当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis.

Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis.

Abstract：

:Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder leading to progressive tissue fibrosis. Tanshinone IIA (Tan IIA) is a phytochemical extracted from the Chinese herb Salvia miltiorrhiza that exhibits diverse activities. In this study, we attempted to evaluate the potential impact of Tan IIA on the skin fibrosis-related endothelial-to-mesenchymal transition (EndoMT) and investigate the underlying molecular mechanisms. EndoMT-related indexes including morphological characteristics, functional changes, histological parameters, expression levels of extracellular matrix associated genes, and changes in the expression of related biomarkers in dermal fibrosis were assessed. Tan IIA had a strong anti-fibrotic effect through amelioration of skin thickness and collagen deposition. Moreover, Tan IIA partially reversed bleomycin-induced EndoMT both in vivo and in vitro. Additionally, Tan IIA mitigated the diminution of tube formation in endothelial cells induced by bleomycin. Furthermore, mechanistically, the activation of the Akt/mTOR/p70S6K pathway was found to be involved in bleomycin-treated SSc mouse model, which was alleviated by Tan IIA. In summary, these data suggest that Tan IIA alleviates SSc-related dermal fibrosis and EndoMT and that the Akt/mTOR/p70S6K signaling pathway is involved in this regulation, thus supporting the potential of Tan IIA as a disease-modifying candidate agent for treating the vascular damage of SSc.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Jiang Y,Hu F,Li Q,Shen C,Yang J,Li M

doi

10.1016/j.intimp.2019.105968

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

105968

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(19)31125-7

journal_volume

77

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Application of Candida solubilized cell wall beta-glucan in antitumor immunotherapy against P815 mastocytoma in mice.

    abstract：:This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00148-5

    authors： Tokunaka K,Ohno N,Adachi Y,Miura NN,Yadomae T

    更新日期：2002-01-01 00:00:00

  • Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension.

    abstract：:Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and seru...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106789

    authors： Zhong Y,Tang R,Lu Y,Wang W,Xiao C,Meng T,Ao X,Li X,Peng L,Kwadwo Nuro-Gyina P,Zhou Q

    更新日期：2020-10-01 00:00:00

  • A synthetic cyclic peptide derived from Limulus anti-lipopolysaccharide factor neutralizes endotoxin in vitro and in vivo.

    abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.01.015

    authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

    更新日期：2008-06-01 00:00:00

  • Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage.

    abstract：:Intracerebral hemorrhage (ICH) from blood vessel rupture results in parenchymal hematoma formation and neuroinflammation, ultimately leading to neurodegeneration. Several lines of evidence suggest that the severity of ICH-induced neural damage is exacerbated by infiltration of T-cells, monocytes, and especially neutro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106678

    authors： Hijioka M,Futokoro R,Ohto-Nakanishi T,Nakanishi H,Katsuki H,Kitamura Y

    更新日期：2020-08-01 00:00:00

  • Inhaled corticosteroids and risk of pneumonia in patients with chronic obstructive pulmonary disease: A meta-analysis of randomized controlled trials.

    abstract：OBJECTIVE:Inhaled corticosteroids (ICS) are generally used to treat patients with chronic obstructive pulmonary disease (COPD) who suffer from repeated exacerbations. Recently, it was reported that ICS treatment increased the risk of pneumonia in COPD patients. But it is controversial.The objective of this paper is to ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.intimp.2019.105950

    authors： Yang M,Du Y,Chen H,Jiang D,Xu Z

    更新日期：2019-12-01 00:00:00

  • γδ T cells in infection and autoimmunity.

    abstract：:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.03.038

    authors： Hou L,Wang T,Sun J

    更新日期：2015-10-01 00:00:00

  • Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma.

    abstract：:Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II antagonized the bradykinin receptor more potently than any of the other flavonoids derived from this plant. Here, we were investigated its thera...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.01.010

    authors： Jang HY,Ahn KS,Park MJ,Kwon OK,Lee HK,Oh SR

    更新日期：2012-04-01 00:00:00

  • Stimulatory effect of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L., on G-CSF secretion from intestinal epithelial cells.

    abstract：:The inner surface of the intestinal tract possesses a large area of mucosal membranes, and the intestinal epithelial cells exist at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria. The crosstalk that occurs between these compartments serves to maintain intestinal homeostasis, and the c...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.01.006

    authors： Matsumoto T,Moriya M,Sakurai MH,Kiyohara H,Tabuchi Y,Yamada H

    更新日期：2008-04-01 00:00:00

  • Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling.

    abstract：:Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.10.022

    authors： Hairul-Islam MI,Saravanan S,Thirugnanasambantham K,Chellappandian M,Simon Durai Raj C,Karikalan K,Gabriel Paulraj M,Ignacimuthu S

    更新日期：2017-12-01 00:00:00

  • Immunomodulatory properties of Mycoplasma pulmonis. I. Characterization of the immunomodulatory activity.

