当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Th17/Treg imbalance and increased interleukin-21 are associated with liver injury in patients with chronic severe hepatitis B.

Th17/Treg imbalance and increased interleukin-21 are associated with liver injury in patients with chronic severe hepatitis B.

Abstract：

BACKGROUND:Th17/Treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. The aim of the current study was to assess the Treg/Th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepatitis B virus (HBV) infection. METHODS:The proportions of peripheral Th17, Treg and Th1 cells in 7 patients classified as asymptomatic hepatitis B virus carriers (AsCs), 38 patients with low or moderate grade chronic hepatitis B (CHB-LM), 20 patients with chronic severe hepatitis B (CSHB), and 10 healthy controls (HCs) were determined by flow cytometry. The levels of related cytokines and the mRNA expression levels of transcription factors were measured using Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative PCR (RT-PCR), respectively. RESULTS:The Th17 cell frequency and the mRNA expression levels of RORc were increased in the CSHB group. The Treg cell frequency was increased and Th1 cell frequency and the mRNA expression levels of T-bet were decreased in chronic HBV infection. The levels of IL-21 were increased in the CSHB group and were positively correlated with AST, TB and DB in patients with chronic HBV infection. The Th17/Treg ratio was increased in the CSHB group and was positively correlated with liver injury in chronic HBV infection. CONCLUSIONS:Th17/Treg imbalance and increased IL-21 are associated with liver injury in patients with chronic HBV infection. Restoring the Th17/Treg balance may be a novel immunotherapy for patients with CSHB.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Liu B,Gao W,Zhang L,Wang J,Chen M,Peng M,Ren H,Hu P

doi

10.1016/j.intimp.2017.02.019

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

48-55

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(17)30074-7

journal_volume

46

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum.

    abstract：:Hericium erinaceum is a medicinal and edible mushroom with anti-microbial and anti-cancer activities. To evaluate the immunoregulatory functions of H. erinaceum, we prepared water extract from H. erinaceum (WEHE) and investigated its ability to activate macrophages and to induce nitric oxide (NO) production in macroph...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.03.005

    authors： Son CG,Shin JW,Cho JH,Cho CK,Yun CH,Chung W,Han SH

    更新日期：2006-08-01 00:00:00

  • Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells.

    abstract：:Emerging evidences indicated that NLRP3 inflammasome initiates inflammatory response involved in cardiovascular disease. Nicotinic acid (NA) has been known to possess potential anti-inflammatory property. The aim of this study was to investigate the effect of NA on the activation of NLRP3 inflammasome and the underlyi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.09.003

    authors： Li Y,Yang G,Yang X,Wang W,Zhang J,He Y,Zhang W,Jing T,Lin R

    更新日期：2016-11-01 00:00:00

  • Immunomodulatory-based therapy as a potential promising treatment strategy against severe COVID-19 patients: A systematic review.

    abstract：:The global panic of the novel coronavirus disease 2019 (COVID-19) triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent requirement for effective therapy. COVID-19 infection, especially in severely ill patients, is likely to be associated with immune dysregulation, promptin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106942

    authors： Razmi M,Hashemi F,Gheytanchi E,Dehghan Manshadi M,Ghods R,Madjd Z

    更新日期：2020-11-01 00:00:00

  • Immunization in tumor prevention.

    abstract：:Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor rece...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/S1567-5769(03)00026-2

    authors： Forni G,Curcio C,Spadaro M,Iliffe J,Quaglino E,Di Carlo E,Musiani P,Lollini PL

    更新日期：2003-08-01 00:00:00

  • Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation.

    abstract：:We assessed the effects of Zizyphus lotus L. (Desf.) polyphenols (ZLP) on T-cell signaling and proliferation. Our results showed that ZLP exerted no effect on the increases in intracellular free calcium concentrations, [Ca(2+)]i, in human Jurkat T-cells. However, ZLP modulated the thapsigargin-induced increases in [Ca...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.11.013

    authors： Abdoul-Azize S,Bendahmane M,Hichami A,Dramane G,Simonin AM,Benammar C,Sadou H,Akpona S,El Boustani ES,Khan NA

