Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction.


:Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melanocortin receptor 4 agonist that alleviates damage in many nervous system diseases, such as cerebral hemorrhage, traumatic brain injury and chronic neurodegenerative diseases. However, the effect of RO27-3225 on cerebral infarction remains unclear. In this study, we used a mouse model of transient middle cerebral artery occlusion (tMCAO) and administered RO27-3225 or saline to the mice through intraperitoneal injection. RO27-3225 increased the number of Nestin+/BrdU+ cells and doublecortin (DCX)+/BrdU+ cells in the subventricular zone (SVZ) and the number of DCX+/BrdU+ cells in the peri-infarct area on day 7 after tMCAO. Furthermore, RO27-3225 decreased the number of activated microglia (Iba1+ cells with a specific morphology) and the expression levels of Iba1, TNFα, IL6, and iNOS proteins and increased the number of PDGFRβ+ cells in the peri-infarct region on day 3 after tMCAO. Finally, RO27-3225-treated mice exhibited significantly decreased infarct volumes, brain water contents, and neurological deficits after cerebral infarction. Thus, RO27-3225 can improve the outcomes following cerebral infarction, partially by regulating neurogenesis in the SVZ, PDGFRβ+ cell survival and neuroinflammation in the peri-infarct zone. Our research reveals that RO27-3225 is a potential new treatment for cerebral infarction.


Int Immunopharmacol


Zhang Y,Wang J,Zhang D,Lu Z,Man J




Has Abstract


2020-04-01 00:00:00












  • DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner.

    abstract::Endotoxin can stimulate inflammatory cytokine release from monocytes/macrophages and result in septic shock. Glycyrrhetinic acid (GA), the main bioactive component of licorice, possesses substantial anti-inflammatory activity. Here, we explored effect of 11-deoxy-18α-glycyrrhetinic acid-30-ethyl ester (DGAEE), a newly...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Luo J,Liu M,Wu X,Dou Y,Xia Y,Dai Y,Wei Z

    更新日期:2015-12-01 00:00:00

  • 1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome.

    abstract::Radiation exposure poses a significant threat to public health, which can lead to acute hematopoietic system and intestinal system injuries due to their higher radiation sensitivity. Hence, antioxidants and thiol-reducing agents could have a potential protective effect against this complication. The dithiol compound 1...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Li K,Zhang J,Cao J,Li X,Tian H

    更新日期:2019-11-01 00:00:00

  • Inhibition of spleen tyrosine kinase signaling protects against acute lung injury through blockade of NADPH oxidase and IL-17A in neutrophils and γδ T cells respectively in mice.

    abstract::Acute lung injury (ALI) is one of the most serious complications in critically ill patients which often leads to morbidity and mortality. ALI characterized by severe inflammation of lungs occurs due to uncontrolled inflammatory immune response. However, the immunological mechanism(s) are far from being understood. The...

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    authors: Nadeem A,Ahmad SF,Al-Harbi NO,Al-Harbi MM,Ibrahim KE,Kundu S,Attia SM,Alanazi WA,AlSharari SD

    更新日期:2019-03-01 00:00:00

  • Indirubin-3'-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain.

    abstract::Deciphering the molecular mechanisms of amyloid pathology and glial cell-mediated neuroinflammation, offers a novel avenue for therapeutic intervention against neurodegeneration. Recent findings demonstrate a crucial link between activation of glycogen synthase kinase-3β (GSK-3β), amyloid deposition and a neuroinflamm...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Sathiya Priya C,Vidhya R,Kalpana K,Anuradha CV

    更新日期:2019-05-01 00:00:00

  • TRIP6 accelerates the proliferation and migration of fetal airway smooth muscle cells by enhancing YAP activation.

    abstract::The thyroid receptor interactor protein 6 (TRIP6) has emerged as a key regulator for the proliferation and migration of various cells. However, whether TRIP6 is involved in regulating the proliferation and migration of airway smooth muscle (ASM) cells in the progression of pediatric asthma remains undetermined. The pr...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wei F,Hao Y

    更新日期:2020-03-06 00:00:00

  • Progesterone suppresses Aβ42-induced neuroinflammation by enhancing autophagy in astrocytes.

