当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

Big Potassium (BK) ion channels in biology, disease and possible targets for cancer immunotherapy.

Abstract：

:The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, stretch-activated potassium channel, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own distinctive roles for that tissue type. The BKα channel contains the pore that releases potassium ions from intracellular stores. This ion channel is found on the cell membrane, endoplasmic reticulum, Golgi and mitochondria. Complex splicing pathways produce different isoforms. The BKα channels can be phosphorylated, palmitoylated and myristylated. BK is composed of a homo-tetramer that interacts with β and γ chains. These accessory proteins provide a further modulating effect on the functions of BKα channels. BK channels play important roles in cell division and migration. In this review, we will focus on the biology of the BK channel, especially its role, and its immune response towards cancer. Recent proteomic studies have linked BK channels with various proteins. Some of these interactions offer further insight into the role that BK channels have with cancers, especially with brain tumors. This review shows that BK channels have a complex interplay with intracellular components of cancer cells and still have plenty of secrets to be discovered.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Ge L,Hoa NT,Wilson Z,Arismendi-Morillo G,Kong XT,Tajhya RB,Beeton C,Jadus MR

doi

10.1016/j.intimp.2014.06.040

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

427-43

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(14)00254-9

journal_volume

22

pub_type

杂志文章,评审

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway.

    abstract：:Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-infla...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.10.008

    authors： Funakoshi-Tago M,Ohsawa K,Ishikawa T,Nakamura F,Ueda F,Narukawa Y,Kiuchi F,Tamura H,Tago K,Kasahara T

    更新日期：2016-11-01 00:00:00

  • Effects of three anti-TNF-alpha drugs: etanercept, infliximab and pirfenidone on release of TNF-alpha in medium and TNF-alpha associated with the cell in vitro.

    abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a vital component of the inflammatory process and its aberrant over-expression has been linked to numerous disease states. New treatment strategies have sought to reduce circulating TNF-alpha, either with neutralizing anti-TNF-alpha binding proteins such as etanercept or via ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.01.013

    authors： Grattendick KJ,Nakashima JM,Feng L,Giri SN,Margolin SB

    更新日期：2008-05-01 00:00:00

  • ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx.

    abstract：:Monocytes recruited and adhering to the inflamed arteries are crucial for atherosclerosis development. Here, we report the role of zinc (Zn2+) homeostasis in monocyte adhesion and recruitment. By comparing the expression levels of Zn2+ transporters between non-adhering and adhering monocytes, we found that the Zn2+ im...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.06.018

    authors： Cheng G,Chang FJ,You PH,Lin J,Huang XY,Wu HY,Yan L,Deng JZ,You HJ,Sun CF

    更新日期：2018-09-01 00:00:00

  • Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion.

    abstract：:The present study was conducted to evaluate the efficacy of paternal lymphocyte (PL) immunotherapy and its relation with the development of mixed lymphocyte reaction blocking antibodies (MLR-Bf) and the success of pregnancy outcome in women with recurrent spontaneous abortion (RSA). A total of 124 women with unknown c...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.intimp.2004.01.001

    authors： Pandey MK,Agrawal S

    更新日期：2004-02-01 00:00:00

  • Effect of antipyretics on polymorphonuclear leukocyte functions in children.

    abstract：:The aim of this study was to investigate whether fever and antipyretic drugs had an adverse effect on human polymorphonuclear leukocyte (PMN) functions (phagocytic and intracellular killing activity). Twenty febrile children with an axillary temperature of 39-40 degrees C and 20 healthy children without fever were inc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00136-4

    authors： Gürer US,Palanduz A,Gürbüz B,Yildirmak Y,Cevikbaş A,Kayaalp N

    更新日期：2002-10-01 00:00:00

  • Correlation of Tc17 cells at early stages after allogeneic hematopoietic stem cell transplantation with acute graft-versus-host disease.

    abstract：:Acute graft-versus-host disease (aGVHD) is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, IL-17-producing T cells including Th17 and Tc17 cells have been implicated in immune-related diseases. However, their roles in aGVHD remain uncertain. In the study, we analyzed IL-17-producin...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.11.003

    authors： Wang L,Zhao P,Song L,Yan F,Shi C,Li Y,Han M,Lan K

    更新日期：2016-12-01 00:00:00

  • Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1.

