当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia.

CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia.

Abstract：

:Staphylococcus aureus is a major causative microorganism in community- and healthcare-acquired pneumonia. CD5L is an important protein in the control of immune homeostasis. In this study, we found that patients with S. aureus pneumonia displayed increased levels of circulating CD5L. Likewise, mice with S. aureus pneumonia had elevated CD5L levels in the lungs. Anti-CD5L antibody protected mice from lethal pneumonia induced by methicillin-resistant S. aureus. The survival benefit obtained with antibody against CD5L was associated with an improvement of bacterial clearance and a reduction of pulmonary inflammatory cytokines and chemokines. Conversely, co-injection of recombinant CD5L and S. aureus markedly increased the lethality of S. aureus pneumonia. These findings suggest that CD5L contributed to the immunopathology of S. aureus pneumonia.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Gao X,Yan X,Zhang Q,Yin Y,Cao J

doi

10.1016/j.intimp.2019.03.057

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

40-47

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(19)30049-9

journal_volume

72

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Combination treatment of low dose Anti-Thymocyte Globulin (ATG), Rituximab and high dose Sirolimus as induction agents in immune-conditioned recipients.

    abstract：UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2006.09.013

    authors： Ravichandran P,Natrajan T,Jaganathan R

    更新日期：2006-12-20 00:00:00

  • Epigallocatechin-3-gallate reduces liver and immune system damage in Acinetobacter baumannii-loaded mice with restraint stress.

    abstract：AIM:Due to the significant increase in the antimicrobial resistance of Acinetobacter baumannii (A. baumannii), new drugs to block the progression of infection are strongly needed. Epigallocatechin-3-gallate (EGCG), a major component of green tea, has exhibited potential activity against A. baumannii in vitro. The aim o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107346

    authors： Yan Q,Hao S,Shi F,Zou Y,Song X,Li L,Li Y,Guo H,He R,Zhao L,Ye G,Tang H

    更新日期：2021-01-04 00:00:00

  • Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.

    abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.05.012

    authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

    更新日期：2014-08-01 00:00:00

  • Impact of culture medium on CD4(+) CD25(high)CD127(lo/neg) Treg expansion for the purpose of clinical application.

    abstract：:A recently discovered population of lymphocytes, called T regulatory cells (Tregs), is characterized by expression of transcription factor Forkhead box P3 (FoxP3). These cells have been successfully used as therapeutic treatments and prophylaxis for graft-versus-host disease (GVHD) and diabetes and might become an att...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.016

    authors： Gołąb K,Krzystyniak A,Marek-Trzonkowska N,Misawa R,Wang LJ,Wang X,Cochet O,Tibudan M,Langa P,Millis JM,Trzonkowski P,Witkowski P

    更新日期：2013-07-01 00:00:00

  • Combined standard and novel immunosuppressive substances affect B-lymphocyte function.

    abstract：:A considerable fraction of renal transplanted patients is susceptible to humoral rejection. Today well-established therapy regimens are available to control antibody-mediated rejection in the short term. Nevertheless, donor-specific antibodies persist and graft function deteriorates over time. This might be due to ins...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.025

    authors： Matz M,Lehnert M,Lorkowski C,Fabritius K,Weber UA,Mashreghi MF,Neumayer HH,Budde K

    更新日期：2013-04-01 00:00:00

  • MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis.

    abstract：OBJECTIVE:Ankylosing spondylitis (AS) is a disease characterized by inflammation of the sacroiliac joint and the attachment point of the spine. This study aimed to investigate the effect of microRNA (miR)-204-targeted GSDMD on fibroblast-like synoviocytes (FLSs) in AS. METHODS:miR-204, GSDMD, pyrolysis-related genes (...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107227

    authors： Gu G,Huo Y,Xu G,Li L,Yu J,Sheng L,Yin Z

    更新日期：2021-02-01 00:00:00

  • Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder in which lymphocytic infiltration mediated mainly by pro-inflammatory cytokines. In this study, we examined the effect of combined exercise training on the levels of IFN-γ, IL-4 and IL-17 in the plasma and the supernatant of peripheral blood lymp...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.08.008

    authors： Golzari Z,Shabkhiz F,Soudi S,Kordi MR,Hashemi SM

    更新日期：2010-11-01 00:00:00

  • 1,25‑Dihydroxyvitamin D regulates macrophage polarization and ameliorates experimental inflammatory bowel disease by suppressing miR-125b.