    abstract：:For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00078-9

    authors： Romero-Rojas A,Ponce-Hernández C,Ciprián A,Estrada-Parra S,Hadden JW

    更新日期：2001-09-01 00:00:00

  • Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway.

    abstract：:The aims of this study were to elucidate the immunomodulatory effects of glycyrrhizin (GL) on CD4(+)T cell responses during liver fibrogenesis. To obtain in vivo evidence about the effects of GL on CD4(+)T cells in livers and spleens of concanavalin A (ConA)-induced mouse model, mice were administrated with ConA toget...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.08.013

    authors： Tu CT,Li J,Wang FP,Li L,Wang JY,Jiang W

    更新日期：2012-12-01 00:00:00

  • Chlorophyllin suppresses interleukin-1 beta expression in lipopolysaccharide-activated RAW 264.7 cells.

    abstract：:Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages. In the present study, we show that CHL inhibited IL-1beta production and its mRNA expression in a lipopolysaccharide (LPS)-stimulated murine macrophage cell-line, RAW 264.7. The inhibitory effect...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.08.012

    authors： Yun CH,Jeon YJ,Yang Y,Ju HR,Han SH

    更新日期：2006-02-01 00:00:00

  • Influenza virus-like particles composed of conserved influenza proteins and GPI-anchored CCL28/GM-CSF fusion proteins enhance protective immunity against homologous and heterologous viruses.

    abstract：:Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine approaches are hindered by the need to routinely reformulate vaccine compositions in an effort to account for t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.07.011

    authors： Liu J,Ren Z,Wang H,Zhao Y,Wilker PR,Yu Z,Sun W,Wang T,Feng N,Li Y,Wang H,Ji X,Li N,Yang S,He H,Qin C,Gao Y,Xia X

    更新日期：2018-10-01 00:00:00

  • Naloxone can improve the anti-tumor immunity by reducing the CD4+CD25+Foxp3+ regulatory T cells in BALB/c mice.

    abstract：:New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.08.008

    authors： Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

    更新日期：2009-11-01 00:00:00

  • DA-9601 suppresses 2, 4-dinitrochlorobenzene and dust mite extract-induced atopic dermatitis-like skin lesions.

    abstract：:DA-9601 (Stillen™) is a novel anti-peptic formulation prepared from the ethanol extracts of Artemisia asiatica possessing anti-oxidative, anti-allergic and anti-inflammatory activities. However, their effect on atopic dermatitis (AD) has not been studied yet. In this study, we report that topical application of DA-960...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.04.005

    authors： Choi EJ,Lee S,Hwang JS,Im SH,Jun CD,Lee HS,Kim SH

    更新日期：2011-09-01 00:00:00

  • Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657.

    abstract：:Endothelial cells play an important role in inflammatory diseases like rheumatoid arthritis by recruitment of inflammatory cells. The cytokines TNF-alpha and IL-1beta are major inducers of endothelial cell activation and are stimulators of inflammatory signal transduction pathway involving p38 MAPK (mitogen-activated ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.03.005

    authors： Westra J,Kułdo JM,van Rijswijk MH,Molema G,Limburg PC

    更新日期：2005-07-01 00:00:00

  • Natural product derived immune-regulatory agents.

    abstract：:We can now declare that the clinical goal of immune intervention as a therapeutic strategy for neoplastic, infectious, autoimmune and inflammatory diseases, has been achieved and in many instances obtained regulatory approval. Although, interest in and optimism for this approach has fluctuated, in the last 20years, im...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2016.02.025

    authors： Talmadge JE

    更新日期：2016-08-01 00:00:00

  • Function of follicular helper T cell is impaired and correlates with survival time in non-small cell lung cancer.

    abstract：:Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide. The PD-1/PD-L1 interaction plays important roles in cancer immunology, and expression of PD-L1 has been discovered in NSCLC tumor cells. Since follicular helper T (Tfh) cells have characteristic high PD-1 expression,...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.10.014

    authors： Ma QY,Huang DY,Zhang HJ,Chen J,Miller W,Chen XF

    更新日期：2016-12-01 00:00:00

  • The role of kinins in the proliferation of fibroblast primed with TNF in scratch wound assay: Kinins and cell proliferation.

    abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.09.036

    authors： França AJVBDV,De Faveri R,Nunes R,Steimbach VMB,Santin JR,Quintão NLM

    更新日期：2018-12-01 00:00:00

  • Virulizin, a novel immunotherapy agent, stimulates TNFalpha expression in monocytes/macrophages in vitro and in vivo.

    abstract：:Virulizin, a novel biological response modifier, has demonstrated broad antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cancer and prostate cancer. Previous studies have demonstrated a significant role of macrophages and NK cells in the anti...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2007.06.001

    authors： Li H,Cao MY,Lee Y,Benatar T,Lee V,Feng N,Gu X,Liu P,Jin H,Wang M,Der S,Lightfoot J,Wright JA,Young AH

