Relationship between certain T helper cytokines and ANA staining: who is the helper?

abstract：:A procedure was developed for the determination of low levels of the anthraquinones aloe-emodin and aloin A (barbalin) in aloe products based on gas chromatography/mass spectrometry (GC/MS) of the trimethyl silyl (TMS) derivatives of these analytes in the presence of Chrysophanol used as internal standard. The method ...

journal_title：International immunopharmacology

authors： ElSohly MA,Gul W,Murphy TP

更新日期：2004-12-20 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced TLR4-NF-(K)B signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic infection. Although many studies support the role of selenium in protecting against the development of prostate cancer secondary to chronic prostatitis, the mechanism ...

journal_title：International immunopharmacology

authors： Pei Z,Li H,Guo Y,Jin Y,Lin D

更新日期：2010-01-01 00:00:00

abstract：:Anemoside B4 (B4) is a compound extracted from Pulsatilla chinensis(P. chinensis). Pharmacological studies have proved that it has certain anti-inflammatory activity. Acute ulcerative colitis (ulcerative colitis) is a non-specific inflammatory disease whose pathogenesis is not completely known, and there is no effecti...

journal_title：International immunopharmacology

authors： Ma H,Zhou M,Duan W,Chen L,Wang L,Liu P

更新日期：2020-10-01 00:00:00

abstract：:We had reported that in the ischemic heart, locally formed bradykinin (BK) and angiotensin II (Ang II) activate B2- and AT1-receptors on sympathetic nerve terminals (SNE), promoting reversal of the norepinephrine (NE) transporter in an outward direction (i.e., carrier-mediated NE release). Although both BK and Ang II ...

journal_title：International immunopharmacology

authors： Levi R,Silver RB,Mackins CJ,Seyedi N,Koyama M

更新日期：2002-12-01 00:00:00

abstract：:Despite the use of increasingly specific immunosuppressive therapy, rejection remains the leading cause of death in cardiac transplant patients. Endomyocardial biopsy (EMB) is the gold standard for early detection and monitoring of cardiac transplant rejection. However, this approach is invasive and not suitable for r...

journal_title：International immunopharmacology

authors： Zupan I,Vrtovec B,Breskvar UD,Gabrijelcic T

更新日期：2005-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) synovial fibroblasts produce inflammatory mediators, which destruct cartilage and bone in RA joint. The aim of this study is to investigate the effect of myricetin on inflammatory cytokine/matrix metalloproteinase (MMP) production and mitogen-activated protein kinases (MAPKs) in IL-1beta-stim...

journal_title：International immunopharmacology

authors： Lee YS,Choi EM

更新日期：2010-07-01 00:00:00

abstract：:Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-infla...

journal_title：International immunopharmacology

authors： Funakoshi-Tago M,Ohsawa K,Ishikawa T,Nakamura F,Ueda F,Narukawa Y,Kiuchi F,Tamura H,Tago K,Kasahara T

更新日期：2016-11-01 00:00:00

abstract：:Dipeptidyl-peptidase 4 (DPP-4) inhibitor (sitagliptin) is a novel anti-hyperglycemia drug in the treatment of type 2 diabetes. However, its potential in type 1 diabetes is still unclear. Recent studies show that increased infection, especially respiratory tract infection, is significantly associated with DPP-4 inhibit...

journal_title：International immunopharmacology

authors： He X,Li W,Xie Y,Zhao Y

更新日期：2020-11-01 00:00:00

abstract：:Lung cancer is the major cause of cancer-related mortality and is a growing economic burden worldwide. Chemoprevention has emerged as a very effective preventive measure against carcinogenesis and several bioactive compounds in diet have shown their cancer curative potential on lung cancer. Naringenin (NRG), a predomi...

journal_title：International immunopharmacology

authors： Bodduluru LN,Kasala ER,Madhana RM,Barua CC,Hussain MI,Haloi P,Borah P

更新日期：2016-01-01 00:00:00

abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

journal_title：International immunopharmacology

authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

更新日期：2001-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic immuno-inflammatory disease of the central nervous system characterized by demyelination and axonal damage. Cognitive changes are common in individuals with MS since inflammatory molecules secreted by microglia interfere with the physiological mechanisms of synaptic plasticity. Acc...

