当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway.

Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway.

Abstract：

:Recent studies showed that Madecassoside (MAD), a pentacyclic triterpene isolated from Centella asitica (L.), was used as a therapeutic agent in wound healing and also as an anti-inflammatory, anti-oxidative activities and anti-aging agent. However, its role in cancer has not been elucidated. In our present study, hepatocyte growth factor (HGF) induced the phosphorylation of its corresponding receptor cMET, increased expression of cyclo-oxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in human hepatocellular carcinoma (HCC) cells lines (HepG2 and SMMC-77), and this effect was inhibited by MAD in a dose-dependent manner. In addition, MAD exhibited significant anti-proliferative and anti-invasive effect in HGF-induced HepG2 and SMMC-77 cells. Moreover, MAD inhibited the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and the protein kinase C (PKC) activity in HGF-induced HepG2 and SMMC-77 cells. This conclusion was consistent with the effect of selective COX-2 inhibitor (NS-398) and knockdown of COX-2 by siRNA on attenuating the proliferation and invasiveness potential, and over-expression of COX-2 on abolishing the effects of MAD on proliferation and invasiveness potential, and was also in parallel with the effect of PKC inhibitor (Bisindolylmaleimide) on inhibiting PKC activity, MEK/ERK1/2 inhibitor (PD98059) inhibited MEK/ERK1/2 pathways in HGF-induced HepG2 and SMMC-77 cells. Collectively, MAD could inhibit the HGF-activated proliferation and invasiveness of HCC cells via regulating the activation of cMET-PKC-ERK1/2-COX-2-PGE2 cascade, which indicated that MAD might help control HGF-linked HCC.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Li Z,You K,Li J,Wang Y,Xu H,Gao B,Wang J

doi

10.1016/j.intimp.2016.01.027

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

24-32

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30027-3

journal_volume

33

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models.

    abstract：:AST2017-01 mainly consists of Rumex crispus and -Cordyceps militaris and has been widely consumed as an herbal medicine or functional food in Korea. Here we investigated the influences of AST2017-01 and its active component, chrysophanol on human mast cell (HMC-1 cell) and human keratinocyte (HaCaT cell)-mediated infl...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.11.019

    authors： Jeong HJ,Kim HY,Kim HM

    更新日期：2018-01-01 00:00:00

  • Alterations in peripheral blood B cells in systemic lupus erythematosus patients with renal insufficiency.

    abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is one of the autoimmune diseases, believed to be closely related to hyperactivity of B cells, overproduction of autoantibodies and immune complex formation and deposition in affected tissue. The autoreactive inflammation leads to multiorgan damage with kidney dysfunction in...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106451

    authors： Wardowska A,Komorniczak M,Skoniecka A,Bułło-Piontecka B,Lisowska KA,Dębska-Ślizień MA,Pikuła M

    更新日期：2020-06-01 00:00:00

  • Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension.

    abstract：:Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and seru...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106789

    authors： Zhong Y,Tang R,Lu Y,Wang W,Xiao C,Meng T,Ao X,Li X,Peng L,Kwadwo Nuro-Gyina P,Zhou Q

    更新日期：2020-10-01 00:00:00

  • Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling.

    abstract：:Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.10.022

    authors： Hairul-Islam MI,Saravanan S,Thirugnanasambantham K,Chellappandian M,Simon Durai Raj C,Karikalan K,Gabriel Paulraj M,Ignacimuthu S

    更新日期：2017-12-01 00:00:00

  • Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review.

    abstract：:Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.06.023

    authors： Majdalawieh AF,Fayyad MW

    更新日期：2015-09-01 00:00:00

  • Iguratimod (T-614) suppresses RANKL-induced osteoclast differentiation and migration in RAW264.7 cells via NF-κB and MAPK pathways.

    abstract：INTRODUCTION:Iguratimod (T-614) has been confirmed as a highly efficacious and safe novel disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis therapy in China and Japan due to its potent anti-inflammation effect. Here, we investigate the effects of Iguratimod on osteoclast differentiation, migration ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.03.038

    authors： Gan K,Yang L,Xu L,Feng X,Zhang Q,Wang F,Tan W,Zhang M

    更新日期：2016-06-01 00:00:00

  • Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy.

    abstract：BACKGROUND:Severe acute pancreatitis (SAP) is a common threat to human health. In the present study, we aimed to investigate the underlying mechanisms by which p38α in macrophages contributes to SAP. We used conditional knockout of p38α in macrophages and p38 MAPK inhibitors to understand the effects of p38α in macroph...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105940

    authors： Fan HN,Chen W,Fan LN,Wu JT,Zhu JS,Zhang J

    更新日期：2019-12-01 00:00:00

  • Increased Galectin-9 expression, a prognostic biomarker of aGVHD, regulates the immune response through the Galectin-9 induced MDSC pathway after allogeneic hematopoietic stem cell transplantation.

    abstract：:Galectin-9 (Gal-9) is a β-galactoside-binding soluble lectin family member that exerts its primary biological functions via specific glycoconjugate interactions. Gal-9 expression is closely related to tumor occurrence, development, metastasis and prognosis. In transplant immunology, a high level of Gal-9 expression ha...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106929

    authors： Yin J,Li L,Wang C,Zhang Y

    更新日期：2020-11-01 00:00:00

  • A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice.

