A promising therapeutic target for psoriasis: Neuropeptides in human skin.

abstract：:Immunosuppressive drugs are widely used in the therapy of autoimmune disorders to suppress autoreactive T cells. The immune system is regulated by the release of cytokines. Cytokine are potent immunomodulatory molecules that act as mediators of inflammation and the immune response. Primarily secreted by T cell and mac...

journal_title：International immunopharmacology

authors： Pawlik A,Baskiewicz-Masiuk M,Machalinski B,Gawronska-Szklarz B

更新日期：2006-03-01 00:00:00

abstract：:Monocytes and macrophages of individuals with allergic diseases express increased levels of the low-affinity IgE receptors (FcepsilonRII or CD23) on their surfaces. The cross-linking of CD23-bound IgE antibody by allergen activates the cells to release inflammatory mediators. In mast cells, the binding of IgE to the h...

journal_title：International immunopharmacology

authors： Ezeamuzie CI,Al-Attiyah R,Shihab PK,Al-Radwan R

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Increases in galactose-deficient IgA1 (Gd-IgA1) play a crucial role in the pathogenesis of IgA nephropathy (IgAN), and several recent experiments have shown that microRNAs (miRNAs) are involved in regulating the development and physiological function of the kidney. The aims of this study were to identify miRN...

journal_title：International immunopharmacology

authors： Liu D,Xia M,Liu Y,Tan X,He L,Liu Y,Chen G,Liu H

更新日期：2020-02-29 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a late phase inflammatory mediator in many inflammatory diseases. Extracellular HMGB1 could bind to many membrane receptors to activate downstream signaling molecules and promote inflammation resulting in cell and tissue damage. In our previous work, we found cannabinoid receptor Ⅱ...

journal_title：International immunopharmacology

authors： Zhou H,Du R,Li G,Bai Z,Ma J,Mao C,Wang J,Gui H

更新日期：2020-01-01 00:00:00

abstract：:Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...

journal_title：International immunopharmacology

authors： Hairul-Islam MI,Saravanan S,Thirugnanasambantham K,Chellappandian M,Simon Durai Raj C,Karikalan K,Gabriel Paulraj M,Ignacimuthu S

更新日期：2017-12-01 00:00:00

abstract：:Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the effects of ellagic acid on acute hepatic injury have not been reported. In the present study, we investigated the effects of ellagic acid on...

journal_title：International immunopharmacology

authors： Gu L,Deng WS,Liu Y,Jiang CH,Sun LC,Sun XF,Xu Q,Zhou H

更新日期：2014-10-01 00:00:00

abstract：:Oral contraceptives (OC) may cause intrahepatic cholestasis or increase a pre-established liver damage. OC effects on hepatic injury biochemical markers remain contradictory and the role of cytokines in those processes is fairly unknown. Two doses, simple or double, of the OC combination ethinylestradiol/norgestrel we...

journal_title：International immunopharmacology

authors： Fernández-Martínez E,Pérez-Soto E,González-Hernández C,Ortiz MI,Pérez-Álvarez V,Muriel P,Shibayama M

更新日期：2014-07-01 00:00:00

abstract：:Salmonella typhimurium (ST), as an aggressive bacterium, mainly causes intestinal inflammation and diarrhea. Sodium houttuyfonate (SH) is a derivative of houttuynin in the active oil of Houttuynia cordata, which is stable in nature and has anti-inflammatory activity. In this study, we used BALB/c mice infected with ST...

journal_title：International immunopharmacology

authors： Zhang L,Lv H,Li Y,Dong N,Bi C,Shan A,Wu Z,Shi B

更新日期：2020-12-01 00:00:00

abstract：:The liver is an immunologically unique organ, consisting of resident hematopoietic and parenchymal cells which often contribute to a relatively tolerant microenvironment. It is also becoming increasingly clear that tumor-induced immunosuppression occurs via many of the same cellular mechanisms which contribute to the ...

journal_title：International immunopharmacology

authors： Chan T,Wiltrout RH,Weiss JM

更新日期：2011-07-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) from blood vessel rupture results in parenchymal hematoma formation and neuroinflammation, ultimately leading to neurodegeneration. Several lines of evidence suggest that the severity of ICH-induced neural damage is exacerbated by infiltration of T-cells, monocytes, and especially neutro...

