MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis.

abstract：:Ischemia-reperfusion injury is a common early event in kidney transplantation and contributes to a delay in organ function. Acute tubular necrosis, impaired kidney function and organ leukocyte infiltration are the major findings. The therapeutic potential of stem cells has been the focus of recent research as these ce...

journal_title：International immunopharmacology

authors： da Silva LB,Palma PV,Cury PM,Bueno V

更新日期：2007-12-15 00:00:00

abstract：:We investigated whether Candida beta-D-glucan (CSBG) alters the maturation of dendritic cells (DCs). DC phenotypes were analyzed using FACScan. The expression of surface molecules, including major histocompatibility complex (MHC) classes I and II, as well as CD80 and CD86, increased on DCs that were stimulated with li...

journal_title：International immunopharmacology

authors： Kikuchi T,Ohno N,Ohno T

更新日期：2002-09-01 00:00:00

abstract：:Andrographolide (AG), an ingredient extracted from traditional Chinese herbal medicine Andrographis paniculata, has been demonstrated to have potent anti-inflammatory and anti-oxidative stress properties. The purpose of this study was to investigate whether and how AG attenuated CSE-induced mitochondrial dysfunction, ...

journal_title：International immunopharmacology

authors： Zhang XF,Ding MJ,Cheng C,Zhang Y,Xiang SY,Lu J,Liu ZB

更新日期：2020-04-01 00:00:00

abstract：:Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor rece...

journal_title：International immunopharmacology

authors： Forni G,Curcio C,Spadaro M,Iliffe J,Quaglino E,Di Carlo E,Musiani P,Lollini PL

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:RIF is clinically defined as the failure of good quality embryos to implant into the uterus following at least three cycles of In Vitro Fertilization/Embryo Transfer (IVF/ET). During human pregnancy, a genetically different fetus is allowed to survive within the uterus despite the maternal recognition of fet...

journal_title：International immunopharmacology

authors： Ahmadi M,Abdolmohamadi-Vahid S,Ghaebi M,Dolati S,Abbaspour-Aghdam S,Danaii S,Berjis K,Madadi-Javid R,Nouri Z,Siahmansouri H,Babaloo Z,Nouri M,Yousefi M

更新日期：2019-09-01 00:00:00

abstract：:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whe...

journal_title：International immunopharmacology

authors： Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W

更新日期：2020-04-01 00:00:00

abstract：:Administration of oligomannose-coated liposomes (OMLs) in mice can induce Th1 immune responses against antigens entrapped in the OMLs. In the present study, we investigated the anti-allergic effect of treatment with oligomannose-coated liposomes (OMLs) with entrapped Cry j 1, a major allergen of Japanese cedar pollen ...

journal_title：International immunopharmacology

authors： Ishii M,Koyama A,Iseki H,Narumi H,Yokoyama N,Kojima N

更新日期：2010-09-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by disruption of the alveolar-capillary membrane resulting in pulmonary edema and accumulation of associated proteinaceous alveolar exudate. Initiation of ALI upregulates tumor necrosis factor-α (TNF-α), which activates nuclear factor-kappa B (NF-κB) and mitogen-activated prote...

journal_title：International immunopharmacology

authors： Ko IG,Hwang JJ,Chang BS,Kim SH,Jin JJ,Hwang L,Kim CJ,Choi CW

更新日期：2020-06-01 00:00:00

abstract：:A procedure was developed for the determination of low levels of the anthraquinones aloe-emodin and aloin A (barbalin) in aloe products based on gas chromatography/mass spectrometry (GC/MS) of the trimethyl silyl (TMS) derivatives of these analytes in the presence of Chrysophanol used as internal standard. The method ...

journal_title：International immunopharmacology

authors： ElSohly MA,Gul W,Murphy TP

更新日期：2004-12-20 00:00:00

abstract：:Paraquat is one of the most extensively used herbicides and has high toxicity for humans and animals. However, there is no effective treatment for paraquat poisoning. The aim of the present study was to evaluate the effects of chloroquine on paraquat-induced lung injury in mice. Mice received a single intraperitoneal ...