    更新日期：2013-02-01 00:00:00

  • Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties.

    abstract：BACKGROUND:Hepatic ischemia/reperfusion (I/R) injury occurs in different clinical settings as hepatic transplantation, and different types of shock. I/R injury is the main cause of hepatic damage and failure due to the production of reactive oxygen species (ROS) and inflammatory cytokines. Dimethyl fumarate (DMF), an i...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.106131

    authors： Ibrahim SG,El-Emam SZ,Mohamed EA,Abd Ellah MF

    更新日期：2020-03-01 00:00:00

  • Benzylamine and methylamine, substrates of semicarbazide-sensitive amine oxidase, attenuate inflammatory response induced by lipopolysaccharide.

    abstract：:Current evidence indicates that semicarbazide-sensitive amine oxidase (SSAO) substrates possess insulin-mimic effect, which was thought to play an anti-inflammatory role. The purpose of the present study was to determine whether SSAO substrates benzylamine (BZA) and methylamine (MA) attenuate inflammatory response ind...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.03.002

    authors： Lin Z,Li H,Luo H,Zhang Y,Luo W

    更新日期：2011-08-01 00:00:00

  • A synthetic cyclic peptide derived from Limulus anti-lipopolysaccharide factor neutralizes endotoxin in vitro and in vivo.

    abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.01.015

    authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

    更新日期：2008-06-01 00:00:00

  • Kinin system in lupus nephritis.

    abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1567-5769(01)00109-6

    authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

    更新日期：2001-09-01 00:00:00

  • Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-gamma.

    abstract：:Human melanoma Colo 679 cells were made resistant to doxorubicin (adriamycin, ADM) by continuous exposure to ascending concentrations of the drug and Colo/ADM80; a variant which grew continuously in the presence of 80 ng/ml of ADM was thus established. Human peripheral blood mononuclear cells (PBMC) produced interfero...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(00)00026-6

    authors： Micallef MJ,Darmanin S,Buhagiar JA,Camilleri-Podesta MT,Yamauchi H,Kurimoto M,Inglott AS,Ellul-Micallef R

    更新日期：2001-02-01 00:00:00

  • Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation.

    abstract：:Inflammation and oxidative stress play important roles in the progression of renal damage. The natural polyphenol naringenin is known to exert potent antioxidant and anti-inflammatory effects. In this study, we have investigated the effect of naringenin on kidney dysfunction, fibrosis, endoplasmic reticulum (ER) stres...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.05.050

    authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Suzuki K,Nakamura M,Ueno K,Watanabe K

    更新日期：2015-09-01 00:00:00

  • Diabetes teratogenicity is accompanied by alterations in macrophages and T cell subpopulations in the uterus and lymphoid organs.

    abstract：:Insulin-dependent diabetes mellitus is a well-known teratogen, which might cause growth retardation, malformations and fetal death. We have previously shown, that potentiation of the maternal immune system (immunopotentiation) might protect the embryo from diabetes teratogenicity. Therefore, in the present study we fu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.05.018

    authors： Savion S,Gidon-Dabush S,Fein A,Torchinsky A,Toder V

    更新日期：2004-10-01 00:00:00

  • Immune-related adverse events from combination immunotherapy in cancer patients: A comprehensive meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:Although available evidence from clinical trials has shown that immune checkpoint inhibitors (ICIs) combination therapy can lead to a series of immune-related adverse events (irAEs), the overall risk of irAEs on combination therapy has yet not been systematically reported. Therefore, we performed a meta-anal...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.intimp.2018.08.014

    authors： Zhang B,Wu Q,Zhou YL,Guo X,Ge J,Fu J

    更新日期：2018-10-01 00:00:00

  • Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide.

    abstract：:The objective of this study was to define the role of complement activation in the acute and transient toxicities associated with administration of phosphorothioate oligonucleotides in monkeys. In the absence of complement inhibitor, complement activation blocker-2 (CAB-2), i.v. infusion of 20 mg/kg ISIS 2302 produced...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00142-x

    authors： Henry SP,Beattie G,Yeh G,Chappel A,Giclas P,Mortari A,Jagels MA,Kornbrust DJ,Levin AA

