Abstract:
:We studied the suitability of our murine model for the treatment trials of atopic dermatitis (AD). In this model topical application of ovalbumin (OVA) together with bacterial superantigen, staphylococcal enterotoxin B (SEB) induces a cutaneous disease resembling AD. Injured mouse skin was treated with three different drugs: a class III corticosteroid, a calcineurin inhibitor and a type 4 phosphodiesterase inhibitor. One-week treatment with corticosteroid and phosphodiesterase inhibitor remarkably decreased both epidermal and dermal thickness, whereas the calcineurin inhibitor affected only the epidermal thickness. All investigated drugs reduced the infiltration of eosinophils and mast cells onto OVA/SEB sensitized skin areas, whereas CD4+ and CD8+ T cells as well as CD11c+ dendritic cells variously diminished after corticosteroid and calcineurin inhibitor treatments. Cutaneous expression of interleukin -4, -13, -10 and interferon-gamma also decreased differently depending on drug type. Interestingly, the calcineurin inhibitor and phosphodiesterase inhibitor increased total IgE antibodies and decreased SEB-specific IgG2a antibodies in OVA/SEB sensitized mice. All these drugs can ameliorate cutaneous inflammation, although the degree of recovery depends on the type of the drug. In summary, our results show that this mouse model can be used to test new topical treatments for AD.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Lehto M,Savinko T,Wolff H,Kvist PH,Kemp K,Lauerma A,Alenius Hdoi
10.1016/j.intimp.2010.01.001subject
Has Abstractpub_date
2010-04-01 00:00:00pages
377-84issue
4eissn
1567-5769issn
1878-1705pii
S1567-5769(10)00004-4journal_volume
10pub_type
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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更新日期:2017-05-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.06.024
更新日期:2014-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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