journal_title：International immunopharmacology

authors： Araújo SMDR,Duarte-Silva E,Marinho CGS,Oliveira WH,França MER,Lós D,Peron G,Tomaz L,Bonfanti AP,Verinaud L,Peixoto CA

更新日期：2020-08-01 00:00:00

abstract：:Microglial inflammation induced by ischemic stroke aggravates brain damage. MicroRNAs (miRNAs) have emerged as pivotal regulators in ischemic stroke-induced inflammation in microglial cells. miR-665-3p has been reported as a critical inflammation-associated miRNA. However, whether miR-665-3p participates in regulating...

journal_title：International immunopharmacology

authors： Zhang X,Feng Y,Li J,Zheng L,Shao Y,Zhu F,Sun X

更新日期：2020-08-01 00:00:00

abstract：:Oridonin is a natural compound purified from Rabdosia rubescens that has remarkable anti-inflammatory and antitumor activities. Although oridonin has been used in traditional Chinese medicine for many years to treat inflammatory diseases, the underlying mechanisms of these activities are not well understood. In this p...

journal_title：International immunopharmacology

authors： Guo W,Zheng P,Zhang J,Ming L,Zhou C,Zhang S

更新日期：2013-12-01 00:00:00

abstract：:There is increasing evidence that neuronal factors can affect hematopoietic cell proliferation. Endogenous opioids with specificity for several opioid receptor classes were tested for their ability to inhibit murine and human hematopoietic progenitor cell proliferation. Tyr-MIF, an opioid tetrapeptide (H-Tyr-Pro-Leu-G...

journal_title：International immunopharmacology

authors： Horowitz D,Callahan JF,Pelus LM,Fukuda S,King AG

更新日期：2002-04-01 00:00:00

abstract：:Prenylated flavonoids are a unique class of naturally occurring flavonoids that have various pharmacological activities. In the present study, we investigated the anti-inflammatory effect in murine macrophages of a prenylated flavonoid, 10-oxomornigrol F (OMF), which was isolated from the twigs of Morus alba (Moraceae...

journal_title：International immunopharmacology

authors： Tran PL,Tran PT,Tran HNK,Lee S,Kim O,Min BS,Lee JH

更新日期：2018-02-01 00:00:00

abstract：:The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the ...

journal_title：International immunopharmacology

authors： Jiang S,Golshayan D,Tsang J,Lombardi G,Lechler RI

更新日期：2006-12-20 00:00:00

abstract：:Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

journal_title：International immunopharmacology

authors： Sahu KK,Pandey RS

更新日期：2016-10-01 00:00:00

abstract：:This study was conducted to investigate the protective roles of soy isoflavone in weaned pigs challenged with lipopolysaccharide (LPS). A total of 72 weaned piglets (14 days of age) were randomly allotted into either 0 (control group) or 40 mg/kg soy isoflavone (ISO) supplementation group. On days 7 and 14, half of th...

journal_title：International immunopharmacology

authors： Zhu C,Wu Y,Jiang Z,Zheng C,Wang L,Yang X,Ma X,Gao K,Hu Y

更新日期：2015-09-01 00:00:00

abstract：:Human melanoma Colo 679 cells were made resistant to doxorubicin (adriamycin, ADM) by continuous exposure to ascending concentrations of the drug and Colo/ADM80; a variant which grew continuously in the presence of 80 ng/ml of ADM was thus established. Human peripheral blood mononuclear cells (PBMC) produced interfero...

journal_title：International immunopharmacology

authors： Micallef MJ,Darmanin S,Buhagiar JA,Camilleri-Podesta MT,Yamauchi H,Kurimoto M,Inglott AS,Ellul-Micallef R

更新日期：2001-02-01 00:00:00

abstract：:Hereditary Angioedema (HAE) is a rare, autosomal dominant disease caused by mutations in SERPING1 gene leading to dysfunction/deficiency of C1-esterase inhibitor (C1-INH) protein and subsequent dysregulation of the contact system and bradykinin overproduction. As functional C1-INH (fC1-INH) levels are reduced in HAE t...