journal_title：International immunopharmacology

authors： Hijioka M,Futokoro R,Ohto-Nakanishi T,Nakanishi H,Katsuki H,Kitamura Y

更新日期：2020-08-01 00:00:00

abstract：:It is generally accepted that the appropriate boost of early immune response will control viral replications and limit the immune-mediated pathology in viral hepatitis. However, poor immunity results in viral persistence, chronic inflammation and finally liver cirrhosis and carcinoma. As a peripheral non-lymphoid orga...

journal_title：International immunopharmacology

authors： Liang Y,Kwota Z,Sun J

更新日期：2016-10-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:Previous studies have suggested that stearoyl lysophosphatidlycholine (LPC) protects against lethal experimental sepsis by inhibiting lipopolysaccharide (LPS)-induced extracellular release of high-mobility group box 1 (HMGB1). However, limited information exists on the mechanism by which stearoyl-LPC suppresses the ex...

journal_title：International immunopharmacology

authors： Kim JM,Han HJ,Hur YH,Quan H,Kwak SH,Choi JI,Bae HB

更新日期：2015-09-01 00:00:00

abstract：:Dietary ingredients can decrease the risk of a variety of human cancers. Quercetin (3,3',4',5,7-pentahydroxyflavone) has a long history of consumption as part of the normal human diet and is able to induce growth inhibition in multiple cancer cells. In an attempt to generate more potent therapeutic effect for breast c...

journal_title：International immunopharmacology

authors： Du G,Lin H,Yang Y,Zhang S,Wu X,Wang M,Ji L,Lu L,Yu L,Han G

更新日期：2010-07-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder leading to progressive tissue fibrosis. Tanshinone IIA (Tan IIA) is a phytochemical extracted from the Chinese herb Salvia miltiorrhiza that exhibits diverse activities. In this study, we attempted to evaluate the potential impact of Tan IIA ...

journal_title：International immunopharmacology

authors： Jiang Y,Hu F,Li Q,Shen C,Yang J,Li M

更新日期：2019-12-01 00:00:00

abstract：:Inflammation occurs as a result of acute trauma, invasion of the host by different pathogens, pathogen-associated molecular patterns (PAMPs) or chronic cellular stress generating damage-associated molecular patterns (DAMPs). Thus inflammation may occur under both sterile inflammatory conditions including certain cance...

journal_title：International immunopharmacology

authors： Kumar V

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:The purpose of this study is to evaluate the therapeutic efficacy and the role of PD-1/PD-L1 pathway in tongue squamous cell carcinoma (TSCC) patients treated with radical operation combined with chemotherapy and improving cytokine induced killer cells (iCIKs) transfer. METHODS:Thirteen patients who receive...

journal_title：International immunopharmacology

authors： Huang X,Zhang J,Li X,Huang H,Liu Y,Yu M,Zhang Y,Wang H

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:A new strategy of adoptive and passive immunotherapy involves combining dendritic cells (DCs) with a subset of natural killer T lymphocytes termed cytokine-induced killer (CIK) cells. The objective of this systematic review and meta-analysis was to evaluate the safety and efficacy of DC-CIK therapy vs. placebo,...

journal_title：International immunopharmacology

authors： Chen R,Deng X,Wu H,Peng P,Wen B,Li F,Li F

更新日期：2014-10-01 00:00:00

abstract：:The opioid peptide methionine-enkephalin (MENK) has significant immunomodulatory ability in addition to its neurotransmitter function. Since neutral endopeptidase (NEP, CD10, enkephalinase EC 3.4.24.11) cleaves opioid peptides, the presence and activity of NEP in neutrophils from different persons might be responsible...

journal_title：International immunopharmacology

authors： Balog T,Marotti T,Abramić M,Beusan-Svoboda I,Sobocanec S,Hrsak I

更新日期：2001-03-01 00:00:00

abstract：:Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFNalpha differently regulated the expression of granzymes in NK cells. Althoug...