    abstract：:The neuropharmacological properties of cocaine are known to be associated with the activation of sigma-1 receptors. Cocaine also has been shown to alter both cytokine production and HIV-1 expression in mononuclear phagocytes, including microglial cells. This study tested the hypothesis that sigma-1 receptors and trans...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.12.005

    authors： Gekker G,Hu S,Sheng WS,Rock RB,Lokensgard JR,Peterson PK

    更新日期：2006-06-01 00:00:00

  • AA092, an annonaceous acetogenin mimetic, attenuates angiogenesis in a mouse model of inflammation-induced corneal neovascularization.

    abstract：:Previous studies demonstrated that annonaceous acetogenin (AA) was an antitumor drug with anti-angiogenic activity. However, the effect of AA on ocular neovascular disorders remains unclear. The aim of the present study is to explore the effect of AA092, an annonaceous acetogenin mimetic, on corneal neovascularization...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.08.009

    authors： Zhang J,Zhou H,Jiang S,Jin J,Li W,Wang W,Su SB

    更新日期：2015-10-01 00:00:00

  • Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis.

    abstract：:There is currently no specific drug for the treatment of sepsis and antibiotic administration is considered the best option, despite numerous issues. Therefore, the development of drugs to control the pathogen-induced inflammatory responses associated with sepsis is essential. To address this, our study examined the t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.05.051

    authors： Lee SJ,Gharbi A,You JS,Han HD,Kang TH,Hong SH,Park WS,Jung ID,Park YM

    更新日期：2019-08-01 00:00:00

  • Induction of pro-inflammatory cytokine production in thymocytes by the immune response modifiers Imiquimod and Gardiquimod™.

    abstract：:An emerging role is postulated for IL-17-producing thymocytes, which in their majority consist of IL-17-producing CD4(+) cells. For these, a specific role in the immediate defense against infectious pathogens is suggested, independent from the development of an adaptive immune response in the immune periphery. Immune ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.06.023

    authors： Weber A,Zimmermann C,Mausberg AK,Kieseier BC,Hartung HP,Hofstetter HH

    更新日期：2013-10-01 00:00:00

  • Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway.

    abstract：:Recent studies showed that Madecassoside (MAD), a pentacyclic triterpene isolated from Centella asitica (L.), was used as a therapeutic agent in wound healing and also as an anti-inflammatory, anti-oxidative activities and anti-aging agent. However, its role in cancer has not been elucidated. In our present study, hep...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.01.027

    authors： Li Z,You K,Li J,Wang Y,Xu H,Gao B,Wang J

    更新日期：2016-04-01 00:00:00

  • Changes in maternal and fetal nicotine distribution after maternal administration of monoclonal nicotine-specific antibody to rats.

    abstract：:Vaccination against nicotine to elicit the production of nicotine-specific antibodies is a potential treatment for tobacco addiction which reduces nicotine distribution from serum to brain. Vaccination of pregnant rats also reduces the distribution of maternally-administered nicotine to the fetal brain. Whether this i...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.06.013

    authors： Keyler DE,Lesage MG,Dufek MB,Pentel PR

    更新日期：2006-11-01 00:00:00

  • Growth arrest-specific protein 6 (Gas6) attenuates inflammatory injury and apoptosis in iodine-induced NOD.H-2h4 mice.

    abstract：PURPOSE:Growth arrest-specific protein 6 (Gas6) is a vitamin K-dependent protein that plays an important role in the pathogenesis of autoimmune diseases. The purpose of this study was to explore the expression of Gas6 and its effects on autoimmune thyroiditis (AIT). METHOD:A total of 24 male NOD.H-2h4 mice were random...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.04.038

    authors： Sun X,Guan H,Peng S,Zhao Y,Zhang L,Wang X,Li C,Shan Z,Teng W

    更新日期：2019-08-01 00:00:00

  • Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy.

    abstract：BACKGROUND:Severe acute pancreatitis (SAP) is a common threat to human health. In the present study, we aimed to investigate the underlying mechanisms by which p38α in macrophages contributes to SAP. We used conditional knockout of p38α in macrophages and p38 MAPK inhibitors to understand the effects of p38α in macroph...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105940

    authors： Fan HN,Chen W,Fan LN,Wu JT,Zhu JS,Zhang J

    更新日期：2019-12-01 00:00:00

  • Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway.