    更新日期：2002-11-01 00:00:00

  • The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages.

    abstract：:The present study reports the anti-mycobacterial activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol) as well as its influence on macrophage functions. Lapachol (L) did not induce apoptosis/necrosis of THP-1 macrophages at ≤32 μg/mL. Mycobacterium avium liquid growth was arrested by ≥32 μg/mL and...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.08.023

    authors： Oliveira RA,Azevedo-Ximenes E,Luzzati R,Garcia RC

    更新日期：2010-11-01 00:00:00

  • Dendritic cells with an increased PD-L1 by TGF-β induce T cell anergy for the cytotoxicity of hepatocellular carcinoma cells.

    abstract：:The effects of TGF-β on dendritic cells (DCs) in the tumor microenvironment are not well-understood. In this study, we investigated the effect of TGF-β on the induction of programmed death ligand-1 (PD-L1) expression in DCs and the underlying mechanism, and we further investigated the influence of the DCs with PD-L1 e...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.02.027

    authors： Song S,Yuan P,Wu H,Chen J,Fu J,Li P,Lu J,Wei W

    更新日期：2014-05-01 00:00:00

  • Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.

    abstract：:Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Neverthel...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106928

    authors： Mirzaei R,Mohammadzadeh R,Mahdavi F,Badrzadeh F,Kazemi S,Ebrahimi M,Soltani F,Kazemi S,Jeda AS,Darvishmotevalli M,Yousefimashouf R,Keyvani H,Karampoor S

    更新日期：2020-11-01 00:00:00

  • Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway.

    abstract：:Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored the regulatory mechanism of the gut flora in the host defense against lipopolysaccharide (LPS)-induced ALI through the TLR4/NF-k...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107272

    authors： Tang J,Xu L,Zeng Y,Gong F

    更新日期：2021-02-01 00:00:00

  • Generation of two high affinity anti-mouse FcRn antibodies: Inhibition of IgG recycling in wild type mice and effect in a mouse model of immune thrombocytopenia.

    abstract：:Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by pathogenic immunoglobulin G (IgG) autoantibodies that bind to platelets, causing their phagocytic removal and leading to reductions in platelet number. The neonatal Fc receptor (FcRn) selectively salvages and recycles IgG, including pathog...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.11.040

    authors： Smith B,Christodoulou L,Clargo A,Eddleston A,Greenslade K,Lightwood D,Shock A,Tyson K,Brennan FR

    更新日期：2019-01-01 00:00:00

  • Effects of hydroxyethyl starch (130 kD) on brain inflammatory response and outcome during normotensive sepsis.

    abstract：BACKGROUND:During sepsis, the dysfunction of blood-brain barrier (BBB) was mediated by inflammation and subsequently caused sepsis-associated encephalopathy. Hydroxyethyl starch (HES, 130/0.4) is most widely used for volume replacement to maintain or improve tissue perfusion in patients with sepsis, trauma, and shock. ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.04.020

    authors： Feng X,Zhang F,Dong R,Wang H,Liu J,Liu X,Li W,Yao J,Xu J,Yu B

    更新日期：2010-08-01 00:00:00

  • Concentration-dependent activity of mometasone furoate and dexamethasone on blood eosinophils isolated from atopic children: modulation of Mac-1 expression and chemotaxis.

    abstract：:Treatment of asthma with corticosteroids results in downregulation of eosinophilic airway inflammation. We evaluated in vitro the activity of an "inhaled" corticosteroid, mometasone furoate (MF), and of a "systemic" corticosteroid, dexamethasone (DEX), on eosinophil functions, i.e. adhesion molecule expression and cel...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.07.029

    authors： Sale R,Sabatini F,Silvestri M,Serpero L,Petecchia L,Rossi GA

    更新日期：2004-12-15 00:00:00

  • Histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits anti-inflammatory activities through induction of mitochondrial damage and apoptosis in activated lymphocytes.

