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The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.

Abstract：

:Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2',4'-dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin chalcone. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Yadav VR,Prasad S,Sung B,Aggarwal BB

doi

10.1016/j.intimp.2010.12.006

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

295-309

issue

3

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(10)00409-1

journal_volume

11

pub_type

杂志文章,评审

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