当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells.

Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells.

Abstract：

:Probiotics, defined as live microbial food supplements which improve the health of the host, have obtained increasing medical importance. In the intestine they may prevent the overgrowth of pathogenic bacteria, increase the resistance of the gut to invasion by pathogens and ameliorate disease processes by inducting the secretion of soluble factors such as cytokines and antimicrobial beta-peptides. One important class of human antimicrobial peptides is the family of defensins. Human beta-defensin 2 (HBD-2) is a major inducible peptide which plays an important role in host defense and represents a link between innate and adaptive immune responses. This linkage is in part mediated through the recognition of conserved bacterial products or bacteria by Toll-like receptors (TLRs). The aim of this study was to investigate the effects of Lactobacillus plantarum on intestinal epithelial cells. We found that Caco-2 cells exposed to L. plantarum bacteria significantly induced HBD-2 mRNA expression and HBD-2 secretion in a dose- (16+/-1.4 pg/ml and 31.5+/-2.3 pg/ml at MOI 10 and 50, respectively) and time-dependent manner, but not HBD-3, compared to controls; in addition, when LPS was added to cells for 48 h, the interleukin (IL)-23 secretion (850+/-5.4 pg/ml) and IL-23 mRNA expression increased; while it was reduced when LPS was cocultured with L. plantarum (330+/-4.2 pg/ml). The L. plantarum-induced increase in HBD-2 expression is inhibited by anti-TLR-2 neutralizing antibodies, in the same way the pre-treatment with the anti-TLR-2 antibody inhibited the production of IL-23 induced by LPS in Caco-2 cells. The results of our study help to achieve a better understanding of how the intestinal epithelium participates in the innate immune response to commensal bacteria and pathogens in the gut.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Paolillo R,Romano Carratelli C,Sorrentino S,Mazzola N,Rizzo A

doi

10.1016/j.intimp.2009.07.008

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1265-71

issue

11

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(09)00222-7

journal_volume

9

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Immunogenic cross-reaction among outer membrane proteins of Gram-negative bacteria.

    abstract：:In the present study, antigenic cross-reactivity of OMPs was investigated in several species of bacterial pathogens. Heterogeneous mouse or fish antisera were used to ascertain OMPs with cross-reactivity and cluster analysis was performed to analyze the distribution of cross-antigenic OMPs in diverse bacterial strains...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.02.008

    authors： Xu C,Wang S,Zhaoxia Z,Peng X

    更新日期：2005-07-01 00:00:00

  • Enhanced hematopoietic protection from radiation by the combination of genistein and captopril.

    abstract：:The hematopoietic system is sensitive to radiation injury, and mortality can occur due to blood cell deficiency and stem cell loss. Genistein and the angiotensin converting enzyme (ACE) inhibitor captopril are two agents shown to protect the hematopoietic system from radiation injury. In this study we examined the com...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.12.029

    authors： Day RM,Davis TA,Barshishat-Kupper M,McCart EA,Tipton AJ,Landauer MR

    更新日期：2013-02-01 00:00:00

  • Transplantation of Aire-overexpressing bone marrow-derived dendritic cells delays the onset of type 1 diabetes.

    abstract：:Autoimmune regulator (Aire) plays an indispensable role in maintaining central immune tolerance by promoting the ectopic expression of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), which lead to the deletion of autoreactive T cells or the induction of Tregs a...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.05.023

    authors： Li D,Zhao B,Luo Y,Limbara S,Zhao B,Zou X,Yang W,Li Y

    更新日期：2017-08-01 00:00:00

  • Receptors for chemotactic formyl peptides as pharmacological targets.

    abstract：:Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes. In addition to the bacterial peptide fMLF and the...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1567-5769(01)00150-3

    authors： Le Y,Yang Y,Cui Y,Yazawa H,Gong W,Qiu C,Wang JM

    更新日期：2002-01-01 00:00:00

  • Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice.

    abstract：:Lung innate immune response plays an important role in the clearance of pathogens from lungs, however, profound activation of innate immune cells (alveolar macrophages or neutrophils) can lead to development of acute lung inflammation or injury by producing various pro-inflammatory molecules (IL-1, TNF-alpha and H2O2 ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.04.008

    authors： Kumar V,Harjai K,Chhibber S

    更新日期：2010-07-01 00:00:00

  • Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity.