    abstract::Autophagy is an intracellular catabolic mechanism essential for recycling intracellular unfolding protein and eliminating toxic protein aggregates. Several studies have shown that deficient autophagy is implicated in the development of Alzheimer's disease (AD) progression. To date, rapidly emerging evidence suggests t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hong Y,Liu Y,Zhang G,Wu H,Hou Y

    更新日期:2018-01-01 00:00:00

  • Trans sodium crocetinate alleviates ischemia/reperfusion-induced myocardial oxidative stress and apoptosis via the SIRT3/FOXO3a/SOD2 signaling pathway.

    abstract::Trans sodium crocetinate (TSC) has been reported to exert a protective effect against cerebral ischemia/reperfusion (I/R) injury. However, whether TSC protects against myocardial ischemia/reperfusion (MI/R) injury remains unknown. Herein, we found that TSC treatment reduced myocardial infract size and elevated serum L...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Chang G,Chen Y,Zhang H,Zhou W

    更新日期:2019-06-01 00:00:00

  • The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity.

    abstract::H1-antihistamines are known to be important modulators of inflammatory response. However, the information about the influence of these drugs on reactive nitrogen species generation is still controversial. The main aim of the present study was to investigate the effects of selected H1-antihistamines on nitric oxide pro...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Králová J,Racková L,Pekarová M,Kubala L,Nosál R,Jancinová V,Cíz M,Lojek A

    更新日期:2009-07-01 00:00:00

  • miR-181a regulates Th17 cells distribution via up-regulated BCL-2 in primary biliary cholangitis.

    abstract:BACKGROUND:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by destruction of small intrahepatic bile ducts. Recent studies suggest that miRNAs play a critical role in the pathogenesis of liver diseases. However the role served by miRNAs in the pathogenesis of PBC is still not clear. METH...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Song Y,Yang H,Jiang K,Wang BM,Lin R

    更新日期:2018-11-01 00:00:00

  • Tiron ameliorates oxidative stress and inflammation in a murine model of airway remodeling.

    abstract::Airway remodeling includes lung structural changes that have a role in the irreversibility of pulmonary dysfunction shown in chronic bronchial asthmatics. The current experiment investigated the effect of the mitochondrial antioxidant, tiron in comparison with dexamethasone (DEXA) on airway remodeling in chronic asthm...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: El-Sherbeeny NA,Hassan ZA,Ateyya H

    更新日期:2016-10-01 00:00:00

  • Studies on pharmacological properties of mucus and sting venom of Potamotrygon cf. henlei.

    abstract::Stingrays from the Potamotrygon cf. henlei species are widely distributed in high numbers throughout the rivers of central-west Brazil, being the source of numerous envenomations occurring in the dry season, posing a serious public health problem even if not properly reported. The accidents usually involve fishermen a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Monteiro-dos-Santos J,Conceição K,Seibert CS,Marques EE,Silva PI Jr,Soares AB,Lima C,Lopes-Ferreira M

    更新日期:2011-09-01 00:00:00

  • Combined ischemic and rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice.

    abstract::Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the effects of ischemic and rapamycin preconditioning on IR injury in old livers. Young (8-week-old) and aged (60-week-old) mice were subjected to IR or a sham control procedure. The ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Jiang T,Zhan F,Rao Z,Pan X,Zhong W,Sun Y,Wang P,Lu L,Zhou H,Wang X

    更新日期:2019-09-01 00:00:00

  • Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro.

    abstract::Neuroinflammation mediated by NLRP-1 inflammasome plays an important role in the pathogenesis of neurodegeneration diseases such as Alzheimer's disease (AD). Chronic glucocorticoids (GCs) exposure has deleterious effect on the structure and function of neurons and was found to be correlated with development and progre...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhang B,Zhang Y,Xu T,Yin Y,Huang R,Wang Y,Zhang J,Huang D,Li W

    更新日期:2017-08-01 00:00:00

  • Adoptive immunotherapy for non-small cell lung cancer by NK and cytotoxic T lymphocytes mixed effector cells: retrospective clinical observation.

