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Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation.

Abstract：

:IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear healthy and do not exhibit overt clinical or laboratory abnormalities. We induced comparable levels of aAb-IL-6 in different mouse strains by vaccination with immunogenic IL-6 analogues. We observed that the induced aAb-IL-6 protected against collagen-induced arthritis and experimental allergic encephalitis. Furthermore, aAb-IL-6 carrying mice displayed increased plasma TNFalpha concentrations upon challenge with LPS. Taken together, induction of IL-6 autoantibodies was possible in different mouse strains. The autoantibodies influenced experimental inflammation. This immunotherapeutic principle might be a viable alternative in immune competent humans suffering from disorders driven by IL-6.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Galle P,Jensen L,Andersson C,Cuzzocrea S,Di Paola R,Nicoletti F,Svenson M,Bendtzen K,Thomsen AR,Hansen MB

doi

10.1016/j.intimp.2007.08.026

subject

Has Abstract

pub_date

2007-12-15 00:00:00

pages

1704-13

issue

13

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(07)00279-2

journal_volume

7

pub_type

杂志文章

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