglyoxal is a normal metabolite and has the potential to affect a wide variety of cellular processes. In particular, it can act selectively against malignant cells. The study described herein was to investigate whether methylglyoxal can enhance the non-specific immunity of the host against tumor cells. Methylglyoxal increased the number of macrophages in the peritoneal cavity of both normal and tumor-bearing mice. It also elevated the phagocytic capacity of macrophages in both these groups of animals. This activation of macrophages was brought about by increased production of Reactive Oxygen Intermediates (ROIs) and Reactive Nitrogen Intermediates (RNIs). The possible mechanism for the production of ROIs and RNIs can be attributed to stimulation of the respiratory burst enzyme NADPH oxidase and iNOS, respectively. IFN-gamma, which is a regulatory molecule of iNOS pathway also showed an elevated level by methylglyoxal. TNF-alpha, which is an important cytokine for oxygen independent killing by macrophage also increased by methylglyoxal in both tumor-bearing and non tumor-bearing animals. Methylglyoxal also played a role in the proliferation and cytotoxicity of splenic lymphocytes. In short, it can be concluded that methylglyoxal profoundly stimulates the immune system against tumor cells.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Bhattacharyya N,Pal A,Patra S,Haldar AK,Roy S,Ray Mdoi
10.1016/j.intimp.2008.06.005subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1503-12issue
11eissn
1567-5769issn
1878-1705pii
S1567-5769(08)00181-1journal_volume
8pub_type
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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doi:10.1016/j.intimp.2019.04.011
更新日期:2019-07-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2012.02.009
更新日期:2012-04-01 00:00:00
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doi:10.1016/s1567-5769(02)00065-6
更新日期:2002-07-01 00:00:00
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更新日期:2001-03-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2008.07.006
更新日期:2008-12-10 00:00:00
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doi:10.1016/j.intimp.2019.05.012
更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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doi:10.1016/j.intimp.2005.03.005
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pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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doi:10.1016/j.intimp.2017.09.020
更新日期:2017-11-01 00:00:00
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doi:10.1016/j.intimp.2016.06.018
更新日期:2016-09-01 00:00:00
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更新日期:2019-03-01 00:00:00
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doi:10.1016/j.intimp.2020.106929
更新日期:2020-11-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2013.01.017
更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-03-01 00:00:00