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Differential anti-inflammatory and analgesic effects by enantiomers of zaltoprofen in rodents.

Abstract：

:In the present study, we investigated the effect of zaltoprofen enantiomers on inflammation and pain and compared their effect with racemic zaltoprofen. S(+)-zaltoprofen potently inhibited the inflammatory response in carrageenan-induced paw edema model, whereas R(-)-zaltoprofen did not. Moreover, the anti-inflammatory effect of S(+)-zaltoprofen was stronger than that of racemic zaltoprofen, suggesting that S(+)-zaltoprofen is an active component of racemic zaltoprofen in terms of anti-inflammatory activity. In contrast, the results of acetic acid-induced writhing model demonstrated that no significant analgesic effect was observed by racemic zaltoprofen and zaltoprofen enantiomers at doses used in carrageenan-induced paw edema model. However, racemic zaltoprofen and zaltoprofen enantiomers all exerted an analgesic effect at higher doses, which is inconsistent with the result of carrageenan-induced paw edema model. Gastric ulcers induced by racemic zaltoprofen and zaltoprofen enantiomers were minimal. Taken together, these results suggest that S(+)-zaltoprofen is a potent and active anti-inflammatory component of racemic zaltoprofen, but both S(+)-zaltoprofen and R(-)-zaltoprofen might seem to contribute to the analgesic effect of racemic zaltoprofen.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Cho IJ,Lee CW,Lee MY,Kang MR,Yun J,Oh SJ,Han SB,Lee K,Park SK,Kim HM,Jung SH,Kang JS

doi

10.1016/j.intimp.2013.05.008

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

457-60

issue

4

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(13)00188-4

journal_volume

16

pub_type

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