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Evaluation of gene expression in human lymphocytes activated in the presence of melatonin.

Abstract：

:The effect of melatonin on the expression of genes previously correlated to T lymphocyte activation (HLA-DRB, thymosin beta 10 (beta-Tim)) and to Lymphokine Activated Killer (LAK) activity (beta-Tim, Tumour Rejection Antigen (TRA 1), nRap 2) was investigated in phytohemagglutinin (PHA)-stimulated human lymphocyte cultures. The aim was to find an enhancing effect of this substance on anti-tumoral immune defences as suggested by studies on tumour progression in mice and clinical immunotherapy trials in humans. mRNA obtained from melatonin-treated and -untreated PHA-stimulated lymphocytes was retrotranscribed and amplified by RT-PCR using primers based on the sequences of the selected genes. The results suggest that melatonin does not increase T and LAK cell responses: in fact, a reduction in the transcription of all the considered genes was observed. These data are correlated with the antiproliferative effect of melatonin observed in in vitro treated lymphocytes.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Capelli E,Campo I,Panelli S,Damiani G,Barbone MG,Lucchelli A,Cuccia M

doi

10.1016/s1567-5769(02)00021-8

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

885-92

issue

7

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(02)00021-8

journal_volume

2

pub_type

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