    abstract：BACKGROUND:IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic inflammatory/autoimmune mediated diseases. Experimental models of arthritis and clinical indications have highlighted an...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.12.011

    authors： Zaky DS,El-Nahrery EM

    更新日期：2016-02-01 00:00:00

  • Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte.

    abstract：:In the present study, possible role of phosphodiesterase 7 (PDE7) in development and function of cytotoxic T lymphocyte (CTL) was examined using ASB16165, a specific inhibitor for PDE7. ASB16165 inhibited generation of CTL activity in mixed lymphocyte reaction (MLR), in which splenocytes from C57BL/6N mice were stimul...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.10.005

    authors： Kadoshima-Yamaoka K,Murakawa M,Goto M,Tanaka Y,Inoue H,Murafuji H,Hayashi Y,Nagahira K,Miura K,Nakatsuka T,Chamoto K,Fukuda Y,Nishimura T

    更新日期：2009-01-01 00:00:00

  • Serum immunoglobulin G provides early risk prediction in immunoglobulin A nephropathy.

    abstract：BACKGROUND:Immunoglobulin A (IgA) nephropathy (IgAN) is a common primary glomerular disease that potentially leads to renal failure, risk prediction of declining kidney function is crucial for early clinical management. Immunoglobulin G (IgG) is an important constituent of the immune system and serves as the preferred ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.10.044

    authors： Liu D,You J,Liu Y,Tang X,Tan X,Xia M,Wu L,Chen G,He L,Zhu X,Liu H

    更新日期：2019-01-01 00:00:00

  • Berberine suppresses IL-33-induced inflammatory responses in mast cells by inactivating NF-κB and p38 signaling.

    abstract：:Berberine (BBR) possesses many pharmacological characteristics including anti-inflammation, anti-allergy, anti-angiogenesis and anti-tumor. However, the effects and mechanisms of BBR on IL-33-induced mast cell inflammatory responses are kept unknown. To investigate these, rat peritoneal mast cells (RPMCs) were isolate...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.11.009

    authors： Li W,Yin N,Tao W,Wang Q,Fan H,Wang Z

    更新日期：2019-01-01 00:00:00

  • Epigallocatechin-3-gallate reduces liver and immune system damage in Acinetobacter baumannii-loaded mice with restraint stress.

    abstract：AIM:Due to the significant increase in the antimicrobial resistance of Acinetobacter baumannii (A. baumannii), new drugs to block the progression of infection are strongly needed. Epigallocatechin-3-gallate (EGCG), a major component of green tea, has exhibited potential activity against A. baumannii in vitro. The aim o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107346

    authors： Yan Q,Hao S,Shi F,Zou Y,Song X,Li L,Li Y,Guo H,He R,Zhao L,Ye G,Tang H

    更新日期：2021-01-04 00:00:00

  • Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2.

    abstract：:While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106258

    authors： Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

    更新日期：2020-04-01 00:00:00

  • Bothrops moojeni venom and BmooLAAO-I downmodulate CXCL8/IL-8 and CCL2/MCP-1 production and oxidative burst response, and upregulate CD11b expression in human neutrophils.

    abstract：:Bothrops snake venoms contain biologically active components, including L-amino acid oxidases (LAAO) that induce significant leukocyte accumulation at inflammatory sites characterized by early neutrophil infiltration. As it remains unclear how snake venoms modulate neutrophil activation and chemokine production, here ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106154

    authors： Pereira-Crott LS,Casare-Ogasawara TM,Ambrosio L,Chaim LFP,de Morais FR,Cintra ACO,Canicoba NC,Tucci LFF,Torqueti MR,Sampaio SV,Marzocchi-Machado CM,Castro FA

    更新日期：2020-03-01 00:00:00

  • LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.

    abstract：:Hypoxia and the resultant decreases in cerebral blood flow in the perinatal period can lead to neonatal hypoxic-ischemic (HI) brain injury, which can, in turn, cause severe disability or even death. However, the efficacy of current treatment strategies remains limited. Several studies have demonstrated that lipoxin A4...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107095

    authors： Zhu JJ,Yu BY,Fu CC,He MZ,Zhu JH,Chen BW,Zheng YH,Chen SQ,Fu XQ,Li PJ,Lin ZL

    更新日期：2020-12-01 00:00:00

  • Geniposide inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.

