Abstract:
:Rheumatoid arthritis is a common autoimmune disease primarily characterized by chronic inflammation, the formation of an invasive pannus, and destruction of the joints. In the present study, we employed real-time PCR and western blot analysis to investigate the role of dulaglutide in human fibroblast-like synoviocytes (FLS). The results of our study show that dulaglutide exerted a powerful protective effect by rescuing mitochondrial membrane potential, inhibiting the production of NOX-4, and abrogating TNF-α-induced downregulation of the antioxidant GSH. Our findings demonstrate that dulaglutide significantly ameliorated the expression of proinflammatory cytokines and chemokines including IL-1β, IL-6, MCP-1, and HMGB-1. Matrix metalloproteinases mediate cartilage destruction, thereby aiding in pannus formation. Our findings indicate that dulaglutide treatment significantly downregulated the expression of MMP-3 and MMP-13, two crucial degradative enzymes. Importantly, the results of our study demonstrate that the beneficial effects of dulaglutide are mediated through the JNK/NF-κB signaling pathway, which has been suggested as a potential treatment target against RA. Taken together, the results of this study show that dulaglutide may exert significant protective effects against the progression of RA induced by TNF-α.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Zheng W,Pan H,Wei L,Gao F,Lin Xdoi
10.1016/j.intimp.2019.05.034subject
Has Abstractpub_date
2019-09-01 00:00:00pages
105649eissn
1567-5769issn
1878-1705pii
S1567-5769(19)30741-6journal_volume
74pub_type
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journal_title:International immunopharmacology
pub_type: 杂志文章
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.intimp.2007.02.006
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.12.017
更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.intimp.2019.02.053
更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.intimp.2006.04.018
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pub_type: 杂志文章
doi:10.1016/j.intimp.2014.06.041
更新日期:2014-10-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2020.106336
更新日期:2020-06-01 00:00:00
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doi:10.1016/j.intimp.2019.04.011
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pub_type: 杂志文章
doi:10.1016/j.intimp.2020.106789
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pub_type: 杂志文章
doi:10.1016/j.intimp.2018.06.008
更新日期:2018-08-01 00:00:00
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doi:10.1016/j.intimp.2019.105802
更新日期:2019-10-01 00:00:00
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doi:10.1016/j.intimp.2012.02.005
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1016/j.intimp.2019.05.033
更新日期:2019-08-01 00:00:00