journal_title：International immunopharmacology

authors： Zhang B,Zhang J,Tian Z

更新日期：2008-07-01 00:00:00

abstract：:A high Treg/CD8 T cell ratio in ovarian carcinoma was negatively associated with the prognosis of the patients. The human follicular regulatory T (Tfr) cells are a newly characterized subset of Treg cells with features of both follicular helper T (Tfh) cells (CXCR5+) and canonical Treg cells (CD25+Foxp3+). The role of...

journal_title：International immunopharmacology

authors： Li L,Ma Y,Xu Y

更新日期：2019-03-01 00:00:00

abstract：:The objective of this study was to define the role of complement activation in the acute and transient toxicities associated with administration of phosphorothioate oligonucleotides in monkeys. In the absence of complement inhibitor, complement activation blocker-2 (CAB-2), i.v. infusion of 20 mg/kg ISIS 2302 produced...

journal_title：International immunopharmacology

authors： Henry SP,Beattie G,Yeh G,Chappel A,Giclas P,Mortari A,Jagels MA,Kornbrust DJ,Levin AA

更新日期：2002-11-01 00:00:00

abstract：:Problem due to disc degeneration is frequently found in the aging population. However, severe pain and accompanying end plate inflammation is only found in a small subset of patients, who can be of a younger age than most people with severe disc degeneration, with no apparent cause. We hypothesized that deficiencies i...

journal_title：International immunopharmacology

authors： Xu C,Zhang M,Li K,Ni M,Bai Y,Zhang J,Song X,Wang J

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by destruction of small intrahepatic bile ducts. Recent studies suggest that miRNAs play a critical role in the pathogenesis of liver diseases. However the role served by miRNAs in the pathogenesis of PBC is still not clear. METH...

journal_title：International immunopharmacology

authors： Song Y,Yang H,Jiang K,Wang BM,Lin R

更新日期：2018-11-01 00:00:00

abstract：:B cell activating factor (BAFF), a member of the tumor necrosis factor family, is critical to B cell survival, proliferation, maturation, and immunoglobulin secretion and to T cell activation. In the present study, the full-length cDNA of BAFF from the South African clawed frog (Xenopus laevis, designated xlBAFF) was ...

journal_title：International immunopharmacology

authors： Yang L,Zhou L,Zong X,Cao X,Ji X,Gu W,Zhang S

更新日期：2013-03-01 00:00:00

abstract：:Previously it was shown that treatment with mycophenolate mofetil (MMF) attenuated renal inflammation and glomerular injury in a model of diabetes. However, the mechanism involved in the renoprotective effects of MMF in experimental diabetes has not been clearly delineated. Diabetes was induced by injection of strepto...

journal_title：International immunopharmacology

authors： Wu YG,Lin H,Qi XM,Wu GZ,Qian H,Zhao M,Shen JJ,Lin ST

更新日期：2006-03-01 00:00:00

abstract：:The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, nitric oxide synthase (NOS) activity was measured in cerebral frontal cortex slices by produ...

journal_title：International immunopharmacology

authors： Orman B,Sterin-Borda L,De Couto Pita A,Reina S,Borda E

更新日期：2007-12-05 00:00:00

abstract：:Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS). After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact ...

journal_title：International immunopharmacology

authors： Zhang Y,Liu J,Jia W,Zhao A,Li T

更新日期：2005-12-01 00:00:00

abstract：:Anemoside B4 (B4) is a compound extracted from Pulsatilla chinensis(P. chinensis). Pharmacological studies have proved that it has certain anti-inflammatory activity. Acute ulcerative colitis (ulcerative colitis) is a non-specific inflammatory disease whose pathogenesis is not completely known, and there is no effecti...

journal_title：International immunopharmacology

authors： Ma H,Zhou M,Duan W,Chen L,Wang L,Liu P

更新日期：2020-10-01 00:00:00

abstract：:Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness (AHR), and airway remodeling. Astilbic acid, extracted from the medicinal herb Astilbe chinensis, is used as a headache remedy in traditional medicine and has anti-pyretic and analgesic effects. However, the effect of astilbic a...

journal_title：International immunopharmacology

authors： Yuk JE,Lee MY,Kwon OK,Cai XF,Jang HY,Oh SR,Lee HK,Ahn KS

更新日期：2011-02-01 00:00:00