    abstract：:Isoflavones, which are phytoestrogens present in large quantities in soy and soy-derived products, have estrogenic activity, inhibit protein tyrosine kinase, and exert other effects in the human body. Thus, the recent spread of soy consumption in Western populations emphasizes the need to more fully understand the pot...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.04.011

    authors： Zhao JH,Sun SJ,Horiguchi H,Arao Y,Kanamori N,Kikuchi A,Oguma E,Kayama F

    更新日期：2005-10-01 00:00:00

  • The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.

    abstract：:1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1 during treatment with glucocorticoids ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.01.003

    authors： Sinniah A,Yazid S,Perretti M,Solito E,Flower RJ

    更新日期：2016-03-01 00:00:00

  • Primary immunosuppression with tacrolimus after liver transplantation: 12-years follow-up.

    abstract：:The early safety and efficacy of tacrolimus after liver transplantation has been shown in two multicenter trials. Herein, we report our single-center long-term follow-up of a randomized controlled trial. As part of a European multicenter trial, 121 patients entered the study at our institution and were randomly assign...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.intimp.2004.09.014

    authors： Jonas S,Neuhaus R,Junge G,Klupp J,Theruvat T,Langrehr JM,Settmacher U,Neuhaus P

    更新日期：2005-01-01 00:00:00

  • Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity.

    abstract：BACKGROUND:IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic inflammatory/autoimmune mediated diseases. Experimental models of arthritis and clinical indications have highlighted an...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.12.011

    authors： Zaky DS,El-Nahrery EM

    更新日期：2016-02-01 00:00:00

  • The role of pirfenidone in alkali burn rat cornea.

    abstract：:To evaluate the effects of pirfenidone in the treatment of HUVEC using an in vitro model and on rat corneal wound healing, edema, cornea neovascularization (CNV) and inflammation after alkali burn in vivo model. In vitro, CCK-8 assay was used to detect the effect of pirfenidone on the viability of HUVECs. The effects ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.08.032

    authors： Jiang N,Ma M,Li Y,Su T,Zhou XZ,Ye L,Yuan Q,Zhu P,Min Y,Shi W,Xu X,Lv J,Shao Y

    更新日期：2018-11-01 00:00:00

  • Fosfomycin inhibits neutrophil function via a protein kinase C-dependent signaling pathway.

    abstract：:We investigated effects of fosfomycin (FOM) on neutrophil function, specifically the oxidative burst and adhesion molecule expression (CD11b/CD18, or MAC-1) using flow cytometry assay. Preincubation of polymorphonuclear leukocytes (PMNL) with FOM from 1 to 100 microg/ml prior to stimulation by phorbol 12-myristate 13-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00194-1

    authors： Hamada M,Honda J,Yoshimuta T,Fumimori T,Okamoto M,Aizawa H

    更新日期：2002-03-01 00:00:00

  • Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines.

    abstract：:The alteration of T helper 1 (TH1) and TH2 responses and related cell-mediated immunity has been supposed to be associated with the immunological pathogenesis in the development of schizophrenia. Increasing evidence suggested the alteration of cytokines in accordance with the antipsychotic treatment as well, so that t...

    journal_title：International immunopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.intimp.2005.10.004

    authors： Pae CU,Yoon CH,Kim TS,Kim JJ,Park SH,Lee CU,Lee SJ,Lee C,Paik IH

    更新日期：2006-04-01 00:00:00

  • Icariin attenuates glucocorticoid insensitivity mediated by repeated psychosocial stress on an ovalbumin-induced murine model of asthma.

    abstract：:Evidence shows that psychosocial stress exacerbates asthma, but there is little intervention to alleviate negative effects of psychosocial stress on asthma. We investigated the role of icariin in anti-inflammation and anti-anxiety potential in a murine model combined psychosocial stress with allergic exposure. The res...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.01.009

    authors： Li B,Duan X,Xu C,Wu J,Liu B,Du Y,Luo Q,Jin H,Gong W,Dong J

    更新日期：2014-04-01 00:00:00

  • Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters.

    abstract：:Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2010.07.016

    authors： Inoue K,Koike E,Takano H

    更新日期：2010-11-01 00:00:00

  • Preparation and characterization of a new monoclonal antibody against CXCR4 using lentivirus vector.

    abstract：:CXCR4 is a member of chemokine receptors and plays a vital role in numerous diseases and cancer processes, which makes the CXCR4/CXCL12 chemotactic axis a potential therapeutic target. In this study, we used lentiviral vectors as a novel technology to produce a monoclonal antibody against CXCR4. Lentivirus vector pLV-...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.04.020

    authors： Li X,Kuang Y,Huang X,Zou L,Huang L,Yang T,Li W,Yang Y

    更新日期：2016-07-01 00:00:00

  • Indirubin-3'-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain.

