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DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.

Abstract：

:Acute lung injury (ALI) is a severe disease characterized by several inflammatory responses in the lung with high mortality. We applied a mouse model of the pulmonary inflammation induced by the intratracheal instillation of bleomycin which is widely used to induce ALI and fibrosis in animal models. We hypothesized that DNA methyltransferase inhibitor, 5-azacytidine (5-Aza), with its anti-inflammatory benefits, might attenuate bleomycin-induced ALI through the alleviation of inflammation in the lung. We quantified white blood cells with cell blood count (CBC) test, lung inflammation by analyzing cells in the collected bronchoalveolar lavage fluid (BALF) and histological analysis of the lung tissues, and gene expression levels by real-time PCR. Intratracheal administration of bleomycin in mice induced pulmonary inflammation, characterized by increased neutrophil infiltration and inflammatory cytokine expression in the lungs. Mice treated with 5-Aza showed a significant reduction of lung neutrophilia, together with lower expressions of CXCL2 and MCP-1. Furthermore, 5-Aza treatment decreased the expression of proinflammatory cytokines in the lung tissue. Collectively, our data show that DNA methyltransferase inhibitor can alleviate the lung inflammation of bleomycin-induced ALI, indicating an alternative treatment option for the inflammation-triggered lung injury.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Lu CH,Chen CM,Ma J,Wu CJ,Chen LC,Kuo ML

doi

10.1016/j.intimp.2020.106542

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

106542

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(19)32962-5

journal_volume

84

pub_type

杂志文章

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