    abstract::The objective of the current study was to retrospectively investigate the efficacy of adaptive transfer of natural killer (NK) and cytotoxic T lymphocytes mixed effector (NKTm) cells in non-small cell lung cancer (NSCLC) patients in comparison to a control group of NSCLC patients. NKTm cells were obtained by ex vivo e...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Zhang G,Zhao H,Wu J,Li J,Xiang Y,Wang G,Wu L,Jiao S

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  • A model based on tumor-infiltrating immune cells for predicting the relapse rates of patients with testicular germ cell tumors.

    abstract:OBJECTIVE:The activities of tumor-infiltrating immune cells (TIICs) play an important role in the outcomes of many types of cancers. Here, we sought to describe the landscape of TIICs in testicular germ cell tumors (TGCT) and to develop a prognostic model based on this information. METHODS:The Cell-type Identification...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang Y,Ji C,Liu J,Wang Y,Song N,Cao P

    更新日期:2020-09-01 00:00:00

  • Sixteen-year history of rituximab therapy for 1085 pemphigus vulgaris patients: A systematic review.

    abstract::Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...

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    pub_type: 杂志文章,评审


    authors: Tavakolpour S,Mahmoudi H,Balighi K,Abedini R,Daneshpazhooh M

    更新日期:2018-01-01 00:00:00

  • The evaluation of endothelin 1 (EDN1) and endothelin receptor type A (EDNRA) gene polymorphisms in Hashimoto's thyroiditis.

    abstract:PURPOSE:Endothelin1 (EDN1) is well established marker of inflammation. The functions of EDN1 are mediated mainly by endothelin receptors type A (EDNRA). The etiopathogenesis of Hashimoto's thyroiditis (HT) remains still elusive although the role of chronic inflammation and subsequent endothelial dysfunction has been es...

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    pub_type: 杂志文章


    authors: Aydin AF,Vural P,Oruç ÇU,Doğru-Abbasoğlu S,Özderya A,Karadağ B,Uysal M

    更新日期:2014-07-01 00:00:00

  • Nordihydroguaiaretic acid (NDGA) and α-mangostin inhibit the growth of Mycobacterium tuberculosis by inducing autophagy.

    abstract::Tuberculosis (TB) remains as a global health problem. The prevalence of this infection is related to the association with other diseases, such as HIV, neglect treatment and misuse of antibiotics. Hence, the identification of new drugs is required to eradicate TB. Possible alternatives to existing antibiotics include p...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Guzmán-Beltrán S,Rubio-Badillo MÁ,Juárez E,Hernández-Sánchez F,Torres M

    更新日期:2016-02-01 00:00:00

  • Therapeutic drug monitoring and safety of voriconazole in elderly patients.

    abstract:BACKGROUND:Data on therapeutic drug monitoring of voriconazole in elderly patients are limited. Impaired liver function and an inflammatory state in elderly individuals are hypothesized to impact the voriconazole serum level. METHODS:A total of 166 adult patients (317 trough concentrations) who underwent voriconazole ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Cheng L,Xiang R,Liu F,Li Y,Chen H,Yao P,Sun F,Xia P

    更新日期:2020-01-01 00:00:00

  • Attenuation of IL-32-induced caspase-1 and nuclear factor-κB activations by acteoside.

    abstract::Acteoside has anti-inflammatory and antioxidant potentials. Nevertheless, little information is available about the pharmacological mechanism of acteoside. Here, we report the regulatory effects and underlying mechanisms of acteoside on interleukin (IL)-32-induced inflammatory reactions using human monocytes cells lin...

    journal_title:International immunopharmacology

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    authors: Nam SY,Kim HM,Jeong HJ

    更新日期:2015-12-01 00:00:00

  • Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells.

    abstract::In our previous study, we reported the isolation of a novel humulene derivative, 5-hydroxyzerumbone, from Zingiber zerumbet and its inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 mouse macrophage cells. This study was performed to examine its mechanism of action on th...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Min HY,Kim MS,Jang DS,Park EJ,Seo EK,Lee SK

    更新日期:2009-07-01 00:00:00

  • Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation.