journal_title：International immunopharmacology

authors： Shen H,Wu N,Wang Y,Zhao H,Zhang L,Li T,Zhao M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The precision-cut kidney slice (PCKS) model appears to be a useful ex vivo model of renal fibrosis. However, little in-depth molecular investigation on the PCKS model has been performed. Therefore, the aim of this study will be to investigate and validate the molecular validity of this model. METHODS:The PC...

journal_title：International immunopharmacology

authors： Zhang S,Liu Q,Xiao J,Lei J,Liu Y,Xu H,Hong Z

更新日期：2016-05-01 00:00:00

abstract：:In the presence of TGF-β, CD4+CD62L+T cells can be induced to CD4+CD25+FoxP3+ regulatory T cells (iTregs). In our previous work, we have shown that adoptive transfer of iTregs promoted liver recovery from ischemia reperfusion injury (IRI). In this study, we examined the molecular mechanism underlying the liver IRI att...

journal_title：International immunopharmacology

authors： Feng M,Wang Q,Zhang F,Lu L

更新日期：2012-01-01 00:00:00

abstract：:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...

journal_title：International immunopharmacology

authors： Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

更新日期：2017-10-01 00:00:00

abstract：:With the introduction of biological agents, over the last two decades treatment prospects in many medical fields including Rheumatology have experienced an exciting revolution. The advent of biological therapy for specifically rheumatic diseases has provided more effective control of both the underlying disease, and s...

journal_title：International immunopharmacology

authors： Lie G,Sciascia S,Cuadrado MJ

更新日期：2015-08-01 00:00:00

abstract：:MALT lymphoma-translocation protein 1 (Malt1) protease activity is triggered by stimulation of various immune receptors. Activation of Malt1 protease induces cleavage of negative regulators for immune responses, resulting in lymphocytes activation. Although Malt1 protease mediates the signaling process downstream of t...

journal_title：International immunopharmacology

authors： Nakamura Y,Yokoyama K,Igaki K,Tsuchimori N

更新日期：2018-03-01 00:00:00

abstract：:To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved ...

journal_title：International immunopharmacology

authors： Mueller S,Liebmann C,Reissmann S

更新日期：2002-12-01 00:00:00

abstract：:CXCR4 is a member of chemokine receptors and plays a vital role in numerous diseases and cancer processes, which makes the CXCR4/CXCL12 chemotactic axis a potential therapeutic target. In this study, we used lentiviral vectors as a novel technology to produce a monoclonal antibody against CXCR4. Lentivirus vector pLV-...

journal_title：International immunopharmacology

authors： Li X,Kuang Y,Huang X,Zou L,Huang L,Yang T,Li W,Yang Y

更新日期：2016-07-01 00:00:00

abstract：:Platelets have been proved to exacerbate influenza infection and its complications. Inhibition of platelet activation may be a feasible method for preventing severe infection and secondary acute lung injury (ALI). Isofraxidin (IFD) is a natural coumarin isolated from the plants Sarcandra glabra and Siberian ginseng, a...

journal_title：International immunopharmacology

authors： Jin L,Ying ZH,Yu CH,Zhang HH,Yu WY,Wu XN

更新日期：2020-07-01 00:00:00

abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...

journal_title：International immunopharmacology

authors： Vorup-Jensen T,Sørensen ES,Jensen UB,Schwaeble W,Kawasaki T,Ma Y,Uemura K,Wakamiya N,Suzuki Y,Jensen TG,Takahashi K,Ezekowitz RA,Thiel S,Jensenius JC

更新日期：2001-04-01 00:00:00

abstract：:Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracell...

journal_title：International immunopharmacology

authors： Pedregosa JF,Haidar AA,Hirata AE,Franco M,Gomes GN,Bueno V

更新日期：2011-09-01 00:00:00

abstract：:Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects. The objective of the study is to investigate the effects of melatonin in hepatic ischemia/reperfusion (I/R) induced lung injury and explore its underlying mechanisms. Hepatic I/R injury was induced via portal vein and h...