    abstract：:Our group recently reported the strong anti-inflammatory effects of geniposide (Gen), a bioactive iridoid glucoside derived from gardenia jasminoides, in a mouse acute lung injury model. Herein, we hypothesized that Gen might also have potential therapeutic benefits in treatment of asthma, which was tested in a mouse ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.06.028

    authors： Deng Y,Guan M,Xie X,Yang X,Xiang H,Li H,Zou L,Wei J,Wang D,Deng X

    更新日期：2013-11-01 00:00:00

  • Severe impairment of anti-cancer effect of lipoteichoic acid-related molecule isolated from a penicillin-killed Streptococcus pyogenes in toll-like receptor 4-deficient mice.

    abstract：:A lipoteichoic acid-related molecule (OK-PSA) isolated from OK-432, a penicillin-killed Streptococcus pyogenes, is a potent inducer of Th1 cytokines, and elicits anti-cancer effect in tumor-bearing mice. Toll-like receptor (TLR) 4 is a member of the recently identified toll-like receptor family of proteins that has be...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00103-5

    authors： Okamoto M,Oshikawa T,Ohe G,Nishikawa H,Furuichi S,Tano T,Moriya Y,Saito M,Sato M

    更新日期：2001-09-01 00:00:00

  • Serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis: A systematic review and meta-analysis.

    abstract：OBJECTIVES:Various studies have researched the serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis (AS), but the results were inconclusive. The purpose of this study was to systematically evaluate the correlations between serum levels of these adipokines and AS. METHODS:Electronic ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.intimp.2017.09.029

    authors： Yang J,Zhang X,Ma Y,Wu M,Hu X,Han R,Yuan Y,Wang M,Chen M,Jiang S,Tong J,Xu S,Xu J,Shuai Z,Zou Y,Pan F

    更新日期：2017-11-01 00:00:00

  • Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages.

    abstract：:In this study, we report evidences that Mycobacterium tuberculosis (MTB)-induced apoptosis in macrophages is reduced by a broad-spectrum hydroxamic acid-based matrix metalloproteinase (MMP) inhibitor, Batimastat (BB-94). In particular, we show that BB-94 administration to MTB-infected macrophages inhibits apoptosis an...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/S1567-5769(03)00202-9

    authors： Santucci MB,Ciaramella A,Mattei M,Sumerska T,Fraziano M

    更新日期：2003-11-01 00:00:00

  • MicroRNA-665-3p attenuates oxygen-glucose deprivation-evoked microglial cell apoptosis and inflammatory response by inhibiting NF-κB signaling via targeting TRIM8.

    abstract：:Microglial inflammation induced by ischemic stroke aggravates brain damage. MicroRNAs (miRNAs) have emerged as pivotal regulators in ischemic stroke-induced inflammation in microglial cells. miR-665-3p has been reported as a critical inflammation-associated miRNA. However, whether miR-665-3p participates in regulating...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106650

    authors： Zhang X,Feng Y,Li J,Zheng L,Shao Y,Zhu F,Sun X

    更新日期：2020-08-01 00:00:00

  • Immunomodulatory properties of Cumaside.

    abstract：:The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with original glycosides d...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.01.017

    authors： Aminin DL,Pinegin BV,Pichugina LV,Zaporozhets TS,Agafonova IG,Boguslavski VM,Silchenko AS,Avilov SA,Stonik VA

    更新日期：2006-07-01 00:00:00

  • Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.

    abstract：BACKGROUND:The role of vitamin D in the susceptibility and severity of various viral diseases has been well documented. Recently, some reports highlighted the possible importance of vitamin D in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although India receives adequate sunlight throughout the year, ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107001

    authors： Padhi S,Suvankar S,Panda VK,Pati A,Panda AK

    更新日期：2020-11-01 00:00:00

  • Rescue of iCIKs transfer from PD-1/PD-L1 immune inhibition in patients with resectable tongue squamous cell carcinoma (TSCC).

    abstract：OBJECTIVES:The purpose of this study is to evaluate the therapeutic efficacy and the role of PD-1/PD-L1 pathway in tongue squamous cell carcinoma (TSCC) patients treated with radical operation combined with chemotherapy and improving cytokine induced killer cells (iCIKs) transfer. METHODS:Thirteen patients who receive...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2018.04.011

    authors： Huang X,Zhang J,Li X,Huang H,Liu Y,Yu M,Zhang Y,Wang H

    更新日期：2018-06-01 00:00:00

  • Function of follicular helper T cell is impaired and correlates with survival time in non-small cell lung cancer.