    abstract：:This report sought to establish the mechanistic role of sirtuin-1 (Sirt1), a NAD+-dependent deacetylase in the modulation of primary biliary cholangitis (PBC) pathogenesis. 64 PBC patients (diagnosed based on practice guidelines for American Association for the Study of Liver Diseases) and 60 healthy controls were inc...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106386

    authors： Li Y,Xi Y,Tao G,Xu G,Yang Z,Fu X,Liang Y,Qian J,Cui Y,Jiang T

    更新日期：2020-06-01 00:00:00

  • Sirolimus as a new drug to treat RIF patients with elevated Th17/Treg ratio: A double-blind, phase II randomized clinical trial.

    abstract：BACKGROUND:RIF is clinically defined as the failure of good quality embryos to implant into the uterus following at least three cycles of In Vitro Fertilization/Embryo Transfer (IVF/ET). During human pregnancy, a genetically different fetus is allowed to survive within the uterus despite the maternal recognition of fet...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.intimp.2019.105730

    authors： Ahmadi M,Abdolmohamadi-Vahid S,Ghaebi M,Dolati S,Abbaspour-Aghdam S,Danaii S,Berjis K,Madadi-Javid R,Nouri Z,Siahmansouri H,Babaloo Z,Nouri M,Yousefi M

    更新日期：2019-09-01 00:00:00

  • Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury.

    abstract：:Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially fatal disease that is unpredictable and independent of the dose of the drug. Increasing evidence suggests that the majority of IDILI cases are immune-mediated, and the aberrant activation of inflammasome plays a vital role in progression. Psoral...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107352

    authors： Wang Y,Xu G,Wang Z,Li R,Zhan X,Liu H,Qin Q,Li W,Wang X,Zhang M,Tang J,Bai Z,Xiao X

    更新日期：2021-01-07 00:00:00

  • A novel chrysin thiazole derivative polarizes macrophages to an M1 phenotype via targeting TLR4.

    abstract：:Tumor-associated macrophages (TAMs) are an important cause of tumorigenesis and tumor development. M2 macrophages can promote tumor growth while M1 macrophages kill tumor cells, therefore, polarizing macrophages to achieve a functional M1 phenotype could effectively play its anti-tumor role. In the current study, we s...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106986

    authors： Feng X,Yu W,Cao L,Meng F,Cong M

    更新日期：2020-11-01 00:00:00

  • Imperatorin suppresses IL-1β-induced iNOS expression via inhibiting ERK-MAPK/AP1 signaling in primary human OA chondrocytes.

    abstract：:Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1β (IL-1β) induced express...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106612

    authors： Ahmad N,Ansari MY,Bano S,Haqqi TM

    更新日期：2020-08-01 00:00:00

  • Novel trisaccharide based phospholipids as immunomodulators.

    abstract：:A focused library of novel mannosylated glycophospholipids was synthesized employing imidate coupling and H-phosphate phosphorylation methods. All novel glycophospholipids were evaluated for their receptor interactions by molecular docking studies. Docking studies revealed dendritic cell-specific intercellular adhesio...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105684

    authors： Bonam SR,Bhunia D,Muller S,Nerella SG,Alvala M,Halmuthur Mahabalarao SK

    更新日期：2019-09-01 00:00:00

  • Crosstalk between Toll-like receptor 3 and Notch signaling contributes to CD14+ monocytes activity in enterovirus 71 infected hand, foot, and mouth disease.

    abstract：:Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.04.031

    authors： Hao J,Li P,Tian Y,Wang Y,Li S,Wang L,Li S

    更新日期：2018-07-01 00:00:00

  • Enhanced immunogenicity and cross-reactivity of HIV-1 V3-peptide and multiple antigen peptides conjugated to distinct carrier proteins.

    abstract：:To be effective, vaccines against the highly variable HIV-1 must elicit antibodies to a huge number of clinical isolates. For this purpose, new strategies to overcome this variability are needed. We previously reported a useful immunogenic strategy which consists of conjugating multiple antigen peptides (MAPs) to HBsA...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2009.08.026

    authors： Cruz LJ,Cabrales A,Iglesias E,Aguilar JC,González LJ,Reyes O

    更新日期：2009-11-01 00:00:00

  • Absolute reduction of regulatory T cells and regulatory effect of short-term and low-dose IL-2 in polymyositis or dermatomyositis.