    abstract：:Macrophages are highly plastic cells. Depending on stimulation, macrophages rapidly polarize to functionally distinct phenotypes that are involved in the pathogenesis of inflammatory bowel disease (IBD). 1,25‑Dihydroxyvitamin D (1,25(OH)2D3) has immunomodulatory activity, and 1,25(OH)2D3 deficiency is correlated with ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.12.015

    authors： Zhu X,Zhu Y,Li C,Yu J,Ren D,Qiu S,Nie Y,Yu X,Xu X,Zhu W

    更新日期：2019-02-01 00:00:00

  • Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

    abstract：:Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107026

    authors： Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

    更新日期：2020-12-01 00:00:00

  • Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage.

    abstract：:Ulcerative colitis (UC), an idiopathic inflammatory bowel disease, not only affects millions of patients worldwide, but also increases the risk of colon cancer. Geniposide is an iridoid glycoside and has many biological activities such as anti-inflammatory and antioxidant. However, its protective efficacy and mechanis...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.05.033

    authors： Zhang Z,Li Y,Shen P,Li S,Lu X,Liu J,Cao Y,Liu B,Fu Y,Zhang N

    更新日期：2017-08-01 00:00:00

  • Comparison of peripheral blood B cell subset ratios and B cell-related cytokine levels between ocular and generalized myasthenia gravis.

    abstract：BACKGROUND:The pathogenesis of myasthenia gravis (MG) depends upon T and B cells, as well as complement and cytokines. The activation of functional subpopulations of T and B cells is the basis of the immune response. However, the activation levels of T and B cell subsets remain unclear in the pathogenesis of MG. Here, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106130

    authors： Hu Y,Wang J,Rao J,Xu X,Cheng Y,Yan L,Wu Y,Wu N,Wu X

    更新日期：2020-03-01 00:00:00

  • DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner.

    abstract：:Endotoxin can stimulate inflammatory cytokine release from monocytes/macrophages and result in septic shock. Glycyrrhetinic acid (GA), the main bioactive component of licorice, possesses substantial anti-inflammatory activity. Here, we explored effect of 11-deoxy-18α-glycyrrhetinic acid-30-ethyl ester (DGAEE), a newly...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.09.025

    authors： Luo J,Liu M,Wu X,Dou Y,Xia Y,Dai Y,Wei Z

    更新日期：2015-12-01 00:00:00

  • Activation of PPARγ by Curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells.

    abstract：:Curcumin shows protective effects on various diseases due to its anti-inflammatory and anti-oxidative functions; however, its effect on organ transplantation has not been fully elucidated. To understand its role in liver ischemia/reperfusion (I/R) injury, we studied its impact on orthotopic liver transplantation (OLT)...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.07.013

    authors： Liu Y,Zhang W,Cheng Y,Miao C,Gong J,Wang M

    更新日期：2018-09-01 00:00:00

  • Isofraxidin ameliorated influenza viral inflammation in rodents via inhibiting platelet aggregation.

    abstract：:Platelets have been proved to exacerbate influenza infection and its complications. Inhibition of platelet activation may be a feasible method for preventing severe infection and secondary acute lung injury (ALI). Isofraxidin (IFD) is a natural coumarin isolated from the plants Sarcandra glabra and Siberian ginseng, a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106521

    authors： Jin L,Ying ZH,Yu CH,Zhang HH,Yu WY,Wu XN

    更新日期：2020-07-01 00:00:00

  • Adiponectin inhibits proliferation of vascular endothelial cells induced by Ox-LDL by promoting dephosphorylation of Caveolin-1 and depolymerization of eNOS and up-regulating release of NO.

    abstract：:Oxidized low density lipoprotein (ox-LDL) can induce the proliferation and differentiation of endothelial cells, which is one of the important mechanisms of ox-LDL atherosclerosis. Adiponectin is an endogenous bioactive polypeptide secreted by adipocytes, it participates in the metabolism of fat and glucose. It has th...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.017

    authors： Lu Y,Gao X,Wang R,Sun J,Guo B,Wei R,Jia Y

    更新日期：2019-08-01 00:00:00

  • Iguratimod (T-614) suppresses RANKL-induced osteoclast differentiation and migration in RAW264.7 cells via NF-κB and MAPK pathways.