    更新日期：2007-10-01 00:00:00

  • Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice.

    abstract：:Resveratrol is a polyphenol abundantly found in red grape skin and is effective against antiaging and anti-inflammation associated with immune responses. In this study, we have investigated the effect of resveratrol on skin lesion, high mobility group box (HMGB)1 and inflammation pathway in an atopic dermatitis (AD) m...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.10.014

    authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Watanabe K

    更新日期：2014-12-01 00:00:00

  • Intrahepatic regulation of antiviral T cell responses at initial stages of viral infection.

    abstract：:It is generally accepted that the appropriate boost of early immune response will control viral replications and limit the immune-mediated pathology in viral hepatitis. However, poor immunity results in viral persistence, chronic inflammation and finally liver cirrhosis and carcinoma. As a peripheral non-lymphoid orga...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2016.07.021

    authors： Liang Y,Kwota Z,Sun J

    更新日期：2016-10-01 00:00:00

  • Immunization in tumor prevention.

    abstract：:Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor rece...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/S1567-5769(03)00026-2

    authors： Forni G,Curcio C,Spadaro M,Iliffe J,Quaglino E,Di Carlo E,Musiani P,Lollini PL

    更新日期：2003-08-01 00:00:00

  • Comparison in the effects of IL-2, IL-12, IL-15 and IFNalpha on gene regulation of granzymes of human NK cell line NK-92.

    abstract：:Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFNalpha differently regulated the expression of granzymes in NK cells. Althoug...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.03.001

    authors： Zhang B,Zhang J,Tian Z

    更新日期：2008-07-01 00:00:00

  • Studies on pharmacological properties of mucus and sting venom of Potamotrygon cf. henlei.

    abstract：:Stingrays from the Potamotrygon cf. henlei species are widely distributed in high numbers throughout the rivers of central-west Brazil, being the source of numerous envenomations occurring in the dry season, posing a serious public health problem even if not properly reported. The accidents usually involve fishermen a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.03.019

    authors： Monteiro-dos-Santos J,Conceição K,Seibert CS,Marques EE,Silva PI Jr,Soares AB,Lima C,Lopes-Ferreira M

    更新日期：2011-09-01 00:00:00

  • Characterization of avian thymic hormone and chicken parvalbumin 3 target cells.

    abstract：:Avian thymic hormone (ATH) is a β-parvalbumin produced by epithelial cells in the thymic cortex and in the eyes of chickens. Chicken parvalbumin 3 (CPV3) is a homologous protein produced in the thymus and in hair cells of the chicken ear. ATH circulates in the blood on a five-day cycle and stimulates cell-mediated imm...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.12.013

    authors： Novak Kujundžić R,Steffens WL,Brewer JM,Henzl MT,Ragland WL

    更新日期：2013-02-01 00:00:00

  • Effect of sildenafil on neuroinflammation and synaptic plasticity pathways in experimental autoimmune encephalomyelitis.

    abstract：:Multiple sclerosis (MS) is a chronic immuno-inflammatory disease of the central nervous system characterized by demyelination and axonal damage. Cognitive changes are common in individuals with MS since inflammatory molecules secreted by microglia interfere with the physiological mechanisms of synaptic plasticity. Acc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106581

    authors： Araújo SMDR,Duarte-Silva E,Marinho CGS,Oliveira WH,França MER,Lós D,Peron G,Tomaz L,Bonfanti AP,Verinaud L,Peixoto CA

    更新日期：2020-08-01 00:00:00

  • Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction.

    abstract：:Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melanocortin receptor 4 agonist that alleviates damage in many nervous system diseases, such as cerebral hemorrhage, traumat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106281

    authors： Zhang Y,Wang J,Zhang D,Lu Z,Man J

    更新日期：2020-04-01 00:00:00

  • Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production.

    abstract：:Experimental autoimmune encephalomylitis (EAE), an animal mode of multiple sclerosis (MS), was previously considered that be mediated by Th1 cells. However, a number of recent studies provided strong evidence that T helper cells that produce IL-17 play a dominant role in the pathogenesis of EAE. Curcumin (1,7-Bis 94-h...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.01.025

    authors： Xie L,Li XK,Funeshima-Fuji N,Kimura H,Matsumoto Y,Isaka Y,Takahara S

    更新日期：2009-05-01 00:00:00

  • Combined IMIG and immune Ig attenuates inflammatory colitis in mice.

    abstract：BACKGROUND:Using a combination of homologous and heterologous (mouse/human) polyclonal anti-idiotypic Igs and immune Igs in BALB/c mice we have previously reported attenuation of allergic type responses following OVA immunization. We have now investigated attenuation of an inflammatory colitis in C57BL/6 mice receiving...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106464

    authors： Gorczynski RM,Hoffmann G

    更新日期：2020-06-01 00:00:00