    abstract：AIM:The study aimed to investigate the changes in peripherallymphocyte and CD4+T subsets and to observe the regulatory effect of low-dose interleukin-2 (ld-IL2) on these cells in polymyositis or dermatomyositis (PM/DM). METHODS:Lymphocyte subsets (CD3+T, CD4+T, CD8+T, B and natural killer (NK) cells), CD4+T subsets (T...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105912

    authors： Feng M,Guo H,Zhang C,Wang Y,Liang Z,Zhao X,Qin Y,Wu Y,Liu G,Gao C,Luo J

    更新日期：2019-12-01 00:00:00

  • DA-9601 suppresses 2, 4-dinitrochlorobenzene and dust mite extract-induced atopic dermatitis-like skin lesions.

    abstract：:DA-9601 (Stillen™) is a novel anti-peptic formulation prepared from the ethanol extracts of Artemisia asiatica possessing anti-oxidative, anti-allergic and anti-inflammatory activities. However, their effect on atopic dermatitis (AD) has not been studied yet. In this study, we report that topical application of DA-960...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.04.005

    authors： Choi EJ,Lee S,Hwang JS,Im SH,Jun CD,Lee HS,Kim SH

    更新日期：2011-09-01 00:00:00

  • Curcumin represses the activity of inhibitor-κB kinase in dextran sulfate sodium-induced colitis by S-nitrosylation.

    abstract：:In this study, we investigated the preventive effects of curcumin using dextran sulfate sodium (DSS)-induced colitis and the potential role of curcumin in regulation of anti-inflammation through S-nitrosylation. After curcumin treatment for 6days, the body weight and disease activity index of DSS-induced mice was alle...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.05.015

    authors： Kao NJ,Hu JY,Wu CS,Kong ZL

    更新日期：2016-09-01 00:00:00

  • DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.

    abstract：:Acute lung injury (ALI) is a severe disease characterized by several inflammatory responses in the lung with high mortality. We applied a mouse model of the pulmonary inflammation induced by the intratracheal instillation of bleomycin which is widely used to induce ALI and fibrosis in animal models. We hypothesized th...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106542

    authors： Lu CH,Chen CM,Ma J,Wu CJ,Chen LC,Kuo ML

    更新日期：2020-07-01 00:00:00

  • MiR-130b attenuates vascular inflammation via negatively regulating tumor progression locus 2 (Tpl2) expression.

    abstract：:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.07.020

    authors： Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

    更新日期：2017-10-01 00:00:00

  • Comparison of the efficacy of IGIV-C, 10% (caprylate/chromatography) and IGIV-SD, 10% as replacement therapy in primary immune deficiency. A randomized double-blind trial.

    abstract：:A novel method of large-scale chromatography has been developed to improve recovery and purity of immunoglobulin G (IgG) from pooled plasma. The current study compares safety, toxicity and efficacy of two intravenous immunoglobulin products: a novel formulation, IGIV caprylate/chromatography (IGIV-C; Gamunex, 10%) and...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s1567-5769(03)00134-6

    authors： Roifman CM,Schroeder H,Berger M,Sorensen R,Ballow M,Buckley RH,Gewurz A,Korenblat P,Sussman G,Lemm G

    更新日期：2003-09-01 00:00:00

  • Immunomodulation by ethanolic extract of Boerhaavia diffusa roots.

    abstract：:We have earlier reported that ethanolic extract of Boerhaavia diffusa, a plant used in Indian traditional system of medicine, significantly inhibits the cell proliferation. This led us to evaluate the immunomodulatory properties of this plant extract on various in vitro tests such as human natural killer (NK) cell cyt...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00031-0

    authors： Mehrotra S,Mishra KP,Maurya R,Srimal RC,Singh VK

    更新日期：2002-06-01 00:00:00

  • Evaluation of gene expression in human lymphocytes activated in the presence of melatonin.

    abstract：:The effect of melatonin on the expression of genes previously correlated to T lymphocyte activation (HLA-DRB, thymosin beta 10 (beta-Tim)) and to Lymphokine Activated Killer (LAK) activity (beta-Tim, Tumour Rejection Antigen (TRA 1), nRap 2) was investigated in phytohemagglutinin (PHA)-stimulated human lymphocyte cult...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(02)00021-8

    authors： Capelli E,Campo I,Panelli S,Damiani G,Barbone MG,Lucchelli A,Cuccia M

    更新日期：2002-06-01 00:00:00