    abstract：INTRODUCTION:Iguratimod (T-614) has been confirmed as a highly efficacious and safe novel disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis therapy in China and Japan due to its potent anti-inflammation effect. Here, we investigate the effects of Iguratimod on osteoclast differentiation, migration ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.03.038

    authors： Gan K,Yang L,Xu L,Feng X,Zhang Q,Wang F,Tan W,Zhang M

    更新日期：2016-06-01 00:00:00

  • Activation of macrophages and lymphocytes by methylglyoxal against tumor cells in the host.

    abstract：:Methylglyoxal is a normal metabolite and has the potential to affect a wide variety of cellular processes. In particular, it can act selectively against malignant cells. The study described herein was to investigate whether methylglyoxal can enhance the non-specific immunity of the host against tumor cells. Methylglyo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.06.005

    authors： Bhattacharyya N,Pal A,Patra S,Haldar AK,Roy S,Ray M

    更新日期：2008-11-01 00:00:00

  • Diabetes teratogenicity is accompanied by alterations in macrophages and T cell subpopulations in the uterus and lymphoid organs.

    abstract：:Insulin-dependent diabetes mellitus is a well-known teratogen, which might cause growth retardation, malformations and fetal death. We have previously shown, that potentiation of the maternal immune system (immunopotentiation) might protect the embryo from diabetes teratogenicity. Therefore, in the present study we fu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.05.018

    authors： Savion S,Gidon-Dabush S,Fein A,Torchinsky A,Toder V

    更新日期：2004-10-01 00:00:00

  • Retinoic acid modulates IL-4, IL-10 and MCP-1 pathways in immune mediated hepatitis and interrupts CD4+ T cells infiltration.

    abstract：AIMS:Immune mediated liver injury includes activation of different immune pathways that requires various modalities to control their consequences. The current study involves evaluation of retinoic acid (RA) modulatory effects on immune responses induced in concanavalin A (ConA) model of acute hepatitis. MAIN METHODS:M...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105808

    authors： Elshal M,Abu-Elsaad N,El-Karef A,Ibrahim T

    更新日期：2019-10-01 00:00:00

  • Chromatin remodeling complex in Treg function.

    abstract：:Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2009.01.019

    authors： Jani A,Chi T,Wan YY

    更新日期：2009-05-01 00:00:00

  • Immune reconstitution after autologous hematopoietic transplantation with Lin-, CD34+, Thy-1lo selected or intact stem cell products.

    abstract：:In sequential studies, we compared immune reconstitution following high-dose chemotherapy (HDT) and stem cell transplantation (SCT) using intact mobilized peripheral blood stem cell (PSC) in intermediate grade non-Hodgkin's lymphoma (NHL) patients and CD34(+), lineage-negative (Lin(-)), Thy-1(lo) (CD34(+)Lin(-)Thy-1(l...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2007.03.006

    authors： Singh RK,Varney ML,Leutzinger C,Vose JM,Bierman PJ,Buyukberber S,Ino K,Loh K,Nichols C,Inwards D,Rifkin R,Talmadge JE

    更新日期：2007-08-01 00:00:00

  • A non-peptide antagonist unusually selective for the human form of the bradykinin B2 receptor.

    abstract：:Analgesic and anti-inflammatory applications for non-peptide bradykinin (BK) B2 receptor antagonists have been documented in rats. However, very large species differences in affinity were also noted within this class of drugs, making the preclinical development of relevant drugs difficult. Bradyzide is a potent antago...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00180-2

    authors： Marceau F,Fortin JP,Morissette G,Dziadulewicz EK

    更新日期：2003-10-01 00:00:00

  • Altered microbial community structure in PI3Kγ knockout mice with colitis impeding relief of inflammation: Establishment of new indices for intestinal microbial disorder.

    abstract：:Lipopolysaccharide stimulates the intestinal microbiome to activate phosphoinositide 3 kinase (PI3K) signaling via several pathways; however, the direct effect that PI3K has on the intestinal bacterial community remains unclear. Herein, we investigate changes in the colonic microbiome of colitis PI3Kγ-knockout (PI3Kγ-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105901

    authors： Li Y,Chen QQ,Yuan J,Chen Z,Du HT,Wan J

    更新日期：2020-02-01 00:00:00

  • cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts.