journal_title：International immunopharmacology

authors： Chockalingam PS,Zhou Z,Garg BK,Boehringer H,Chung R,Fait S

更新日期：2020-06-01 00:00:00

abstract：:Monocytes and macrophages of individuals with allergic diseases express increased levels of the low-affinity IgE receptors (FcepsilonRII or CD23) on their surfaces. The cross-linking of CD23-bound IgE antibody by allergen activates the cells to release inflammatory mediators. In mast cells, the binding of IgE to the h...

journal_title：International immunopharmacology

authors： Ezeamuzie CI,Al-Attiyah R,Shihab PK,Al-Radwan R

更新日期：2009-08-01 00:00:00

abstract：:Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS). After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact ...

journal_title：International immunopharmacology

authors： Zhang Y,Liu J,Jia W,Zhao A,Li T

更新日期：2005-12-01 00:00:00

abstract：:Skin cutaneous melanoma (SKCM) is the most invasive form of skin cancer with poor prognosis. Growing evidence has demonstrated that tumor immune microenvironment plays a key contributing role in tumorigenesis and predicting clinical outcomes. The aim of this study was to recognize immune classification and a reliable ...

journal_title：International immunopharmacology

authors： Hu B,Wei Q,Zhou C,Ju M,Wang L,Chen L,Li Z,Wei M,He M,Zhao L

更新日期：2020-12-01 00:00:00

abstract：:Herbal medicine, Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.), was administered to mice with Behcet's disease (BD)-like symptoms induced by herpes simplex virus (HSV). BD is a chronic recurrent inflammatory disease. Herba Taraxaci (6 mg) was administered alone or in combination with 2 microg of colchicine to BD-l...

journal_title：International immunopharmacology

authors： Sohn S,Bang D,Lee SI,Kim YA,Lee ES,Ha JY,Kim JH,Choi SY,Lee S

更新日期：2003-05-01 00:00:00

abstract：:In our previous study, we reported the isolation of a novel humulene derivative, 5-hydroxyzerumbone, from Zingiber zerumbet and its inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 mouse macrophage cells. This study was performed to examine its mechanism of action on th...

journal_title：International immunopharmacology

authors： Min HY,Kim MS,Jang DS,Park EJ,Seo EK,Lee SK

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

journal_title：International immunopharmacology

authors： Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

更新日期：2021-02-01 00:00:00

abstract：:Dihydrofisetin is a flavanonol derived from some edible wild herbs and traditional Chinese medicines. It has been found to possess many biological activities. However, the anti-inflammatory potential of Dihydrofisetin remains uncharacterized. The aim of the present study was to investigate the anti-inflammatory activi...

journal_title：International immunopharmacology

authors： Li KK,Shen SS,Deng X,Shiu HT,Siu WS,Leung PC,Ko CH,Cheng BH

更新日期：2018-01-01 00:00:00

abstract：:Accumulating evidence indicates that microRNA-146a (miR-146a), a well-known anti-inflammatory miRNA, acts as a negative feedback regulator of the innate immune response, but its role in modulation of inflammatory bowel disease (IBD) remains unclear and the issue related to the stability of exogenous miR-146a in blood ...

journal_title：International immunopharmacology

authors： Wu H,Fan H,Shou Z,Xu M,Chen Q,Ai C,Dong Y,Liu Y,Nan Z,Wang Y,Yu T,Liu X

更新日期：2019-03-01 00:00:00

abstract：:Due to the broad anti-inflammatory and immunomodulatory actions of phosphodiesterase (PDE) 4 inhibitors, it has been proposed that PDE4 inhibitors might be efficacious for skin disorders such as atopic dermatitis. KF66490 is a newly developed PDE4 inhibitor that inhibits PDE4B (IC(50)=220 nM) and the production of tum...

journal_title：International immunopharmacology

authors： Harada D,Takada C,Nosaka Y,Takashima Y,Kobayashi K,Takaba K,Manabe H

更新日期：2009-01-01 00:00:00

abstract：:Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes. In addition to the bacterial peptide fMLF and the...

journal_title：International immunopharmacology

authors： Le Y,Yang Y,Cui Y,Yazawa H,Gong W,Qiu C,Wang JM

更新日期：2002-01-01 00:00:00