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Depression linked to higher antibodies production against estrogenized insulin in type 1 diabetes.

Abstract：

:Depression has been commonly associated with type 1 diabetes (T1D) and insulin covalently modified with catecholestrogens (CEs) was found in serum of these T1D patients. This study aimed to know whether depression link to higher antibodies against estrogenized insulin in T1D. ELISA (direct binding and competition) and quantitative precipitin titration were used to detect antibodies and their affinities against estrogenized insulin in the serum of 66 depressed T1D (DT1D) patients (out of 110 T1D) and 41 control subjects. Antibodies from DT1D patients showed high binding specificity to estrogenized insulin (2-hydroestradiol-insulin; 2-OHE2-Ins) in comparison to overall T1D patients (p < 0.05) or control subjects (p < 0.001). However, T1D sera demonstrate high recognition to 2-OHE2-Ins as compared to Ins (p < 0.05) or 2-OHE2 (p < 0.001). The affinity of antibodies from DT1D and T1D patients was 1.32 × 10-7 M and 1.43 × 10-7 M, respectively. Depression linked to higher antibodies production against estrogenized insulin in T1D. Furthermore, depression in T1D generates inflammatory conditions that further increased antibodies production in T1D patients.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Khan WA,Malik A,Khan MWA

doi

10.1016/j.intimp.2020.106712

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

106712

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)31401-6

journal_volume

86

pub_type

杂志文章

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