    abstract：:Cathepsin K (Cat K) is the major cysteine protease expressed in osteoclast and is thought to play a key role in matrix degradation during bone resorption. It is shown that the intracellular maturation of Cat K was prevented by the cAMP antagonist, Rp-cAMP, and the protein kinase A (PKA) inhibitors of KT5720 and H89. I...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.01.005

    authors： Park YG,Kim YH,Kang SK,Kim CH

    更新日期：2006-06-01 00:00:00

  • Adoptive immunotherapy for non-small cell lung cancer by NK and cytotoxic T lymphocytes mixed effector cells: retrospective clinical observation.

    abstract：:The objective of the current study was to retrospectively investigate the efficacy of adaptive transfer of natural killer (NK) and cytotoxic T lymphocytes mixed effector (NKTm) cells in non-small cell lung cancer (NSCLC) patients in comparison to a control group of NSCLC patients. NKTm cells were obtained by ex vivo e...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.04.026

    authors： Zhang G,Zhao H,Wu J,Li J,Xiang Y,Wang G,Wu L,Jiao S

    更新日期：2014-08-01 00:00:00

  • In vitro anti-allergic activity of the fungal metabolite pyridovericin.

    abstract：:Mast cells play a critical role during the development of an allergic response. Upon activation by an antigen and IgE, via FcεRI receptors, mast cells release histamine and other mediators that initiate and propagate immediate hypersensitivity reactions. Mast cells also secrete cytokines that regulate the immune respo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.01.017

    authors： de Souza Santos M,Jonis Andrioli W,Freire de Morais Del Lama MP,Kenupp Bastos J,Nanayakkara NP,Zumstein Georgetto Naal RM

    更新日期：2013-03-01 00:00:00

  • Microparticles in red cell concentrates prime polymorphonuclear neutrophils and cause acute lung injury in a two-event mouse model.

    abstract：:Red cell-derived microparticles (RMPs) are potential mediators of transfusion-related acute lung injury (TRALI). The aim of this study was to investigate the effects of microparticles present in red cell concentrates (RCC) on polymorphonuclear neutrophil (PMN) respiratory burst and acute lung injury (ALI) in mice. Mic...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.11.029

    authors： Xie R,Yang Y,Zhu Y,Gao L,Jiang X,Sun J,Bian M,Yang J

    更新日期：2018-02-01 00:00:00

  • Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage.

    abstract：:Intracerebral hemorrhage (ICH) from blood vessel rupture results in parenchymal hematoma formation and neuroinflammation, ultimately leading to neurodegeneration. Several lines of evidence suggest that the severity of ICH-induced neural damage is exacerbated by infiltration of T-cells, monocytes, and especially neutro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106678

    authors： Hijioka M,Futokoro R,Ohto-Nakanishi T,Nakanishi H,Katsuki H,Kitamura Y

    更新日期：2020-08-01 00:00:00

  • 2,3,5,6-Tetramethylpyrazine of Ephedra sinica regulates melanogenesis and inflammation in a UVA-induced melanoma/keratinocytes co-culture system.

    abstract：BACKGROUND:2,3,5,6-Tetramethylpyrazine (TMP) is known as a composition of Ephedra sinica and it has been used in the treatment of several disorders such as asthma, heart failure, rhinitis, and urinary incontinence. It has been reported that TMP inhibits melanoma metastasis and suppression angiogenesis by VEGF. OBJECTI...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.11.028

    authors： Yeom GG,Min S,Kim SY

    更新日期：2014-02-01 00:00:00

  • Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated murine macrophages.

    abstract：:Several sesquiterpene lactones that have been isolated from medicinal plants are known to have many pharmacological activities. In this study, we investigated the anti-inflammatory effects of zedoarondiol, a sesquiterpene lactone isolated from the rhizoma of Curcuma heyneana, in lipopolysaccharide (LPS)-stimulated mac...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.04.012

    authors： Cho W,Nam JW,Kang HJ,Windono T,Seo EK,Lee KT

    更新日期：2009-08-01 00:00:00