    abstract：:Deciphering the molecular mechanisms of amyloid pathology and glial cell-mediated neuroinflammation, offers a novel avenue for therapeutic intervention against neurodegeneration. Recent findings demonstrate a crucial link between activation of glycogen synthase kinase-3β (GSK-3β), amyloid deposition and a neuroinflamm...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.02.053

    authors： Sathiya Priya C,Vidhya R,Kalpana K,Anuradha CV

    更新日期：2019-05-01 00:00:00

  • Bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by upregulating microRNA-26a expression.

    abstract：OBJECTIVE:Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been widely applied in disease therapies. However, the role of BMSCs-derived exosomes in depression remains obscure. This study aims to explore the mechanism of BMSCs-derived exosomal microRNA-26a (miR-26a) on hippocampal neuronal injury of depr...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106285

    authors： Guo H,Huang B,Wang Y,Zhang Y,Ma Q,Ren Y

    更新日期：2020-02-20 00:00:00

  • Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor.

    abstract：PURPOSE:We examined the effects of the immunosuppressive neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) on rat endotoxin-induced uveitis, and to measure the expression of inflammatory cytokines and chemokines with and without the alpha-MSH treatment over the course of the disease. METHODS:We injected Le...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2004.04.011

    authors： Nishida T,Miyata S,Itoh Y,Mizuki N,Ohgami K,Shiratori K,Ilieva IB,Ohno S,Taylor AW

    更新日期：2004-08-01 00:00:00

  • Immunotherapeutic modulation of the suppressive liver and tumor microenvironments.

    abstract：:The liver is an immunologically unique organ, consisting of resident hematopoietic and parenchymal cells which often contribute to a relatively tolerant microenvironment. It is also becoming increasingly clear that tumor-induced immunosuppression occurs via many of the same cellular mechanisms which contribute to the ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2010.12.024

    authors： Chan T,Wiltrout RH,Weiss JM

    更新日期：2011-07-01 00:00:00

  • Anti-nicotine vaccines: Comparison of adjuvanted CRM197 and Qb-VLP conjugate formulations for immunogenicity and function in non-human primates.

    abstract：:Anti-nicotine vaccines comprise nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). Unfortunately, those tested clinically have failed to improve overall long term quit rates. We had shown in mice that carrier, hapten, linker, hapten load (number of haptens per carrier molecule), aggregation and ad...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2015.09.012

    authors： McCluskie MJ,Thorn J,Gervais DP,Stead DR,Zhang N,Benoit M,Cartier J,Kim IJ,Bhattacharya K,Finneman JI,Merson JR,Davis HL

    更新日期：2015-12-01 00:00:00

  • Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis.

    abstract：:Interleukin (IL)-35 plays an important role in the pathogenesis of rheumatoid arthritis (RA), which is characterized by tumor necrosis factor (TNF)-α activated bone loss beginning early and persisting over time. The aim of this study was to explore the effects and signaling pathway of IL-35 on osteoblasts differentiat...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105810

    authors： Li Y,Yuan L,Jiang S,Liu S,Xia L,Shen H,Lu J

    更新日期：2019-10-01 00:00:00

  • Future perspectives of a cardiac non-neuronal acetylcholine system targeting cardiovascular diseases as an adjunctive tool for metabolic intervention.

    abstract：:It has been several years since the function of the non-neuronal cholinergic system was independently reported in cardiomyocytes by several research groups. Although these findings initially seemed to be negligible and insignificant, extraordinary findings about cardiomyocytes were subsequently reported in studies inv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.05.029

    authors： Kakinuma Y

    更新日期：2015-11-01 00:00:00

  • Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

    abstract：:Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the present study aims to explore whether the anti-depressive effect of curcu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2018.12.012

    authors： Zhang WY,Guo YJ,Han WX,Yang MQ,Wen LP,Wang KY,Jiang P

    更新日期：2019-02-01 00:00:00

  • Development of a novel method to measure macrophage migration inhibitory factor (MIF) in sera of patients with rheumatoid arthritis by combined electrochemical immunosensor.

    abstract：:Macrophage migration inhibitory factor (MIF) has a multitude of biological activity and is associated with a number of inflammatory and immune diseases, including rheumatoid arthritis (RA). The increased serum levels of MIF in patients not only suggest this protein as a marker for disease progression, but also as a po...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.01.032

    authors： Li S,Zhang R,Li P,Yi W,Zhang Z,Chen S,Su S,Zhao L,Hu C

    更新日期：2008-06-01 00:00:00

  • Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK.

    abstract：:Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.04.002

    authors： Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

    更新日期：2017-06-01 00:00:00

  • GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

    abstract：:Chronic cold stress has long-term dramatic effects on the animal immune and neuroendocrine systems. As one of the important regions of the brain, the hippocampus is the main region involved in response to stressors. Nevertheless, the impact to the hippocampus following cold exposure and the underlying mechanism involv...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106908

    authors： Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

    更新日期：2020-12-01 00:00:00

  • Comparison in the effects of IL-2, IL-12, IL-15 and IFNalpha on gene regulation of granzymes of human NK cell line NK-92.

    abstract：:Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFNalpha differently regulated the expression of granzymes in NK cells. Althoug...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.03.001

    authors： Zhang B,Zhang J,Tian Z

    更新日期：2008-07-01 00:00:00