    abstract：:Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide. The PD-1/PD-L1 interaction plays important roles in cancer immunology, and expression of PD-L1 has been discovered in NSCLC tumor cells. Since follicular helper T (Tfh) cells have characteristic high PD-1 expression,...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.10.014

    authors： Ma QY,Huang DY,Zhang HJ,Chen J,Miller W,Chen XF

    更新日期：2016-12-01 00:00:00

  • Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes.

    abstract：:Regular bathing in the Blue Lagoon has beneficial effects on psoriasis. Previously, we showed that exopolysaccharides (EPS-Ca) secreted by Cyanobacterium aponinum, a dominating organism in the Blue Lagoon, increased IL-10 secretion by human dendritic cells (DCs). In addition, co-culturing allogeneic CD4+ T cells with ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.01.044

    authors： Gudmundsdottir AB,Brynjolfsdottir A,Olafsdottir ES,Hardardottir I,Freysdottir J

    更新日期：2019-04-01 00:00:00

  • Intravenous immunoglobulin treatment in a HIV-1 positive patient with Guillain-Barré syndrome.

    abstract：:We report the case of an HIV-1 positive patient with primary demyelinating neuropathy (Guillain-Barré syndrome); after intravenous immunoglobulin treatment (IVIG), he presented with an increase in CD4 and CD8 cell counts and a decrease in plasma viral load. Currently, there is little reported research regarding IVIG t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.09.023

    authors： Rosca EC,Rosca O,Simu M

    更新日期：2015-12-01 00:00:00

  • Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa.

    abstract：OBJECTIVE:This study aims to select the most effective anti-Rheumatoid Arthritis (RA) component of flavonoids from Daphne genkwa Sieb. et Zucc. by anti-inflammatory and immunomodulatory effects in vitro, and to elucidate the mechanism. METHODS:The anti-inflammatory and immunomodulatory effects of total flavonoids (TF)...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106384

    authors： Sun YW,Bao Y,Yu H,Chen QJ,Lu F,Zhai S,Zhang CF,Li F,Wang CZ,Yuan CS

    更新日期：2020-06-01 00:00:00

  • Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction.

    abstract：:Cerebral infarction causes severe social and economic burdens to patients due to its high morbidity and mortality rates, and the available treatments are limited. RO27-3225 is a highly selective melanocortin receptor 4 agonist that alleviates damage in many nervous system diseases, such as cerebral hemorrhage, traumat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106281

    authors： Zhang Y,Wang J,Zhang D,Lu Z,Man J

    更新日期：2020-04-01 00:00:00

  • Combined ischemic and rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice.

    abstract：:Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the effects of ischemic and rapamycin preconditioning on IR injury in old livers. Young (8-week-old) and aged (60-week-old) mice were subjected to IR or a sham control procedure. The ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105711

    authors： Jiang T,Zhan F,Rao Z,Pan X,Zhong W,Sun Y,Wang P,Lu L,Zhou H,Wang X

    更新日期：2019-09-01 00:00:00

  • Macrophage immunomodulatory activity of extracellular polysaccharide (PEP) of Antarctic bacterium Pseudoaltermonas sp.S-5.

    abstract：:Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Galactose in a ratio o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.02.009

    authors： Bai Y,Zhang P,Chen G,Cao J,Huang T,Chen K

    更新日期：2012-04-01 00:00:00

  • Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion.

    abstract：:The present study was conducted to evaluate the efficacy of paternal lymphocyte (PL) immunotherapy and its relation with the development of mixed lymphocyte reaction blocking antibodies (MLR-Bf) and the success of pregnancy outcome in women with recurrent spontaneous abortion (RSA). A total of 124 women with unknown c...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.intimp.2004.01.001

    authors： Pandey MK,Agrawal S

    更新日期：2004-02-01 00:00:00

  • Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality.

    abstract：:Baicalein (5,6,7-trihydroxyflavone), isolated from the root of traditional Chinese herb Scutellaria baicalensis Georgi, has anti-inflammatory and anti-oxidative activities. This study explored the protective and modulatory mechanisms of baicalein on neuroinflammation, oxidative stress and metabolic abnormality in lipo...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106092

    authors： Yan JJ,Du GH,Qin XM,Gao L

    更新日期：2020-02-01 00:00:00