    abstract::We investigated the anti-inflammatory effects of sauchinone, a lignan isolated from Saururus chinensis, and the underlying mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. To assess the effects of sauchinone on LPS-induced macrophages activation, we measured the production of tumor necrosis factor (TNF...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Bae HB,Li M,Son JK,Seo CS,Chung SH,Kim SJ,Jeong CW,Lee HG,Kim W,Park HC,Kwak SH

    更新日期:2010-09-01 00:00:00

  • Cudratricusxanthone A from Cudrania tricuspidata suppresses pro-inflammatory mediators through expression of anti-inflammatory heme oxygenase-1 in RAW264.7 macrophages.

    abstract::Cudratricusxanthone A (CTXA), isolated from the roots of Cudrania tricuspidata Bureau (Moraceae) has an isoprenylated xanthone skeleton that is known to exert a variety of biological activities. In the present study, we demonstrated that CTXA inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Jeong GS,Lee DS,Kim YC

    更新日期:2009-02-01 00:00:00

  • Knockdown of hepatic aquaglyceroporin-9 alleviates high fat diet-induced non-alcoholic fatty liver disease in rats.

    abstract::Non-alcoholic fatty liver disease (NAFLD) has emerged as a common public health problem that can progress to end-stage liver disease. Although the function of aquaglyceroporin-9 (AQP9) as a glycerol channel has been proven, the mechanism of AQP9 in the development of NAFLD is poorly understood. To investigate the effe...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Cai C,Wang C,Ji W,Liu B,Kang Y,Hu Z,Jiang Z

    更新日期:2013-03-01 00:00:00

  • New thiazolidinedione LPSF/GQ-2 inhibits NFκB and MAPK activation in LPS-induced acute lung inflammation.

    abstract::Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as poten...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Santos LAMD,Rodrigues GB,Mota FVB,França MER,de Souza Barbosa KP,Oliveira WH,Rocha SWS,Lós DB,Silva AKS,Silva TGD,Peixoto CA

    更新日期:2018-04-01 00:00:00

  • S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation.

    abstract::Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-in...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Khajevand-Khazaei MR,Azimi S,Sedighnejad L,Salari S,Ghorbanpour A,Baluchnejadmojarad T,Mohseni-Moghaddam P,Khamse S,Roghani M

    更新日期:2019-04-01 00:00:00

  • Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages.

    abstract::The anti-inflammatory effects of glycyrol, a benzofuran coumarin isolated from Glycyrrhizae Radix, were studied. Glycyrol of 5, 25 and 50 microM dose-dependently inhibited nitric oxide (NO) production by down-regulating inducible nitric oxide synthase (iNOS), and alleviated cyclooxygenase-2 (COX-2) expression in LPS-s...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shin EM,Zhou HY,Guo LY,Kim JA,Lee SH,Merfort I,Kang SS,Kim HS,Kim S,Kim YS

    更新日期:2008-11-01 00:00:00

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    abstract::The aim of this study was to investigate whether fever and antipyretic drugs had an adverse effect on human polymorphonuclear leukocyte (PMN) functions (phagocytic and intracellular killing activity). Twenty febrile children with an axillary temperature of 39-40 degrees C and 20 healthy children without fever were inc...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Gürer US,Palanduz A,Gürbüz B,Yildirmak Y,Cevikbaş A,Kayaalp N

    更新日期:2002-10-01 00:00:00

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    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Moon DO,Park SY,Heo MS,Kim KC,Park C,Ko WS,Choi YH,Kim GY

    更新日期:2006-12-05 00:00:00

  • Heparin changes the conformation of high-mobility group protein 1 and decreases its affinity toward receptor for advanced glycation endproducts in vitro.

    abstract::High-mobility group protein 1 (HMGB1) has been identified as a late-acting mediator of inflammation. The receptor for advanced glycation end products (RAGE) is the main receptor and mediates the cytokine activity of HMGB1. Since HMGB1 also exhibits heparin-binding activity, we investigated whether heparin interferes w...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Ling Y,Yang ZY,Yin T,Li L,Yuan WW,Wu HS,Wang CY

    更新日期:2011-02-01 00:00:00