    abstract：:Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been proven to be an anti-cancer agent. Its anti-inflammatory activities have recently been observed both in in vitro and in vivo models. Yet its action on lymphocytes and the underlying mechanism are still not well known. In this study, in o...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2012.02.005

    authors： Shi ZJ,Ouyang DY,Zhu JS,Xu LH,He XH

    更新日期：2012-04-01 00:00:00

  • Liposomal methylprednisolone differentially regulates the expression of TNF and IL-10 in human alveolar macrophages.

    abstract：:Glucocorticoids (GC) are frequently used for therapy of various inflammatory lung diseases by either systemic or inhalative application. Because the oral application often has various side effects and because the inhalative application is not as potent, new formulations of GCs are required. We evaluated the effect of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.09.033

    authors： Frankenberger M,Häussinger K,Ziegler-Heitbrock L

    更新日期：2005-02-01 00:00:00

  • Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity.

    abstract：:Kappa opioid agonists alter some immune functions of macrophages, and T- and B-lymphocytes. The mouse thymoma cell lines R1.G1 and R1EGO express only kappa-opioid receptors and these kappa-opioid receptors are coupled to an inhibitory GTP-binding regulatory protein. Binding of kappa-opioid agonists to the opioid recep...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(00)00011-4

    authors： Martin-Kleiner I,Bidlack JM

    更新日期：2001-01-01 00:00:00

  • The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease.

    abstract：:Coronary atherosclerotic heart disease (CHD) is currently regarded as a chronic inflammatory disease. The inflammatory cytokine neopterin (NP) is a new predictor of the stable type of atherosclerotic plaque, and this study focused on the relationship between neopterin, Gensini score and high-sensitivity C-reactive pro...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.11.013

    authors： Lyu Y,Jiang X,Dai W

    更新日期：2015-02-01 00:00:00

  • Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.

    abstract：:Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet. In the present study, non-cytotoxic level of ampelopsin sign...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.12.001

    authors： Qi S,Xin Y,Guo Y,Diao Y,Kou X,Luo L,Yin Z

    更新日期：2012-01-01 00:00:00

  • Progesterone as an immunomodulatory molecule.

    abstract：:Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens gamma/delta TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator prot...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s1567-5769(01)00035-2

    authors： Szekeres-Bartho J,Barakonyi A,Par G,Polgar B,Palkovics T,Szereday L

    更新日期：2001-06-01 00:00:00

  • Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-α and IL-1β release and augmentation of IL-10 production.

    abstract：:Lipopolysaccharide (LPS) plays an important role in Gram-negative bacteria-induced sepsis and multiple organ dysfunction syndrome, which are still the leading cause of high mortality in intensive care units. Although paeoniflorin (Pae) has reportedly exhibited anti-inflammatory effect and protection against immunologi...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.11.012

    authors： Cao W,Zhang W,Liu J,Wang Y,Peng X,Lu D,Qi R,Wang Y,Wang H

    更新日期：2011-02-01 00:00:00

  • Total glucosides of paeony can reduce the hepatotoxicity caused by Methotrexate and Leflunomide combination treatment of active rheumatoid arthritis.

    abstract：OBJECTIVE:Total glucosides of paeony (TGP) have been confirmed to exert anti-inflammatory and hepatoprotective effects. Methotrexate (MTX) and Leflunomide (LEF) combination has a better efficacy in the treatment of active rheumatoid arthritis (RA), but hepatotoxicity was observed. In this study, we investigated the eff...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.intimp.2015.08.008

    authors： Xiang N,Li XM,Zhang MJ,Zhao DB,Zhu P,Zuo XX,Yang M,Su Y,Li ZG,Chen Z,Li XP

    更新日期：2015-09-01 00:00:00

  • A promising therapeutic target for psoriasis: Neuropeptides in human skin.

    abstract：:Psoriasis is a chronic inflammatory skin disease featured by excessive proliferation of keratinocytes, clearly defined round erythema and dry, scaly plaques, long-term inflammatory cells infiltration in skin lesions. However, the physiopathological mechanism of psoriasis is still not clearly understood. Neuropeptides,...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.106755

    authors： Zhang Y,Zhang H,Jiang B,Yan S,Lu J

    更新日期：2020-10-01 00:00:00