Abstract:
:The therapeutic effects of intravenous immunoglobulin (IVIG) products were recently studied in Alzheimer's disease (AD) patients. Pilot studies produced encouraging results but phase II and III trials gave disappointing results; a further study is in progress. IVIG products contain antibodies to tau protein, the main component of neurofibrillary tangles (NFTs). The tau used to detect IVIG's anti-tau antibodies in previous studies was non-phosphorylated recombinant human tau-441, but NFT-associated tau is extensively phosphorylated. The objective of this study was to determine if various IVIG products contain specific antibodies to phosphorylated tau (anti-pTau antibodies). ELISAs were used to evaluate binding of six IVIG products to a 12 amino acid peptide, tau 196-207, which was phosphorylated ("pTau peptide") or non-phosphorylated ("non-pTau peptide") at Serine-199 and Serine-202. Both amino acid residues are phosphorylated in AD NFTs. Each IVIG's "anti-pTau antibody ratio" was calculated by dividing its binding to the pTau peptide by its binding to the non-pTau peptide. Seven experiments were performed and data were pooled, with each experiment contributing one data point from each IVIG product. Mean anti-pTau antibody ratios greater than 1.0, suggesting specific antibodies to phosphorylated tau, were found for three IVIG products. Because administration of antibodies to phosphorylated tau has been found to reduce tau-associated pathology in transgenic mouse models of tauopathy, increasing the levels of anti-pTau antibodies, together with other selected antibodies such as anti-Aβ, in IVIG might increase its ability to slow AD's progression.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Loeffler DA,Klaver AC,Coffey MPdoi
10.1016/j.intimp.2015.08.022subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1108-12issue
2eissn
1567-5769issn
1878-1705pii
S1567-5769(15)30080-1journal_volume
28pub_type
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2012.05.004
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2019.105808
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journal_title:International immunopharmacology
pub_type: 杂志文章,meta分析,评审
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2004.12.015
更新日期:2005-06-01 00:00:00
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2020.106541
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2018.06.008
更新日期:2018-08-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.10.022
更新日期:2014-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/S1567-5769(03)00101-2
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2019.05.017
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2015.05.035
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doi:10.1016/j.intimp.2019.02.034
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journal_title:International immunopharmacology
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pub_type: 杂志文章,meta分析
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-09-01 00:00:00