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Inhibition of bone marrow-derived dendritic cell maturation by glabridin.

Abstract：

:Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. Glabridin inhibited lipopolysaccharide-, poly (I:C)-, or zymosan-induced phenotypic maturation of dendritic cells (DCs), as proven by the decreased expression of CD40, CD80, CD86, MHC-I, and MHC-II. Glabridin decreased the functional maturation of DCs, in that glabridin attenuated pro-inflammatory cytokine production of IL-12, IL-1β, TNF-α, and IFN-α/β, enhanced antigen capture capacity, inhibited migration to SDF-1α and MIP-3β, and impaired induction of allogenic T cell activation. We also showed that glabridin inhibited zymosan-induced inflammation in mice. As a mode of action, we showed that glabridin inhibited degradation of IκΒα/β, nuclear translocation of NF-κB p65/p50, and phosphorylation of ERK, JNK, and p38 MAPKs. Taken together, the present results show that glabridin inhibits dendritic cell maturation by blocking NF-κB and MAPK signalings.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Kim JY,Kang JS,Kim HM,Ryu HS,Kim HS,Lee HK,Kim YJ,Hong JT,Kim Y,Han SB

doi

10.1016/j.intimp.2010.06.025

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1185-93

issue

10

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(10)00212-2

journal_volume

10

pub_type

杂志文章

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