journal_title：International immunopharmacology

authors： Zhou L,Zhao D,An H,Zhang H,Jiang C,Yang B

更新日期：2015-12-01 00:00:00

abstract：:Tumor growth occurs by the imbalance between cells with effector function and cells with suppressor/regulatory functions. To investigate this scenario we administered the chemical carcinogen Urethane in BALB/c mice and followed these animals during 120 days to observe lung tumor development. In another set of experime...

journal_title：International immunopharmacology

authors： Rosin FC,Pedregosa JF,de Almeida JS,Bueno V

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Neuroblastoma (NB) is one of the most common childhood tumors that is associated with a poor prognosis. Recently, immunotherapy has been recognized as an effective strategy in the treatment of NB patients. In this study, an immune-related gene pair (IRGP) signature was established for predicting the prognosi...

journal_title：International immunopharmacology

authors： Song J,Zhao Q,Xu Y,Zhu L

更新日期：2020-11-01 00:00:00

abstract：:Isodeoxyelephantopin (IDET) has been identified as an anti-tumor natural constituent whose anti-tumor activity and mechanism have been widely investigated. Since the occurrence and development of cancer usually accompany with inflammation, and tumor signaling shares many components with inflammation signaling, the age...

journal_title：International immunopharmacology

authors： Han Y,Li X,Zhang X,Gao Y,Qi R,Cai R,Qi Y

更新日期：2020-07-01 00:00:00

abstract：:Tuberculosis (TB) remains as a global health problem. The prevalence of this infection is related to the association with other diseases, such as HIV, neglect treatment and misuse of antibiotics. Hence, the identification of new drugs is required to eradicate TB. Possible alternatives to existing antibiotics include p...

journal_title：International immunopharmacology

authors： Guzmán-Beltrán S,Rubio-Badillo MÁ,Juárez E,Hernández-Sánchez F,Torres M

更新日期：2016-02-01 00:00:00

abstract：:Resveratrol is a polyphenol abundantly found in red grape skin and is effective against antiaging and anti-inflammation associated with immune responses. In this study, we have investigated the effect of resveratrol on skin lesion, high mobility group box (HMGB)1 and inflammation pathway in an atopic dermatitis (AD) m...

journal_title：International immunopharmacology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Watanabe K

更新日期：2014-12-01 00:00:00

abstract：:Amaranthus spinosus Linn. (thorny amaranth), a plant that grows in the wild fields of Taiwan, is extensively used in Chinese traditional medicine to treat diabetes. There have been no published studies on the immunological effects of A. spinosus. To determine whether A. spinosus has immuno-modulatory effects and clari...

journal_title：International immunopharmacology

authors： Lin BF,Chiang BL,Lin JY

更新日期：2005-04-01 00:00:00

abstract：:Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridoni...

journal_title：International immunopharmacology

authors： Yu T,Xie W,Sun Y

更新日期：2019-07-01 00:00:00

abstract：:The accumulation of cytosolic dsDNA plays important roles in the regulation of cellular processes. However, whether cytosolic dsDNA is involved in the pathogenesis of rheumatoid arthritis (RA) is not clear. Therefore, the present study investigated the roles of cytosolic dsDNA in the modulation of inflammatory respons...

journal_title：International immunopharmacology

authors： Wang J,Li R,Lin H,Qiu Q,Lao M,Zeng S,Wang C,Xu S,Zou Y,Shi M,Liang L,Xu H,Xiao Y

更新日期：2019-11-01 00:00:00

abstract：:Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and seru...

journal_title：International immunopharmacology

authors： Zhong Y,Tang R,Lu Y,Wang W,Xiao C,Meng T,Ao X,Li X,Peng L,Kwadwo Nuro-Gyina P,Zhou Q

更新日期：2020-10-01 00:00:00