Abstract:
:Neuroinflammation, characterized by the activation of microglia and astrocytes, is important in the pathogenesis of many neurological disorders, such as Alzheimer's disease. Nonsteroidal anti-inflammatory drugs (NSAIDs), a group of chemically heterogenous medications, are used widely in the treatment of inflammation. However, the safety of these drugs is a growing concern due to their side effects on the gastrointestinal tract and liver. Royal jelly (RJ) is a potential functional food produced by the hypopharynx and mandibular salivary glands of nurse bees. In this study, we explored the anti-neuroinflammatory effect of 10-hydroxydecanoic acid (10-HDAA), which is the second most abundant but less studied fatty acid in RJ. We showed that 10-HDAA decreased the lipopolysaccharide (LPS)-induced elevation of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) levels in both microglial BV-2 and N9 cell lines. Compared to the LPS group, the 10-HDAA/LPS treated BV-2 cells had a higher level of the phagocytic receptor TREM2. RNAseq transcriptomic results showed a different transcriptional profile between the LPS group and the 10-HDAA/LPS group in BV-2 cells and the 10-HDAA pre-treatment significantly decreased levels of pro-inflammatory mediators, which were further confirmed by qRT-PCR analysis. Moreover, we found that p53 was a target of 10-HDAA. p53 may mediate the anti-inflammation effect of 10-HDAA in two ways: first by directly deactivating the NLRP3 inflammatory pathway, second by indirectly promoting autophagy. Taken together, our results reveal a novel function of tumor suppressor p53 in the inhibition of neuroinflammation and provide a theoretical basis for broadening the application range of 10-HDAA and RJ.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
You M,Miao Z,Sienkiewicz O,Jiang X,Zhao X,Hu Fdoi
10.1016/j.intimp.2020.106501subject
Has Abstractpub_date
2020-07-01 00:00:00pages
106501eissn
1567-5769issn
1878-1705pii
S1567-5769(19)32845-0journal_volume
84pub_type
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2015.08.022
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2008.07.019
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2020.106404
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2020.106821
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journal_title:International immunopharmacology
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-10-01 00:00:00
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.05.033
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journal_title:International immunopharmacology
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pub_type: 杂志文章
doi:10.1016/j.intimp.2003.08.005
更新日期:2003-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2006.01.005
更新日期:2006-06-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2010.12.006
更新日期:2011-03-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.105886
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2007.02.007
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2004.04.016
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.09.027
更新日期:2016-11-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.02.015
更新日期:2016-08-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2015.12.027
更新日期:2016-02-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2012.06.001
更新日期:2012-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/s1567-5769(01)00078-9
更新日期:2001-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2005.07.016
更新日期:2006-02-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.intimp.2018.08.014
更新日期:2018-10-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2018.06.034
更新日期:2018-09-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2020.106632
更新日期:2020-08-01 00:00:00